3zjt - Revision history

OCA at 11:03, 20 December 2023

OCA — Wed, 20 Dec 2023 11:03:37 GMT

←Older revision		Revision as of 11:03, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='3zjt' size='340' side='right'caption='[[3zjt]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3zjt' size='340' side='right'caption='[[3zjt]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zjt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZJT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zjt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZJT FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=574:[(3AS,4R,6R,6AR)-2-{2-[(1S)-2-AMINO-1-HYDROXYETHYL]PHENYL}-6-(6-AMINO-9H-PURIN-9-YL)TETRAHYDROFURO[3,4-D][1,3,2]DIOXABOROL-4-YL]METHYL+DIHYDROGEN+PHOSPHITE'>574</scene>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=574:[(3AS,4R,6R,6AR)-2-{2-[(1S)-2-AMINO-1-HYDROXYETHYL]PHENYL}-6-(6-AMINO-9H-PURIN-9-YL)TETRAHYDROFURO[3,4-D][1,3,2]DIOXABOROL-4-YL]METHYL+DIHYDROGEN+PHOSPHITE'>574</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zju\|3zju]]~~, ~~[[3zjv\|3zjv]]~~<~~/div></td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Leucine--tRNA_ligase Leucine--tRNA ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.4 6.1.1.4]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zjt OCA], [https://pdbe.org/3zjt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zjt RCSB], [https://www.ebi.ac.uk/pdbsum/3zjt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zjt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zjt OCA], [https://pdbe.org/3zjt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zjt RCSB], [https://www.ebi.ac.uk/pdbsum/3zjt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zjt ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SYL_ECOLI SYL_ECOLI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
		+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Leucine--tRNA ligase]]~~	+	[[Category: Akama T]]
-	[[Category: Akama, T]]	+	[[Category: Alley MRK]]
-	[[Category: Alley~~, M R.K~~]]	+	[[Category: Anugula MR]]
-	[[Category: Anugula~~, M R~~]]	+	[[Category: Baker SJ]]
-	[[Category: Baker~~, S J~~]]	+	[[Category: Bu W]]
-	[[Category: Bu, W]]	+	[[Category: Crepin T]]
-	[[Category: Crepin, T]]	+	[[Category: Cusack S]]
-	[[Category: Cusack, S]]	+	[[Category: DeMarsh PL]]
-	[[Category: DeMarsh~~, P L~~]]	+	[[Category: Feng L]]
-	[[Category: Feng, L]]	+	[[Category: Freund YR]]
-	[[Category: Freund~~, Y R~~]]	+	[[Category: Hernandez V]]
-	[[Category: Hernandez, V]]	+	[[Category: Keramane EM]]
-	[[Category: Keramane~~, E M~~]]	+	[[Category: Liu L]]
-	[[Category: Liu, L]]	+	[[Category: Livermore DM]]
-	[[Category: Livermore~~, D M~~]]	+	[[Category: Mao W]]
-	[[Category: Mao, W]]	+	[[Category: Meewan M]]
-	[[Category: Meewan, M]]	+	[[Category: Mohan M]]
-	[[Category: Mohan, M]]	+	[[Category: Mushtaq S]]
-	[[Category: Mushtaq, S]]	+	[[Category: Nieman JA]]
-	[[Category: Nieman~~, J A~~]]	+	[[Category: OLeary A]]
-	[[Category: OLeary, A]]	+	[[Category: Palencia A]]
-	[[Category: Palencia, A]]	+	[[Category: Plattner JJ]]
-	[[Category: Plattner~~, J J~~]]	+	[[Category: Reddy DS]]
-	[[Category: Reddy~~, D S~~]]	+	[[Category: Rock FL]]
-	[[Category: Rock~~, F L~~]]	+	[[Category: Savariraj K]]
-	[[Category: Savariraj, K]]	+	[[Category: Sexton H]]
-	[[Category: Sexton, H]]	+	[[Category: Sharma R]]
-	[[Category: Sharma, R]]	+	[[Category: Sheoran A]]
-	[[Category: Sheoran, A]]	+	[[Category: Simon NL]]
-	[[Category: Simon~~, N L~~]]	+	[[Category: Singh R]]
-	[[Category: Singh, R]]	+	[[Category: Subedi R]]
-	[[Category: Subedi, R]]	+	[[Category: Warner M]]
-	[[Category: Warner, M]]	+	[[Category: Zhang Y]]
-	[[Category: Zhang, Y]]	+	[[Category: Zhou Y]]
-	[[Category: Zhou, Y]]	+
-	~~[[Category: Aminoacyl trna synthetase]]~~	+
-	~~[[Category: Atp binding]]~~	+
-	~~[[Category: Class i aminoacyl-trna synthetase]]~~	+
-	~~[[Category: Editing synthetase]]~~	+
-	~~[[Category: Ligase-rna complex]]~~	+
-	~~[[Category: Protein biosynthesis~~]]	+

OCA at 05:48, 10 August 2022

OCA — Wed, 10 Aug 2022 05:48:56 GMT

←Older revision		Revision as of 05:48, 10 August 2022
Line 1:		Line 1:

	==Ternary complex of E.coli leucyl-tRNA synthetase, tRNA(Leu)574 and the benzoxaborole AN3017 in the editing conformation==		==Ternary complex of E.coli leucyl-tRNA synthetase, tRNA(Leu)574 and the benzoxaborole AN3017 in the editing conformation==
-	<StructureSection load='3zjt' size='340' side='right' caption='[[3zjt]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='3zjt' size='340' side='right'caption='[[3zjt]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zjt]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZJT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zjt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZJT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=574:[(3AS,4R,6R,6AR)-2-{2-[(1S)-2-AMINO-1-HYDROXYETHYL]PHENYL}-6-(6-AMINO-9H-PURIN-9-YL)TETRAHYDROFURO[3,4-D][1,3,2]DIOXABOROL-4-YL]METHYL+DIHYDROGEN+PHOSPHITE'>574</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=574:[(3AS,4R,6R,6AR)-2-{2-[(1S)-2-AMINO-1-HYDROXYETHYL]PHENYL}-6-(6-AMINO-9H-PURIN-9-YL)TETRAHYDROFURO[3,4-D][1,3,2]DIOXABOROL-4-YL]METHYL+DIHYDROGEN+PHOSPHITE'>574</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zju\|3zju]], [[3zjv\|3zjv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zju\|3zju]], [[3zjv\|3zjv]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Leucine--tRNA_ligase Leucine--tRNA ligase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.4 6.1.1.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Leucine--tRNA_ligase Leucine--tRNA ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.4 6.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zjt OCA], [~~http~~://pdbe.org/3zjt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zjt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zjt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zjt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zjt OCA], [https://pdbe.org/3zjt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zjt RCSB], [https://www.ebi.ac.uk/pdbsum/3zjt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zjt ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:

	==See Also==		==See Also==
		+	*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]
	*[[Transfer RNA (tRNA)\|Transfer RNA (tRNA)]]		*[[Transfer RNA (tRNA)\|Transfer RNA (tRNA)]]
	== References ==		== References ==
Line 27:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Leucine--tRNA ligase]]		[[Category: Leucine--tRNA ligase]]
	[[Category: Akama, T]]		[[Category: Akama, T]]

OCA at 16:32, 27 February 2019

OCA — Wed, 27 Feb 2019 16:32:09 GMT

←Older revision		Revision as of 16:32, 27 February 2019
Line 1:		Line 1:

-	==Ternary complex of E .coli leucyl-tRNA synthetase, tRNA(Leu) and the benzoxaborole AN3017 in the editing conformation==	+	==Ternary complex of E.coli leucyl-tRNA synthetase, tRNA(Leu)574 and the benzoxaborole AN3017 in the editing conformation==
	<StructureSection load='3zjt' size='340' side='right' caption='[[3zjt]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3zjt' size='340' side='right' caption='[[3zjt]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[~~TRNA~~\|~~TRNA~~]]	+	*[[Transfer RNA (tRNA)\|Transfer RNA (tRNA)]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:56, 11 August 2016

OCA — Thu, 11 Aug 2016 10:56:13 GMT

←Older revision		Revision as of 10:56, 11 August 2016
Line 1:		Line 1:
		+
	==Ternary complex of E .coli leucyl-tRNA synthetase, tRNA(Leu) and the benzoxaborole AN3017 in the editing conformation==		==Ternary complex of E .coli leucyl-tRNA synthetase, tRNA(Leu) and the benzoxaborole AN3017 in the editing conformation==
	<StructureSection load='3zjt' size='340' side='right' caption='[[3zjt]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3zjt' size='340' side='right' caption='[[3zjt]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zjt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZJT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zjt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZJT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=574:[(3AS,4R,6R,6AR)-2-{2-[(1S)-2-AMINO-1-HYDROXYETHYL]PHENYL}-6-(6-AMINO-9H-PURIN-9-YL)TETRAHYDROFURO[3,4-D][1,3,2]DIOXABOROL-4-YL]METHYL+DIHYDROGEN+PHOSPHITE'>574</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=574:[(3AS,4R,6R,6AR)-2-{2-[(1S)-2-AMINO-1-HYDROXYETHYL]PHENYL}-6-(6-AMINO-9H-PURIN-9-YL)TETRAHYDROFURO[3,4-D][1,3,2]DIOXABOROL-4-YL]METHYL+DIHYDROGEN+PHOSPHITE'>574</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zju\|3zju]], [[3zjv\|3zjv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zju\|3zju]], [[3zjv\|3zjv]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leucine--tRNA_ligase Leucine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.4 6.1.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leucine--tRNA_ligase Leucine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.4 6.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zjt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zjt RCSB], [http://www.ebi.ac.uk/pdbsum/3zjt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zjt OCA], [http://pdbe.org/3zjt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zjt RCSB], [http://www.ebi.ac.uk/pdbsum/3zjt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zjt ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zjt" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[TRNA\|TRNA]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Leucine--tRNA ligase]]		[[Category: Leucine--tRNA ligase]]
	[[Category: Akama, T]]		[[Category: Akama, T]]

OCA at 07:57, 20 January 2015

OCA — Tue, 20 Jan 2015 07:57:32 GMT

←Older revision		Revision as of 07:57, 20 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_3zjt\| PDB=3zjt \| SCENE= }}~~	+	==Ternary complex of E .coli leucyl-tRNA synthetase, tRNA(Leu) and the benzoxaborole AN3017 in the editing conformation==
-	===Ternary complex of E .coli leucyl-tRNA synthetase, tRNA(Leu) and the benzoxaborole AN3017 in the editing conformation===	+	<StructureSection load='3zjt' size='340' side='right' caption='[[3zjt]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	{~~{ABSTRACT_PUBMED_23295920}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zjt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZJT FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=574:[(3AS,4R,6R,6AR)-2-{2-[(1S)-2-AMINO-1-HYDROXYETHYL]PHENYL}-6-(6-AMINO-9H-PURIN-9-YL)TETRAHYDROFURO[3,4-D][1,3,2]DIOXABOROL-4-YL]METHYL+DIHYDROGEN+PHOSPHITE'>574</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zju\|3zju]], [[3zjv\|3zjv]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leucine--tRNA_ligase Leucine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.4 6.1.1.4] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zjt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zjt RCSB], [http://www.ebi.ac.uk/pdbsum/3zjt PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Gram-negative bacteria cause approximately 70% of the infections in intensive care units. A growing number of bacterial isolates responsible for these infections are resistant to currently available antibiotics and to many in development. Most agents under development are modifications of existing drug classes, which only partially overcome existing resistance mechanisms. Therefore, new classes of Gram-negative antibacterials with truly novel modes of action are needed to circumvent these existing resistance mechanisms. We have previously identified a new a way to inhibit an aminoacyl-tRNA synthetase, leucyl-tRNA synthetase (LeuRS), in fungi via the oxaborole tRNA trapping (OBORT) mechanism. Herein, we show how we have modified the OBORT mechanism using a structure-guided approach to develop a new boron-based antibiotic class, the aminomethylbenzoxaboroles, which inhibit bacterial leucyl-tRNA synthetase and have activity against Gram-negative bacteria by largely evading the main efflux mechanisms in Escherichia coli and Pseudomonas aeruginosa. The lead analogue, AN3365, is active against Gram-negative bacteria, including Enterobacteriaceae bearing NDM-1 and KPC carbapenemases, as well as P. aeruginosa. This novel boron-based antibacterial, AN3365, has good mouse pharmacokinetics and was efficacious against E. coli and P. aeruginosa in murine thigh infection models, which suggest that this novel class of antibacterials has the potential to address this unmet medical need.

-	~~==About this Structure==~~	+	Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria.,Hernandez V, Crepin T, Palencia A, Cusack S, Akama T, Baker SJ, Bu W, Feng L, Freund YR, Liu L, Meewan M, Mohan M, Mao W, Rock FL, Sexton H, Sheoran A, Zhang Y, Zhang YK, Zhou Y, Nieman JA, Anugula MR, Keramane el M, Savariraj K, Reddy DS, Sharma R, Subedi R, Singh R, O'Leary A, Simon NL, De Marsh PL, Mushtaq S, Warner M, Livermore DM, Alley MR, Plattner JJ Antimicrob Agents Chemother. 2013 Mar;57(3):1394-403. doi: 10.1128/AAC.02058-12. , Epub 2013 Jan 7. PMID:23295920<ref>PMID:23295920</ref>
-	~~[[3zjt]] is~~ a ~~2 chain structure~~ with ~~sequence from [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id~~=~~3ZJT OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Leucine--tRNA ligase]]		[[Category: Leucine--tRNA ligase]]
-	[[Category: Akama, T.]]	+	[[Category: Akama, T]]
-	[[Category: Alley, M R.K.]]	+	[[Category: Alley, M R.K]]
-	[[Category: Anugula, M R.]]	+	[[Category: Anugula, M R]]
-	[[Category: Baker, S J.]]	+	[[Category: Baker, S J]]
-	[[Category: Bu, W.]]	+	[[Category: Bu, W]]
-	[[Category: Crepin, T.]]	+	[[Category: Crepin, T]]
-	[[Category: Cusack, S.]]	+	[[Category: Cusack, S]]
-	[[Category: DeMarsh, P L.]]	+	[[Category: DeMarsh, P L]]
-	[[Category: Feng, L.]]	+	[[Category: Feng, L]]
-	[[Category: Freund, Y R.]]	+	[[Category: Freund, Y R]]
-	[[Category: Hernandez, V.]]	+	[[Category: Hernandez, V]]
-	[[Category: Keramane, E M.]]	+	[[Category: Keramane, E M]]
-	[[Category: Liu, L.]]	+	[[Category: Liu, L]]
-	[[Category: Livermore, D M.]]	+	[[Category: Livermore, D M]]
-	[[Category: Mao, W.]]	+	[[Category: Mao, W]]
-	[[Category: Meewan, M.]]	+	[[Category: Meewan, M]]
-	[[Category: Mohan, M.]]	+	[[Category: Mohan, M]]
-	[[Category: Mushtaq, S.]]	+	[[Category: Mushtaq, S]]
-	[[Category: Nieman, J A.]]	+	[[Category: Nieman, J A]]
-	[[Category: OLeary, A.]]	+	[[Category: OLeary, A]]
-	[[Category: Palencia, A.]]	+	[[Category: Palencia, A]]
-	[[Category: Plattner, J J.]]	+	[[Category: Plattner, J J]]
-	[[Category: Reddy, D S.]]	+	[[Category: Reddy, D S]]
-	[[Category: Rock, F L.]]	+	[[Category: Rock, F L]]
-	[[Category: Savariraj, K.]]	+	[[Category: Savariraj, K]]
-	[[Category: Sexton, H.]]	+	[[Category: Sexton, H]]
-	[[Category: Sharma, R.]]	+	[[Category: Sharma, R]]
-	[[Category: Sheoran, A.]]	+	[[Category: Sheoran, A]]
-	[[Category: Simon, N L.]]	+	[[Category: Simon, N L]]
-	[[Category: Singh, R.]]	+	[[Category: Singh, R]]
-	[[Category: Subedi, R.]]	+	[[Category: Subedi, R]]
-	[[Category: Warner, M.]]	+	[[Category: Warner, M]]
-	[[Category: Zhang, Y.]]	+	[[Category: Zhang, Y]]
-	[[Category: Zhou, Y.]]	+	[[Category: Zhou, Y]]
	[[Category: Aminoacyl trna synthetase]]		[[Category: Aminoacyl trna synthetase]]
	[[Category: Atp binding]]		[[Category: Atp binding]]

OCA at 20:23, 17 April 2013

OCA — Wed, 17 Apr 2013 20:23:55 GMT

←Older revision		Revision as of 20:23, 17 April 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_3zjt\| PDB=3zjt \| SCENE= }}
		+	===Ternary complex of E .coli leucyl-tRNA synthetase, tRNA(Leu) and the benzoxaborole AN3017 in the editing conformation===
		+	{{ABSTRACT_PUBMED_23295920}}

-	~~The entry~~ 3zjt is ~~ON HOLD~~	+	==About this Structure==
-		+	[[3zjt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJT OCA].
-	~~Authors~~: ~~Cusack, S~~.~~, Palencia, A~~.~~, Crepin, T~~.~~, Hernandez, V~~., Akama, T., Baker, S.J., Bu, W., ~~Feng~~, L., Freund, Y.R., ~~Liu, L~~., ~~Meewan,~~ M., ~~Mohan~~, M., Mao, W., ~~Rock, F.L~~., ~~Sexton, H~~., ~~Sheoran, A~~.~~, Zhang, Y., Zhang, Y., Zhou, Y.,~~ Nieman, J.A., ~~Anugula, M.R~~., ~~Keramane, E.M~~., ~~Savariraj, K~~., Reddy, D.S., ~~Sharma~~, R., ~~Subedi, R~~.~~, Singh~~, R.~~, OLeary~~, A., Simon, N.L., ~~DeMarsh, P.L~~., ~~Mushtaq, S~~., Warner, M., ~~Livermore, D.M~~., ~~Alley, M.R.K., Plattner, J.J~~.	+	[[Category: Escherichia coli]]
-		+	[[Category: Leucine--tRNA ligase]]
-	~~Description~~: ~~Ternary complex of E .coli leucyl~~-~~tRNA~~ synthetase~~, tRNA(Leu) and the benzoxaborole AN3017 in the editing conformation~~	+	[[Category: Akama, T.]]
		+	[[Category: Alley, M R.K.]]
		+	[[Category: Anugula, M R.]]
		+	[[Category: Baker, S J.]]
		+	[[Category: Bu, W.]]
		+	[[Category: Crepin, T.]]
		+	[[Category: Cusack, S.]]
		+	[[Category: DeMarsh, P L.]]
		+	[[Category: Feng, L.]]
		+	[[Category: Freund, Y R.]]
		+	[[Category: Hernandez, V.]]
		+	[[Category: Keramane, E M.]]
		+	[[Category: Liu, L.]]
		+	[[Category: Livermore, D M.]]
		+	[[Category: Mao, W.]]
		+	[[Category: Meewan, M.]]
		+	[[Category: Mohan, M.]]
		+	[[Category: Mushtaq, S.]]
		+	[[Category: Nieman, J A.]]
		+	[[Category: OLeary, A.]]
		+	[[Category: Palencia, A.]]
		+	[[Category: Plattner, J J.]]
		+	[[Category: Reddy, D S.]]
		+	[[Category: Rock, F L.]]
		+	[[Category: Savariraj, K.]]
		+	[[Category: Sexton, H.]]
		+	[[Category: Sharma, R.]]
		+	[[Category: Sheoran, A.]]
		+	[[Category: Simon, N L.]]
		+	[[Category: Singh, R.]]
		+	[[Category: Subedi, R.]]
		+	[[Category: Warner, M.]]
		+	[[Category: Zhang, Y.]]
		+	[[Category: Zhou, Y.]]
		+	[[Category: Aminoacyl trna synthetase]]
		+	[[Category: Atp binding]]
		+	[[Category: Class i aminoacyl-trna synthetase]]
		+	[[Category: Editing synthetase]]
		+	[[Category: Ligase-rna complex]]
		+	[[Category: Protein biosynthesis]]

OCA: Protected "3zjt" [edit=sysop:move=sysop]

OCA — Wed, 30 Jan 2013 11:48:41 GMT

Protected "3zjt" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:48, 30 January 2013

OCA: New page: '''Unreleased structure''' The entry 3zjt is ON HOLD Authors: Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewa...

OCA — Wed, 30 Jan 2013 11:48:39 GMT

New page: '''Unreleased structure''' The entry 3zjt is ON HOLD Authors: Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewa...

New page

'''Unreleased structure'''

The entry 3zjt is ON HOLD

Authors: Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.

Description: Ternary complex of E .coli leucyl-tRNA synthetase, tRNA(Leu) and the benzoxaborole AN3017 in the editing conformation