3zpv - Revision history

OCA at 11:09, 20 December 2023

OCA — Wed, 20 Dec 2023 11:09:19 GMT

←Older revision		Revision as of 11:09, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='3zpv' size='340' side='right'caption='[[3zpv]], [[Resolution\|resolution]] 2.68Å' scene=''>		<StructureSection load='3zpv' size='340' side='right'caption='[[3zpv]], [[Resolution\|resolution]] 2.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zpv]] is a 36 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZPV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zpv]] is a 36 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZPV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.68Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zpv OCA], [https://pdbe.org/3zpv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zpv RCSB], [https://www.ebi.ac.uk/pdbsum/3zpv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zpv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zpv OCA], [https://pdbe.org/3zpv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zpv RCSB], [https://www.ebi.ac.uk/pdbsum/3zpv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zpv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	~~[[https://www.uniprot.org/uniprot/BCL9_DROME BCL9_DROME]] Involved in signal transduction through the Wnt pathway. [~~[https://www.uniprot.org/uniprot/PYGO_DROME PYGO_DROME]] Involved in signal transduction through the Wnt pathway.	+	[https://www.uniprot.org/uniprot/PYGO_DROME PYGO_DROME] Involved in signal transduction through the Wnt pathway.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drome~~]]	+	[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bienz, M]]	+	[[Category: Bienz M]]
-	[[Category: Fiedler, M]]	+	[[Category: Fiedler M]]
-	[[Category: Mieszczanek, J]]	+	[[Category: Mieszczanek J]]
-	[[Category: Miller~~, T C.R~~]]	+	[[Category: Miller TCR]]
-	[[Category: Rutherford~~, T J~~]]	+	[[Category: Rutherford TJ]]
-	[[Category: Sanchez-Barrena~~, M J]]~~	+	[[Category: Sanchez-Barrena MJ]]
-	~~[[Category: Histone h3 tail binding]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Wnt signaling pathway]]~~	+
-	~~[[Category: Zn finger~~]]	+

OCA at 07:08, 18 August 2022

OCA — Thu, 18 Aug 2022 07:08:42 GMT

←Older revision		Revision as of 07:08, 18 August 2022
Line 1:		Line 1:

	==Crystal structure of Drosophila Pygo PHD finger in complex with Legless HD1 domain==		==Crystal structure of Drosophila Pygo PHD finger in complex with Legless HD1 domain==
-	<StructureSection load='3zpv' size='340' side='right' caption='[[3zpv]], [[Resolution\|resolution]] 2.68Å' scene=''>	+	<StructureSection load='3zpv' size='340' side='right'caption='[[3zpv]], [[Resolution\|resolution]] 2.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zpv]] is a 36 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZPV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZPV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zpv]] is a 36 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZPV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zpv OCA], [~~http~~://pdbe.org/3zpv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zpv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zpv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zpv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zpv OCA], [https://pdbe.org/3zpv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zpv RCSB], [https://www.ebi.ac.uk/pdbsum/3zpv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zpv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BCL9_DROME BCL9_DROME]] Involved in signal transduction through the Wnt pathway. [[~~http~~://www.uniprot.org/uniprot/PYGO_DROME PYGO_DROME]] Involved in signal transduction through the Wnt pathway.	+	[[https://www.uniprot.org/uniprot/BCL9_DROME BCL9_DROME]] Involved in signal transduction through the Wnt pathway. [[https://www.uniprot.org/uniprot/PYGO_DROME PYGO_DROME]] Involved in signal transduction through the Wnt pathway.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Drome]]		[[Category: Drome]]
		+	[[Category: Large Structures]]
	[[Category: Bienz, M]]		[[Category: Bienz, M]]
	[[Category: Fiedler, M]]		[[Category: Fiedler, M]]

OCA at 01:10, 5 August 2016

OCA — Fri, 05 Aug 2016 01:10:21 GMT

←Older revision		Revision as of 01:10, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Drosophila Pygo PHD finger in complex with Legless HD1 domain==		==Crystal structure of Drosophila Pygo PHD finger in complex with Legless HD1 domain==
	<StructureSection load='3zpv' size='340' side='right' caption='[[3zpv]], [[Resolution\|resolution]] 2.68Å' scene=''>		<StructureSection load='3zpv' size='340' side='right' caption='[[3zpv]], [[Resolution\|resolution]] 2.68Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3zpv]] is a 36 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZPV FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zpv]] is a 36 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZPV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zpv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zpv RCSB], [http://www.ebi.ac.uk/pdbsum/3zpv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zpv OCA], [http://pdbe.org/3zpv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zpv RCSB], [http://www.ebi.ac.uk/pdbsum/3zpv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zpv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zpv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:29, 24 December 2014

OCA — Wed, 24 Dec 2014 21:29:11 GMT

←Older revision		Revision as of 21:29, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3zpv\| PDB=3zpv \| SCENE= }}~~	+	==Crystal structure of Drosophila Pygo PHD finger in complex with Legless HD1 domain==
-	===Crystal structure of Drosophila Pygo PHD finger in complex with Legless HD1 domain===	+	<StructureSection load='3zpv' size='340' side='right' caption='[[3zpv]], [[Resolution\|resolution]] 2.68Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24183574}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3zpv]] is a 36 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZPV FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zpv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zpv RCSB], [http://www.ebi.ac.uk/pdbsum/3zpv PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/BCL9_DROME BCL9_DROME]] Involved in signal transduction through the Wnt pathway. [[http://www.uniprot.org/uniprot/PYGO_DROME PYGO_DROME]] Involved in signal transduction through the Wnt pathway.		[[http://www.uniprot.org/uniprot/BCL9_DROME BCL9_DROME]] Involved in signal transduction through the Wnt pathway. [[http://www.uniprot.org/uniprot/PYGO_DROME PYGO_DROME]] Involved in signal transduction through the Wnt pathway.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pygo proteins promote Armadillo- and beta-catenin-dependent transcription, by relieving Groucho-dependent repression of Wnt targets. Their PHD fingers bind histone H3 tail methylated at lysine 4, and to the HD1 domain of their Legless/BCL9 cofactors, linking Pygo to Armadillo/beta-catenin. Intriguingly, fly Pygo orthologs exhibit a tryptophan > phenylalanine substitution in their histone pocket-divider which reduces their affinity for histones. Here, we use X-ray crystallography and NMR, to discover a conspicuous groove bordering this phenylalanine in the Drosophila PHD-HD1 complex-a semi-aromatic cage recognizing asymmetrically methylated arginine 2 (R2me2a), a chromatin mark of silenced genes. Our structural model of the ternary complex reveals a distinct mode of dimethylarginine recognition, involving a polar interaction between R2me2a and its groove, the structural integrity of which is crucial for normal tissue patterning. Notably, humanized fly Pygo derepresses Notch targets, implying an inherent Notch-related function of classical Pygo orthologs, disabled in fly Pygo, which thus appears dedicated to Wnt signaling.

-	~~==About this~~ Structure==	+	Evolutionary Adaptation of the Fly Pygo PHD Finger toward Recognizing Histone H3 Tail Methylated at Arginine 2.,Miller TC, Mieszczanek J, Sanchez-Barrena MJ, Rutherford TJ, Fiedler M, Bienz M Structure. 2013 Oct 30. pii: S0969-2126(13)00364-X. doi:, 10.1016/j.str.2013.09.013. PMID:24183574<ref>PMID:24183574</ref>
-	~~[[3zpv]] is a 36 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Drome Drome]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=3ZPV OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024183574</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Drome]]		[[Category: Drome]]
-	[[Category: Bienz, M.]]	+	[[Category: Bienz, M]]
-	[[Category: Fiedler, M.]]	+	[[Category: Fiedler, M]]
-	[[Category: Mieszczanek, J.]]	+	[[Category: Mieszczanek, J]]
-	[[Category: Miller, T C.R.]]	+	[[Category: Miller, T C.R]]
-	[[Category: Rutherford, T J.]]	+	[[Category: Rutherford, T J]]
-	[[Category: Sanchez-Barrena, M J.]]	+	[[Category: Sanchez-Barrena, M J]]
	[[Category: Histone h3 tail binding]]		[[Category: Histone h3 tail binding]]
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Wnt signaling pathway]]		[[Category: Wnt signaling pathway]]
	[[Category: Zn finger]]		[[Category: Zn finger]]

OCA at 06:54, 13 November 2013

OCA — Wed, 13 Nov 2013 06:54:39 GMT

←Older revision		Revision as of 06:54, 13 November 2013
Line 1:		Line 1:
	{{STRUCTURE_3zpv\| PDB=3zpv \| SCENE= }}		{{STRUCTURE_3zpv\| PDB=3zpv \| SCENE= }}
	===Crystal structure of Drosophila Pygo PHD finger in complex with Legless HD1 domain===		===Crystal structure of Drosophila Pygo PHD finger in complex with Legless HD1 domain===
		+	{{ABSTRACT_PUBMED_24183574}}

	==Function==		==Function==
Line 6:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3zpv]] is a 36 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Drosophila_melanogaster Drosophila melanogaster~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZPV OCA].	+	[[3zpv]] is a 36 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZPV OCA].
-	[[Category: ~~Drosophila melanogaster~~]]	+
		+	==Reference==
		+	<ref group="xtra">PMID:024183574</ref><references group="xtra"/><references/>
		+	[[Category: Drome]]
	[[Category: Bienz, M.]]		[[Category: Bienz, M.]]
	[[Category: Fiedler, M.]]		[[Category: Fiedler, M.]]

OCA at 09:46, 30 October 2013

OCA — Wed, 30 Oct 2013 09:46:28 GMT

←Older revision		Revision as of 09:46, 30 October 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_3zpv\| PDB=3zpv \| SCENE= }}
		+	===Crystal structure of Drosophila Pygo PHD finger in complex with Legless HD1 domain===

-	~~The entry 3zpv is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/BCL9_DROME BCL9_DROME]] Involved in signal transduction through the Wnt pathway. [[http://www.uniprot.org/uniprot/PYGO_DROME PYGO_DROME]] Involved in signal transduction through the Wnt pathway.

-	~~Authors~~: ~~Miller, T~~.C.R.~~, Mieszczanek, J~~.~~, Sanchez~~-~~Barrena~~, M.J., Rutherford, T.J.~~, Fiedler, M., Bienz~~, M.	+	==About this Structure==
-		+	[[3zpv]] is a 36 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZPV OCA].
-	~~Description~~: ~~Crystal structure of Drosophila Pygo PHD~~ finger ~~in complex with Legless HD1 domain~~	+	[[Category: Drosophila melanogaster]]
		+	[[Category: Bienz, M.]]
		+	[[Category: Fiedler, M.]]
		+	[[Category: Mieszczanek, J.]]
		+	[[Category: Miller, T C.R.]]
		+	[[Category: Rutherford, T J.]]
		+	[[Category: Sanchez-Barrena, M J.]]
		+	[[Category: Histone h3 tail binding]]
		+	[[Category: Transcription]]
		+	[[Category: Wnt signaling pathway]]
		+	[[Category: Zn finger]]

OCA at 16:04, 20 March 2013

OCA — Wed, 20 Mar 2013 16:04:25 GMT

←Older revision		Revision as of 16:04, 20 March 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3zpv is ON HOLD	+	The entry 3zpv is ON HOLD until Paper Publication

	Authors: Miller, T.C.R., Mieszczanek, J., Sanchez-Barrena, M.J., Rutherford, T.J., Fiedler, M., Bienz, M.		Authors: Miller, T.C.R., Mieszczanek, J., Sanchez-Barrena, M.J., Rutherford, T.J., Fiedler, M., Bienz, M.

	Description: Crystal structure of Drosophila Pygo PHD finger in complex with Legless HD1 domain		Description: Crystal structure of Drosophila Pygo PHD finger in complex with Legless HD1 domain

OCA: Protected "3zpv" [edit=sysop:move=sysop]

OCA — Wed, 13 Mar 2013 09:41:57 GMT

Protected "3zpv" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:41, 13 March 2013

OCA: New page: '''Unreleased structure''' The entry 3zpv is ON HOLD Authors: Miller, T.C.R., Mieszczanek, J., Sanchez-Barrena, M.J., Rutherford, T.J., Fiedler, M., Bienz, M. Description: Crystal stru...

OCA — Wed, 13 Mar 2013 09:41:56 GMT

New page: '''Unreleased structure''' The entry 3zpv is ON HOLD Authors: Miller, T.C.R., Mieszczanek, J., Sanchez-Barrena, M.J., Rutherford, T.J., Fiedler, M., Bienz, M. Description: Crystal stru...

New page

'''Unreleased structure'''

The entry 3zpv is ON HOLD

Authors: Miller, T.C.R., Mieszczanek, J., Sanchez-Barrena, M.J., Rutherford, T.J., Fiedler, M., Bienz, M.

Description: Crystal structure of Drosophila Pygo PHD finger in complex with Legless HD1 domain