3zqg - Revision history

OCA at 11:09, 20 December 2023

OCA — Wed, 20 Dec 2023 11:09:44 GMT

←Older revision		Revision as of 11:09, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='3zqg' size='340' side='right'caption='[[3zqg]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='3zqg' size='340' side='right'caption='[[3zqg]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zqg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZQG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zqg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZQG FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[2xgc\|2xgc]]~~, [[~~2xpw~~\|~~2xpw~~]], [[1bjz\|1bjz]], [[2x9d\|2x9d]], [[2trt\|2trt]], [[2xpv\|2xpv]], [[2vkv\|2vkv]], [[1ork\|1ork]], [[2xge\|2xge]], [[2x6o\|2x6o]], [[1a6i\|1a6i]], [[2vke\|2vke]], [[1qpi\|1qpi]], [[2xgd\|2xgd]], [[1du7\|1du7]], [[2xrl\|2xrl]], [[2xpt\|2xpt]], [[2xpu\|2xpu]], [[2xb5\|2xb5]], [[1bj0\|1bj0]], [[2xps\|2xps]], [[2tct\|2tct]], [[1bjy\|1bjy]], [[3zqi\|3zqi]], [[3zqf\|3zqf]], [[3zqh\|3zqh]]</div></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.45Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqg OCA], [https://pdbe.org/3zqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zqg RCSB], [https://www.ebi.ac.uk/pdbsum/3zqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zqg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqg OCA], [https://pdbe.org/3zqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zqg RCSB], [https://www.ebi.ac.uk/pdbsum/3zqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zqg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TETR2_ECOLX TETR2_ECOLX]] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.	+	[https://www.uniprot.org/uniprot/TETR4_ECOLX TETR4_ECOLX] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.[https://www.uniprot.org/uniprot/TETR2_ECOLX TETR2_ECOLX] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Berens, C]]	+	[[Category: Berens C]]
-	[[Category: Goeke, D]]	+	[[Category: Goeke D]]
-	[[Category: Goetz, C]]	+	[[Category: Goetz C]]
-	[[Category: Grubmueller, S]]	+	[[Category: Grubmueller S]]
-	[[Category: Hillen, W]]	+	[[Category: Hillen W]]
-	[[Category: Kaspar, D]]	+	[[Category: Kaspar D]]
-	[[Category: Klotzsche, M]]	+	[[Category: Klotzsche M]]
-	[[Category: Muller~~, Y A~~]]	+	[[Category: Muller YA]]
-	[[Category: Sevvana, M]]	+	[[Category: Sevvana M]]
-	[[Category: Stoeckle, C]]	+	[[Category: Stoeckle C]]
-	[[Category: Wimmer, C]]	+	[[Category: Wimmer C]]
-	~~[[Category: Allostery]]~~	+
-	~~[[Category: Inducer]]~~	+
-	~~[[Category: Peptidic effector]]~~	+
-	~~[[Category: Tetr]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 07:09, 18 August 2022

OCA — Thu, 18 Aug 2022 07:09:51 GMT

←Older revision		Revision as of 07:09, 18 August 2022
Line 1:		Line 1:

	==Structure of Tetracycline repressor in complex with antiinducer peptide-TAP2==		==Structure of Tetracycline repressor in complex with antiinducer peptide-TAP2==
-	<StructureSection load='3zqg' size='340' side='right' caption='[[3zqg]], [[Resolution\|resolution]] 2.45Å' scene=''>	+	<StructureSection load='3zqg' size='340' side='right'caption='[[3zqg]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zqg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZQG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zqg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZQG FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xgc\|2xgc]], [[2xpw\|2xpw]], [[1bjz\|1bjz]], [[2x9d\|2x9d]], [[2trt\|2trt]], [[2xpv\|2xpv]], [[2vkv\|2vkv]], [[1ork\|1ork]], [[2xge\|2xge]], [[2x6o\|2x6o]], [[1a6i\|1a6i]], [[2vke\|2vke]], [[1qpi\|1qpi]], [[2xgd\|2xgd]], [[1du7\|1du7]], [[2xrl\|2xrl]], [[2xpt\|2xpt]], [[2xpu\|2xpu]], [[2xb5\|2xb5]], [[1bj0\|1bj0]], [[2xps\|2xps]], [[2tct\|2tct]], [[1bjy\|1bjy]], [[3zqi\|3zqi]], [[3zqf\|3zqf]], [[3zqh\|3zqh]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xgc\|2xgc]], [[2xpw\|2xpw]], [[1bjz\|1bjz]], [[2x9d\|2x9d]], [[2trt\|2trt]], [[2xpv\|2xpv]], [[2vkv\|2vkv]], [[1ork\|1ork]], [[2xge\|2xge]], [[2x6o\|2x6o]], [[1a6i\|1a6i]], [[2vke\|2vke]], [[1qpi\|1qpi]], [[2xgd\|2xgd]], [[1du7\|1du7]], [[2xrl\|2xrl]], [[2xpt\|2xpt]], [[2xpu\|2xpu]], [[2xb5\|2xb5]], [[1bj0\|1bj0]], [[2xps\|2xps]], [[2tct\|2tct]], [[1bjy\|1bjy]], [[3zqi\|3zqi]], [[3zqf\|3zqf]], [[3zqh\|3zqh]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqg OCA], [~~http~~://pdbe.org/3zqg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zqg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zqg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zqg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqg OCA], [https://pdbe.org/3zqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zqg RCSB], [https://www.ebi.ac.uk/pdbsum/3zqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zqg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TETR2_ECOLX TETR2_ECOLX]] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.	+	[[https://www.uniprot.org/uniprot/TETR2_ECOLX TETR2_ECOLX]] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Tetracycline repressor protein\|Tetracycline repressor protein]]	+	*[[Tetracycline repressor protein 3D structures\|Tetracycline repressor protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Berens, C]]		[[Category: Berens, C]]
	[[Category: Goeke, D]]		[[Category: Goeke, D]]

OCA at 16:25, 27 February 2019

OCA — Wed, 27 Feb 2019 16:25:42 GMT

←Older revision		Revision as of 16:25, 27 February 2019
Line 3:		Line 3:
	<StructureSection load='3zqg' size='340' side='right' caption='[[3zqg]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='3zqg' size='340' side='right' caption='[[3zqg]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zqg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZQG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zqg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZQG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xgc\|2xgc]], [[2xpw\|2xpw]], [[1bjz\|1bjz]], [[2x9d\|2x9d]], [[2trt\|2trt]], [[2xpv\|2xpv]], [[2vkv\|2vkv]], [[1ork\|1ork]], [[2xge\|2xge]], [[2x6o\|2x6o]], [[1a6i\|1a6i]], [[2vke\|2vke]], [[1qpi\|1qpi]], [[2xgd\|2xgd]], [[1du7\|1du7]], [[2xrl\|2xrl]], [[2xpt\|2xpt]], [[2xpu\|2xpu]], [[2xb5\|2xb5]], [[1bj0\|1bj0]], [[2xps\|2xps]], [[2tct\|2tct]], [[1bjy\|1bjy]], [[3zqi\|3zqi]], [[3zqf\|3zqf]], [[3zqh\|3zqh]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xgc\|2xgc]], [[2xpw\|2xpw]], [[1bjz\|1bjz]], [[2x9d\|2x9d]], [[2trt\|2trt]], [[2xpv\|2xpv]], [[2vkv\|2vkv]], [[1ork\|1ork]], [[2xge\|2xge]], [[2x6o\|2x6o]], [[1a6i\|1a6i]], [[2vke\|2vke]], [[1qpi\|1qpi]], [[2xgd\|2xgd]], [[1du7\|1du7]], [[2xrl\|2xrl]], [[2xpt\|2xpt]], [[2xpu\|2xpu]], [[2xb5\|2xb5]], [[1bj0\|1bj0]], [[2xps\|2xps]], [[2tct\|2tct]], [[1bjy\|1bjy]], [[3zqi\|3zqi]], [[3zqf\|3zqf]], [[3zqh\|3zqh]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqg OCA], [http://pdbe.org/3zqg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zqg RCSB], [http://www.ebi.ac.uk/pdbsum/3zqg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zqg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqg OCA], [http://pdbe.org/3zqg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zqg RCSB], [http://www.ebi.ac.uk/pdbsum/3zqg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zqg ProSAT]</span></td></tr>
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Berens, C]]		[[Category: Berens, C]]
	[[Category: Goeke, D]]		[[Category: Goeke, D]]

OCA at 13:40, 15 March 2017

OCA — Wed, 15 Mar 2017 13:40:12 GMT

←Older revision		Revision as of 13:40, 15 March 2017
Line 3:		Line 3:
	<StructureSection load='3zqg' size='340' side='right' caption='[[3zqg]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='3zqg' size='340' side='right' caption='[[3zqg]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zqg]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZQG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zqg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZQG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xgc\|2xgc]], [[2xpw\|2xpw]], [[1bjz\|1bjz]], [[2x9d\|2x9d]], [[2trt\|2trt]], [[2xpv\|2xpv]], [[2vkv\|2vkv]], [[1ork\|1ork]], [[2xge\|2xge]], [[2x6o\|2x6o]], [[1a6i\|1a6i]], [[2vke\|2vke]], [[1qpi\|1qpi]], [[2xgd\|2xgd]], [[1du7\|1du7]], [[2xrl\|2xrl]], [[2xpt\|2xpt]], [[2xpu\|2xpu]], [[2xb5\|2xb5]], [[1bj0\|1bj0]], [[2xps\|2xps]], [[2tct\|2tct]], [[1bjy\|1bjy]], [[3zqi\|3zqi]], [[3zqf\|3zqf]], [[3zqh\|3zqh]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xgc\|2xgc]], [[2xpw\|2xpw]], [[1bjz\|1bjz]], [[2x9d\|2x9d]], [[2trt\|2trt]], [[2xpv\|2xpv]], [[2vkv\|2vkv]], [[1ork\|1ork]], [[2xge\|2xge]], [[2x6o\|2x6o]], [[1a6i\|1a6i]], [[2vke\|2vke]], [[1qpi\|1qpi]], [[2xgd\|2xgd]], [[1du7\|1du7]], [[2xrl\|2xrl]], [[2xpt\|2xpt]], [[2xpu\|2xpu]], [[2xb5\|2xb5]], [[1bj0\|1bj0]], [[2xps\|2xps]], [[2tct\|2tct]], [[1bjy\|1bjy]], [[3zqi\|3zqi]], [[3zqf\|3zqf]], [[3zqh\|3zqh]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqg OCA], [http://pdbe.org/3zqg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zqg RCSB], [http://www.ebi.ac.uk/pdbsum/3zqg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zqg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqg OCA], [http://pdbe.org/3zqg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zqg RCSB], [http://www.ebi.ac.uk/pdbsum/3zqg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zqg ProSAT]</span></td></tr>
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus coli migula 1895]]
	[[Category: Berens, C]]		[[Category: Berens, C]]
	[[Category: Goeke, D]]		[[Category: Goeke, D]]

OCA at 04:07, 5 August 2016

OCA — Fri, 05 Aug 2016 04:07:44 GMT

←Older revision		Revision as of 04:07, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of Tetracycline repressor in complex with antiinducer peptide-TAP2==		==Structure of Tetracycline repressor in complex with antiinducer peptide-TAP2==
	<StructureSection load='3zqg' size='340' side='right' caption='[[3zqg]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='3zqg' size='340' side='right' caption='[[3zqg]], [[Resolution\|resolution]] 2.45Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3zqg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZQG FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zqg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZQG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xgc\|2xgc]], [[2xpw\|2xpw]], [[1bjz\|1bjz]], [[2x9d\|2x9d]], [[2trt\|2trt]], [[2xpv\|2xpv]], [[2vkv\|2vkv]], [[1ork\|1ork]], [[2xge\|2xge]], [[2x6o\|2x6o]], [[1a6i\|1a6i]], [[2vke\|2vke]], [[1qpi\|1qpi]], [[2xgd\|2xgd]], [[1du7\|1du7]], [[2xrl\|2xrl]], [[2xpt\|2xpt]], [[2xpu\|2xpu]], [[2xb5\|2xb5]], [[1bj0\|1bj0]], [[2xps\|2xps]], [[2tct\|2tct]], [[1bjy\|1bjy]], [[3zqi\|3zqi]], [[3zqf\|3zqf]], [[3zqh\|3zqh]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xgc\|2xgc]], [[2xpw\|2xpw]], [[1bjz\|1bjz]], [[2x9d\|2x9d]], [[2trt\|2trt]], [[2xpv\|2xpv]], [[2vkv\|2vkv]], [[1ork\|1ork]], [[2xge\|2xge]], [[2x6o\|2x6o]], [[1a6i\|1a6i]], [[2vke\|2vke]], [[1qpi\|1qpi]], [[2xgd\|2xgd]], [[1du7\|1du7]], [[2xrl\|2xrl]], [[2xpt\|2xpt]], [[2xpu\|2xpu]], [[2xb5\|2xb5]], [[1bj0\|1bj0]], [[2xps\|2xps]], [[2tct\|2tct]], [[1bjy\|1bjy]], [[3zqi\|3zqi]], [[3zqf\|3zqf]], [[3zqh\|3zqh]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zqg RCSB], [http://www.ebi.ac.uk/pdbsum/3zqg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqg OCA], [http://pdbe.org/3zqg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zqg RCSB], [http://www.ebi.ac.uk/pdbsum/3zqg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zqg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zqg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 15:42, 25 December 2014

OCA — Thu, 25 Dec 2014 15:42:47 GMT

←Older revision		Revision as of 15:42, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zqg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZQG FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zqg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZQG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xgc\|2xgc]], [[2xpw\|2xpw]], [[1bjz\|1bjz]], [[2x9d\|2x9d]], [[2trt\|2trt]], [[2xpv\|2xpv]], [[2vkv\|2vkv]], [[1ork\|1ork]], [[2xge\|2xge]], [[2x6o\|2x6o]], [[1a6i\|1a6i]], [[2vke\|2vke]], [[1qpi\|1qpi]], [[2xgd\|2xgd]], [[1du7\|1du7]], [[2xrl\|2xrl]], [[2xpt\|2xpt]], [[2xpu\|2xpu]], [[2xb5\|2xb5]], [[1bj0\|1bj0]], [[2xps\|2xps]], [[2tct\|2tct]], [[1bjy\|1bjy]], [[3zqi\|3zqi]], [[3zqf\|3zqf]], [[3zqh\|3zqh]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xgc\|2xgc]], [[2xpw\|2xpw]], [[1bjz\|1bjz]], [[2x9d\|2x9d]], [[2trt\|2trt]], [[2xpv\|2xpv]], [[2vkv\|2vkv]], [[1ork\|1ork]], [[2xge\|2xge]], [[2x6o\|2x6o]], [[1a6i\|1a6i]], [[2vke\|2vke]], [[1qpi\|1qpi]], [[2xgd\|2xgd]], [[1du7\|1du7]], [[2xrl\|2xrl]], [[2xpt\|2xpt]], [[2xpu\|2xpu]], [[2xb5\|2xb5]], [[1bj0\|1bj0]], [[2xps\|2xps]], [[2tct\|2tct]], [[1bjy\|1bjy]], [[3zqi\|3zqi]], [[3zqf\|3zqf]], [[3zqh\|3zqh]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zqg RCSB], [http://www.ebi.ac.uk/pdbsum/3zqg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zqg RCSB], [http://www.ebi.ac.uk/pdbsum/3zqg PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TETR2_ECOLX TETR2_ECOLX]] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 12:		Line 14:
	An Exclusive alpha/beta Code Directs Allostery in TetR-Peptide Complexes.,Sevvana M, Goetz C, Goeke D, Wimmer C, Berens C, Hillen W, Muller YA J Mol Biol. 2011 Dec 9. PMID:22178479<ref>PMID:22178479</ref>		An Exclusive alpha/beta Code Directs Allostery in TetR-Peptide Complexes.,Sevvana M, Goetz C, Goeke D, Wimmer C, Berens C, Hillen W, Muller YA J Mol Biol. 2011 Dec 9. PMID:22178479<ref>PMID:22178479</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>

Line 22:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
-	[[Category: Berens, C.]]	+	[[Category: Berens, C]]
-	[[Category: Goeke, D.]]	+	[[Category: Goeke, D]]
-	[[Category: Goetz, C.]]	+	[[Category: Goetz, C]]
-	[[Category: Grubmueller, S.]]	+	[[Category: Grubmueller, S]]
-	[[Category: Hillen, W.]]	+	[[Category: Hillen, W]]
-	[[Category: Kaspar, D.]]	+	[[Category: Kaspar, D]]
-	[[Category: Klotzsche, M.]]	+	[[Category: Klotzsche, M]]
-	[[Category: Muller, Y A.]]	+	[[Category: Muller, Y A]]
-	[[Category: Sevvana, M.]]	+	[[Category: Sevvana, M]]
-	[[Category: Stoeckle, C.]]	+	[[Category: Stoeckle, C]]
-	[[Category: Wimmer, C.]]	+	[[Category: Wimmer, C]]
	[[Category: Allostery]]		[[Category: Allostery]]
	[[Category: Inducer]]		[[Category: Inducer]]

OCA at 07:23, 5 June 2014

OCA — Thu, 05 Jun 2014 07:23:59 GMT

←Older revision		Revision as of 07:23, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3zqg.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of Tetracycline repressor in complex with antiinducer peptide-TAP2==
		+	<StructureSection load='3zqg' size='340' side='right' caption='[[3zqg]], [[Resolution\|resolution]] 2.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zqg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZQG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xgc\|2xgc]], [[2xpw\|2xpw]], [[1bjz\|1bjz]], [[2x9d\|2x9d]], [[2trt\|2trt]], [[2xpv\|2xpv]], [[2vkv\|2vkv]], [[1ork\|1ork]], [[2xge\|2xge]], [[2x6o\|2x6o]], [[1a6i\|1a6i]], [[2vke\|2vke]], [[1qpi\|1qpi]], [[2xgd\|2xgd]], [[1du7\|1du7]], [[2xrl\|2xrl]], [[2xpt\|2xpt]], [[2xpu\|2xpu]], [[2xb5\|2xb5]], [[1bj0\|1bj0]], [[2xps\|2xps]], [[2tct\|2tct]], [[1bjy\|1bjy]], [[3zqi\|3zqi]], [[3zqf\|3zqf]], [[3zqh\|3zqh]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zqg RCSB], [http://www.ebi.ac.uk/pdbsum/3zqg PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The allosteric mechanism of one of the best characterized bacterial transcription regulators, tetracycline repressor (TetR), has recently been questioned. Tetracycline binding induces cooperative folding of TetR, as suggested by recent unfolding studies, rather than switching between two defined conformational states, namely a DNA-binding-competent conformation and a non-DNA-binding conformation. Upon ligand binding, a host of near-native multiconformational structures collapse into a single, highly stabilized protein conformation that is no longer able to bind DNA. Here, structure-function studies performed with four synthetic peptides that bind to TetR and mimic the function of low-molecular-weight effectors, such as tetracyclines, provide new means to discriminate between different allosteric models. Whereas two inducing peptides bind in an extended beta-like conformation, two anti-inducing peptides form an alpha-helix in the effector binding site of TetR. This exclusive bimodal interaction mode coincides with two distinct overall conformations of TetR, namely one that is identical with induced TetR and one that mirrors the DNA-bound state of TetR. Urea-induced unfolding studies show no increase in thermodynamic stability for any of the peptide complexes, although fluorescence measurements demonstrate peptide binding to TetR. This strongly suggests that, at least for these peptide effectors, a classical two-state allosteric model best describes TetR function.

-	<!--	+	An Exclusive alpha/beta Code Directs Allostery in TetR-Peptide Complexes.,Sevvana M, Goetz C, Goeke D, Wimmer C, Berens C, Hillen W, Muller YA J Mol Biol. 2011 Dec 9. PMID:22178479<ref>PMID:22178479</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3zqg"~~, ~~creates the "Structure Box" on the page.~~	+
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded)~~,	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3zqg\| PDB=3zqg \| SCENE= }}~~	+

-	~~===Structure~~ of ~~Tetracycline repressor in complex with antiinducer peptide-TAP2===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-		+	==See Also==
-	~~<!--~~	+	*[[Tetracycline repressor protein\|Tetracycline repressor protein]]
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22178479}}, adds the Publication Abstract to the page~~	+	== References ==
-	~~(as it appears on PubMed at http://www.pubmed.gov), where 22178479 is the PubMed ID number.~~	+	<references/>
-	~~-->~~	+	__TOC__
-	~~{{ABSTRACT_PUBMED_22178479}}~~	+	</StructureSection>
-		+	[[Category: Bacillus coli migula 1895]]
-	==~~About this Structure~~==	+
-	[[~~3zqg~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli,_escherichia_coli Escherichia coli, escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQG OCA].	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022178479<~~/~~ref~~><~~references group="xtra"~~/>	+
-	[[Category: ~~Escherichia coli, escherichia~~ coli]]	+
	[[Category: Berens, C.]]		[[Category: Berens, C.]]
	[[Category: Goeke, D.]]		[[Category: Goeke, D.]]

OCA at 05:47, 8 February 2012

OCA — Wed, 08 Feb 2012 05:47:03 GMT

←Older revision		Revision as of 05:47, 8 February 2012
Line 1:		Line 1:
-	[[Image:3zqg.~~jpg~~\|left\|200px]]	+	[[Image:3zqg.png\|left\|200px]]

	<!--		<!--

OCA at 07:30, 28 December 2011

OCA — Wed, 28 Dec 2011 07:30:45 GMT

←Older revision		Revision as of 07:30, 28 December 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3zqg.jpg\|left\|200px]]

-	The ~~entry 3zqg~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3zqg", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3zqg\| PDB=3zqg \| SCENE= }}

-	~~Authors: Sevvana, M., Goeke, D., Stoeckle, C., Kaspar, D., Grubmueller, S., Goetz, C., Wimmer, C., Berens, C., Klotzsche, M., Muller, Y., Hillen, W.~~	+	===Structure of Tetracycline repressor in complex with antiinducer peptide-TAP2===

-	~~Description~~: Structure ~~of Tetracycline repressor in complex~~ with ~~antiinducer peptide~~-~~TAP2~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22178479}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22178479 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22178479}}
		+
		+	==About this Structure==
		+	[[3zqg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli,_escherichia_coli Escherichia coli, escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQG OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022178479</ref><references group="xtra"/>
		+	[[Category: Escherichia coli, escherichia coli]]
		+	[[Category: Berens, C.]]
		+	[[Category: Goeke, D.]]
		+	[[Category: Goetz, C.]]
		+	[[Category: Grubmueller, S.]]
		+	[[Category: Hillen, W.]]
		+	[[Category: Kaspar, D.]]
		+	[[Category: Klotzsche, M.]]
		+	[[Category: Muller, Y A.]]
		+	[[Category: Sevvana, M.]]
		+	[[Category: Stoeckle, C.]]
		+	[[Category: Wimmer, C.]]
		+	[[Category: Allostery]]
		+	[[Category: Inducer]]
		+	[[Category: Peptidic effector]]
		+	[[Category: Tetr]]
		+	[[Category: Transcription]]

OCA at 16:25, 22 June 2011

OCA — Wed, 22 Jun 2011 16:25:25 GMT

←Older revision		Revision as of 16:25, 22 June 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3zqg is ON HOLD	+	The entry 3zqg is ON HOLD until Paper Publication

	Authors: Sevvana, M., Goeke, D., Stoeckle, C., Kaspar, D., Grubmueller, S., Goetz, C., Wimmer, C., Berens, C., Klotzsche, M., Muller, Y., Hillen, W.		Authors: Sevvana, M., Goeke, D., Stoeckle, C., Kaspar, D., Grubmueller, S., Goetz, C., Wimmer, C., Berens, C., Klotzsche, M., Muller, Y., Hillen, W.

	Description: Structure of Tetracycline repressor in complex with antiinducer peptide-TAP2		Description: Structure of Tetracycline repressor in complex with antiinducer peptide-TAP2