3zrb - Revision history

OCA at 10:42, 9 May 2024

OCA — Thu, 09 May 2024 10:42:19 GMT

←Older revision		Revision as of 10:42, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='3zrb' size='340' side='right'caption='[[3zrb]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3zrb' size='340' side='right'caption='[[3zrb]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zrb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZRB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zrb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZRB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OR8:2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE'>OR8</scene>, <scene name='pdbligand=ORC:(R)-N-[1-[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]ETHYL]-3,5-DIMETHYLISOXAZOLE-4-SULFONAMIDE'>ORC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2c7a\|2c7a]], [[2w8y\|2w8y]], [[1a28\|1a28]], [[1zuc\|1zuc]], [[3zr7\|3zr7]], [[1sqn\|1sqn]], [[1sr7\|1sr7]], [[1e3k\|1e3k]], [[3zra\|3zra]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OR8:2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE'>OR8</scene>, <scene name='pdbligand=ORC:(R)-N-[1-[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]ETHYL]-3,5-DIMETHYLISOXAZOLE-4-SULFONAMIDE'>ORC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zrb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zrb OCA], [https://pdbe.org/3zrb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zrb RCSB], [https://www.ebi.ac.uk/pdbsum/3zrb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zrb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zrb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zrb OCA], [https://pdbe.org/3zrb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zrb RCSB], [https://www.ebi.ac.uk/pdbsum/3zrb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zrb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN]] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref>	+	[https://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Azevedo, R]]	+	[[Category: Azevedo R]]
-	[[Category: Brown~~, A R~~]]	+	[[Category: Brown AR]]
-	[[Category: Dechering, K]]	+	[[Category: Dechering K]]
-	[[Category: Hamilton~~, N M]]~~	+	[[Category: Hamilton NM]]
-	~~[[Category: Lam, T Wai~~]]	+	[[Category: Lusher SJ]]
-	[[Category: Lusher~~, S J~~]]	+	[[Category: Mcguire R]]
-	[[Category: Mcguire, R]]	+	[[Category: Nimz O]]
-	[[Category: Nimz, O]]	+	[[Category: Oubrie A]]
-	[[Category: Oubrie, A]]	+	[[Category: Raaijmakers HCA]]
-	[[Category: Raaijmakers~~, H C.A]]~~	+	[[Category: Vu-Pham D]]
-	~~[[Category: Vlieg, J de~~]]	+	[[Category: Wai Lam T]]
-	[[Category: Vu-Pham, D]]	+	[[Category: De Vlieg J]]
-	[[Category: ~~Agonist~~]]	+
-	[[Category: ~~Antagonist]]~~	+
-	~~[[Category: Receptor~~]]	+

OCA at 07:11, 18 August 2022

OCA — Thu, 18 Aug 2022 07:11:58 GMT

←Older revision		Revision as of 07:11, 18 August 2022
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	<StructureSection load='3zrb' size='340' side='right'caption='[[3zrb]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3zrb' size='340' side='right'caption='[[3zrb]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zrb]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZRB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zrb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZRB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OR8:2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE'>OR8</scene>, <scene name='pdbligand=ORC:(R)-N-[1-[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]ETHYL]-3,5-DIMETHYLISOXAZOLE-4-SULFONAMIDE'>ORC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OR8:2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE'>OR8</scene>, <scene name='pdbligand=ORC:(R)-N-[1-[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]ETHYL]-3,5-DIMETHYLISOXAZOLE-4-SULFONAMIDE'>ORC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c7a\|2c7a]], [[2w8y\|2w8y]], [[1a28\|1a28]], [[1zuc\|1zuc]], [[3zr7\|3zr7]], [[1sqn\|1sqn]], [[1sr7\|1sr7]], [[1e3k\|1e3k]], [[3zra\|3zra]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2c7a\|2c7a]], [[2w8y\|2w8y]], [[1a28\|1a28]], [[1zuc\|1zuc]], [[3zr7\|3zr7]], [[1sqn\|1sqn]], [[1sr7\|1sr7]], [[1e3k\|1e3k]], [[3zra\|3zra]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zrb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zrb OCA], [~~http~~://pdbe.org/3zrb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zrb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zrb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zrb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zrb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zrb OCA], [https://pdbe.org/3zrb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zrb RCSB], [https://www.ebi.ac.uk/pdbsum/3zrb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zrb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN]] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref>	+	[[https://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN]] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:27, 1 January 2020

OCA — Wed, 01 Jan 2020 13:27:56 GMT

←Older revision		Revision as of 13:27, 1 January 2020
Line 1:		Line 1:

	==Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators==		==Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators==
-	<StructureSection load='3zrb' size='340' side='right' caption='[[3zrb]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3zrb' size='340' side='right'caption='[[3zrb]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zrb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZRB FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zrb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZRB FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 3zrb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3zrb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Progesterone receptor\|Progesterone receptor]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Azevedo, R]]		[[Category: Azevedo, R]]
	[[Category: Brown, A R]]		[[Category: Brown, A R]]

OCA at 08:49, 27 December 2017

OCA — Wed, 27 Dec 2017 08:49:19 GMT

←Older revision		Revision as of 08:49, 27 December 2017
Line 1:		Line 1:

-	==~~STRUCTURAL BASIS FOR AGONISM AND ANTAGONISM FOR A SET OF CHEMICALLY RELATED PROGESTERONE RECEPTOR MODULATORS~~==	+	==Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators==
	<StructureSection load='3zrb' size='340' side='right' caption='[[3zrb]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3zrb' size='340' side='right' caption='[[3zrb]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 34:		Line 34:
	[[Category: Oubrie, A]]		[[Category: Oubrie, A]]
	[[Category: Raaijmakers, H C.A]]		[[Category: Raaijmakers, H C.A]]
-	[[Category: Vlieg, J De]]	+	[[Category: Vlieg, J de]]
	[[Category: Vu-Pham, D]]		[[Category: Vu-Pham, D]]
	[[Category: Agonist]]		[[Category: Agonist]]
	[[Category: Antagonist]]		[[Category: Antagonist]]
	[[Category: Receptor]]		[[Category: Receptor]]

OCA at 18:56, 4 August 2016

OCA — Thu, 04 Aug 2016 18:56:18 GMT

←Older revision		Revision as of 18:56, 4 August 2016
Line 1:		Line 1:
		+
	==STRUCTURAL BASIS FOR AGONISM AND ANTAGONISM FOR A SET OF CHEMICALLY RELATED PROGESTERONE RECEPTOR MODULATORS==		==STRUCTURAL BASIS FOR AGONISM AND ANTAGONISM FOR A SET OF CHEMICALLY RELATED PROGESTERONE RECEPTOR MODULATORS==
	<StructureSection load='3zrb' size='340' side='right' caption='[[3zrb]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3zrb' size='340' side='right' caption='[[3zrb]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zrb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZRB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zrb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZRB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OR8:2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE'>OR8</scene>, <scene name='pdbligand=ORC:(R)-N-[1-[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]ETHYL]-3,5-DIMETHYLISOXAZOLE-4-SULFONAMIDE'>ORC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OR8:2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE'>OR8</scene>, <scene name='pdbligand=ORC:(R)-N-[1-[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]ETHYL]-3,5-DIMETHYLISOXAZOLE-4-SULFONAMIDE'>ORC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c7a\|2c7a]], [[2w8y\|2w8y]], [[1a28\|1a28]], [[1zuc\|1zuc]], [[3zr7\|3zr7]], [[1sqn\|1sqn]], [[1sr7\|1sr7]], [[1e3k\|1e3k]], [[3zra\|3zra]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c7a\|2c7a]], [[2w8y\|2w8y]], [[1a28\|1a28]], [[1zuc\|1zuc]], [[3zr7\|3zr7]], [[1sqn\|1sqn]], [[1sr7\|1sr7]], [[1e3k\|1e3k]], [[3zra\|3zra]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zrb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zrb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zrb RCSB], [http://www.ebi.ac.uk/pdbsum/3zrb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zrb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zrb OCA], [http://pdbe.org/3zrb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zrb RCSB], [http://www.ebi.ac.uk/pdbsum/3zrb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zrb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zrb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Azevedo, R]]		[[Category: Azevedo, R]]
	[[Category: Brown, A R]]		[[Category: Brown, A R]]

OCA at 18:27, 24 December 2014

OCA — Wed, 24 Dec 2014 18:27:15 GMT

←Older revision		Revision as of 18:27, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zrb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZRB FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zrb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZRB FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OR8:2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE'>OR8</scene>, <scene name='pdbligand=ORC:(R)-N-[1-[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]ETHYL]-3,5-DIMETHYLISOXAZOLE-4-SULFONAMIDE'>ORC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OR8:2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE'>OR8</scene>, <scene name='pdbligand=ORC:(R)-N-[1-[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]ETHYL]-3,5-DIMETHYLISOXAZOLE-4-SULFONAMIDE'>ORC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c7a\|2c7a]], [[2w8y\|2w8y]], [[1a28\|1a28]], [[1zuc\|1zuc]], [[3zr7\|3zr7]], [[1sqn\|1sqn]], [[1sr7\|1sr7]], [[1e3k\|1e3k]], [[3zra\|3zra]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c7a\|2c7a]], [[2w8y\|2w8y]], [[1a28\|1a28]], [[1zuc\|1zuc]], [[3zr7\|3zr7]], [[1sqn\|1sqn]], [[1sr7\|1sr7]], [[1e3k\|1e3k]], [[3zra\|3zra]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zrb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zrb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zrb RCSB], [http://www.ebi.ac.uk/pdbsum/3zrb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zrb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zrb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zrb RCSB], [http://www.ebi.ac.uk/pdbsum/3zrb PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN]] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Azevedo, R.]]	+	[[Category: Azevedo, R]]
-	[[Category: Brown, A R.]]	+	[[Category: Brown, A R]]
-	[[Category: Dechering, K.]]	+	[[Category: Dechering, K]]
-	[[Category: Hamilton, N M.]]	+	[[Category: Hamilton, N M]]
-	[[Category: Lam, T Wai.]]	+	[[Category: Lam, T Wai]]
-	[[Category: Lusher, S J.]]	+	[[Category: Lusher, S J]]
-	[[Category: Mcguire, R.]]	+	[[Category: Mcguire, R]]
-	[[Category: Nimz, O.]]	+	[[Category: Nimz, O]]
-	[[Category: Oubrie, A.]]	+	[[Category: Oubrie, A]]
-	[[Category: Raaijmakers, H C.A.]]	+	[[Category: Raaijmakers, H C.A]]
-	[[Category: Vlieg, J De.]]	+	[[Category: Vlieg, J De]]
-	[[Category: Vu-Pham, D.]]	+	[[Category: Vu-Pham, D]]
	[[Category: Agonist]]		[[Category: Agonist]]
	[[Category: Antagonist]]		[[Category: Antagonist]]
	[[Category: Receptor]]		[[Category: Receptor]]

OCA at 08:32, 5 June 2014

OCA — Thu, 05 Jun 2014 08:32:52 GMT

←Older revision		Revision as of 08:32, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3zrb.~~png~~\|~~left~~\|~~200px~~]]	+	==STRUCTURAL BASIS FOR AGONISM AND ANTAGONISM FOR A SET OF CHEMICALLY RELATED PROGESTERONE RECEPTOR MODULATORS==
		+	<StructureSection load='3zrb' size='340' side='right' caption='[[3zrb]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zrb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZRB FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OR8:2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE'>OR8</scene>, <scene name='pdbligand=ORC:(R)-N-[1-[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]ETHYL]-3,5-DIMETHYLISOXAZOLE-4-SULFONAMIDE'>ORC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c7a\|2c7a]], [[2w8y\|2w8y]], [[1a28\|1a28]], [[1zuc\|1zuc]], [[3zr7\|3zr7]], [[1sqn\|1sqn]], [[1sr7\|1sr7]], [[1e3k\|1e3k]], [[3zra\|3zra]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zrb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zrb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zrb RCSB], [http://www.ebi.ac.uk/pdbsum/3zrb PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween. We describe here two new progesterone receptor ligand binding domain x-ray structures bound to compounds from a structurally related but functionally divergent series, which show different binding modes corresponding to their agonistic or antagonistic nature. In addition, we present a third progesterone receptor ligand binding domain dimer bound to an agonist in monomer A and an antagonist in monomer B, which display binding modes in agreement with the earlier observation that agonists and antagonists from this series adopt different binding modes.

-	<!--	+	Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators.,Lusher SJ, Raaijmakers HC, Vu-Pham D, Dechering K, Lam TW, Brown AR, Hamilton NM, Nimz O, Bosch R, McGuire R, Oubrie A, de Vlieg J J Biol Chem. 2011 Oct 7;286(40):35079-86. Epub 2011 Aug 17. PMID:21849509<ref>PMID:21849509</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3zrb"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3zrb\| PDB=3zrb \| SCENE= }}~~	+

-	~~===STRUCTURAL BASIS FOR AGONISM AND ANTAGONISM FOR A SET OF CHEMICALLY RELATED PROGESTERONE RECEPTOR MODULATORS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21849509}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21849509 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21849509}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3zrb]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRB OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021849509<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Azevedo, R.]]		[[Category: Azevedo, R.]]

OCA at 08:15, 30 October 2011

OCA — Sun, 30 Oct 2011 08:15:32 GMT

←Older revision		Revision as of 08:15, 30 October 2011
Line 1:		Line 1:
-	[[Image:3zrb.~~jpg~~\|left\|200px]]	+	[[Image:3zrb.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===STRUCTURAL BASIS FOR AGONISM AND ANTAGONISM FOR A SET OF CHEMICALLY RELATED PROGESTERONE RECEPTOR MODULATORS===		===STRUCTURAL BASIS FOR AGONISM AND ANTAGONISM FOR A SET OF CHEMICALLY RELATED PROGESTERONE RECEPTOR MODULATORS===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21849509}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21849509 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21849509}}

	==About this Structure==		==About this Structure==
	[[3zrb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRB OCA].		[[3zrb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRB OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021849509</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Azevedo, R.]]		[[Category: Azevedo, R.]]

OCA at 06:36, 17 August 2011

OCA — Wed, 17 Aug 2011 06:36:41 GMT

←Older revision		Revision as of 06:36, 17 August 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3zrb.jpg\|left\|200px]]

-	The ~~entry 3zrb~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3zrb", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3zrb\| PDB=3zrb \| SCENE= }}

-	~~Authors: Lusher, S.J., raaijmakers, H.C.~~A~~., Vu-Pham, D., Dechering, K., Wai Lam, T., Brown, A.R., Hamilton, N.M., Nimz, O., Azevedo, R., Mcguire, R., Oubrie, A., de vlieg, J.~~	+	===STRUCTURAL BASIS FOR AGONISM AND ANTAGONISM FOR A SET OF CHEMICALLY RELATED PROGESTERONE RECEPTOR MODULATORS===

-	~~Description: Structural basis for agonism and antagonism for~~ a ~~set of chemically related progesterone receptor modulators~~	+
		+	==About this Structure==
		+	[[3zrb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRB OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Azevedo, R.]]
		+	[[Category: Brown, A R.]]
		+	[[Category: Dechering, K.]]
		+	[[Category: Hamilton, N M.]]
		+	[[Category: Lam, T Wai.]]
		+	[[Category: Lusher, S J.]]
		+	[[Category: Mcguire, R.]]
		+	[[Category: Nimz, O.]]
		+	[[Category: Oubrie, A.]]
		+	[[Category: Raaijmakers, H C.A.]]
		+	[[Category: Vlieg, J De.]]
		+	[[Category: Vu-Pham, D.]]
		+	[[Category: Agonist]]
		+	[[Category: Antagonist]]
		+	[[Category: Receptor]]

OCA: Protected "3zrb" [edit=sysop:move=sysop]

OCA — Wed, 22 Jun 2011 16:26:21 GMT

Protected "3zrb" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:26, 22 June 2011