3zuy - Revision history

OCA at 07:47, 7 February 2024

OCA — Wed, 07 Feb 2024 07:47:17 GMT

←Older revision		Revision as of 07:47, 7 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zuy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZUY FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zuy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZUY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene>, <scene name='pdbligand=TCH:TAUROCHOLIC+ACID'>TCH</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene>, <scene name='pdbligand=TCH:TAUROCHOLIC+ACID'>TCH</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zuy OCA], [https://pdbe.org/3zuy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zuy RCSB], [https://www.ebi.ac.uk/pdbsum/3zuy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zuy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zuy OCA], [https://pdbe.org/3zuy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zuy RCSB], [https://www.ebi.ac.uk/pdbsum/3zuy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zuy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q9K0A9_NEIMB Q9K0A9_NEIMB]		[https://www.uniprot.org/uniprot/Q9K0A9_NEIMB Q9K0A9_NEIMB]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	High cholesterol levels greatly increase the risk of cardiovascular disease. About 50 per cent of cholesterol is eliminated from the body by its conversion into bile acids. However, bile acids released from the bile duct are constantly recycled, being reabsorbed in the intestine by the apical sodium-dependent bile acid transporter (ASBT, also known as SLC10A2). It has been shown in animal models that plasma cholesterol levels are considerably lowered by specific inhibitors of ASBT, and ASBT is thus a target for hypercholesterolaemia drugs. Here we report the crystal structure of a bacterial homologue of ASBT from Neisseria meningitidis (ASBT(NM)) at 2.2 A. ASBT(NM) contains two inverted structural repeats of five transmembrane helices. A core domain of six helices harbours two sodium ions, and the remaining four helices pack in a row to form a flat, 'panel'-like domain. Overall, the architecture of the protein is remarkably similar to the sodium/proton antiporter NhaA, despite having no detectable sequence homology. The ASBT(NM) structure was captured with the substrate taurocholate present, bound between the core and panel domains in a large, inward-facing, hydrophobic cavity. Residues near this cavity have been shown to affect the binding of specific inhibitors of human ASBT. The position of the taurocholate molecule, together with the molecular architecture, suggests the rudiments of a possible transport mechanism.
-
-	Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT.,Hu NJ, Iwata S, Cameron AD, Drew D Nature. 2011 Oct 5;478(7369):408-11. doi: 10.1038/nature10450. PMID:21976025<ref>PMID:21976025</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3zuy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Symporter 3D structures\|Symporter 3D structures]]		*[[Symporter 3D structures\|Symporter 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 05:49, 31 May 2023

OCA — Wed, 31 May 2023 05:49:21 GMT

←Older revision		Revision as of 05:49, 31 May 2023
Line 3:		Line 3:
	<StructureSection load='3zuy' size='340' side='right'caption='[[3zuy]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3zuy' size='340' side='right'caption='[[3zuy]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zuy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"diplokokkus_intracellularis_meningitidis"_(sic)_weichselbaum_1887 "diplokokkus intracellularis~~ meningitidis~~" (sic) weichselbaum 1887~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZUY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zuy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZUY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene>, <scene name='pdbligand=TCH:TAUROCHOLIC+ACID'>TCH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene>, <scene name='pdbligand=TCH:TAUROCHOLIC+ACID'>TCH</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zux\|3zux]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zuy OCA], [https://pdbe.org/3zuy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zuy RCSB], [https://www.ebi.ac.uk/pdbsum/3zuy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zuy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zuy OCA], [https://pdbe.org/3zuy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zuy RCSB], [https://www.ebi.ac.uk/pdbsum/3zuy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zuy ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9K0A9_NEIMB Q9K0A9_NEIMB]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cameron~~, A D~~]]	+	[[Category: Neisseria meningitidis]]
-	[[Category: Drew, D]]	+	[[Category: Cameron AD]]
-	[[Category: Hu, N J]]	+	[[Category: Drew D]]
-	[[Category: Iwata, S]]	+	[[Category: Hu N-J]]
-	~~[[Category: Membrane protein]]~~	+	[[Category: Iwata S]]
-	~~[[Category: Transport protein~~]]	+

OCA at 07:20, 18 August 2022

OCA — Thu, 18 Aug 2022 07:20:01 GMT

←Older revision		Revision as of 07:20, 18 August 2022
Line 1:		Line 1:

	==Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT.==		==Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT.==
-	<StructureSection load='3zuy' size='340' side='right' caption='[[3zuy]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='3zuy' size='340' side='right'caption='[[3zuy]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zuy]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"diplokokkus_intracellularis_meningitidis"_(sic)_weichselbaum_1887 "diplokokkus intracellularis meningitidis" (sic) weichselbaum 1887]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZUY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zuy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"diplokokkus_intracellularis_meningitidis"_(sic)_weichselbaum_1887 "diplokokkus intracellularis meningitidis" (sic) weichselbaum 1887]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZUY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene>, <scene name='pdbligand=TCH:TAUROCHOLIC+ACID'>TCH</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene>, <scene name='pdbligand=TCH:TAUROCHOLIC+ACID'>TCH</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zux\|3zux]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zux\|3zux]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zuy OCA], [~~http~~://pdbe.org/3zuy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zuy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zuy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zuy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zuy OCA], [https://pdbe.org/3zuy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zuy RCSB], [https://www.ebi.ac.uk/pdbsum/3zuy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zuy ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 19:

	==See Also==		==See Also==
-	*[[Symporter\|Symporter]]	+	*[[Symporter 3D structures\|Symporter 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Cameron, A D]]		[[Category: Cameron, A D]]
	[[Category: Drew, D]]		[[Category: Drew, D]]

OCA at 16:15, 27 February 2019

OCA — Wed, 27 Feb 2019 16:15:33 GMT

←Older revision		Revision as of 16:15, 27 February 2019
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF A BACTERIAL HOMOLOGUE OF THE BILE ACID SODIUM SYMPORTER~~ ASBT.==	+	==Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT.==
	<StructureSection load='3zuy' size='340' side='right' caption='[[3zuy]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3zuy' size='340' side='right' caption='[[3zuy]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 3zuy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3zuy" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Symporter\|Symporter]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:16, 11 August 2016

OCA — Thu, 11 Aug 2016 13:16:28 GMT

←Older revision		Revision as of 13:16, 11 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF A BACTERIAL HOMOLOGUE OF THE BILE ACID SODIUM SYMPORTER ASBT.==		==CRYSTAL STRUCTURE OF A BACTERIAL HOMOLOGUE OF THE BILE ACID SODIUM SYMPORTER ASBT.==
	<StructureSection load='3zuy' size='340' side='right' caption='[[3zuy]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3zuy' size='340' side='right' caption='[[3zuy]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zuy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Neisseria_meningitidis Neisseria~~ meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZUY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zuy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplokokkus_intracellularis_meningitidis"_(sic)_weichselbaum_1887 "diplokokkus intracellularis meningitidis" (sic) weichselbaum 1887]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZUY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene>, <scene name='pdbligand=TCH:TAUROCHOLIC+ACID'>TCH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene>, <scene name='pdbligand=TCH:TAUROCHOLIC+ACID'>TCH</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zux\|3zux]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zux\|3zux]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zuy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zuy RCSB], [http://www.ebi.ac.uk/pdbsum/3zuy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zuy OCA], [http://pdbe.org/3zuy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zuy RCSB], [http://www.ebi.ac.uk/pdbsum/3zuy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zuy ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zuy" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Neisseria meningitidis]]
	[[Category: Cameron, A D]]		[[Category: Cameron, A D]]
	[[Category: Drew, D]]		[[Category: Drew, D]]

OCA at 10:13, 4 January 2015

OCA — Sun, 04 Jan 2015 10:13:17 GMT

←Older revision		Revision as of 10:13, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zuy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZUY FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zuy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZUY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene>, <scene name='pdbligand=TCH:TAUROCHOLIC+ACID'>TCH</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene>, <scene name='pdbligand=TCH:TAUROCHOLIC+ACID'>TCH</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zux\|3zux]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zux\|3zux]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zuy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zuy RCSB], [http://www.ebi.ac.uk/pdbsum/3zuy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zuy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zuy RCSB], [http://www.ebi.ac.uk/pdbsum/3zuy PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 13:
	Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT.,Hu NJ, Iwata S, Cameron AD, Drew D Nature. 2011 Oct 5;478(7369):408-11. doi: 10.1038/nature10450. PMID:21976025<ref>PMID:21976025</ref>		Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT.,Hu NJ, Iwata S, Cameron AD, Drew D Nature. 2011 Oct 5;478(7369):408-11. doi: 10.1038/nature10450. PMID:21976025<ref>PMID:21976025</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Neisseria meningitidis]]		[[Category: Neisseria meningitidis]]
-	[[Category: Cameron, A D.]]	+	[[Category: Cameron, A D]]
-	[[Category: Drew, D.]]	+	[[Category: Drew, D]]
-	[[Category: Hu, N J.]]	+	[[Category: Hu, N J]]
-	[[Category: Iwata, S.]]	+	[[Category: Iwata, S]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 07:12, 5 June 2014

OCA — Thu, 05 Jun 2014 07:12:50 GMT

←Older revision		Revision as of 07:12, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3zuy.~~png~~\|~~left~~\|~~200px~~]]	+	==CRYSTAL STRUCTURE OF A BACTERIAL HOMOLOGUE OF THE BILE ACID SODIUM SYMPORTER ASBT.==
		+	<StructureSection load='3zuy' size='340' side='right' caption='[[3zuy]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zuy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZUY FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene>, <scene name='pdbligand=TCH:TAUROCHOLIC+ACID'>TCH</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zux\|3zux]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zuy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zuy RCSB], [http://www.ebi.ac.uk/pdbsum/3zuy PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	High cholesterol levels greatly increase the risk of cardiovascular disease. About 50 per cent of cholesterol is eliminated from the body by its conversion into bile acids. However, bile acids released from the bile duct are constantly recycled, being reabsorbed in the intestine by the apical sodium-dependent bile acid transporter (ASBT, also known as SLC10A2). It has been shown in animal models that plasma cholesterol levels are considerably lowered by specific inhibitors of ASBT, and ASBT is thus a target for hypercholesterolaemia drugs. Here we report the crystal structure of a bacterial homologue of ASBT from Neisseria meningitidis (ASBT(NM)) at 2.2 A. ASBT(NM) contains two inverted structural repeats of five transmembrane helices. A core domain of six helices harbours two sodium ions, and the remaining four helices pack in a row to form a flat, 'panel'-like domain. Overall, the architecture of the protein is remarkably similar to the sodium/proton antiporter NhaA, despite having no detectable sequence homology. The ASBT(NM) structure was captured with the substrate taurocholate present, bound between the core and panel domains in a large, inward-facing, hydrophobic cavity. Residues near this cavity have been shown to affect the binding of specific inhibitors of human ASBT. The position of the taurocholate molecule, together with the molecular architecture, suggests the rudiments of a possible transport mechanism.

-	~~<!--~~	+	Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT.,Hu NJ, Iwata S, Cameron AD, Drew D Nature. 2011 Oct 5;478(7369):408-11. doi: 10.1038/nature10450. PMID:21976025<ref>PMID:21976025</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3zuy"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3zuy\| PDB=3zuy \| SCENE= }}~~	+

-	~~===CRYSTAL STRUCTURE OF A BACTERIAL HOMOLOGUE OF THE BILE ACID SODIUM SYMPORTER ASBT.===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21976025}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21976025 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21976025}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3zuy]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUY OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021976025<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Neisseria meningitidis]]		[[Category: Neisseria meningitidis]]
	[[Category: Cameron, A D.]]		[[Category: Cameron, A D.]]

OCA at 07:05, 30 October 2011

OCA — Sun, 30 Oct 2011 07:05:38 GMT

←Older revision		Revision as of 07:05, 30 October 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3zuy.png\|left\|200px]]

-	The ~~entry 3zuy~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3zuy", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3zuy\| PDB=3zuy \| SCENE= }}

-	~~Authors: Hu, N.-J., Iwata, S., Cameron,~~ A.~~, Drew, D.~~	+	===CRYSTAL STRUCTURE OF A BACTERIAL HOMOLOGUE OF THE BILE ACID SODIUM SYMPORTER ASBT.===

-	~~Description~~: ~~Crystal structure of a bacterial homologue of~~ the ~~bile acid sodium symporter ASBT~~.	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21976025}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21976025 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21976025}}
		+
		+	==About this Structure==
		+	[[3zuy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUY OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021976025</ref><references group="xtra"/>
		+	[[Category: Neisseria meningitidis]]
		+	[[Category: Cameron, A D.]]
		+	[[Category: Drew, D.]]
		+	[[Category: Hu, N J.]]
		+	[[Category: Iwata, S.]]
		+	[[Category: Membrane protein]]
		+	[[Category: Transport protein]]

OCA at 05:59, 17 August 2011

OCA — Wed, 17 Aug 2011 05:59:43 GMT

←Older revision		Revision as of 05:59, 17 August 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3zuy is ON HOLD until ~~sometime in the future~~	+	The entry 3zuy is ON HOLD until Paper Publication

	Authors: Hu, N.-J., Iwata, S., Cameron, A., Drew, D.		Authors: Hu, N.-J., Iwata, S., Cameron, A., Drew, D.

	Description: Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT.		Description: Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT.

OCA: Protected "3zuy" [edit=sysop:move=sysop]

OCA — Wed, 27 Jul 2011 05:49:31 GMT

Protected "3zuy" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:49, 27 July 2011