3zp6 - Revision history

OCA at 07:07, 18 August 2022

OCA — Thu, 18 Aug 2022 07:07:17 GMT

←Older revision		Revision as of 07:07, 18 August 2022
Line 1:		Line 1:

	==INFLUENZA VIRUS (VN1194) H5 E190D mutant HA with LSTc==		==INFLUENZA VIRUS (VN1194) H5 E190D mutant HA with LSTc==
-	<StructureSection load='3zp6' size='340' side='right' caption='[[3zp6]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='3zp6' size='340' side='right'caption='[[3zp6]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zp6]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZP6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZP6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zp6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZP6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~GAL~~:~~BETA~~-D-~~GALACTOSE~~'>~~GAL~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zp0\|3zp0]], [[3zp1\|3zp1]], [[3zp2\|3zp2]], [[3zp3\|3zp3]], [[3zpa\|3zpa]], [[3zpb\|3zpb]]</td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zp6 OCA], [~~http~~://pdbe.org/3zp6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zp6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zp6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zp6 ProSAT]</span></td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zp0\|3zp0]], [[3zp1\|3zp1]], [[3zp2\|3zp2]], [[3zp3\|3zp3]], [[3zpa\|3zpa]], [[3zpb\|3zpb]]</div></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zp6 OCA], [https://pdbe.org/3zp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zp6 RCSB], [https://www.ebi.ac.uk/pdbsum/3zp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zp6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]	+	[[https://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:

	==See Also==		==See Also==
-	*[[Hemagglutinin\|Hemagglutinin]]	+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Gamblin, S J]]		[[Category: Gamblin, S J]]
	[[Category: Liu, J]]		[[Category: Liu, J]]

OCA at 16:52, 27 February 2019

OCA — Wed, 27 Feb 2019 16:52:34 GMT

←Older revision		Revision as of 16:52, 27 February 2019
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zp6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZP6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZP6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zp6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZP6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZP6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~GAL~~:~~BETA~~-D-~~GALACTOSE~~'>~~GAL~~</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zp0\|3zp0]], [[3zp1\|3zp1]], [[3zp2\|3zp2]], [[3zp3\|3zp3]], [[3zpa\|3zpa]], [[3zpb\|3zpb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zp0\|3zp0]], [[3zp1\|3zp1]], [[3zp2\|3zp2]], [[3zp3\|3zp3]], [[3zpa\|3zpa]], [[3zpb\|3zpb]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zp6 OCA], [http://pdbe.org/3zp6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zp6 RCSB], [http://www.ebi.ac.uk/pdbsum/3zp6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zp6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zp6 OCA], [http://pdbe.org/3zp6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zp6 RCSB], [http://www.ebi.ac.uk/pdbsum/3zp6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zp6 ProSAT]</span></td></tr>

OCA at 11:19, 5 August 2016

OCA — Fri, 05 Aug 2016 11:19:56 GMT

←Older revision		Revision as of 11:19, 5 August 2016
Line 1:		Line 1:
		+
	==INFLUENZA VIRUS (VN1194) H5 E190D mutant HA with LSTc==		==INFLUENZA VIRUS (VN1194) H5 E190D mutant HA with LSTc==
	<StructureSection load='3zp6' size='340' side='right' caption='[[3zp6]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3zp6' size='340' side='right' caption='[[3zp6]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zp0\|3zp0]], [[3zp1\|3zp1]], [[3zp2\|3zp2]], [[3zp3\|3zp3]], [[3zpa\|3zpa]], [[3zpb\|3zpb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zp0\|3zp0]], [[3zp1\|3zp1]], [[3zp2\|3zp2]], [[3zp3\|3zp3]], [[3zpa\|3zpa]], [[3zpb\|3zpb]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zp6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zp6 RCSB], [http://www.ebi.ac.uk/pdbsum/3zp6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zp6 OCA], [http://pdbe.org/3zp6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zp6 RCSB], [http://www.ebi.ac.uk/pdbsum/3zp6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zp6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zp6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 01:58, 25 December 2014

OCA — Thu, 25 Dec 2014 01:58:06 GMT

←Older revision		Revision as of 01:58, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zp6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zp6 RCSB], [http://www.ebi.ac.uk/pdbsum/3zp6 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zp6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zp6 RCSB], [http://www.ebi.ac.uk/pdbsum/3zp6 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:47, 21 December 2014

OCA — Sun, 21 Dec 2014 09:47:11 GMT

←Older revision		Revision as of 09:47, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3zp6\| PDB=3zp6 \| SCENE= }}~~	+	==INFLUENZA VIRUS (VN1194) H5 E190D mutant HA with LSTc==
-	===INFLUENZA VIRUS (VN1194) H5 E190D mutant HA with LSTc===	+	<StructureSection load='3zp6' size='340' side='right' caption='[[3zp6]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24050651}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zp6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZP6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZP6 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zp0\|3zp0]], [[3zp1\|3zp1]], [[3zp2\|3zp2]], [[3zp3\|3zp3]], [[3zpa\|3zpa]], [[3zpb\|3zpb]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zp6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zp6 RCSB], [http://www.ebi.ac.uk/pdbsum/3zp6 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	As avian influenza A(H5N1) viruses continue to circulate in Asia and Africa, global concerns of an imminent pandemic persist. Recent experimental studies suggest that efficient transmission between humans of current H5N1 viruses only requires a few genetic changes. An essential step is alteration of the virus hemagglutinin from preferential binding to avian receptors for the recognition of human receptors present in the upper airway. We have identified receptor-binding changes which emerged during H5N1 infection of humans, due to single amino acid substitutions, Ala134Val and Ile151Phe, in the hemagglutinin. Detailed biological, receptor-binding, and structural analyses revealed reduced binding of the mutated viruses to avian-like receptors, but without commensurate increased binding to the human-like receptors investigated, possibly reflecting a receptor-binding phenotype intermediate in adaptation to more human-like characteristics. These observations emphasize that evolution in nature of avian H5N1 viruses to efficient binding of human receptors is a complex multistep process.

-	~~==Function==~~	+	Changes in the hemagglutinin of H5N1 viruses during human infection - Influence on receptor binding.,Crusat M, Liu J, Palma AS, Childs RA, Liu Y, Wharton SA, Lin YP, Coombs PJ, Martin SR, Matrosovich M, Chen Z, Stevens DJ, Hien VM, Thanh TT, Nhu LN, Nguyet LA, Ha DQ, van Doorn HR, Hien TT, Conradt HS, Kiso M, Gamblin SJ, Chai W, Skehel JJ, Hay AJ, Farrar J, de Jong MD, Feizi T Virology. 2013 Sep 17. pii: S0042-6822(13)00481-9. doi:, 10.1016/j.virol.2013.08.010. PMID:24050651<ref>PMID:24050651</ref>
-	~~[[http://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA]] Binds to sialic acid~~-~~containing receptors~~ on ~~the cell surface~~, ~~bringing about the attachment of the virus particle to the cell~~. ~~This attachment induces virion internalization of about two third of the virus particles through clathrin~~-~~dependent endocytosis and about one third through a clathrin~~- ~~and caveolin-independent pathway~~. ~~Plays a major role in the determination of host range restriction and virulence~~. ~~Class I viral fusion protein~~. ~~Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane~~. ~~Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide~~. ~~Several trimers are required to form a competent fusion pore (By similarity)~~.~~[RuleBase~~:~~RU003324][SAAS~~:~~SAAS008980_004_327643]~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3zp6]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/9infa 9infa]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3ZP6 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024050651</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Hemagglutinin\|Hemagglutinin]]
-	~~[[Category: 9infa]]~~	+	== References ==
-	[[Category: Gamblin, S J.]]	+	<references/>
-	[[Category: Liu, J.]]	+	__TOC__
-	[[Category: Skehel, J J.]]	+	</StructureSection>
-	[[Category: Stevens, D J.]]	+	[[Category: Gamblin, S J]]
		+	[[Category: Liu, J]]
		+	[[Category: Skehel, J J]]
		+	[[Category: Stevens, D J]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 11:49, 20 November 2013

OCA — Wed, 20 Nov 2013 11:49:41 GMT

←Older revision		Revision as of 11:49, 20 November 2013
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3zp6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Influenza_a_virus Influenza a virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZP6 OCA].	+	[[3zp6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZP6 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:024050651</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:024050651</ref><references group="xtra"/><references/>
-	[[Category: ~~Influenza a virus~~]]	+	[[Category: 9infa]]
	[[Category: Gamblin, S J.]]		[[Category: Gamblin, S J.]]
	[[Category: Liu, J.]]		[[Category: Liu, J.]]

OCA at 07:26, 2 October 2013

OCA — Wed, 02 Oct 2013 07:26:31 GMT

←Older revision		Revision as of 07:26, 2 October 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_3zp6\| PDB=3zp6 \| SCENE= }}
		+	===INFLUENZA VIRUS (VN1194) H5 E190D mutant HA with LSTc===
		+	{{ABSTRACT_PUBMED_24050651}}

-	~~The entry 3zp6 is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]

-	~~Authors~~: ~~LIU, J~~.~~, STEVENS, D~~.J.~~, GAMBLIN, S~~.J.~~, SKEHEL, J~~.J.	+	==About this Structure==
		+	[[3zp6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZP6 OCA].

-	~~Description~~: ~~INFLUENZA VIRUS (VN1194) H5 E190D mutant HA with LSTc~~	+	==Reference==
		+	<ref group="xtra">PMID:024050651</ref><references group="xtra"/><references/>
		+	[[Category: Influenza a virus]]
		+	[[Category: Gamblin, S J.]]
		+	[[Category: Liu, J.]]
		+	[[Category: Skehel, J J.]]
		+	[[Category: Stevens, D J.]]
		+	[[Category: Viral protein]]

OCA at 09:41, 13 March 2013

OCA — Wed, 13 Mar 2013 09:41:25 GMT

←Older revision		Revision as of 09:41, 13 March 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3zp6 is ON HOLD	+	The entry 3zp6 is ON HOLD until Paper Publication

	Authors: LIU, J., STEVENS, D.J., GAMBLIN, S.J., SKEHEL, J.J.		Authors: LIU, J., STEVENS, D.J., GAMBLIN, S.J., SKEHEL, J.J.

	Description: INFLUENZA VIRUS (VN1194) H5 E190D mutant HA with LSTc		Description: INFLUENZA VIRUS (VN1194) H5 E190D mutant HA with LSTc

OCA: Protected "3zp6" [edit=sysop:move=sysop]

OCA — Wed, 06 Mar 2013 13:36:05 GMT

Protected "3zp6" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:36, 6 March 2013

OCA: New page: '''Unreleased structure''' The entry 3zp6 is ON HOLD Authors: LIU, J., STEVENS, D.J., GAMBLIN, S.J., SKEHEL, J.J. Description: INFLUENZA VIRUS (VN1194) H5 E190D mutant HA with LSTc

OCA — Wed, 06 Mar 2013 13:36:04 GMT

New page: '''Unreleased structure''' The entry 3zp6 is ON HOLD Authors: LIU, J., STEVENS, D.J., GAMBLIN, S.J., SKEHEL, J.J. Description: INFLUENZA VIRUS (VN1194) H5 E190D mutant HA with LSTc

New page

'''Unreleased structure'''

The entry 3zp6 is ON HOLD

Authors: LIU, J., STEVENS, D.J., GAMBLIN, S.J., SKEHEL, J.J.

Description: INFLUENZA VIRUS (VN1194) H5 E190D mutant HA with LSTc