3zjy - Revision history

OCA at 11:03, 20 December 2023

OCA — Wed, 20 Dec 2023 11:03:53 GMT

←Older revision		Revision as of 11:03, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='3zjy' size='340' side='right'caption='[[3zjy]], [[Resolution\|resolution]] 3.60Å' scene=''>		<StructureSection load='3zjy' size='340' side='right'caption='[[3zjy]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zjy]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZJY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zjy]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZJY FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GTP:GUANOSINE~~-~~5-TRIPHOSPHATE'>GTP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height~~: ~~3em;~~'>~~[[3zkv\|3zkv]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zjy OCA], [https://pdbe.org/3zjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zjy RCSB], [https://www.ebi.ac.uk/pdbsum/3zjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zjy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zjy OCA], [https://pdbe.org/3zjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zjy RCSB], [https://www.ebi.ac.uk/pdbsum/3zjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zjy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> [[https://www.uniprot.org/uniprot/IF1AX_HUMAN IF1AX_HUMAN]] Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. [[https://www.uniprot.org/uniprot/IPO13_HUMAN IPO13_HUMAN]] Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.<ref>PMID:11447110</ref> <ref>PMID:15143176</ref>	+	[https://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bono, F]]	+	[[Category: Bono F]]
-	[[Category: Gruenwald, M]]	+	[[Category: Gruenwald M]]
-	[[Category: Lazzaretti, D]]	+	[[Category: Lazzaretti D]]
-	~~[[Category: Active transport]]~~	+
-	~~[[Category: Cell nucleus]]~~	+
-	~~[[Category: Multiprotein complex]]~~	+
-	~~[[Category: Nucleocytoplasmic transport]]~~	+
-	~~[[Category: Ran gtp-binding protein]]~~	+
-	~~[[Category: Rna-binding protein]]~~	+
-	~~[[Category: Translation~~]]	+

OCA at 05:49, 10 August 2022

OCA — Wed, 10 Aug 2022 05:49:10 GMT

←Older revision		Revision as of 05:49, 10 August 2022
Line 1:		Line 1:

	==Crystal Structure of Importin 13 - RanGTP - eIF1A complex==		==Crystal Structure of Importin 13 - RanGTP - eIF1A complex==
-	<StructureSection load='3zjy' size='340' side='right' caption='[[3zjy]], [[Resolution\|resolution]] 3.60Å' scene=''>	+	<StructureSection load='3zjy' size='340' side='right'caption='[[3zjy]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zjy]] is a 7 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZJY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zjy]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZJY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zkv\|3zkv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zkv\|3zkv]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zjy OCA], [~~http~~://pdbe.org/3zjy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zjy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zjy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zjy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zjy OCA], [https://pdbe.org/3zjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zjy RCSB], [https://www.ebi.ac.uk/pdbsum/3zjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zjy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> [[~~http~~://www.uniprot.org/uniprot/IF1AX_HUMAN IF1AX_HUMAN]] Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. [[~~http~~://www.uniprot.org/uniprot/IPO13_HUMAN IPO13_HUMAN]] Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.<ref>PMID:11447110</ref> <ref>PMID:15143176</ref>	+	[[https://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> [[https://www.uniprot.org/uniprot/IF1AX_HUMAN IF1AX_HUMAN]] Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. [[https://www.uniprot.org/uniprot/IPO13_HUMAN IPO13_HUMAN]] Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.<ref>PMID:11447110</ref> <ref>PMID:15143176</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Eukaryotic initiation factor\|Eukaryotic initiation factor]]	+	*[[Eukaryotic initiation factor 3D structures\|Eukaryotic initiation factor 3D structures]]
-	*[[GTP-binding protein\|GTP-binding protein]]	+	*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]
-	*[[Importin\|Importin]]	+	*[[Importin 3D structures\|Importin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bono, F]]		[[Category: Bono, F]]
	[[Category: Gruenwald, M]]		[[Category: Gruenwald, M]]

OCA at 22:05, 5 August 2016

OCA — Fri, 05 Aug 2016 22:05:31 GMT

←Older revision		Revision as of 22:05, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Importin 13 - RanGTP - eIF1A complex==		==Crystal Structure of Importin 13 - RanGTP - eIF1A complex==
	<StructureSection load='3zjy' size='340' side='right' caption='[[3zjy]], [[Resolution\|resolution]] 3.60Å' scene=''>		<StructureSection load='3zjy' size='340' side='right' caption='[[3zjy]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zjy]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZJY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zjy]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZJY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zkv\|3zkv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zkv\|3zkv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zjy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zjy RCSB], [http://www.ebi.ac.uk/pdbsum/3zjy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zjy OCA], [http://pdbe.org/3zjy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zjy RCSB], [http://www.ebi.ac.uk/pdbsum/3zjy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zjy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zjy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
		+	*[[Eukaryotic initiation factor\|Eukaryotic initiation factor]]
	*[[GTP-binding protein\|GTP-binding protein]]		*[[GTP-binding protein\|GTP-binding protein]]
	*[[Importin\|Importin]]		*[[Importin\|Importin]]
Line 25:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bono, F]]		[[Category: Bono, F]]
	[[Category: Gruenwald, M]]		[[Category: Gruenwald, M]]

OCA at 06:14, 25 December 2014

OCA — Thu, 25 Dec 2014 06:14:31 GMT

←Older revision		Revision as of 06:14, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3zjy\| PDB=3zjy \| SCENE= }}~~	+	==Crystal Structure of Importin 13 - RanGTP - eIF1A complex==
-	===Crystal Structure of Importin 13 - RanGTP - eIF1A complex===	+	<StructureSection load='3zjy' size='340' side='right' caption='[[3zjy]], [[Resolution\|resolution]] 3.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23435562}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3zjy]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZJY FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zkv\|3zkv]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zjy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zjy RCSB], [http://www.ebi.ac.uk/pdbsum/3zjy PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> [[http://www.uniprot.org/uniprot/IF1AX_HUMAN IF1AX_HUMAN]] Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. [[http://www.uniprot.org/uniprot/IPO13_HUMAN IPO13_HUMAN]] Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.<ref>PMID:11447110</ref> <ref>PMID:15143176</ref>		[[http://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> [[http://www.uniprot.org/uniprot/IF1AX_HUMAN IF1AX_HUMAN]] Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. [[http://www.uniprot.org/uniprot/IPO13_HUMAN IPO13_HUMAN]] Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.<ref>PMID:11447110</ref> <ref>PMID:15143176</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Importin13 (Imp13) is a bidirectional karyopherin that can mediate both import and export of cargoes. Imp13 recognizes several import cargoes, which include the exon junction complex components Mago-Y14 and the E2 SUMO-conjugating enzyme Ubc9, and one known export cargo, the translation initiation factor 1A (eIF1A). To understand how Imp13 can perform double duty, we determined the 3.6-A crystal structure of Imp13 in complex with RanGTP and with eIF1A. eIF1A binds at the inner surface of the Imp13 C-terminal arch adjacent and concomitantly to RanGTP illustrating how eIF1A can be exported by Imp13. Moreover, the 3.0-A structure of Imp13 in its unbound state reveals the existence of an open conformation in the cytoplasm that explains export cargo release and completes the export branch of the Imp13 pathway. Finally, we demonstrate that Imp13 is able to bind and export eIF1A in vivo and that its function is essential.
		+
		+	Structural basis for the nuclear export activity of Importin13.,Grunwald M, Lazzaretti D, Bono F EMBO J. 2013 Mar 20;32(6):899-913. doi: 10.1038/emboj.2013.29. Epub 2013 Feb 22. PMID:23435562<ref>PMID:23435562</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3zjy]] is~~ a ~~7 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJY OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	<references ~~group="xtra"~~/><~~references~~/>	+	*[[GTP-binding protein\|GTP-binding protein]]
		+	*[[Importin\|Importin]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bono, F.]]	+	[[Category: Bono, F]]
-	[[Category: Gruenwald, M.]]	+	[[Category: Gruenwald, M]]
-	[[Category: Lazzaretti, D.]]	+	[[Category: Lazzaretti, D]]
	[[Category: Active transport]]		[[Category: Active transport]]
	[[Category: Cell nucleus]]		[[Category: Cell nucleus]]

OCA at 22:38, 10 April 2013

OCA — Wed, 10 Apr 2013 22:38:57 GMT

←Older revision		Revision as of 22:38, 10 April 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_3zjy\| PDB=3zjy \| SCENE= }}
		+	===Crystal Structure of Importin 13 - RanGTP - eIF1A complex===
		+	{{ABSTRACT_PUBMED_23435562}}

-	The ~~entry 3zjy~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> [[http://www.uniprot.org/uniprot/IF1AX_HUMAN IF1AX_HUMAN]] Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. [[http://www.uniprot.org/uniprot/IPO13_HUMAN IPO13_HUMAN]] Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.<ref>PMID:11447110</ref> <ref>PMID:15143176</ref>

-	~~Authors~~: ~~Gruenwald, M~~.~~, Lazzaretti, D~~.~~, Bono, F~~.	+	==About this Structure==
		+	[[3zjy]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJY OCA].

-	~~Description~~: ~~Crystal Structure of Importin 13~~ -~~RanGTP~~ -~~eIF1A complex~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Bono, F.]]
		+	[[Category: Gruenwald, M.]]
		+	[[Category: Lazzaretti, D.]]
		+	[[Category: Active transport]]
		+	[[Category: Cell nucleus]]
		+	[[Category: Multiprotein complex]]
		+	[[Category: Nucleocytoplasmic transport]]
		+	[[Category: Ran gtp-binding protein]]
		+	[[Category: Rna-binding protein]]
		+	[[Category: Translation]]

OCA at 12:15, 6 February 2013

OCA — Wed, 06 Feb 2013 12:15:16 GMT

←Older revision		Revision as of 12:15, 6 February 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3zjy is ON HOLD	+	The entry 3zjy is ON HOLD until Paper Publication

	Authors: Gruenwald, M., Lazzaretti, D., Bono, F.		Authors: Gruenwald, M., Lazzaretti, D., Bono, F.

	Description: Crystal Structure of Importin 13 -RanGTP -eIF1A complex		Description: Crystal Structure of Importin 13 -RanGTP -eIF1A complex

OCA: Protected "3zjy" [edit=sysop:move=sysop]

OCA — Wed, 30 Jan 2013 11:48:52 GMT

Protected "3zjy" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:48, 30 January 2013

OCA: New page: '''Unreleased structure''' The entry 3zjy is ON HOLD Authors: Gruenwald, M., Lazzaretti, D., Bono, F. Description: Crystal Structure of Importin 13 -RanGTP -eIF1A complex

OCA — Wed, 30 Jan 2013 11:48:51 GMT

New page: '''Unreleased structure''' The entry 3zjy is ON HOLD Authors: Gruenwald, M., Lazzaretti, D., Bono, F. Description: Crystal Structure of Importin 13 -RanGTP -eIF1A complex

New page

'''Unreleased structure'''

The entry 3zjy is ON HOLD

Authors: Gruenwald, M., Lazzaretti, D., Bono, F.

Description: Crystal Structure of Importin 13 -RanGTP -eIF1A complex