3zr1 - Revision history

OCA at 11:10, 20 December 2023

OCA — Wed, 20 Dec 2023 11:10:28 GMT

←Older revision		Revision as of 11:10, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='3zr1' size='340' side='right'caption='[[3zr1]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3zr1' size='340' side='right'caption='[[3zr1]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zr1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZR1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZR1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zr1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZR1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZR1 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1iry\|1iry]], [[3zr0\|3zr0]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">NUDT1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zr1 OCA], [https://pdbe.org/3zr1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zr1 RCSB], [https://www.ebi.ac.uk/pdbsum/3zr1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zr1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zr1 OCA], [https://pdbe.org/3zr1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zr1 RCSB], [https://www.ebi.ac.uk/pdbsum/3zr1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zr1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>	+	[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Desroses, M]]	+	[[Category: Desroses M]]
-	[[Category: Helleday, T]]	+	[[Category: Helleday T]]
-	[[Category: Hogbom, M]]	+	[[Category: Hogbom M]]
-	[[Category: Jemth, A]]	+	[[Category: Jemth A]]
-	[[Category: Loseva, O]]	+	[[Category: Loseva O]]
-	[[Category: Stenmark, P]]	+	[[Category: Stenmark P]]
-	[[Category: Svensson~~, L M]]~~	+	[[Category: Svensson LM]]
-	~~[[Category: Hydrolase~~]]	+

OCA at 07:11, 18 August 2022

OCA — Thu, 18 Aug 2022 07:11:26 GMT

←Older revision		Revision as of 07:11, 18 August 2022
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF HUMAN~~ MTH1==	+	==Crystal structure of human MTH1==
-	<StructureSection load='3zr1' size='340' side='right' caption='[[3zr1]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='3zr1' size='340' side='right'caption='[[3zr1]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zr1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZR1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZR1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zr1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZR1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZR1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iry\|1iry]], [[3zr0\|3zr0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1iry\|1iry]], [[3zr0\|3zr0]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUDT1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUDT1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zr1 OCA], [~~http~~://pdbe.org/3zr1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zr1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zr1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zr1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zr1 OCA], [https://pdbe.org/3zr1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zr1 RCSB], [https://www.ebi.ac.uk/pdbsum/3zr1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zr1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>	+	[[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[7%2C8-dihydro-8-oxoguanine triphosphatase\|7%2C8-dihydro-8-oxoguanine triphosphatase]]	+	*[[7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures\|7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Desroses, M]]		[[Category: Desroses, M]]
	[[Category: Helleday, T]]		[[Category: Helleday, T]]

OCA at 17:30, 4 August 2016

OCA — Thu, 04 Aug 2016 17:30:20 GMT

←Older revision		Revision as of 17:30, 4 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF HUMAN MTH1==		==CRYSTAL STRUCTURE OF HUMAN MTH1==
	<StructureSection load='3zr1' size='340' side='right' caption='[[3zr1]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3zr1' size='340' side='right' caption='[[3zr1]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZR1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZR1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iry\|1iry]], [[3zr0\|3zr0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iry\|1iry]], [[3zr0\|3zr0]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUDT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUDT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zr1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zr1 RCSB], [http://www.ebi.ac.uk/pdbsum/3zr1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zr1 OCA], [http://pdbe.org/3zr1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zr1 RCSB], [http://www.ebi.ac.uk/pdbsum/3zr1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zr1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zr1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Desroses, M]]		[[Category: Desroses, M]]
	[[Category: Helleday, T]]		[[Category: Helleday, T]]

OCA at 17:36, 24 December 2014

OCA — Wed, 24 Dec 2014 17:36:49 GMT

←Older revision		Revision as of 17:36, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZR1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZR1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iry\|1iry]], [[3zr0\|3zr0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iry\|1iry]], [[3zr0\|3zr0]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUDT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUDT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zr1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zr1 RCSB], [http://www.ebi.ac.uk/pdbsum/3zr1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zr1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zr1 RCSB], [http://www.ebi.ac.uk/pdbsum/3zr1 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[7%2C8-dihydro-8-oxoguanine triphosphatase\|7%2C8-dihydro-8-oxoguanine triphosphatase]]
	== References ==		== References ==
	<references/>		<references/>
Line 21:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Desroses, M.]]	+	[[Category: Desroses, M]]
-	[[Category: Helleday, T.]]	+	[[Category: Helleday, T]]
-	[[Category: Hogbom, M.]]	+	[[Category: Hogbom, M]]
-	[[Category: Jemth, A.]]	+	[[Category: Jemth, A]]
-	[[Category: Loseva, O.]]	+	[[Category: Loseva, O]]
-	[[Category: Stenmark, P.]]	+	[[Category: Stenmark, P]]
-	[[Category: Svensson, L M.]]	+	[[Category: Svensson, L M]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 08:00, 5 June 2014

OCA — Thu, 05 Jun 2014 08:00:06 GMT

←Older revision		Revision as of 08:00, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3zr1.~~png~~\|~~left~~\|~~200px~~]]	+	==CRYSTAL STRUCTURE OF HUMAN MTH1==
		+	<StructureSection load='3zr1' size='340' side='right' caption='[[3zr1]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZR1 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iry\|1iry]], [[3zr0\|3zr0]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUDT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zr1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zr1 RCSB], [http://www.ebi.ac.uk/pdbsum/3zr1 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	MTH1 hydrolyzes oxidized nucleotide triphosphates, thereby preventing them from being incorporated into DNA. We here present the structures of human MTH1 (1.9A) and its complex with the product 8-oxo-dGMP (1.8A). Unexpectedly MTH1 binds the nucleotide in the anti conformation with no direct interaction between the 8-oxo group and the protein. We suggest that the specificity depends on the stabilization of an enol tautomer of the 8-oxo form of dGTP. The binding of the product induces no major structural changes. The structures reveal the mode of nucleotide binding in MTH1 and provide the structural basis for inhibitor design.

-	<!--	+	Crystal structure of human MTH1 and the 8-oxo-dGMP product complex.,Svensson LM, Jemth AS, Desroses M, Loseva O, Helleday T, Hogbom M, Stenmark P FEBS Lett. 2011 Aug 19;585(16):2617-21. Epub 2011 Jul 23. PMID:21787772<ref>PMID:21787772</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3zr1"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3zr1\| PDB=3zr1 \| SCENE= }}~~	+

-	~~===CRYSTAL STRUCTURE OF HUMAN MTH1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21787772}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21787772 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21787772}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3zr1]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZR1 OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021787772<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Desroses, M.]]		[[Category: Desroses, M.]]

OCA at 06:05, 24 August 2011

OCA — Wed, 24 Aug 2011 06:05:12 GMT

←Older revision		Revision as of 06:05, 24 August 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3zr1.png\|left\|200px]]

-	The ~~entry 3zr1~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3zr1", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3zr1\| PDB=3zr1 \| SCENE= }}

-	~~Authors: Svensson, L.M., Jemth, A., Desroses, M., Loseva, O., Helleday, T., Hogbom, M., Stenmark, P.~~	+	===CRYSTAL STRUCTURE OF HUMAN MTH1===

-	~~Description~~: ~~Crystal~~ structure ~~of human MTH1~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21787772}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21787772 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21787772}}
		+
		+	==About this Structure==
		+	[[3zr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZR1 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021787772</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Desroses, M.]]
		+	[[Category: Helleday, T.]]
		+	[[Category: Hogbom, M.]]
		+	[[Category: Jemth, A.]]
		+	[[Category: Loseva, O.]]
		+	[[Category: Stenmark, P.]]
		+	[[Category: Svensson, L M.]]
		+	[[Category: Hydrolase]]

OCA: Protected "3zr1" [edit=sysop:move=sysop]

OCA — Wed, 22 Jun 2011 16:26:01 GMT

Protected "3zr1" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:26, 22 June 2011

OCA: New page: '''Unreleased structure''' The entry 3zr1 is ON HOLD until Paper Publication Authors: Svensson, L.M., Jemth, A., Desroses, M., Loseva, O., Helleday, T., Hogbom, M., Stenmark, P. Descri...

OCA — Wed, 22 Jun 2011 16:26:00 GMT

New page: '''Unreleased structure''' The entry 3zr1 is ON HOLD until Paper Publication Authors: Svensson, L.M., Jemth, A., Desroses, M., Loseva, O., Helleday, T., Hogbom, M., Stenmark, P. Descri...

New page

'''Unreleased structure'''

The entry 3zr1 is ON HOLD until Paper Publication

Authors: Svensson, L.M., Jemth, A., Desroses, M., Loseva, O., Helleday, T., Hogbom, M., Stenmark, P.

Description: Crystal structure of human MTH1