3zqs - Revision history

OCA at 11:10, 20 December 2023

OCA — Wed, 20 Dec 2023 11:10:15 GMT

←Older revision		Revision as of 11:10, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='3zqs' size='340' side='right'caption='[[3zqs]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3zqs' size='340' side='right'caption='[[3zqs]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zqs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZQS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zqs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZQS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqs OCA], [https://pdbe.org/3zqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zqs RCSB], [https://www.ebi.ac.uk/pdbsum/3zqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zqs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqs OCA], [https://pdbe.org/3zqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zqs RCSB], [https://www.ebi.ac.uk/pdbsum/3zqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zqs ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/FANCL_HUMAN FANCL_HUMAN]] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/FANCL_HUMAN FANCL_HUMAN] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FANCL_HUMAN FANCL_HUMAN]] Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.<ref>PMID:12973351</ref> <ref>PMID:16916645</ref> <ref>PMID:17938197</ref> <ref>PMID:19111657</ref> <ref>PMID:19589784</ref>	+	[https://www.uniprot.org/uniprot/FANCL_HUMAN FANCL_HUMAN] Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.<ref>PMID:12973351</ref> <ref>PMID:16916645</ref> <ref>PMID:17938197</ref> <ref>PMID:19111657</ref> <ref>PMID:19589784</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Ubiquitin--protein ligase]]~~	+	[[Category: Cole AR]]
-	[[Category: Cole~~, A R~~]]	+	[[Category: Hodson C]]
-	[[Category: Hodson, C]]	+	[[Category: Purkiss-Trew A]]
-	[[Category: Purkiss-Trew, A]]	+	[[Category: Walden H]]
-	[[Category: Walden, H]]	+
-	~~[[Category: Ligase~~]]	+

OCA at 07:10, 18 August 2022

OCA — Thu, 18 Aug 2022 07:10:47 GMT

←Older revision		Revision as of 07:10, 18 August 2022
Line 1:		Line 1:

	==Human FANCL central domain==		==Human FANCL central domain==
-	<StructureSection load='3zqs' size='340' side='right' caption='[[3zqs]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3zqs' size='340' side='right'caption='[[3zqs]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zqs]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZQS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zqs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZQS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqs OCA], [~~http~~://pdbe.org/3zqs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zqs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zqs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zqs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqs OCA], [https://pdbe.org/3zqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zqs RCSB], [https://www.ebi.ac.uk/pdbsum/3zqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zqs ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/FANCL_HUMAN FANCL_HUMAN]] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.	+	[[https://www.uniprot.org/uniprot/FANCL_HUMAN FANCL_HUMAN]] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FANCL_HUMAN FANCL_HUMAN]] Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.<ref>PMID:12973351</ref> <ref>PMID:16916645</ref> <ref>PMID:17938197</ref> <ref>PMID:19111657</ref> <ref>PMID:19589784</ref>	+	[[https://www.uniprot.org/uniprot/FANCL_HUMAN FANCL_HUMAN]] Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.<ref>PMID:12973351</ref> <ref>PMID:16916645</ref> <ref>PMID:17938197</ref> <ref>PMID:19111657</ref> <ref>PMID:19589784</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]	+	*[[Ubiquitin protein ligase 3D structures\|Ubiquitin protein ligase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ubiquitin--protein ligase]]		[[Category: Ubiquitin--protein ligase]]
	[[Category: Cole, A R]]		[[Category: Cole, A R]]

OCA at 16:46, 27 February 2019

OCA — Wed, 27 Feb 2019 16:46:12 GMT

←Older revision		Revision as of 16:46, 27 February 2019
Line 1:		Line 1:

-	==~~HUMAN~~ FANCL ~~CENTRAL DOMAIN~~==	+	==Human FANCL central domain==
	<StructureSection load='3zqs' size='340' side='right' caption='[[3zqs]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3zqs' size='340' side='right' caption='[[3zqs]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 18:07, 11 August 2016

OCA — Thu, 11 Aug 2016 18:07:53 GMT

←Older revision		Revision as of 18:07, 11 August 2016
Line 1:		Line 1:
		+
	==HUMAN FANCL CENTRAL DOMAIN==		==HUMAN FANCL CENTRAL DOMAIN==
	<StructureSection load='3zqs' size='340' side='right' caption='[[3zqs]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3zqs' size='340' side='right' caption='[[3zqs]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zqs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZQS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zqs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZQS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zqs RCSB], [http://www.ebi.ac.uk/pdbsum/3zqs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqs OCA], [http://pdbe.org/3zqs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zqs RCSB], [http://www.ebi.ac.uk/pdbsum/3zqs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zqs ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/FANCL_HUMAN FANCL_HUMAN]] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FANCL_HUMAN FANCL_HUMAN]] Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.<ref>PMID:12973351</ref> <ref>PMID:16916645</ref> <ref>PMID:17938197</ref> <ref>PMID:19111657</ref> <ref>PMID:19589784</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zqs" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 22:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ubiquitin--protein ligase]]		[[Category: Ubiquitin--protein ligase]]
	[[Category: Cole, A R]]		[[Category: Cole, A R]]

OCA at 09:44, 4 January 2015

OCA — Sun, 04 Jan 2015 09:44:57 GMT

←Older revision		Revision as of 09:44, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zqs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZQS FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zqs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZQS FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zqs RCSB], [http://www.ebi.ac.uk/pdbsum/3zqs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zqs RCSB], [http://www.ebi.ac.uk/pdbsum/3zqs PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ubiquitin--protein ligase]]		[[Category: Ubiquitin--protein ligase]]
-	[[Category: Cole, A R.]]	+	[[Category: Cole, A R]]
-	[[Category: Hodson, C.]]	+	[[Category: Hodson, C]]
-	[[Category: Purkiss-Trew, A.]]	+	[[Category: Purkiss-Trew, A]]
-	[[Category: Walden, H.]]	+	[[Category: Walden, H]]
	[[Category: Ligase]]		[[Category: Ligase]]

OCA at 07:55, 5 June 2014

OCA — Thu, 05 Jun 2014 07:55:29 GMT

←Older revision		Revision as of 07:55, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3zqs.~~png~~\|~~left\|200px~~]]	+	==HUMAN FANCL CENTRAL DOMAIN==
		+	<StructureSection load='3zqs' size='340' side='right' caption='[[3zqs]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zqs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZQS FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zqs RCSB], [http://www.ebi.ac.uk/pdbsum/3zqs PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Fanconi Anemia (FA) pathway is essential for the repair of DNA interstrand cross-links. At the heart of this pathway is the monoubiquitination of the FANCI/FANCD2 (ID) complex by the multiprotein 'core complex' containing the E3 ubiquitin ligase FANCL. Vertebrate organisms have the 8-protein core complex, while invertebrates apparently do not. We report here the structure of the central domain of human FANCL in comparison with the recently solved Drosophila melanogaster FANCL. Our data represent the first structural detail into the catalytic core of the human system, and reveal that the central fold of FANCL is conserved between species. However, there are macromolecular differences between the FANCL proteins that may account for the apparent distinctions in core complex requirements between the vertebrate and invertebrate FA pathways. In addition we characterize the binding of human FANCL with its partners, Ube2t, FANCD2 and FANCI. Mutational analysis reveals, which residues are required for substrate binding, and we also show the domain required for E2 binding.

-	~~<!--~~	+	Structural analysis of human FANCL, the E3 ligase in the fanconi anemia pathway.,Hodson C, Cole AR, Lewis LP, Miles JA, Purkiss-Trew A, Walden H J Biol Chem. 2011 Jul 20. PMID:21775430<ref>PMID:21775430</ref>
-	~~The line below this paragraph, containing "STRUCTURE_3zqs"~~, ~~creates~~ the ~~"Structure Box" on~~ the ~~page~~.	+
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded)~~,	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3zqs\| PDB=3zqs \| SCENE= }}~~	+

-	~~===HUMAN FANCL CENTRAL DOMAIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-		+	==See Also==
-	~~<!--~~	+	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21775430}}, adds the Publication Abstract to the page~~	+	== References ==
-	~~(as it appears on PubMed at http://www.pubmed.gov), where 21775430 is the PubMed ID number.~~	+	<references/>
-	~~-->~~	+	__TOC__
-	~~{{ABSTRACT_PUBMED_21775430}}~~	+	</StructureSection>
-		+
-	==~~About this Structure~~==	+
-	[[~~3zqs~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQS OCA].	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021775430<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ubiquitin--protein ligase]]		[[Category: Ubiquitin--protein ligase]]

OCA at 07:51, 3 August 2011

OCA — Wed, 03 Aug 2011 07:51:55 GMT

←Older revision		Revision as of 07:51, 3 August 2011
Line 9:		Line 9:
	{{STRUCTURE_3zqs\| PDB=3zqs \| SCENE= }}		{{STRUCTURE_3zqs\| PDB=3zqs \| SCENE= }}

-	===~~E3 LIGASE~~===	+	===HUMAN FANCL CENTRAL DOMAIN===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21775430}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21775430 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21775430}}

	==About this Structure==		==About this Structure==
	[[3zqs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQS OCA].		[[3zqs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQS OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021775430</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ubiquitin--protein ligase]]		[[Category: Ubiquitin--protein ligase]]

OCA at 06:17, 27 July 2011

OCA — Wed, 27 Jul 2011 06:17:56 GMT

←Older revision		Revision as of 06:17, 27 July 2011
Line 1:		Line 1:
-	[[Image:3zqs.~~jpg~~\|left\|200px]]	+	[[Image:3zqs.png\|left\|200px]]

	<!--		<!--

OCA at 07:02, 20 July 2011

OCA — Wed, 20 Jul 2011 07:02:11 GMT

←Older revision		Revision as of 07:02, 20 July 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3zqs.jpg\|left\|200px]]

-	The ~~entry 3zqs~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3zqs", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3zqs\| PDB=3zqs \| SCENE= }}

-	~~Authors: Hodson, C., Cole, A.R., Purkiss-Trew, A., Walden, H.~~	+	===E3 LIGASE===

-	~~Description~~: E3 ligase	+
		+	==About this Structure==
		+	[[3zqs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQS OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Ubiquitin--protein ligase]]
		+	[[Category: Cole, A R.]]
		+	[[Category: Hodson, C.]]
		+	[[Category: Purkiss-Trew, A.]]
		+	[[Category: Walden, H.]]
		+	[[Category: Ligase]]

OCA: Protected "3zqs" [edit=sysop:move=sysop]

OCA — Wed, 22 Jun 2011 16:25:44 GMT

Protected "3zqs" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:25, 22 June 2011