3znl - Revision history

OCA at 11:07, 20 December 2023

OCA — Wed, 20 Dec 2023 11:07:03 GMT

←Older revision		Revision as of 11:07, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='3znl' size='340' side='right'caption='[[3znl]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3znl' size='340' side='right'caption='[[3znl]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3znl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Influenza_a_virus~~ Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZNL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3znl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Vietnam/1194/2004(H5N1)) Influenza A virus (A/Vietnam/1194/2004(H5N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZNL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=~~NAG~~:N-~~ACETYL~~-~~D-GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~FUC~~:ALPHA-~~L-FUCOSE~~'>~~FUC~~</scene>, <scene name='pdbligand=~~GLA~~:~~ALPHA+~~D-~~GALACTOSE~~'>~~GLA~~</scene>, <scene name='pdbligand=NGS:2-(ACETYLAMINO)-2-DEOXY-6-O-SULFO-BETA-D-GLUCOPYRANOSE'>NGS</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene~~></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NGS:2-(ACETYLAMINO)-2-DEOXY-6-O-SULFO-BETA-D-GLUCOPYRANOSE'>NGS</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3znk\|3znk]], [[3znm\|3znm]]</div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3znl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3znl OCA], [https://pdbe.org/3znl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3znl RCSB], [https://www.ebi.ac.uk/pdbsum/3znl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3znl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3znl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3znl OCA], [https://pdbe.org/3znl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3znl RCSB], [https://www.ebi.ac.uk/pdbsum/3znl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3znl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]	+	[https://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]

	==See Also==		==See Also==
Line 16:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Influenza a virus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bovin, N]]	+	[[Category: Bovin N]]
-	[[Category: Coombs, P]]	+	[[Category: Coombs P]]
-	[[Category: Gamblin~~, S J~~]]	+	[[Category: Gamblin SJ]]
-	[[Category: Martin~~, S R~~]]	+	[[Category: Martin SR]]
-	[[Category: Skehel~~, J J~~]]	+	[[Category: Skehel JJ]]
-	[[Category: Tuzikov, A]]	+	[[Category: Tuzikov A]]
-	[[Category: Walker~~, P A~~]]	+	[[Category: Walker PA]]
-	[[Category: Xiong, X]]	+	[[Category: Xiong X]]
-	~~[[Category: Avian flu]]~~	+
-	~~[[Category: Fucosylated sialoside]]~~	+
-	~~[[Category: Fucosylation]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Sialic acid]]~~	+
-	~~[[Category: Sialyllactosamine]]~~	+
-	~~[[Category: Sulfated sialoside]]~~	+
-	~~[[Category: Sulfation]]~~	+
-	~~[[Category: Viral protein]]~~	+
-	~~[[Category: Virus receptor~~]]	+

OCA at 07:03, 18 August 2022

OCA — Thu, 18 Aug 2022 07:03:22 GMT

←Older revision		Revision as of 07:03, 18 August 2022
Line 1:		Line 1:

	==H5 Haemagglutinin in Complex with 6-O-Sulfo-Sialyl-Lewis X (Sulfated Lewis X)==		==H5 Haemagglutinin in Complex with 6-O-Sulfo-Sialyl-Lewis X (Sulfated Lewis X)==
-	<StructureSection load='3znl' size='340' side='right' caption='[[3znl]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='3znl' size='340' side='right'caption='[[3znl]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3znl]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZNL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3znl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZNL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=~~FUC~~:~~ALPHA~~-L-~~FUCOSE~~'>~~FUC~~</scene>, <scene name='pdbligand=~~GLA~~:ALPHA+D-~~GALACTOSE~~'>~~GLA~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL-~~D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=NGS:2-(ACETYLAMINO)-2-DEOXY-6-O-SULFO-BETA-D-GLUCOPYRANOSE'>NGS</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=NGS:2-(ACETYLAMINO)-2-DEOXY-6-O-SULFO-BETA-D-GLUCOPYRANOSE'>NGS</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3znk\|3znk]], [[3znm\|3znm]]</td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3znl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3znl OCA], [~~http~~://pdbe.org/3znl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3znl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3znl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3znl ProSAT]</span></td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3znk\|3znk]], [[3znm\|3znm]]</div></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3znl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3znl OCA], [https://pdbe.org/3znl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3znl RCSB], [https://www.ebi.ac.uk/pdbsum/3znl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3znl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]	+	[[https://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]

	==See Also==		==See Also==
-	*[[Hemagglutinin\|Hemagglutinin]]	+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
		+	[[Category: Large Structures]]
	[[Category: Bovin, N]]		[[Category: Bovin, N]]
	[[Category: Coombs, P]]		[[Category: Coombs, P]]

OCA at 16:40, 27 February 2019

OCA — Wed, 27 Feb 2019 16:40:14 GMT

←Older revision		Revision as of 16:40, 27 February 2019
Line 3:		Line 3:
	<StructureSection load='3znl' size='340' side='right' caption='[[3znl]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3znl' size='340' side='right' caption='[[3znl]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3znl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Influenza_a_virus_(a/viet_nam/1194/2004(h5n1))~~ Influenza a virus ~~(a/viet nam/1194/2004(h5n1))~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZNL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3znl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZNL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=~~NAG~~:N-~~ACETYL~~-~~D-GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~FUC~~:ALPHA-~~L-FUCOSE~~'>~~FUC~~</scene>, <scene name='pdbligand=~~GLA~~:~~ALPHA+~~D-~~GALACTOSE~~'>~~GLA~~</scene>, <scene name='pdbligand=NGS:2-(ACETYLAMINO)-2-DEOXY-6-O-SULFO-BETA-D-GLUCOPYRANOSE'>NGS</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NGS:2-(ACETYLAMINO)-2-DEOXY-6-O-SULFO-BETA-D-GLUCOPYRANOSE'>NGS</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3znk\|3znk]], [[3znm\|3znm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3znk\|3znk]], [[3znm\|3znm]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3znl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3znl OCA], [http://pdbe.org/3znl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3znl RCSB], [http://www.ebi.ac.uk/pdbsum/3znl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3znl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3znl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3znl OCA], [http://pdbe.org/3znl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3znl RCSB], [http://www.ebi.ac.uk/pdbsum/3znl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3znl ProSAT]</span></td></tr>
Line 16:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Influenza a virus]]
	[[Category: Bovin, N]]		[[Category: Bovin, N]]
	[[Category: Coombs, P]]		[[Category: Coombs, P]]

OCA at 15:02, 4 August 2016

OCA — Thu, 04 Aug 2016 15:02:39 GMT

←Older revision		Revision as of 15:02, 4 August 2016
Line 1:		Line 1:
		+
	==H5 Haemagglutinin in Complex with 6-O-Sulfo-Sialyl-Lewis X (Sulfated Lewis X)==		==H5 Haemagglutinin in Complex with 6-O-Sulfo-Sialyl-Lewis X (Sulfated Lewis X)==
	<StructureSection load='3znl' size='340' side='right' caption='[[3znl]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3znl' size='340' side='right' caption='[[3znl]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3znk\|3znk]], [[3znm\|3znm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3znk\|3znk]], [[3znm\|3znm]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3znl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3znl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3znl RCSB], [http://www.ebi.ac.uk/pdbsum/3znl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3znl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3znl OCA], [http://pdbe.org/3znl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3znl RCSB], [http://www.ebi.ac.uk/pdbsum/3znl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3znl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 16:04, 24 December 2014

OCA — Wed, 24 Dec 2014 16:04:30 GMT

←Older revision		Revision as of 16:04, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3znl\| PDB=3znl \| SCENE= }}~~	+	==H5 Haemagglutinin in Complex with 6-O-Sulfo-Sialyl-Lewis X (Sulfated Lewis X)==
-	===H5 Haemagglutinin in Complex with 6-O-Sulfo-Sialyl-Lewis X (Sulfated Lewis X)===	+	<StructureSection load='3znl' size='340' side='right' caption='[[3znl]], [[Resolution\|resolution]] 2.50Å' scene=''>
-		+	== Structural highlights ==
-	==Function==	+	<table><tr><td colspan='2'>[[3znl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/viet_nam/1194/2004(h5n1)) Influenza a virus (a/viet nam/1194/2004(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZNL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=NGS:2-(ACETYLAMINO)-2-DEOXY-6-O-SULFO-BETA-D-GLUCOPYRANOSE'>NGS</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3znk\|3znk]], [[3znm\|3znm]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3znl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3znl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3znl RCSB], [http://www.ebi.ac.uk/pdbsum/3znl PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]		[[http://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]

-	==~~About this Structure~~==	+	==See Also==
-	[[~~3znl~~]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/viet_nam/1194/2004(h5n1)) Influenza a virus (a/viet nam/1194/2004(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNL OCA].	+	*[[Hemagglutinin\|Hemagglutinin]]
-		+	__TOC__
-	~~==Reference==~~	+	</StructureSection>
-	~~<ref group="xtra">PMID:024036174</ref><references group="xtra"/>~~<~~references~~/>	+	[[Category: Bovin, N]]
-	[[Category: Bovin, N.]]	+	[[Category: Coombs, P]]
-	[[Category: Coombs, P.]]	+	[[Category: Gamblin, S J]]
-	[[Category: Gamblin, S J.]]	+	[[Category: Martin, S R]]
-	[[Category: Martin, S R.]]	+	[[Category: Skehel, J J]]
-	[[Category: Skehel, J J.]]	+	[[Category: Tuzikov, A]]
-	[[Category: Tuzikov, A.]]	+	[[Category: Walker, P A]]
-	[[Category: Walker, P A.]]	+	[[Category: Xiong, X]]
-	[[Category: Xiong, X.]]	+
	[[Category: Avian flu]]		[[Category: Avian flu]]
	[[Category: Fucosylated sialoside]]		[[Category: Fucosylated sialoside]]

OCA at 08:59, 27 November 2013

OCA — Wed, 27 Nov 2013 08:59:14 GMT

←Older revision		Revision as of 08:59, 27 November 2013
Line 6:		Line 6:

	==About this Structure==		==About this Structure==
-	[[3znl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Influenza_a_virus~~ Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNL OCA].	+	[[3znl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/viet_nam/1194/2004(h5n1)) Influenza a virus (a/viet nam/1194/2004(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNL OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:024036174</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:024036174</ref><references group="xtra"/><references/>
-	[[Category: Influenza a virus]]
	[[Category: Bovin, N.]]		[[Category: Bovin, N.]]
	[[Category: Coombs, P.]]		[[Category: Coombs, P.]]

OCA at 08:11, 29 September 2013

OCA — Sun, 29 Sep 2013 08:11:34 GMT

←Older revision		Revision as of 08:11, 29 September 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_3znl\| PDB=3znl \| SCENE= }}
		+	===H5 Haemagglutinin in Complex with 6-O-Sulfo-Sialyl-Lewis X (Sulfated Lewis X)===

-	~~The entry 3znl is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]

-	~~Authors~~: ~~Xiong, X~~.~~, Tuzikov, A~~.~~, Coombs, P~~.~~, Martin, S.R., Walker, P.A., Gamblin, S.J~~.~~, Bovin, N~~.~~, Skehel, J~~.J.	+	==About this Structure==
		+	[[3znl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNL OCA].

-	~~Description~~: ~~H5 Haemagglutinin in Complex with 6-O-Sulfo-Sialyl-Lewis~~ X (Sulfated ~~Lewis X)~~	+	==Reference==
		+	<ref group="xtra">PMID:024036174</ref><references group="xtra"/><references/>
		+	[[Category: Influenza a virus]]
		+	[[Category: Bovin, N.]]
		+	[[Category: Coombs, P.]]
		+	[[Category: Gamblin, S J.]]
		+	[[Category: Martin, S R.]]
		+	[[Category: Skehel, J J.]]
		+	[[Category: Tuzikov, A.]]
		+	[[Category: Walker, P A.]]
		+	[[Category: Xiong, X.]]
		+	[[Category: Avian flu]]
		+	[[Category: Fucosylated sialoside]]
		+	[[Category: Fucosylation]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Sialic acid]]
		+	[[Category: Sialyllactosamine]]
		+	[[Category: Sulfated sialoside]]
		+	[[Category: Sulfation]]
		+	[[Category: Viral protein]]
		+	[[Category: Virus receptor]]

OCA at 11:58, 24 July 2013

OCA — Wed, 24 Jul 2013 11:58:52 GMT

←Older revision		Revision as of 11:58, 24 July 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3znl is ON HOLD	+	The entry 3znl is ON HOLD until Paper Publication

	Authors: Xiong, X., Tuzikov, A., Coombs, P., Martin, S.R., Walker, P.A., Gamblin, S.J., Bovin, N., Skehel, J.J.		Authors: Xiong, X., Tuzikov, A., Coombs, P., Martin, S.R., Walker, P.A., Gamblin, S.J., Bovin, N., Skehel, J.J.

	Description: H5 Haemagglutinin in Complex with 6-O-Sulfo-Sialyl-Lewis X (Sulfated Lewis X)		Description: H5 Haemagglutinin in Complex with 6-O-Sulfo-Sialyl-Lewis X (Sulfated Lewis X)

OCA: Protected "3znl" [edit=sysop:move=sysop]

OCA — Wed, 27 Feb 2013 14:06:58 GMT

Protected "3znl" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:06, 27 February 2013

OCA: New page: '''Unreleased structure''' The entry 3znl is ON HOLD Authors: Xiong, X., Tuzikov, A., Coombs, P., Martin, S.R., Walker, P.A., Gamblin, S.J., Bovin, N., Skehel, J.J. Description: H5 Hae...

OCA — Wed, 27 Feb 2013 14:06:56 GMT

New page: '''Unreleased structure''' The entry 3znl is ON HOLD Authors: Xiong, X., Tuzikov, A., Coombs, P., Martin, S.R., Walker, P.A., Gamblin, S.J., Bovin, N., Skehel, J.J. Description: H5 Hae...

New page

'''Unreleased structure'''

The entry 3znl is ON HOLD

Authors: Xiong, X., Tuzikov, A., Coombs, P., Martin, S.R., Walker, P.A., Gamblin, S.J., Bovin, N., Skehel, J.J.

Description: H5 Haemagglutinin in Complex with 6-O-Sulfo-Sialyl-Lewis X (Sulfated Lewis X)