3zs0 - Revision history

OCA at 11:11, 20 December 2023

OCA — Wed, 20 Dec 2023 11:11:07 GMT

←Older revision		Revision as of 11:11, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zs0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZS0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zs0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZS0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=~~HEM~~:~~PROTOPORPHYRIN+IX+CONTAINING+FE~~'>~~HEM~~</scene>, <scene name='pdbligand=~~NAG~~:N-~~ACETYL~~-~~D-GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~SO4~~:~~SULFATE~~+~~ION~~'>~~SO4~~</scene>, <scene name='pdbligand=~~ZS0~~:3-(4-~~FLUOROBENZYL)-2-THIOXO-1,2,3,7-TETRAHYDRO-6H-PURIN-6-ONE~~'>~~ZS0~~</scene>, <scene name='pdbligand=~~FUC~~:~~ALPHA~~-L-~~FUCOSE~~'>~~FUC~~</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA-D-MANNOSE~~'>~~MAN~~</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~CSO~~:S-~~HYDROXYCYSTEINE'>CSO</scene></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZS0:3-(4-FLUOROBENZYL)-2-THIOXO-1,2,3,7-TETRAHYDRO-6H-PURIN-6-ONE'>ZS0</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[1cxp\|1cxp]]~~, ~~[[1dnu\|1dnu]]~~, ~~[[1d7w\|1d7w]]~~, ~~[[3zs1\|3zs1]], [[1d5l\|1d5l]], [[1d2v\|1d2v]], [[1dnw\|1dnw]], [[1mhl\|1mhl]], [[1myp\|1myp]]</div></td></tr>~~	+
-	~~<tr id='activity~~'>~~<td class="sblockLbl"><b>Activity:~~</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Myeloperoxidase Myeloperoxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.2.2 1.11.2.2] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zs0 OCA], [https://pdbe.org/3zs0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zs0 RCSB], [https://www.ebi.ac.uk/pdbsum/3zs0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zs0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zs0 OCA], [https://pdbe.org/3zs0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zs0 RCSB], [https://www.ebi.ac.uk/pdbsum/3zs0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zs0 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/PERM_HUMAN PERM_HUMAN]] Defects in MPO are the cause of myeloperoxidase deficiency (MPOD) [MIM:[https://omim.org/entry/254600 254600]]. A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis.<ref>PMID:8142659</ref> <ref>PMID:7904599</ref> <ref>PMID:8621627</ref> <ref>PMID:9637725</ref> <ref>PMID:9354683</ref>	+	[https://www.uniprot.org/uniprot/PERM_HUMAN PERM_HUMAN] Defects in MPO are the cause of myeloperoxidase deficiency (MPOD) [MIM:[https://omim.org/entry/254600 254600]. A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis.<ref>PMID:8142659</ref> <ref>PMID:7904599</ref> <ref>PMID:8621627</ref> <ref>PMID:9637725</ref> <ref>PMID:9354683</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PERM_HUMAN PERM_HUMAN]] Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.	+	[https://www.uniprot.org/uniprot/PERM_HUMAN PERM_HUMAN] Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 33:		Line 31:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Myeloperoxidase]]~~	+	[[Category: Auchere F]]
-	[[Category: Auchere, F]]	+	[[Category: Bernlind A]]
-	[[Category: Bernlind, A]]	+	[[Category: Eriksson H]]
-	[[Category: Eriksson, H]]	+	[[Category: Forbes LV]]
-	[[Category: Forbes~~, L V~~]]	+	[[Category: Gustavsson S]]
-	[[Category: Gustavsson, S]]	+	[[Category: Jameson GN]]
-	[[Category: Jameson~~, G N~~]]	+	[[Category: Kettle AJ]]
-	[[Category: Kettle~~, A J~~]]	+	[[Category: Lundquist S]]
-	[[Category: Lundquist, S]]	+	[[Category: Magon NJ]]
-	[[Category: Magon~~, N J~~]]	+	[[Category: Markgren PO]]
-	[[Category: Markgren~~, P O~~]]	+	[[Category: Norman H]]
-	[[Category: Norman, H]]	+	[[Category: Schmidt S]]
-	[[Category: Schmidt, S]]	+	[[Category: Senthilmohan R]]
-	[[Category: Senthilmohan, R]]	+	[[Category: Sjogren T]]
-	[[Category: Sjogren, T]]	+	[[Category: Svensson M]]
-	[[Category: Svensson, M]]	+	[[Category: Tiden AK]]
-	[[Category: Tiden~~, A K]]~~	+
-	~~[[Category: Enzyme inactivation]]~~	+
-	~~[[Category: Hypochlorous acid]]~~	+
-	~~[[Category: Inflammation]]~~	+
-	~~[[Category: Neutrophil]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 07:13, 18 August 2022

OCA — Thu, 18 Aug 2022 07:13:24 GMT

OCA at 13:28, 1 January 2020

OCA — Wed, 01 Jan 2020 13:28:04 GMT

←Older revision		Revision as of 13:28, 1 January 2020
Line 1:		Line 1:

	==Human Myeloperoxidase inactivated by TX2==		==Human Myeloperoxidase inactivated by TX2==
-	<StructureSection load='3zs0' size='340' side='right' caption='[[3zs0]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='3zs0' size='340' side='right'caption='[[3zs0]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zs0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZS0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zs0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZS0 FirstGlance]. <br>
Line 23:		Line 23:
	</div>		</div>
	<div class="pdbe-citations 3zs0" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3zs0" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Myeloperoxidase\|Myeloperoxidase]]
		+	*[[Sandbox WWC11\|Sandbox WWC11]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Myeloperoxidase]]		[[Category: Myeloperoxidase]]
	[[Category: Auchere, F]]		[[Category: Auchere, F]]

OCA at 07:37, 17 January 2018

OCA — Wed, 17 Jan 2018 07:37:18 GMT

←Older revision		Revision as of 07:37, 17 January 2018
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zs0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZS0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zs0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZS0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZS0:3-(4-FLUOROBENZYL)-2-THIOXO-1,2,3,7-TETRAHYDRO-6H-PURIN-6-ONE'>ZS0~~</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZS0:3-(4-FLUOROBENZYL)-2-THIOXO-1,2,3,7-TETRAHYDRO-6H-PURIN-6-ONE'>ZS0</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cxp\|1cxp]], [[1dnu\|1dnu]], [[1d7w\|1d7w]], [[3zs1\|3zs1]], [[1d5l\|1d5l]], [[1d2v\|1d2v]], [[1dnw\|1dnw]], [[1mhl\|1mhl]], [[1myp\|1myp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cxp\|1cxp]], [[1dnu\|1dnu]], [[1d7w\|1d7w]], [[3zs1\|3zs1]], [[1d5l\|1d5l]], [[1d2v\|1d2v]], [[1dnw\|1dnw]], [[1mhl\|1mhl]], [[1myp\|1myp]]</td></tr>
Line 23:		Line 23:
	</div>		</div>
	<div class="pdbe-citations 3zs0" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3zs0" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Myeloperoxidase\|Myeloperoxidase]]
-	*[[Sandbox WWC11\|Sandbox WWC11]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:34, 11 August 2016

OCA — Thu, 11 Aug 2016 17:34:59 GMT

←Older revision		Revision as of 17:34, 11 August 2016
Line 1:		Line 1:
		+
	==Human Myeloperoxidase inactivated by TX2==		==Human Myeloperoxidase inactivated by TX2==
	<StructureSection load='3zs0' size='340' side='right' caption='[[3zs0]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3zs0' size='340' side='right' caption='[[3zs0]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cxp\|1cxp]], [[1dnu\|1dnu]], [[1d7w\|1d7w]], [[3zs1\|3zs1]], [[1d5l\|1d5l]], [[1d2v\|1d2v]], [[1dnw\|1dnw]], [[1mhl\|1mhl]], [[1myp\|1myp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cxp\|1cxp]], [[1dnu\|1dnu]], [[1d7w\|1d7w]], [[3zs1\|3zs1]], [[1d5l\|1d5l]], [[1d2v\|1d2v]], [[1dnw\|1dnw]], [[1mhl\|1mhl]], [[1myp\|1myp]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Myeloperoxidase Myeloperoxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.2.2 1.11.2.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Myeloperoxidase Myeloperoxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.2.2 1.11.2.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zs0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zs0 RCSB], [http://www.ebi.ac.uk/pdbsum/3zs0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zs0 OCA], [http://pdbe.org/3zs0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zs0 RCSB], [http://www.ebi.ac.uk/pdbsum/3zs0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zs0 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 22:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zs0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Myeloperoxidase\|Myeloperoxidase]]		*[[Myeloperoxidase\|Myeloperoxidase]]
		+	*[[Sandbox WWC11\|Sandbox WWC11]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:28, 21 January 2015

OCA — Wed, 21 Jan 2015 11:28:11 GMT

←Older revision		Revision as of 11:28, 21 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zs0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZS0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zs0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZS0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZS0:3-(4-FLUOROBENZYL)-2-THIOXO-1,2,3,7-TETRAHYDRO-6H-PURIN-6-ONE'>ZS0</scene>, <scene name='pdbligand=~~FU4~~:~~2,6~~-~~ANHYDRO~~-~~1-DEOXY-D-GALACTITOL~~'>~~FU4~~</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZS0:3-(4-FLUOROBENZYL)-2-THIOXO-1,2,3,7-TETRAHYDRO-6H-PURIN-6-ONE'>ZS0</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cxp\|1cxp]], [[1dnu\|1dnu]], [[1d7w\|1d7w]], [[3zs1\|3zs1]], [[1d5l\|1d5l]], [[1d2v\|1d2v]], [[1dnw\|1dnw]], [[1mhl\|1mhl]], [[1myp\|1myp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cxp\|1cxp]], [[1dnu\|1dnu]], [[1d7w\|1d7w]], [[3zs1\|3zs1]], [[1d5l\|1d5l]], [[1d2v\|1d2v]], [[1dnw\|1dnw]], [[1mhl\|1mhl]], [[1myp\|1myp]]</td></tr>

OCA at 10:06, 21 December 2014

OCA — Sun, 21 Dec 2014 10:06:06 GMT

←Older revision		Revision as of 10:06, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3zs0~~\| ~~PDB~~=3zs0 \| ~~SCENE~~= }}	+	==Human Myeloperoxidase inactivated by TX2==
-	===~~Human~~ Myeloperoxidase ~~inactivated~~ by ~~TX2~~===	+	<StructureSection load='3zs0' size='340' side='right' caption='[[3zs0]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21880720}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zs0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZS0 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZS0:3-(4-FLUOROBENZYL)-2-THIOXO-1,2,3,7-TETRAHYDRO-6H-PURIN-6-ONE'>ZS0</scene>, <scene name='pdbligand=FU4:2,6-ANHYDRO-1-DEOXY-D-GALACTITOL'>FU4</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cxp\|1cxp]], [[1dnu\|1dnu]], [[1d7w\|1d7w]], [[3zs1\|3zs1]], [[1d5l\|1d5l]], [[1d2v\|1d2v]], [[1dnw\|1dnw]], [[1mhl\|1mhl]], [[1myp\|1myp]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Myeloperoxidase Myeloperoxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.2.2 1.11.2.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zs0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zs0 RCSB], [http://www.ebi.ac.uk/pdbsum/3zs0 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/PERM_HUMAN PERM_HUMAN]] Defects in MPO are the cause of myeloperoxidase deficiency (MPOD) [MIM:[http://omim.org/entry/254600 254600]]. A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis.<ref>PMID:8142659</ref> <ref>PMID:7904599</ref> <ref>PMID:8621627</ref> <ref>PMID:9637725</ref> <ref>PMID:9354683</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PERM_HUMAN PERM_HUMAN]] Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Myeloperoxidase (MPO) is a prime candidate for promoting oxidative stress during inflammation. This abundant enzyme of neutrophils uses hydrogen peroxide to oxidize chloride to highly reactive and toxic chlorine bleach. We have identified 2-thioxanthines as potent mechanism-based inactivators of MPO. Mass spectrometry and x-ray crystal structures revealed that these inhibitors become covalently attached to the heme prosthetic groups of the enzyme. We propose a mechanism whereby 2-thioxanthines are oxidized, and their incipient free radicals react with the heme groups of the enzyme before they can exit the active site. 2-Thioxanthines inhibited MPO in plasma and decreased protein chlorination in a mouse model of peritonitis. They slowed but did not prevent neutrophils from killing bacteria and were poor inhibitors of thyroid peroxidase. Our study shows that MPO is susceptible to the free radicals it generates, and this Achilles' heel of the enzyme can be exploited to block oxidative stress during inflammation.

-	~~==Disease==~~	+	2-thioxanthines are mechanism-based inactivators of myeloperoxidase that block oxidative stress during inflammation.,Tiden AK, Sjogren T, Svensson M, Bernlind A, Senthilmohan R, Auchere F, Norman H, Markgren PO, Gustavsson S, Schmidt S, Lundquist S, Forbes LV, Magon NJ, Paton LN, Jameson GN, Eriksson H, Kettle AJ J Biol Chem. 2011 Oct 28;286(43):37578-89. Epub 2011 Aug 31. PMID:21880720<ref>PMID:21880720</ref>
-	~~[[http://www.uniprot.org/uniprot/PERM_HUMAN PERM_HUMAN]] Defects in MPO~~ are ~~the cause~~ of myeloperoxidase ~~deficiency~~ (~~MPOD~~) ~~[MIM~~:~~[http://omim~~.~~org/entry/254600 254600]]~~. ~~A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis.<ref>~~PMID:~~8142659</ref><ref>PMID:7904599</ref><ref>PMID:8621627</ref><ref>PMID:9637725</ref>~~<ref>PMID:~~9354683~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/PERM_HUMAN PERM_HUMAN]] Part~~ of the ~~host defense system of polymorphonuclear leukocytes~~. ~~It is responsible for microbicidal activity against a wide range of organisms~~. ~~In the stimulated PMN, MPO catalyzes the production~~ of ~~hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity~~.	+	</div>
-		+
-	~~==About this Structure==~~	+
-	~~[[3zs0]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZS0 OCA].~~	+

	==See Also==		==See Also==
	*[[Myeloperoxidase\|Myeloperoxidase]]		*[[Myeloperoxidase\|Myeloperoxidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021880720</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Myeloperoxidase]]		[[Category: Myeloperoxidase]]
-	[[Category: Auchere, F.]]	+	[[Category: Auchere, F]]
-	[[Category: Bernlind, A.]]	+	[[Category: Bernlind, A]]
-	[[Category: Eriksson, H.]]	+	[[Category: Eriksson, H]]
-	[[Category: Forbes, L V.]]	+	[[Category: Forbes, L V]]
-	[[Category: Gustavsson, S.]]	+	[[Category: Gustavsson, S]]
-	[[Category: Jameson, G N.]]	+	[[Category: Jameson, G N]]
-	[[Category: Kettle, A J.]]	+	[[Category: Kettle, A J]]
-	[[Category: Lundquist, S.]]	+	[[Category: Lundquist, S]]
-	[[Category: Magon, N J.]]	+	[[Category: Magon, N J]]
-	[[Category: Markgren, P O.]]	+	[[Category: Markgren, P O]]
-	[[Category: Norman, H.]]	+	[[Category: Norman, H]]
-	[[Category: Schmidt, S.]]	+	[[Category: Schmidt, S]]
-	[[Category: Senthilmohan, R.]]	+	[[Category: Senthilmohan, R]]
-	[[Category: Sjogren, T.]]	+	[[Category: Sjogren, T]]
-	[[Category: Svensson, M.]]	+	[[Category: Svensson, M]]
-	[[Category: Tiden, A K.]]	+	[[Category: Tiden, A K]]
	[[Category: Enzyme inactivation]]		[[Category: Enzyme inactivation]]
	[[Category: Hypochlorous acid]]		[[Category: Hypochlorous acid]]

OCA at 03:02, 25 March 2013

OCA — Mon, 25 Mar 2013 03:02:28 GMT

←Older revision		Revision as of 03:02, 25 March 2013
Line 1:		Line 1:
-	[[Image:3zs0.png\|left\|200px]]
-
	{{STRUCTURE_3zs0\| PDB=3zs0 \| SCENE= }}		{{STRUCTURE_3zs0\| PDB=3zs0 \| SCENE= }}
-
	===Human Myeloperoxidase inactivated by TX2===		===Human Myeloperoxidase inactivated by TX2===
		+	{{ABSTRACT_PUBMED_21880720}}

-	~~{{ABSTRACT_PUBMED_21880720}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/PERM_HUMAN PERM_HUMAN]] Defects in MPO are the cause of myeloperoxidase deficiency (MPOD) [MIM:[http://omim.org/entry/254600 254600]]. A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis.<ref>PMID:8142659</ref><ref>PMID:7904599</ref><ref>PMID:8621627</ref><ref>PMID:9637725</ref><ref>PMID:9354683</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/PERM_HUMAN PERM_HUMAN]] Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021880720</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021880720</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Myeloperoxidase]]		[[Category: Myeloperoxidase]]

OCA at 08:29, 20 October 2012

OCA — Sat, 20 Oct 2012 08:29:07 GMT

←Older revision		Revision as of 08:29, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3zs0]] is a 4 chain structure ~~of [[Myeloperoxidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZS0 OCA].	+	[[3zs0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZS0 OCA].

	==See Also==		==See Also==

OCA at 04:56, 15 August 2012

OCA — Wed, 15 Aug 2012 04:56:36 GMT

←Older revision		Revision as of 04:56, 15 August 2012
Line 3:		Line 3:
	{{STRUCTURE_3zs0\| PDB=3zs0 \| SCENE= }}		{{STRUCTURE_3zs0\| PDB=3zs0 \| SCENE= }}

-	===~~HUMAN MYELOPEROXIDASE INACTIVATED BY~~ TX2===	+	===Human Myeloperoxidase inactivated by TX2===

		+	{{ABSTRACT_PUBMED_21880720}}

	==About this Structure==		==About this Structure==
Line 11:		Line 12:
	==See Also==		==See Also==
	*[[Myeloperoxidase\|Myeloperoxidase]]		*[[Myeloperoxidase\|Myeloperoxidase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021880720</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Myeloperoxidase]]		[[Category: Myeloperoxidase]]

←Older revision		Revision as of 07:13, 18 August 2022
Line 3:		Line 3:
	<StructureSection load='3zs0' size='340' side='right'caption='[[3zs0]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3zs0' size='340' side='right'caption='[[3zs0]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zs0]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZS0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZS0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zs0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZS0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL~~</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC~~</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM~~</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN~~</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZS0:3-(4-FLUOROBENZYL)-2-THIOXO-1,2,3,7-TETRAHYDRO-6H-PURIN-6-ONE'>ZS0</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZS0:3-(4-FLUOROBENZYL)-2-THIOXO-1,2,3,7-TETRAHYDRO-6H-PURIN-6-ONE'>ZS0</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cxp\|1cxp]], [[1dnu\|1dnu]], [[1d7w\|1d7w]], [[3zs1\|3zs1]], [[1d5l\|1d5l]], [[1d2v\|1d2v]], [[1dnw\|1dnw]], [[1mhl\|1mhl]], [[1myp\|1myp]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cxp\|1cxp]], [[1dnu\|1dnu]], [[1d7w\|1d7w]], [[3zs1\|3zs1]], [[1d5l\|1d5l]], [[1d2v\|1d2v]], [[1dnw\|1dnw]], [[1mhl\|1mhl]], [[1myp\|1myp]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Myeloperoxidase Myeloperoxidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.2.2 1.11.2.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Myeloperoxidase Myeloperoxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.2.2 1.11.2.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zs0 OCA], [~~http~~://pdbe.org/3zs0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zs0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zs0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zs0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zs0 OCA], [https://pdbe.org/3zs0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zs0 RCSB], [https://www.ebi.ac.uk/pdbsum/3zs0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zs0 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/PERM_HUMAN PERM_HUMAN]] Defects in MPO are the cause of myeloperoxidase deficiency (MPOD) [MIM:[~~http~~://omim.org/entry/254600 254600]]. A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis.<ref>PMID:8142659</ref> <ref>PMID:7904599</ref> <ref>PMID:8621627</ref> <ref>PMID:9637725</ref> <ref>PMID:9354683</ref>	+	[[https://www.uniprot.org/uniprot/PERM_HUMAN PERM_HUMAN]] Defects in MPO are the cause of myeloperoxidase deficiency (MPOD) [MIM:[https://omim.org/entry/254600 254600]]. A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis.<ref>PMID:8142659</ref> <ref>PMID:7904599</ref> <ref>PMID:8621627</ref> <ref>PMID:9637725</ref> <ref>PMID:9354683</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PERM_HUMAN PERM_HUMAN]] Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.	+	[[https://www.uniprot.org/uniprot/PERM_HUMAN PERM_HUMAN]] Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==