3ztj - Revision history

OCA at 07:17, 18 August 2022

OCA — Thu, 18 Aug 2022 07:17:05 GMT

←Older revision		Revision as of 07:17, 18 August 2022
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	==Structure of influenza A neutralizing antibody selected from cultures of single human plasma cells in complex with human H3 Influenza haemagglutinin.==		==Structure of influenza A neutralizing antibody selected from cultures of single human plasma cells in complex with human H3 Influenza haemagglutinin.==
-	<StructureSection load='3ztj' size='340' side='right' caption='[[3ztj]], [[Resolution\|resolution]] 3.41Å' scene=''>	+	<StructureSection load='3ztj' size='340' side='right'caption='[[3ztj]], [[Resolution\|resolution]] 3.41Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ztj]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human] and [~~http~~://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZTJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ztj]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZTJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vir\|2vir]], [[1qu1\|1qu1]], [[2viu\|2viu]], [[1ha0\|1ha0]], [[1htm\|1htm]], [[5hmg\|5hmg]], [[2vit\|2vit]], [[2vis\|2vis]], [[2hmg\|2hmg]], [[1hgg\|1hgg]], [[1eo8\|1eo8]], [[3hmg\|3hmg]], [[4hmg\|4hmg]], [[1qfu\|1qfu]], [[1j8h\|1j8h]], [[3ztn\|3ztn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vir\|2vir]], [[1qu1\|1qu1]], [[2viu\|2viu]], [[1ha0\|1ha0]], [[1htm\|1htm]], [[5hmg\|5hmg]], [[2vit\|2vit]], [[2vis\|2vis]], [[2hmg\|2hmg]], [[1hgg\|1hgg]], [[1eo8\|1eo8]], [[3hmg\|3hmg]], [[4hmg\|4hmg]], [[1qfu\|1qfu]], [[1j8h\|1j8h]], [[3ztn\|3ztn]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ztj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ztj OCA], [~~http~~://pdbe.org/3ztj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ztj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ztj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ztj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ztj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ztj OCA], [https://pdbe.org/3ztj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ztj RCSB], [https://www.ebi.ac.uk/pdbsum/3ztj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ztj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HEMA_I68A0 HEMA_I68A0]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.	+	[[https://www.uniprot.org/uniprot/HEMA_I68A0 HEMA_I68A0]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
-	*[[Hemagglutinin\|Hemagglutinin]]	+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
		+	*[[3D structures of human antibody\|3D structures of human antibody]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 30:
	[[Category: Human]]		[[Category: Human]]
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
		+	[[Category: Large Structures]]
	[[Category: Collins, P J]]		[[Category: Collins, P J]]
	[[Category: Gamblin, S J]]		[[Category: Gamblin, S J]]

OCA at 16:38, 27 February 2019

OCA — Wed, 27 Feb 2019 16:38:42 GMT

←Older revision		Revision as of 16:38, 27 February 2019
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	<StructureSection load='3ztj' size='340' side='right' caption='[[3ztj]], [[Resolution\|resolution]] 3.41Å' scene=''>		<StructureSection load='3ztj' size='340' side='right' caption='[[3ztj]], [[Resolution\|resolution]] 3.41Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ztj]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZTJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ztj]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZTJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vir\|2vir]], [[1qu1\|1qu1]], [[2viu\|2viu]], [[1ha0\|1ha0]], [[1htm\|1htm]], [[5hmg\|5hmg]], [[2vit\|2vit]], [[2vis\|2vis]], [[2hmg\|2hmg]], [[1hgg\|1hgg]], [[1eo8\|1eo8]], [[3hmg\|3hmg]], [[4hmg\|4hmg]], [[1qfu\|1qfu]], [[1j8h\|1j8h]], [[3ztn\|3ztn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vir\|2vir]], [[1qu1\|1qu1]], [[2viu\|2viu]], [[1ha0\|1ha0]], [[1htm\|1htm]], [[5hmg\|5hmg]], [[2vit\|2vit]], [[2vis\|2vis]], [[2hmg\|2hmg]], [[1hgg\|1hgg]], [[1eo8\|1eo8]], [[3hmg\|3hmg]], [[4hmg\|4hmg]], [[1qfu\|1qfu]], [[1j8h\|1j8h]], [[3ztn\|3ztn]]</td></tr>
Line 21:		Line 21:

	==See Also==		==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	*[[Hemagglutinin\|Hemagglutinin]]		*[[Hemagglutinin\|Hemagglutinin]]
-	*[[3D structures of antibody\|3D structures of antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
	[[Category: Collins, P J]]		[[Category: Collins, P J]]

OCA at 16:29, 25 January 2017

OCA — Wed, 25 Jan 2017 16:29:14 GMT

←Older revision		Revision as of 16:29, 25 January 2017
Line 3:		Line 3:
	<StructureSection load='3ztj' size='340' side='right' caption='[[3ztj]], [[Resolution\|resolution]] 3.41Å' scene=''>		<StructureSection load='3ztj' size='340' side='right' caption='[[3ztj]], [[Resolution\|resolution]] 3.41Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ztj]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Human Human~~] and [http://en.wikipedia.org/wiki/~~I68a0 I68a0~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZTJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ztj]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZTJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vir\|2vir]], [[1qu1\|1qu1]], [[2viu\|2viu]], [[1ha0\|1ha0]], [[1htm\|1htm]], [[5hmg\|5hmg]], [[2vit\|2vit]], [[2vis\|2vis]], [[2hmg\|2hmg]], [[1hgg\|1hgg]], [[1eo8\|1eo8]], [[3hmg\|3hmg]], [[4hmg\|4hmg]], [[1qfu\|1qfu]], [[1j8h\|1j8h]], [[3ztn\|3ztn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vir\|2vir]], [[1qu1\|1qu1]], [[2viu\|2viu]], [[1ha0\|1ha0]], [[1htm\|1htm]], [[5hmg\|5hmg]], [[2vit\|2vit]], [[2vis\|2vis]], [[2hmg\|2hmg]], [[1hgg\|1hgg]], [[1eo8\|1eo8]], [[3hmg\|3hmg]], [[4hmg\|4hmg]], [[1qfu\|1qfu]], [[1j8h\|1j8h]], [[3ztn\|3ztn]]</td></tr>
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human]]~~	+	[[Category: Influenza a virus]]
-	~~[[Category: I68a0~~]]	+
	[[Category: Collins, P J]]		[[Category: Collins, P J]]
	[[Category: Gamblin, S J]]		[[Category: Gamblin, S J]]

OCA at 12:14, 5 August 2016

OCA — Fri, 05 Aug 2016 12:14:46 GMT

←Older revision		Revision as of 12:14, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of influenza A neutralizing antibody selected from cultures of single human plasma cells in complex with human H3 Influenza haemagglutinin.==		==Structure of influenza A neutralizing antibody selected from cultures of single human plasma cells in complex with human H3 Influenza haemagglutinin.==
	<StructureSection load='3ztj' size='340' side='right' caption='[[3ztj]], [[Resolution\|resolution]] 3.41Å' scene=''>		<StructureSection load='3ztj' size='340' side='right' caption='[[3ztj]], [[Resolution\|resolution]] 3.41Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ztj]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Influenza_a_virus_(a/aichi/2/1968(h3n2)) Influenza a virus (a/aichi/2/1968(h3n2))~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZTJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ztj]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/I68a0 I68a0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZTJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vir\|2vir]], [[1qu1\|1qu1]], [[2viu\|2viu]], [[1ha0\|1ha0]], [[1htm\|1htm]], [[5hmg\|5hmg]], [[2vit\|2vit]], [[2vis\|2vis]], [[2hmg\|2hmg]], [[1hgg\|1hgg]], [[1eo8\|1eo8]], [[3hmg\|3hmg]], [[4hmg\|4hmg]], [[1qfu\|1qfu]], [[1j8h\|1j8h]], [[3ztn\|3ztn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vir\|2vir]], [[1qu1\|1qu1]], [[2viu\|2viu]], [[1ha0\|1ha0]], [[1htm\|1htm]], [[5hmg\|5hmg]], [[2vit\|2vit]], [[2vis\|2vis]], [[2hmg\|2hmg]], [[1hgg\|1hgg]], [[1eo8\|1eo8]], [[3hmg\|3hmg]], [[4hmg\|4hmg]], [[1qfu\|1qfu]], [[1j8h\|1j8h]], [[3ztn\|3ztn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ztj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ztj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ztj RCSB], [http://www.ebi.ac.uk/pdbsum/3ztj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ztj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ztj OCA], [http://pdbe.org/3ztj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ztj RCSB], [http://www.ebi.ac.uk/pdbsum/3ztj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ztj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ztj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Antibody\|Antibody]]
	*[[Hemagglutinin\|Hemagglutinin]]		*[[Hemagglutinin\|Hemagglutinin]]
		+	*[[3D structures of antibody\|3D structures of antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
		+	[[Category: I68a0]]
	[[Category: Collins, P J]]		[[Category: Collins, P J]]
	[[Category: Gamblin, S J]]		[[Category: Gamblin, S J]]

OCA at 02:21, 25 December 2014

OCA — Thu, 25 Dec 2014 02:21:54 GMT

←Older revision		Revision as of 02:21, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ztj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ztj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ztj RCSB], [http://www.ebi.ac.uk/pdbsum/3ztj PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ztj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ztj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ztj RCSB], [http://www.ebi.ac.uk/pdbsum/3ztj PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HEMA_I68A0 HEMA_I68A0]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:25, 21 December 2014

OCA — Sun, 21 Dec 2014 09:25:30 GMT

←Older revision		Revision as of 09:25, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3ztj\| PDB=3ztj \| SCENE= }}~~	+	==Structure of influenza A neutralizing antibody selected from cultures of single human plasma cells in complex with human H3 Influenza haemagglutinin.==
-	===Structure of influenza A neutralizing antibody selected from cultures of single human plasma cells in complex with human H3 Influenza haemagglutinin.===	+	<StructureSection load='3ztj' size='340' side='right' caption='[[3ztj]], [[Resolution\|resolution]] 3.41Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21798894}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ztj]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/aichi/2/1968(h3n2)) Influenza a virus (a/aichi/2/1968(h3n2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZTJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vir\|2vir]], [[1qu1\|1qu1]], [[2viu\|2viu]], [[1ha0\|1ha0]], [[1htm\|1htm]], [[5hmg\|5hmg]], [[2vit\|2vit]], [[2vis\|2vis]], [[2hmg\|2hmg]], [[1hgg\|1hgg]], [[1eo8\|1eo8]], [[3hmg\|3hmg]], [[4hmg\|4hmg]], [[1qfu\|1qfu]], [[1j8h\|1j8h]], [[3ztn\|3ztn]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ztj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ztj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ztj RCSB], [http://www.ebi.ac.uk/pdbsum/3ztj PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The isolation of broadly neutralizing antibodies against influenza A viruses has been a long-sought goal for therapeutic approaches and vaccine design. Using a single-cell culture method for screening large numbers of human plasma cells, we isolated a neutralizing monoclonal antibody that recognized the hemagglutinin (HA) glycoprotein of all 16 subtypes and neutralized both group 1 and group 2 influenza A viruses. Passive transfer of this antibody conferred protection to mice and ferrets. Complexes with HAs from the group 1 H1 and the group 2 H3 subtypes analyzed by x-ray crystallography showed that the antibody bound to a conserved epitope in the F subdomain. This antibody may be used for passive protection and to inform vaccine design because of its broad specificity and neutralization potency.

-	~~==Function==~~	+	A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins.,Corti D, Voss J, Gamblin SJ, Codoni G, Macagno A, Jarrossay D, Vachieri SG, Pinna D, Minola A, Vanzetta F, Silacci C, Fernandez-Rodriguez BM, Agatic G, Bianchi S, Giacchetto-Sasselli I, Calder L, Sallusto F, Collins P, Haire LF, Temperton N, Langedijk JP, Skehel JJ, Lanzavecchia A Science. 2011 Jul 28. PMID:21798894<ref>PMID:21798894</ref>
-	~~[[http://www.uniprot.org/uniprot/HEMA_I68A0 HEMA_I68A0]]~~ Binds to ~~sialic acid~~-~~containing receptors on the cell surface~~, ~~bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin~~-~~dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class~~ I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, ~~releasing the fusion hydrophobic peptide~~. ~~Several trimers are required to form a competent fusion pore~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3ztj]] is a 12 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_a_virus_(~~a~~/aichi/2/1968(h3n2)) Influenza a virus (a/aichi/2/1968(h3n2))]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3ZTJ OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:021798894</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Antibody\|Antibody]]
		+	*[[Hemagglutinin\|Hemagglutinin]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Collins, P J.]]	+	[[Category: Collins, P J]]
-	[[Category: Gamblin, S J.]]	+	[[Category: Gamblin, S J]]
-	[[Category: Haire, L F.]]	+	[[Category: Haire, L F]]
-	[[Category: Skehel, J J.]]	+	[[Category: Skehel, J J]]
-	[[Category: Vachieri, S G.]]	+	[[Category: Vachieri, S G]]
-	[[Category: Voss, J E.]]	+	[[Category: Voss, J E]]
	[[Category: Immune system-viral protein complex]]		[[Category: Immune system-viral protein complex]]
	[[Category: Monoclonal antibody]]		[[Category: Monoclonal antibody]]
	[[Category: X31]]		[[Category: X31]]

OCA at 16:29, 19 June 2013

OCA — Wed, 19 Jun 2013 16:29:02 GMT

←Older revision		Revision as of 16:29, 19 June 2013
Line 3:		Line 3:
	{{ABSTRACT_PUBMED_21798894}}		{{ABSTRACT_PUBMED_21798894}}

-	==~~About this Structure~~==	+	==Function==
-	[~~[3ztj]] is a 12 chain structure with sequence from~~ [http://en.~~wikipedia~~.org/~~wiki~~/~~Homo_sapiens Homo sapiens~~] and ~~[http://en~~.~~wikipedia.org/wiki/Influenza_a_virus Influenza~~ a ~~virus]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=3ZTJ OCA]~~.	+	[[http://www.uniprot.org/uniprot/HEMA_I68A0 HEMA_I68A0]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

-	==~~See Also~~==	+	==About this Structure==
-	*[[~~Antibody\|Antibody~~]]	+	[[3ztj]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/aichi/2/1968(h3n2)) Influenza a virus (a/aichi/2/1968(h3n2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTJ OCA].
-	*[[~~Hemagglutinin\|Hemagglutinin~~]]	+

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021798894</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021798894</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Influenza a virus]]
	[[Category: Collins, P J.]]		[[Category: Collins, P J.]]
	[[Category: Gamblin, S J.]]		[[Category: Gamblin, S J.]]

OCA at 10:58, 11 March 2013

OCA — Mon, 11 Mar 2013 10:58:12 GMT

←Older revision		Revision as of 10:58, 11 March 2013
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-	[[Image:3ztj.png\|left\|200px]]
-
	{{STRUCTURE_3ztj\| PDB=3ztj \| SCENE= }}		{{STRUCTURE_3ztj\| PDB=3ztj \| SCENE= }}
-
	===Structure of influenza A neutralizing antibody selected from cultures of single human plasma cells in complex with human H3 Influenza haemagglutinin.===		===Structure of influenza A neutralizing antibody selected from cultures of single human plasma cells in complex with human H3 Influenza haemagglutinin.===
-
	{{ABSTRACT_PUBMED_21798894}}		{{ABSTRACT_PUBMED_21798894}}

Line 11:		Line 7:

	==See Also==		==See Also==
		+	*[[Antibody\|Antibody]]
	*[[Hemagglutinin\|Hemagglutinin]]		*[[Hemagglutinin\|Hemagglutinin]]

OCA at 11:35, 20 October 2012

OCA — Sat, 20 Oct 2012 11:35:17 GMT

←Older revision		Revision as of 11:35, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3ztj]] is a 12 chain structure ~~of [[Hemagglutinin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTJ OCA].	+	[[3ztj]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTJ OCA].

	==See Also==		==See Also==

OCA at 05:48, 5 September 2012

OCA — Wed, 05 Sep 2012 05:48:49 GMT

←Older revision		Revision as of 05:48, 5 September 2012
Line 3:		Line 3:
	{{STRUCTURE_3ztj\| PDB=3ztj \| SCENE= }}		{{STRUCTURE_3ztj\| PDB=3ztj \| SCENE= }}

-	===~~STRUCTURE OF INFLUENZA~~ A ~~NEUTRALIZING ANTIBODY SELECTED FROM CULTURES OF SINGLE HUMAN PLASMA CELLS IN COMPLEX WITH HUMAN~~ H3 ~~INFLUENZA HAEMAGGLUTININ~~.===	+	===Structure of influenza A neutralizing antibody selected from cultures of single human plasma cells in complex with human H3 Influenza haemagglutinin.===

	{{ABSTRACT_PUBMED_21798894}}		{{ABSTRACT_PUBMED_21798894}}