3znn - Revision history

OCA at 11:07, 20 December 2023

OCA — Wed, 20 Dec 2023 11:07:10 GMT

←Older revision		Revision as of 11:07, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='3znn' size='340' side='right'caption='[[3znn]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3znn' size='340' side='right'caption='[[3znn]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3znn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZNN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3znn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZNN FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=4WL:4H~~-~~THIENO~~[~~3,2-B~~]~~PYROLE-5-CARBOXYLIC+ACID'>4WL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;'>~~[~~[3zno\|3zno]]~~, ~~[[3znp\|3znp~~]~~], [[3znq\|3znq]]</div~~></td><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4WL:4H-THIENO[3,2-B]PYROLE-5-CARBOXYLIC+ACID'>4WL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/D-amino-acid_oxidase D-amino-acid oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.3 1.4.3.3]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3znn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3znn OCA], [https://pdbe.org/3znn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3znn RCSB], [https://www.ebi.ac.uk/pdbsum/3znn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3znn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3znn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3znn OCA], [https://pdbe.org/3znn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3znn RCSB], [https://www.ebi.ac.uk/pdbsum/3znn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3znn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/OXDA_HUMAN OXDA_HUMAN]] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.<ref>PMID:17303072</ref>	+	[https://www.uniprot.org/uniprot/OXDA_HUMAN OXDA_HUMAN] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.<ref>PMID:17303072</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~D-amino-acid oxidase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Allen~~, M S~~]]	+	[[Category: Allen MS]]
-	[[Category: Bowen~~, C A~~]]	+	[[Category: Bowen CA]]
-	[[Category: Chytil, M]]	+	[[Category: Chytil M]]
-	[[Category: Fang~~, Q K~~]]	+	[[Category: Fang QK]]
-	[[Category: Foglesong~~, R J~~]]	+	[[Category: Foglesong RJ]]
-	[[Category: Hardy~~, L W~~]]	+	[[Category: Hardy LW]]
-	[[Category: Heffernan~~, M L.R~~]]	+	[[Category: Heffernan MLR]]
-	[[Category: Hopkins~~, S C~~]]	+	[[Category: Hopkins SC]]
-	[[Category: Jones~~, S W~~]]	+	[[Category: Jones SW]]
-	[[Category: Koch, P]]	+	[[Category: Koch P]]
-	[[Category: Large~~, T H~~]]	+	[[Category: Large TH]]
-	[[Category: Melnick, L]]	+	[[Category: Melnick L]]
-	[[Category: Molla, G]]	+	[[Category: Molla G]]
-	[[Category: Nardini, M]]	+	[[Category: Nardini M]]
-	[[Category: Oliet~~, S H.R~~]]	+	[[Category: Oliet SHR]]
-	[[Category: Orsini~~, M A~~]]	+	[[Category: Orsini MA]]
-	[[Category: Panatier, A]]	+	[[Category: Panatier A]]
-	[[Category: Piubelli, L]]	+	[[Category: Piubelli L]]
-	[[Category: Pollegioni, L]]	+	[[Category: Pollegioni L]]
-	[[Category: Saraswat~~, L D~~]]	+	[[Category: Saraswat LD]]
-	[[Category: Soukri, M]]	+	[[Category: Soukri M]]
-	[[Category: Spear~~, K L~~]]	+	[[Category: Spear KL]]
-	[[Category: Varney~~, M A]]~~	+	[[Category: Varney MA]]
-	~~[[Category: Flavooxidase]]~~	+
-	~~[[Category: Neurotransmission]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 07:03, 18 August 2022

OCA — Thu, 18 Aug 2022 07:03:18 GMT

←Older revision		Revision as of 07:03, 18 August 2022
Line 1:		Line 1:

	==IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN==		==IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN==
-	<StructureSection load='3znn' size='340' side='right' caption='[[3znn]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='3znn' size='340' side='right'caption='[[3znn]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3znn]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZNN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3znn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZNN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4WL:4H-THIENO[3,2-B]PYROLE-5-CARBOXYLIC+ACID'>4WL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4WL:4H-THIENO[3,2-B]PYROLE-5-CARBOXYLIC+ACID'>4WL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zno\|3zno]], [[3znp\|3znp]], [[3znq\|3znq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zno\|3zno]], [[3znp\|3znp]], [[3znq\|3znq]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/D-amino-acid_oxidase D-amino-acid oxidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.3 1.4.3.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/D-amino-acid_oxidase D-amino-acid oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.3 1.4.3.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3znn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3znn OCA], [~~http~~://pdbe.org/3znn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3znn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3znn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3znn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3znn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3znn OCA], [https://pdbe.org/3znn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3znn RCSB], [https://www.ebi.ac.uk/pdbsum/3znn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3znn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/OXDA_HUMAN OXDA_HUMAN]] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.<ref>PMID:17303072</ref>	+	[[https://www.uniprot.org/uniprot/OXDA_HUMAN OXDA_HUMAN]] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.<ref>PMID:17303072</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Amino acid oxidase\|Amino acid oxidase]]	+	*[[Amino acid oxidase 3D structures\|Amino acid oxidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	[[Category: D-amino-acid oxidase]]		[[Category: D-amino-acid oxidase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Allen, M S]]		[[Category: Allen, M S]]
	[[Category: Bowen, C A]]		[[Category: Bowen, C A]]

OCA at 17:48, 5 August 2016

OCA — Fri, 05 Aug 2016 17:48:00 GMT

←Older revision		Revision as of 17:48, 5 August 2016
Line 1:		Line 1:
		+
	==IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN==		==IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN==
	<StructureSection load='3znn' size='340' side='right' caption='[[3znn]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3znn' size='340' side='right' caption='[[3znn]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3znn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZNN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3znn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZNN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4WL:4H-THIENO[3,2-B]PYROLE-5-CARBOXYLIC+ACID'>4WL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4WL:4H-THIENO[3,2-B]PYROLE-5-CARBOXYLIC+ACID'>4WL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zno\|3zno]], [[3znp\|3znp]], [[3znq\|3znq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zno\|3zno]], [[3znp\|3znp]], [[3znq\|3znq]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/D-amino-acid_oxidase D-amino-acid oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.3 1.4.3.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/D-amino-acid_oxidase D-amino-acid oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.3 1.4.3.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3znn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3znn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3znn RCSB], [http://www.ebi.ac.uk/pdbsum/3znn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3znn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3znn OCA], [http://pdbe.org/3znn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3znn RCSB], [http://www.ebi.ac.uk/pdbsum/3znn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3znn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3znn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: D-amino-acid oxidase]]		[[Category: D-amino-acid oxidase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Allen, M S]]		[[Category: Allen, M S]]
	[[Category: Bowen, C A]]		[[Category: Bowen, C A]]

OCA at 20:44, 25 December 2014

OCA — Thu, 25 Dec 2014 20:44:50 GMT

←Older revision		Revision as of 20:44, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3znn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3znn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3znn RCSB], [http://www.ebi.ac.uk/pdbsum/3znn PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3znn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3znn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3znn RCSB], [http://www.ebi.ac.uk/pdbsum/3znn PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/OXDA_HUMAN OXDA_HUMAN]] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.<ref>PMID:17303072</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:48, 21 December 2014

OCA — Sun, 21 Dec 2014 09:48:34 GMT

←Older revision		Revision as of 09:48, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3znn\| PDB=3znn \| SCENE= }}~~	+	==IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN==
-	===IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN===	+	<StructureSection load='3znn' size='340' side='right' caption='[[3znn]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23631755}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3znn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZNN FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4WL:4H-THIENO[3,2-B]PYROLE-5-CARBOXYLIC+ACID'>4WL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zno\|3zno]], [[3znp\|3znp]], [[3znq\|3znq]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/D-amino-acid_oxidase D-amino-acid oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.3 1.4.3.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3znn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3znn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3znn RCSB], [http://www.ebi.ac.uk/pdbsum/3znn PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We characterized the mechanism and pharmacodynamics of five structurally distinct inhibitors of d-amino acid oxidase. All inhibitors bound the oxidized form of human enzyme with affinity slightly higher than that of benzoate (Kd approximately 2-4 muM). Stopped-flow experiments showed that pyrrole-based inhibitors possessed high affinity (Kd approximately 100-200 nM) and slow release kinetics (k < 0.01 s(-1)) in the presence of substrate, while inhibitors with pendent aromatic groups altered conformations of the active site lid, as evidenced by X-ray crystallography, and showed slower kinetics of association. Rigid bioisosteres of benzoic acid induced a closed-lid conformation, had slower release in the presence of substrate, and were more potent than benzoate. Steady-state d-serine concentrations were described in a PK/PD model, and competition for d-serine sites on NMDA receptors was demonstrated in vivo. DAAO inhibition increased the spatiotemporal influence of glial-derived d-serine, suggesting localized effects on neuronal circuits where DAAO can exert a neuromodulatory role.

-	~~==Function==~~	+	Structural, Kinetic, and Pharmacodynamic Mechanisms of d-Amino Acid Oxidase Inhibition by Small Molecules.,Hopkins SC, Heffernan ML, Saraswat LD, Bowen CA, Melnick L, Hardy LW, Orsini MA, Allen MS, Koch P, Spear KL, Foglesong RJ, Soukri M, Chytil M, Fang QK, Jones SW, Varney MA, Panatier A, Oliet SH, Pollegioni L, Piubelli L, Molla G, Nardini M, Large TH J Med Chem. 2013 May 9;56(9):3710-24. doi: 10.1021/jm4002583. Epub 2013 Apr 30. PMID:23631755<ref>PMID:23631755</ref>
-	~~[[http://www.uniprot.org/uniprot/OXDA_HUMAN OXDA_HUMAN]] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA~~ and ~~contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety~~ of D-~~amino acids with a preference for those having small hydrophobic side chains followed~~ by ~~those bearing polar~~, ~~aromatic~~, ~~and basic groups~~. ~~Does not act on acidic amino acids~~.<ref>PMID:~~17303072~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3znn]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNN OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023631755</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Amino acid oxidase\|Amino acid oxidase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: D-amino-acid oxidase]]		[[Category: D-amino-acid oxidase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Allen, M S.]]	+	[[Category: Allen, M S]]
-	[[Category: Bowen, C A.]]	+	[[Category: Bowen, C A]]
-	[[Category: Chytil, M.]]	+	[[Category: Chytil, M]]
-	[[Category: Fang, Q K.]]	+	[[Category: Fang, Q K]]
-	[[Category: Foglesong, R J.]]	+	[[Category: Foglesong, R J]]
-	[[Category: Hardy, L W.]]	+	[[Category: Hardy, L W]]
-	[[Category: Heffernan, M L.R.]]	+	[[Category: Heffernan, M L.R]]
-	[[Category: Hopkins, S C.]]	+	[[Category: Hopkins, S C]]
-	[[Category: Jones, S W.]]	+	[[Category: Jones, S W]]
-	[[Category: Koch, P.]]	+	[[Category: Koch, P]]
-	[[Category: Large, T H.]]	+	[[Category: Large, T H]]
-	[[Category: Melnick, L.]]	+	[[Category: Melnick, L]]
-	[[Category: Molla, G.]]	+	[[Category: Molla, G]]
-	[[Category: Nardini, M.]]	+	[[Category: Nardini, M]]
-	[[Category: Oliet, S H.R.]]	+	[[Category: Oliet, S H.R]]
-	[[Category: Orsini, M A.]]	+	[[Category: Orsini, M A]]
-	[[Category: Panatier, A.]]	+	[[Category: Panatier, A]]
-	[[Category: Piubelli, L.]]	+	[[Category: Piubelli, L]]
-	[[Category: Pollegioni, L.]]	+	[[Category: Pollegioni, L]]
-	[[Category: Saraswat, L D.]]	+	[[Category: Saraswat, L D]]
-	[[Category: Soukri, M.]]	+	[[Category: Soukri, M]]
-	[[Category: Spear, K L.]]	+	[[Category: Spear, K L]]
-	[[Category: Varney, M A.]]	+	[[Category: Varney, M A]]
	[[Category: Flavooxidase]]		[[Category: Flavooxidase]]
	[[Category: Neurotransmission]]		[[Category: Neurotransmission]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 06:31, 20 June 2013

OCA — Thu, 20 Jun 2013 06:31:47 GMT

←Older revision		Revision as of 06:31, 20 June 2013
Line 10:		Line 10:

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:023631755</ref><references group="xtra"/><references/>
	[[Category: D-amino-acid oxidase]]		[[Category: D-amino-acid oxidase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 07:19, 16 May 2013

OCA — Thu, 16 May 2013 07:19:32 GMT

←Older revision		Revision as of 07:19, 16 May 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_3znn\| PDB=3znn \| SCENE= }}
		+	===IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN===
		+	{{ABSTRACT_PUBMED_23631755}}

-	~~The entry 3znn is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/OXDA_HUMAN OXDA_HUMAN]] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.<ref>PMID:17303072</ref>

-	~~Authors~~: ~~Hopkins, S~~.C.~~, Heffernan, M~~.L., Saraswat, L.D., Bowen, C.A., Melnick, L., Hardy, L.W., Orsini, M.A., Allen, M.S., Koch, P., Spear, K.L., Foglesong, R.J., Soukri, M., Chytil, M., Fang, K., Jones, S.W., Varney, M.A., Panatier, A., Oliet, S.H.R., Pollegioni, L., Piubelli, L., Molla, G.~~, Nardini, M~~.~~, Large, T~~.H.	+	==About this Structure==
		+	[[3znn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNN OCA].

-	~~Description~~: ~~IN VITRO AND IN VIVO INHIBITION OF HUMAN~~ D-~~AMINO ACID OXIDASE~~: ~~REGULATION OF~~ D~~-SERINE CONCENTRATION IN THE BRAIN~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: D-amino-acid oxidase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Allen, M S.]]
		+	[[Category: Bowen, C A.]]
		+	[[Category: Chytil, M.]]
		+	[[Category: Fang, Q K.]]
		+	[[Category: Foglesong, R J.]]
		+	[[Category: Hardy, L W.]]
		+	[[Category: Heffernan, M L.R.]]
		+	[[Category: Hopkins, S C.]]
		+	[[Category: Jones, S W.]]
		+	[[Category: Koch, P.]]
		+	[[Category: Large, T H.]]
		+	[[Category: Melnick, L.]]
		+	[[Category: Molla, G.]]
		+	[[Category: Nardini, M.]]
		+	[[Category: Oliet, S H.R.]]
		+	[[Category: Orsini, M A.]]
		+	[[Category: Panatier, A.]]
		+	[[Category: Piubelli, L.]]
		+	[[Category: Pollegioni, L.]]
		+	[[Category: Saraswat, L D.]]
		+	[[Category: Soukri, M.]]
		+	[[Category: Spear, K L.]]
		+	[[Category: Varney, M A.]]
		+	[[Category: Flavooxidase]]
		+	[[Category: Neurotransmission]]
		+	[[Category: Oxidoreductase]]

OCA at 09:41, 13 March 2013

OCA — Wed, 13 Mar 2013 09:41:03 GMT

←Older revision		Revision as of 09:41, 13 March 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3znn is ON HOLD	+	The entry 3znn is ON HOLD until Paper Publication

	Authors: Hopkins, S.C., Heffernan, M.L., Saraswat, L.D., Bowen, C.A., Melnick, L., Hardy, L.W., Orsini, M.A., Allen, M.S., Koch, P., Spear, K.L., Foglesong, R.J., Soukri, M., Chytil, M., Fang, K., Jones, S.W., Varney, M.A., Panatier, A., Oliet, S.H.R., Pollegioni, L., Piubelli, L., Molla, G., Nardini, M., Large, T.H.		Authors: Hopkins, S.C., Heffernan, M.L., Saraswat, L.D., Bowen, C.A., Melnick, L., Hardy, L.W., Orsini, M.A., Allen, M.S., Koch, P., Spear, K.L., Foglesong, R.J., Soukri, M., Chytil, M., Fang, K., Jones, S.W., Varney, M.A., Panatier, A., Oliet, S.H.R., Pollegioni, L., Piubelli, L., Molla, G., Nardini, M., Large, T.H.

	Description: IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN		Description: IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN

OCA at 13:35, 6 March 2013

OCA — Wed, 06 Mar 2013 13:35:11 GMT

←Older revision		Revision as of 13:35, 6 March 2013
Line 3:		Line 3:
	The entry 3znn is ON HOLD		The entry 3znn is ON HOLD

-	Authors: Hopkins, S.C., Heffernan, M.L., Saraswat, L.D., Bowen, C.A., Melnick, L., Orsini, M.A., Allen, M.S., Koch, P., Spear, K.L., Foglesong, R.J., Soukri, M., Chytil, M., Fang, K., Jones, S.W., Varney, M.A., Panatier, A., Oliet, S.H.R., Pollegioni, L., Piubelli, L., Molla, G., Nardini, M., Large, T.H.	+	Authors: Hopkins, S.C., Heffernan, M.L., Saraswat, L.D., Bowen, C.A., Melnick, L., Hardy, L.W., Orsini, M.A., Allen, M.S., Koch, P., Spear, K.L., Foglesong, R.J., Soukri, M., Chytil, M., Fang, K., Jones, S.W., Varney, M.A., Panatier, A., Oliet, S.H.R., Pollegioni, L., Piubelli, L., Molla, G., Nardini, M., Large, T.H.

	Description: IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN		Description: IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN

OCA at 14:07, 27 February 2013

OCA — Wed, 27 Feb 2013 14:07:00 GMT

←Older revision		Revision as of 14:07, 27 February 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3znn is ON HOLD ~~until sometime in the future~~	+	The entry 3znn is ON HOLD

	Authors: Hopkins, S.C., Heffernan, M.L., Saraswat, L.D., Bowen, C.A., Melnick, L., Orsini, M.A., Allen, M.S., Koch, P., Spear, K.L., Foglesong, R.J., Soukri, M., Chytil, M., Fang, K., Jones, S.W., Varney, M.A., Panatier, A., Oliet, S.H.R., Pollegioni, L., Piubelli, L., Molla, G., Nardini, M., Large, T.H.		Authors: Hopkins, S.C., Heffernan, M.L., Saraswat, L.D., Bowen, C.A., Melnick, L., Orsini, M.A., Allen, M.S., Koch, P., Spear, K.L., Foglesong, R.J., Soukri, M., Chytil, M., Fang, K., Jones, S.W., Varney, M.A., Panatier, A., Oliet, S.H.R., Pollegioni, L., Piubelli, L., Molla, G., Nardini, M., Large, T.H.

	Description: IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN		Description: IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN