3zl1 - Revision history

OCA at 11:04, 20 December 2023

OCA — Wed, 20 Dec 2023 11:04:41 GMT

←Older revision		Revision as of 11:04, 20 December 2023
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	<StructureSection load='3zl1' size='340' side='right'caption='[[3zl1]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='3zl1' size='340' side='right'caption='[[3zl1]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zl1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Escherichia_coli_j96~~ Escherichia coli ~~j96~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZL1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zl1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_J96 Escherichia coli J96]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZL1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BWG:N-{5-[(1R)-1-HYDROXYETHYL]-1,3-THIAZOL-2-YL}-ALPHA-D-MANNOPYRANOSYLAMINE'>BWG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.551Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zl2\|3zl2]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BWG:N-{5-[(1R)-1-HYDROXYETHYL]-1,3-THIAZOL-2-YL}-ALPHA-D-MANNOPYRANOSYLAMINE'>BWG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zl1 OCA], [https://pdbe.org/3zl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zl1 RCSB], [https://www.ebi.ac.uk/pdbsum/3zl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zl1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zl1 OCA], [https://pdbe.org/3zl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zl1 RCSB], [https://www.ebi.ac.uk/pdbsum/3zl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zl1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FIMH_ECOLI FIMH_ECOLI]] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.	+	[https://www.uniprot.org/uniprot/FIMH_ECOLI FIMH_ECOLI] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Escherichia coli ~~j96~~]]	+	[[Category: Escherichia coli J96]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bilyy~~, R O~~]]	+	[[Category: Bilyy RO]]
-	[[Category: Bouckaert, J]]	+	[[Category: Bouckaert J]]
-	[[Category: Brument, S]]	+	[[Category: Brument S]]
-	[[Category: Chalopin, T]]	+	[[Category: Chalopin T]]
-	[[Category: Darfeuille-Michaud, A]]	+	[[Category: Darfeuille-Michaud A]]
-	[[Category: Deniaud, D]]	+	[[Category: Deniaud D]]
-	[[Category: Dumych~~, T I~~]]	+	[[Category: Dumych TI]]
-	[[Category: Gouin~~, S G~~]]	+	[[Category: Gouin SG]]
-	[[Category: Guerardel, Y]]	+	[[Category: Guerardel Y]]
-	[[Category: Moreau, N]]	+	[[Category: Moreau N]]
-	[[Category: Roos, G]]	+	[[Category: Roos G]]
-	[[Category: Sivignon, A]]	+	[[Category: Sivignon A]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Crohn's disease]]~~	+
-	~~[[Category: Immunoglobulin]]~~	+
-	~~[[Category: Thiazole]]~~	+
-	~~[[Category: Type-1 fimbriae~~]]	+

OCA at 05:50, 10 August 2022

OCA — Wed, 10 Aug 2022 05:50:12 GMT

←Older revision		Revision as of 05:50, 10 August 2022
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	==A thiazolyl-mannoside bound to FimH, monoclinic space group==		==A thiazolyl-mannoside bound to FimH, monoclinic space group==
-	<StructureSection load='3zl1' size='340' side='right' caption='[[3zl1]], [[Resolution\|resolution]] 1.55Å' scene=''>	+	<StructureSection load='3zl1' size='340' side='right'caption='[[3zl1]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zl1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Escherichia_coli_j96 Escherichia coli j96]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZL1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZL1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zl1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_j96 Escherichia coli j96]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZL1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BWG:N-{5-[(1R)-1-HYDROXYETHYL]-1,3-THIAZOL-2-YL}-ALPHA-D-MANNOPYRANOSYLAMINE'>BWG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BWG:N-{5-[(1R)-1-HYDROXYETHYL]-1,3-THIAZOL-2-YL}-ALPHA-D-MANNOPYRANOSYLAMINE'>BWG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zl2\|3zl2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zl2\|3zl2]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zl1 OCA], [~~http~~://pdbe.org/3zl1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zl1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zl1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zl1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zl1 OCA], [https://pdbe.org/3zl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zl1 RCSB], [https://www.ebi.ac.uk/pdbsum/3zl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zl1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FIMH_ECOLI FIMH_ECOLI]] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.	+	[[https://www.uniprot.org/uniprot/FIMH_ECOLI FIMH_ECOLI]] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Adhesin\|Adhesin]]	+	*[[Adhesin 3D structures\|Adhesin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli j96]]		[[Category: Escherichia coli j96]]
		+	[[Category: Large Structures]]
	[[Category: Bilyy, R O]]		[[Category: Bilyy, R O]]
	[[Category: Bouckaert, J]]		[[Category: Bouckaert, J]]

OCA at 16:33, 27 February 2019

OCA — Wed, 27 Feb 2019 16:33:37 GMT

←Older revision		Revision as of 16:33, 27 February 2019
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 3zl1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3zl1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Adhesin\|Adhesin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:15, 4 August 2016

OCA — Thu, 04 Aug 2016 11:15:38 GMT

←Older revision		Revision as of 11:15, 4 August 2016
Line 1:		Line 1:
		+
	==A thiazolyl-mannoside bound to FimH, monoclinic space group==		==A thiazolyl-mannoside bound to FimH, monoclinic space group==
	<StructureSection load='3zl1' size='340' side='right' caption='[[3zl1]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='3zl1' size='340' side='right' caption='[[3zl1]], [[Resolution\|resolution]] 1.55Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BWG:N-{5-[(1R)-1-HYDROXYETHYL]-1,3-THIAZOL-2-YL}-ALPHA-D-MANNOPYRANOSYLAMINE'>BWG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BWG:N-{5-[(1R)-1-HYDROXYETHYL]-1,3-THIAZOL-2-YL}-ALPHA-D-MANNOPYRANOSYLAMINE'>BWG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zl2\|3zl2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zl2\|3zl2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zl1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zl1 RCSB], [http://www.ebi.ac.uk/pdbsum/3zl1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zl1 OCA], [http://pdbe.org/3zl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zl1 RCSB], [http://www.ebi.ac.uk/pdbsum/3zl1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zl1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zl1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:45, 24 December 2014

OCA — Wed, 24 Dec 2014 13:45:25 GMT

←Older revision		Revision as of 13:45, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zl1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zl1 RCSB], [http://www.ebi.ac.uk/pdbsum/3zl1 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zl1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zl1 RCSB], [http://www.ebi.ac.uk/pdbsum/3zl1 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FIMH_ECOLI FIMH_ECOLI]] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:15, 21 December 2014

OCA — Sun, 21 Dec 2014 09:15:26 GMT

←Older revision		Revision as of 09:15, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3zl1\| PDB=3zl1 \| SCENE= }}~~	+	==A thiazolyl-mannoside bound to FimH, monoclinic space group==
-	===A thiazolyl-mannoside bound to FimH, monoclinic space group===	+	<StructureSection load='3zl1' size='340' side='right' caption='[[3zl1]], [[Resolution\|resolution]] 1.55Å' scene=''>
-	{~~{ABSTRACT_PUBMED_23795713}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zl1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_j96 Escherichia coli j96]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZL1 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BWG:N-{5-[(1R)-1-HYDROXYETHYL]-1,3-THIAZOL-2-YL}-ALPHA-D-MANNOPYRANOSYLAMINE'>BWG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zl2\|3zl2]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zl1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zl1 RCSB], [http://www.ebi.ac.uk/pdbsum/3zl1 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Adherent-invasive Escherichia coli (AIEC) have previously been shown to induce gut inflammation in patients with Crohn's disease (CD). We developed a set of mannosides to prevent AIEC attachment to the gut by blocking the FimH bacterial adhesin. The crystal structure of the FimH lectin domain in complex with a lead thiazolylaminomannoside highlighted the preferential position for pharmacomodulations. A small library of analogues showing nanomolar affinity for FimH was then developed. Notably, AIEC attachment to intestinal cells was efficiently prevented by the most active compound and at around 10000-fold and 100-fold lower concentrations than mannose and the potent FimH inhibitor heptylmannoside, respectively. An ex vivo assay performed on the colonic tissue of a transgenic mouse model of CD confirmed this antiadhesive potential. Given the key role of AIEC in the chronic intestinal inflammation of CD patients, these results suggest a potential antiadhesive treatment with the FimH inhibitors developed.

-	~~==Function==~~	+	Thiazolylaminomannosides As Potent Antiadhesives of Type 1 Piliated Escherichia coli Isolated from Crohn's Disease Patients.,Brument S, Sivignon A, Dumych TI, Moreau N, Roos G, Guerardel Y, Chalopin T, Deniaud D, Bilyy RO, Darfeuille-Michaud A, Bouckaert J, Gouin SG J Med Chem. 2013 Jun 24. PMID:23795713<ref>PMID:23795713</ref>
-	~~[[http://www.uniprot.org/uniprot/FIMH_ECOLI FIMH_ECOLI]] Involved in regulation of length and mediation of adhesion~~ of ~~type~~ 1 ~~fimbriae (but not necessary for the production of fimbriae)~~. ~~Adhesin responsible for the binding to~~ D-~~mannose~~. ~~It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3zl1]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli_j96 Escherichia coli j96]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3ZL1 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023795713</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli j96]]		[[Category: Escherichia coli j96]]
-	[[Category: Bilyy, R O.]]	+	[[Category: Bilyy, R O]]
-	[[Category: Bouckaert, J.]]	+	[[Category: Bouckaert, J]]
-	[[Category: Brument, S.]]	+	[[Category: Brument, S]]
-	[[Category: Chalopin, T.]]	+	[[Category: Chalopin, T]]
-	[[Category: Darfeuille-Michaud, A.]]	+	[[Category: Darfeuille-Michaud, A]]
-	[[Category: Deniaud, D.]]	+	[[Category: Deniaud, D]]
-	[[Category: Dumych, T I.]]	+	[[Category: Dumych, T I]]
-	[[Category: Gouin, S G.]]	+	[[Category: Gouin, S G]]
-	[[Category: Guerardel, Y.]]	+	[[Category: Guerardel, Y]]
-	[[Category: Moreau, N.]]	+	[[Category: Moreau, N]]
-	[[Category: Roos, G.]]	+	[[Category: Roos, G]]
-	[[Category: Sivignon, A.]]	+	[[Category: Sivignon, A]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Crohn's disease]]		[[Category: Crohn's disease]]

OCA at 15:40, 10 July 2013

OCA — Wed, 10 Jul 2013 15:40:02 GMT

←Older revision		Revision as of 15:40, 10 July 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_3zl1\| PDB=3zl1 \| SCENE= }}
		+	===A thiazolyl-mannoside bound to FimH, monoclinic space group===
		+	{{ABSTRACT_PUBMED_23795713}}

-	~~The entry 3zl1~~ is ~~ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/FIMH_ECOLI FIMH_ECOLI]] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.

-	~~Authors~~: ~~Brument, S~~.~~, Sivignon, A~~.~~, Dumych, T~~.I.~~, Moreau, N~~.~~, Roos, G~~.~~, Guerardel, Y., Chalopin, T., Deniaud, D., Bilyy, R.O., Darfeuille~~-~~Michaud, A., Bouckaert, J., Gouin, S.G~~.	+	==About this Structure==
		+	[[3zl1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_j96 Escherichia coli j96]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZL1 OCA].

-	~~Description~~: ~~A thiazolyl~~-~~mannoside bound to FimH~~, ~~monoclinic space group~~	+	==Reference==
		+	<ref group="xtra">PMID:023795713</ref><references group="xtra"/><references/>
		+	[[Category: Escherichia coli j96]]
		+	[[Category: Bilyy, R O.]]
		+	[[Category: Bouckaert, J.]]
		+	[[Category: Brument, S.]]
		+	[[Category: Chalopin, T.]]
		+	[[Category: Darfeuille-Michaud, A.]]
		+	[[Category: Deniaud, D.]]
		+	[[Category: Dumych, T I.]]
		+	[[Category: Gouin, S G.]]
		+	[[Category: Guerardel, Y.]]
		+	[[Category: Moreau, N.]]
		+	[[Category: Roos, G.]]
		+	[[Category: Sivignon, A.]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Crohn's disease]]
		+	[[Category: Immunoglobulin]]
		+	[[Category: Thiazole]]
		+	[[Category: Type-1 fimbriae]]

OCA at 13:12, 20 February 2013

OCA — Wed, 20 Feb 2013 13:12:19 GMT

←Older revision		Revision as of 13:12, 20 February 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3zl1 is ON HOLD	+	The entry 3zl1 is ON HOLD until Paper Publication

	Authors: Brument, S., Sivignon, A., Dumych, T.I., Moreau, N., Roos, G., Guerardel, Y., Chalopin, T., Deniaud, D., Bilyy, R.O., Darfeuille-Michaud, A., Bouckaert, J., Gouin, S.G.		Authors: Brument, S., Sivignon, A., Dumych, T.I., Moreau, N., Roos, G., Guerardel, Y., Chalopin, T., Deniaud, D., Bilyy, R.O., Darfeuille-Michaud, A., Bouckaert, J., Gouin, S.G.

	Description: A thiazolyl-mannoside bound to FimH, monoclinic space group		Description: A thiazolyl-mannoside bound to FimH, monoclinic space group

OCA: Protected "3zl1" [edit=sysop:move=sysop]

OCA — Wed, 06 Feb 2013 12:15:51 GMT

Protected "3zl1" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:15, 6 February 2013

OCA: New page: '''Unreleased structure''' The entry 3zl1 is ON HOLD Authors: Brument, S., Sivignon, A., Dumych, T.I., Moreau, N., Roos, G., Guerardel, Y., Chalopin, T., Deniaud, D., Bilyy, R.O., Darfe...

OCA — Wed, 06 Feb 2013 12:15:50 GMT

New page: '''Unreleased structure''' The entry 3zl1 is ON HOLD Authors: Brument, S., Sivignon, A., Dumych, T.I., Moreau, N., Roos, G., Guerardel, Y., Chalopin, T., Deniaud, D., Bilyy, R.O., Darfe...

New page

'''Unreleased structure'''

The entry 3zl1 is ON HOLD

Authors: Brument, S., Sivignon, A., Dumych, T.I., Moreau, N., Roos, G., Guerardel, Y., Chalopin, T., Deniaud, D., Bilyy, R.O., Darfeuille-Michaud, A., Bouckaert, J., Gouin, S.G.

Description: A thiazolyl-mannoside bound to FimH, monoclinic space group