3zg0 - Revision history

OCA at 11:01, 20 December 2023

OCA — Wed, 20 Dec 2023 11:01:13 GMT

←Older revision		Revision as of 11:01, 20 December 2023
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	<StructureSection load='3zg0' size='340' side='right'caption='[[3zg0]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3zg0' size='340' side='right'caption='[[3zg0]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zg0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Staam Staam~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZG0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZG0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zg0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZG0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZG0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1W8:CEFTAROLINE'>1W8</scene>, <scene name='pdbligand=AI8:CEFTAROLINE,+BOUND+FORM'>AI8</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zfz\|3zfz]], [[3zg5\|3zg5]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1W8:CEFTAROLINE'>1W8</scene>, <scene name='pdbligand=AI8:CEFTAROLINE,+BOUND+FORM'>AI8</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Serine-type_D-Ala-D-Ala_carboxypeptidase Serine-type D-Ala-D-Ala carboxypeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.16.4 3.4.16.4] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zg0 OCA], [https://pdbe.org/3zg0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zg0 RCSB], [https://www.ebi.ac.uk/pdbsum/3zg0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zg0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zg0 OCA], [https://pdbe.org/3zg0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zg0 RCSB], [https://www.ebi.ac.uk/pdbsum/3zg0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zg0 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0H3JPA5_STAAM A0A0H3JPA5_STAAM]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Serine-type D-Ala-D-Ala carboxypeptidase]]~~	+	[[Category: Staphylococcus aureus subsp. aureus Mu50]]
-	~~[[Category: Staam~~]]	+	[[Category: Hermoso JA]]
-	[[Category: Hermoso~~, J A~~]]	+	[[Category: Otero LH]]
-	[[Category: Otero~~, L H~~]]	+	[[Category: Rojas-Altuve A]]
-	[[Category: Rojas-Altuve, A]]	+
-	~~[[Category: Allosteric site]]~~	+
-	~~[[Category: B-lactam antibiotic]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Mrsa~~]]	+

OCA at 05:45, 10 August 2022

OCA — Wed, 10 Aug 2022 05:45:36 GMT

←Older revision		Revision as of 05:45, 10 August 2022
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	==Crystal structure of ceftaroline acyl-PBP2a from MRSA with non- covalently bound ceftaroline and muramic acid at allosteric site obtained by cocrystallization==		==Crystal structure of ceftaroline acyl-PBP2a from MRSA with non- covalently bound ceftaroline and muramic acid at allosteric site obtained by cocrystallization==
-	<StructureSection load='3zg0' size='340' side='right' caption='[[3zg0]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='3zg0' size='340' side='right'caption='[[3zg0]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zg0]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Staam Staam]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZG0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZG0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zg0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staam Staam]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZG0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZG0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1W8:CEFTAROLINE'>1W8</scene>, <scene name='pdbligand=AI8:CEFTAROLINE,+BOUND+FORM'>AI8</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1W8:CEFTAROLINE'>1W8</scene>, <scene name='pdbligand=AI8:CEFTAROLINE,+BOUND+FORM'>AI8</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zfz\|3zfz]], [[3zg5\|3zg5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zfz\|3zfz]], [[3zg5\|3zg5]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Serine-type_D-Ala-D-Ala_carboxypeptidase Serine-type D-Ala-D-Ala carboxypeptidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.16.4 3.4.16.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Serine-type_D-Ala-D-Ala_carboxypeptidase Serine-type D-Ala-D-Ala carboxypeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.16.4 3.4.16.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zg0 OCA], [~~http~~://pdbe.org/3zg0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zg0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zg0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zg0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zg0 OCA], [https://pdbe.org/3zg0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zg0 RCSB], [https://www.ebi.ac.uk/pdbsum/3zg0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zg0 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Penicillin-binding protein\|Penicillin-binding protein]]	+	*[[Penicillin-binding protein 3D structures\|Penicillin-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Serine-type D-Ala-D-Ala carboxypeptidase]]		[[Category: Serine-type D-Ala-D-Ala carboxypeptidase]]
	[[Category: Staam]]		[[Category: Staam]]

OCA at 08:27, 11 August 2016

OCA — Thu, 11 Aug 2016 08:27:53 GMT

←Older revision		Revision as of 08:27, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of ceftaroline acyl-PBP2a from MRSA with non- covalently bound ceftaroline and muramic acid at allosteric site obtained by cocrystallization==		==Crystal structure of ceftaroline acyl-PBP2a from MRSA with non- covalently bound ceftaroline and muramic acid at allosteric site obtained by cocrystallization==
	<StructureSection load='3zg0' size='340' side='right' caption='[[3zg0]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3zg0' size='340' side='right' caption='[[3zg0]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zg0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus_subsp._aureus_mu50 Staphylococcus aureus subsp. aureus mu50~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZG0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZG0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zg0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staam Staam]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZG0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZG0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1W8:CEFTAROLINE'>1W8</scene>, <scene name='pdbligand=AI8:CEFTAROLINE,+BOUND+FORM'>AI8</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1W8:CEFTAROLINE'>1W8</scene>, <scene name='pdbligand=AI8:CEFTAROLINE,+BOUND+FORM'>AI8</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zfz\|3zfz]], [[3zg5\|3zg5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zfz\|3zfz]], [[3zg5\|3zg5]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine-type_D-Ala-D-Ala_carboxypeptidase Serine-type D-Ala-D-Ala carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.16.4 3.4.16.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine-type_D-Ala-D-Ala_carboxypeptidase Serine-type D-Ala-D-Ala carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.16.4 3.4.16.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zg0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zg0 RCSB], [http://www.ebi.ac.uk/pdbsum/3zg0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zg0 OCA], [http://pdbe.org/3zg0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zg0 RCSB], [http://www.ebi.ac.uk/pdbsum/3zg0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zg0 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zg0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Serine-type D-Ala-D-Ala carboxypeptidase]]		[[Category: Serine-type D-Ala-D-Ala carboxypeptidase]]
-	[[Category: ~~Staphylococcus aureus subsp. aureus mu50~~]]	+	[[Category: Staam]]
	[[Category: Hermoso, J A]]		[[Category: Hermoso, J A]]
	[[Category: Otero, L H]]		[[Category: Otero, L H]]

OCA at 10:37, 4 January 2015

OCA — Sun, 04 Jan 2015 10:37:38 GMT

←Older revision		Revision as of 10:37, 4 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_3zg0\| PDB=3zg0 \| SCENE= }}~~	+	==Crystal structure of ceftaroline acyl-PBP2a from MRSA with non- covalently bound ceftaroline and muramic acid at allosteric site obtained by cocrystallization==
-	===Crystal structure of ceftaroline acyl-PBP2a from MRSA with non- covalently bound ceftaroline and muramic acid at allosteric site obtained by cocrystallization===	+	<StructureSection load='3zg0' size='340' side='right' caption='[[3zg0]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24085846}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zg0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_mu50 Staphylococcus aureus subsp. aureus mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZG0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZG0 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1W8:CEFTAROLINE'>1W8</scene>, <scene name='pdbligand=AI8:CEFTAROLINE,+BOUND+FORM'>AI8</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zfz\|3zfz]], [[3zg5\|3zg5]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine-type_D-Ala-D-Ala_carboxypeptidase Serine-type D-Ala-D-Ala carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.16.4 3.4.16.4] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zg0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zg0 RCSB], [http://www.ebi.ac.uk/pdbsum/3zg0 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The expression of penicillin binding protein 2a (PBP2a) is the basis for the broad clinical resistance to the beta-lactam antibiotics by methicillin-resistant Staphylococcus aureus (MRSA). The high-molecular mass penicillin binding proteins of bacteria catalyze in separate domains the transglycosylase and transpeptidase activities required for the biosynthesis of the peptidoglycan polymer that comprises the bacterial cell wall. In bacteria susceptible to beta-lactam antibiotics, the transpeptidase activity of their penicillin binding proteins (PBPs) is lost as a result of irreversible acylation of an active site serine by the beta-lactam antibiotics. In contrast, the PBP2a of MRSA is resistant to beta-lactam acylation and successfully catalyzes the DD-transpeptidation reaction necessary to complete the cell wall. The inability to contain MRSA infection with beta-lactam antibiotics is a continuing public health concern. We report herein the identification of an allosteric binding domain-a remarkable 60 A distant from the DD-transpeptidase active site-discovered by crystallographic analysis of a soluble construct of PBP2a. When this allosteric site is occupied, a multiresidue conformational change culminates in the opening of the active site to permit substrate entry. This same crystallographic analysis also reveals the identity of three allosteric ligands: muramic acid (a saccharide component of the peptidoglycan), the cell wall peptidoglycan, and ceftaroline, a recently approved anti-MRSA beta-lactam antibiotic. The ability of an anti-MRSA beta-lactam antibiotic to stimulate allosteric opening of the active site, thus predisposing PBP2a to inactivation by a second beta-lactam molecule, opens an unprecedented realm for beta-lactam antibiotic structure-based design.

-	~~==About this Structure==~~	+	How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function.,Otero LH, Rojas-Altuve A, Llarrull LI, Carrasco-Lopez C, Kumarasiri M, Lastochkin E, Fishovitz J, Dawley M, Hesek D, Lee M, Johnson JW, Fisher JF, Chang M, Mobashery S, Hermoso JA Proc Natl Acad Sci U S A. 2013 Oct 1. PMID:24085846<ref>PMID:24085846</ref>
-	~~[[3zg0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_mu50~~ Staphylococcus aureus ~~subsp~~. ~~aureus mu50]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3ZG0 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group~~=~~"xtra">PMID:024085846</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+
		+	==See Also==
		+	*[[Penicillin-binding protein\|Penicillin-binding protein]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Serine-type D-Ala-D-Ala carboxypeptidase]]		[[Category: Serine-type D-Ala-D-Ala carboxypeptidase]]
	[[Category: Staphylococcus aureus subsp. aureus mu50]]		[[Category: Staphylococcus aureus subsp. aureus mu50]]
-	[[Category: Hermoso, J A.]]	+	[[Category: Hermoso, J A]]
-	[[Category: Otero, L H.]]	+	[[Category: Otero, L H]]
-	[[Category: Rojas-Altuve, A.]]	+	[[Category: Rojas-Altuve, A]]
	[[Category: Allosteric site]]		[[Category: Allosteric site]]
	[[Category: B-lactam antibiotic]]		[[Category: B-lactam antibiotic]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Mrsa]]		[[Category: Mrsa]]

OCA at 06:29, 10 October 2013

OCA — Thu, 10 Oct 2013 06:29:07 GMT

←Older revision		Revision as of 06:29, 10 October 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_3zg0\| PDB=3zg0 \| SCENE= }}
		+	===Crystal structure of ceftaroline acyl-PBP2a from MRSA with non- covalently bound ceftaroline and muramic acid at allosteric site obtained by cocrystallization===
		+	{{ABSTRACT_PUBMED_24085846}}

-	~~The entry~~ 3zg0 is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[3zg0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_mu50 Staphylococcus aureus subsp. aureus mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZG0 OCA].

-	~~Authors~~: Otero, L.H., Rojas-Altuve, A.~~, Hermoso, J.A.~~	+	==Reference==
-		+	<ref group="xtra">PMID:024085846</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Crystal structure of ceftaroline acyl~~-~~PBP2a from MRSA with non-covalently bound ceftaroline and muramic acid at allosteric site obtained by cocrystallization~~	+	[[Category: Serine-type D-Ala-D-Ala carboxypeptidase]]
		+	[[Category: Staphylococcus aureus subsp. aureus mu50]]
		+	[[Category: Hermoso, J A.]]
		+	[[Category: Otero, L H.]]
		+	[[Category: Rojas-Altuve, A.]]
		+	[[Category: Allosteric site]]
		+	[[Category: B-lactam antibiotic]]
		+	[[Category: Hydrolase]]
		+	[[Category: Mrsa]]

OCA at 13:11, 20 February 2013

OCA — Wed, 20 Feb 2013 13:11:46 GMT

←Older revision		Revision as of 13:11, 20 February 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3zg0 is ON HOLD	+	The entry 3zg0 is ON HOLD until Paper Publication

	Authors: Otero, L.H., Rojas-Altuve, A., Hermoso, J.A.		Authors: Otero, L.H., Rojas-Altuve, A., Hermoso, J.A.

	Description: Crystal structure of ceftaroline acyl-PBP2a from MRSA with non-covalently bound ceftaroline and muramic acid at allosteric site obtained by cocrystallization		Description: Crystal structure of ceftaroline acyl-PBP2a from MRSA with non-covalently bound ceftaroline and muramic acid at allosteric site obtained by cocrystallization

OCA at 08:38, 2 January 2013

OCA — Wed, 02 Jan 2013 08:38:59 GMT

←Older revision		Revision as of 08:38, 2 January 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3zg0 is ON HOLD ~~until sometime in the future~~	+	The entry 3zg0 is ON HOLD

	Authors: Otero, L.H., Rojas-Altuve, A., Hermoso, J.A.		Authors: Otero, L.H., Rojas-Altuve, A., Hermoso, J.A.

	Description: Crystal structure of ceftaroline acyl-PBP2a from MRSA with non-covalently bound ceftaroline and muramic acid at allosteric site obtained by cocrystallization		Description: Crystal structure of ceftaroline acyl-PBP2a from MRSA with non-covalently bound ceftaroline and muramic acid at allosteric site obtained by cocrystallization

OCA: Protected "3zg0" [edit=sysop:move=sysop]

OCA — Wed, 19 Dec 2012 10:50:09 GMT

Protected "3zg0" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:50, 19 December 2012

OCA: New page: '''Unreleased structure''' The entry 3zg0 is ON HOLD until sometime in the future Authors: Otero, L.H., Rojas-Altuve, A., Hermoso, J.A. Description: Crystal structure of ceftaroline ac...

OCA — Wed, 19 Dec 2012 10:50:08 GMT

New page: '''Unreleased structure''' The entry 3zg0 is ON HOLD until sometime in the future Authors: Otero, L.H., Rojas-Altuve, A., Hermoso, J.A. Description: Crystal structure of ceftaroline ac...

New page

'''Unreleased structure'''

The entry 3zg0 is ON HOLD until sometime in the future

Authors: Otero, L.H., Rojas-Altuve, A., Hermoso, J.A.

Description: Crystal structure of ceftaroline acyl-PBP2a from MRSA with non-covalently bound ceftaroline and muramic acid at allosteric site obtained by cocrystallization