3zv7 - Revision history

OCA at 11:13, 20 December 2023

OCA — Wed, 20 Dec 2023 11:13:52 GMT

←Older revision		Revision as of 11:13, 20 December 2023
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	<StructureSection load='3zv7' size='340' side='right'caption='[[3zv7]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='3zv7' size='340' side='right'caption='[[3zv7]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zv7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Torpedo_californica Torpedo~~ californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZV7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zv7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetronarce_californica Tetronarce californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZV7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NHG:BIS-NORESEROLINE'>NHG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.26Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zgb\|1zgb]], [[1qti\|1qti]], [[1amn\|1amn]], [[1e66\|1e66]], [[2vq6\|2vq6]], [[2ack\|2ack]], [[2j3d\|2j3d]], [[1qii\|1qii]], [[2ckm\|2ckm]], [[1dx6\|1dx6]], [[1qie\|1qie]], [[1qij\|1qij]], [[1acl\|1acl]], [[1odc\|1odc]], [[1w4l\|1w4l]], [[2cmf\|2cmf]], [[2wg0\|2wg0]], [[2j3q\|2j3q]], [[1gqs\|1gqs]], [[2j4f\|2j4f]], [[1e3q\|1e3q]], [[1qik\|1qik]], [[2dfp\|2dfp]], [[2c5f\|2c5f]], [[1ea5\|1ea5]], [[1qif\|1qif]], [[2vjc\|2vjc]], [[1eea\|1eea]], [[2vjb\|2vjb]], [[1qig\|1qig]], [[1qid\|1qid]], [[1zgc\|1zgc]], [[2wfz\|2wfz]], [[2vjd\|2vjd]], [[1jjb\|1jjb]], [[2wg1\|2wg1]], [[1ut6\|1ut6]], [[2vt6\|2vt6]], [[2wg2\|2wg2]], [[2w9i\|2w9i]], [[2vt7\|2vt7]], [[2cek\|2cek]], [[1qim\|1qim]], [[1jga\|1jga]], [[1gpk\|1gpk]], [[3ace\|3ace]], [[1oce\|1oce]], [[1w6r\|1w6r]], [[1som\|1som]], [[1vxo\|1vxo]], [[2vja\|2vja]], [[2w6c\|2w6c]], [[1cfj\|1cfj]], [[2v96\|2v96]], [[1ax9\|1ax9]], [[1w76\|1w76]], [[1u65\|1u65]], [[1h22\|1h22]], [[1eve\|1eve]], [[2c4h\|2c4h]], [[1gqr\|1gqr]], [[2va9\|2va9]], [[2ace\|2ace]], [[1vxr\|1vxr]], [[4ace\|4ace]], [[2c58\|2c58]], [[1hbj\|1hbj]], [[1w75\|1w75]], [[1vot\|1vot]], [[2c5g\|2c5g]], [[2v98\|2v98]], [[1jgb\|1jgb]], [[2xi4\|2xi4]], [[1gpn\|1gpn]], [[1qih\|1qih]], [[1h23\|1h23]], [[1fss\|1fss]], [[1acj\|1acj]], [[2v97\|2v97]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NHG:BIS-NORESEROLINE'>NHG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv7 OCA], [https://pdbe.org/3zv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zv7 RCSB], [https://www.ebi.ac.uk/pdbsum/3zv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zv7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv7 OCA], [https://pdbe.org/3zv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zv7 RCSB], [https://www.ebi.ac.uk/pdbsum/3zv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zv7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~ACES_TORCA ACES_TORCA]~~] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.	+	[https://www.uniprot.org/uniprot/ACES_TETCF ACES_TETCF] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Acetylcholinesterase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Torpedo~~ californica]]	+	[[Category: Tetronarce californica]]
-	[[Category: Bartolucci, C]]	+	[[Category: Bartolucci C]]
-	[[Category: Greig~~, N H~~]]	+	[[Category: Greig NH]]
-	[[Category: Lamba, D]]	+	[[Category: Lamba D]]
-	[[Category: Stojan, J]]	+	[[Category: Stojan J]]
-	~~[[Category: Anti-alzheimer drug]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Neurotransmitter cleavage~~]]	+

OCA at 07:20, 18 August 2022

OCA — Thu, 18 Aug 2022 07:20:28 GMT

←Older revision		Revision as of 07:20, 18 August 2022
Line 3:		Line 3:
	<StructureSection load='3zv7' size='340' side='right'caption='[[3zv7]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='3zv7' size='340' side='right'caption='[[3zv7]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zv7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3ZV7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zv7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZV7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NHG:BIS-NORESEROLINE'>NHG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NHG:BIS-NORESEROLINE'>NHG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zgb\|1zgb]], [[1qti\|1qti]], [[1amn\|1amn]], [[1e66\|1e66]], [[2vq6\|2vq6]], [[2ack\|2ack]], [[2j3d\|2j3d]], [[1qii\|1qii]], [[2ckm\|2ckm]], [[1dx6\|1dx6]], [[1qie\|1qie]], [[1qij\|1qij]], [[1acl\|1acl]], [[1odc\|1odc]], [[1w4l\|1w4l]], [[2cmf\|2cmf]], [[2wg0\|2wg0]], [[2j3q\|2j3q]], [[1gqs\|1gqs]], [[2j4f\|2j4f]], [[1e3q\|1e3q]], [[1qik\|1qik]], [[2dfp\|2dfp]], [[2c5f\|2c5f]], [[1ea5\|1ea5]], [[1qif\|1qif]], [[2vjc\|2vjc]], [[1eea\|1eea]], [[2vjb\|2vjb]], [[1qig\|1qig]], [[1qid\|1qid]], [[1zgc\|1zgc]], [[2wfz\|2wfz]], [[2vjd\|2vjd]], [[1jjb\|1jjb]], [[2wg1\|2wg1]], [[1ut6\|1ut6]], [[2vt6\|2vt6]], [[2wg2\|2wg2]], [[2w9i\|2w9i]], [[2vt7\|2vt7]], [[2cek\|2cek]], [[1qim\|1qim]], [[1jga\|1jga]], [[1gpk\|1gpk]], [[3ace\|3ace]], [[1oce\|1oce]], [[1w6r\|1w6r]], [[1som\|1som]], [[1vxo\|1vxo]], [[2vja\|2vja]], [[2w6c\|2w6c]], [[1cfj\|1cfj]], [[2v96\|2v96]], [[1ax9\|1ax9]], [[1w76\|1w76]], [[1u65\|1u65]], [[1h22\|1h22]], [[1eve\|1eve]], [[2c4h\|2c4h]], [[1gqr\|1gqr]], [[2va9\|2va9]], [[2ace\|2ace]], [[1vxr\|1vxr]], [[4ace\|4ace]], [[2c58\|2c58]], [[1hbj\|1hbj]], [[1w75\|1w75]], [[1vot\|1vot]], [[2c5g\|2c5g]], [[2v98\|2v98]], [[1jgb\|1jgb]], [[2xi4\|2xi4]], [[1gpn\|1gpn]], [[1qih\|1qih]], [[1h23\|1h23]], [[1fss\|1fss]], [[1acj\|1acj]], [[2v97\|2v97]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zgb\|1zgb]], [[1qti\|1qti]], [[1amn\|1amn]], [[1e66\|1e66]], [[2vq6\|2vq6]], [[2ack\|2ack]], [[2j3d\|2j3d]], [[1qii\|1qii]], [[2ckm\|2ckm]], [[1dx6\|1dx6]], [[1qie\|1qie]], [[1qij\|1qij]], [[1acl\|1acl]], [[1odc\|1odc]], [[1w4l\|1w4l]], [[2cmf\|2cmf]], [[2wg0\|2wg0]], [[2j3q\|2j3q]], [[1gqs\|1gqs]], [[2j4f\|2j4f]], [[1e3q\|1e3q]], [[1qik\|1qik]], [[2dfp\|2dfp]], [[2c5f\|2c5f]], [[1ea5\|1ea5]], [[1qif\|1qif]], [[2vjc\|2vjc]], [[1eea\|1eea]], [[2vjb\|2vjb]], [[1qig\|1qig]], [[1qid\|1qid]], [[1zgc\|1zgc]], [[2wfz\|2wfz]], [[2vjd\|2vjd]], [[1jjb\|1jjb]], [[2wg1\|2wg1]], [[1ut6\|1ut6]], [[2vt6\|2vt6]], [[2wg2\|2wg2]], [[2w9i\|2w9i]], [[2vt7\|2vt7]], [[2cek\|2cek]], [[1qim\|1qim]], [[1jga\|1jga]], [[1gpk\|1gpk]], [[3ace\|3ace]], [[1oce\|1oce]], [[1w6r\|1w6r]], [[1som\|1som]], [[1vxo\|1vxo]], [[2vja\|2vja]], [[2w6c\|2w6c]], [[1cfj\|1cfj]], [[2v96\|2v96]], [[1ax9\|1ax9]], [[1w76\|1w76]], [[1u65\|1u65]], [[1h22\|1h22]], [[1eve\|1eve]], [[2c4h\|2c4h]], [[1gqr\|1gqr]], [[2va9\|2va9]], [[2ace\|2ace]], [[1vxr\|1vxr]], [[4ace\|4ace]], [[2c58\|2c58]], [[1hbj\|1hbj]], [[1w75\|1w75]], [[1vot\|1vot]], [[2c5g\|2c5g]], [[2v98\|2v98]], [[1jgb\|1jgb]], [[2xi4\|2xi4]], [[1gpn\|1gpn]], [[1qih\|1qih]], [[1h23\|1h23]], [[1fss\|1fss]], [[1acj\|1acj]], [[2v97\|2v97]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3zv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv7 OCA], [~~http~~://pdbe.org/3zv7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zv7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zv7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zv7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv7 OCA], [https://pdbe.org/3zv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zv7 RCSB], [https://www.ebi.ac.uk/pdbsum/3zv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zv7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ACES_TORCA ACES_TORCA]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.	+	[[https://www.uniprot.org/uniprot/ACES_TORCA ACES_TORCA]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:12, 4 November 2020

OCA — Wed, 04 Nov 2020 08:12:03 GMT

←Older revision		Revision as of 08:12, 4 November 2020
Line 1:		Line 1:

	==Torpedo californica Acetylcholinesterase Inhibition by Bisnorcymserine==		==Torpedo californica Acetylcholinesterase Inhibition by Bisnorcymserine==
-	<StructureSection load='3zv7' size='340' side='right' caption='[[3zv7]], [[Resolution\|resolution]] 2.26Å' scene=''>	+	<StructureSection load='3zv7' size='340' side='right'caption='[[3zv7]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zv7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV7 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZV7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zv7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3ZV7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NHG:BIS-NORESEROLINE'>NHG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NHG:BIS-NORESEROLINE'>NHG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zgb\|1zgb]], [[1qti\|1qti]], [[1amn\|1amn]], [[1e66\|1e66]], [[2vq6\|2vq6]], [[2ack\|2ack]], [[2j3d\|2j3d]], [[1qii\|1qii]], [[2ckm\|2ckm]], [[1dx6\|1dx6]], [[1qie\|1qie]], [[1qij\|1qij]], [[1acl\|1acl]], [[1odc\|1odc]], [[1w4l\|1w4l]], [[2cmf\|2cmf]], [[2wg0\|2wg0]], [[2j3q\|2j3q]], [[1gqs\|1gqs]], [[2j4f\|2j4f]], [[1e3q\|1e3q]], [[1qik\|1qik]], [[2dfp\|2dfp]], [[2c5f\|2c5f]], [[1ea5\|1ea5]], [[1qif\|1qif]], [[2vjc\|2vjc]], [[1eea\|1eea]], [[2vjb\|2vjb]], [[1qig\|1qig]], [[1qid\|1qid]], [[1zgc\|1zgc]], [[2wfz\|2wfz]], [[2vjd\|2vjd]], [[1jjb\|1jjb]], [[2wg1\|2wg1]], [[1ut6\|1ut6]], [[2vt6\|2vt6]], [[2wg2\|2wg2]], [[2w9i\|2w9i]], [[2vt7\|2vt7]], [[2cek\|2cek]], [[1qim\|1qim]], [[1jga\|1jga]], [[1gpk\|1gpk]], [[3ace\|3ace]], [[1oce\|1oce]], [[1w6r\|1w6r]], [[1som\|1som]], [[1vxo\|1vxo]], [[2vja\|2vja]], [[2w6c\|2w6c]], [[1cfj\|1cfj]], [[2v96\|2v96]], [[1ax9\|1ax9]], [[1w76\|1w76]], [[1u65\|1u65]], [[1h22\|1h22]], [[1eve\|1eve]], [[2c4h\|2c4h]], [[1gqr\|1gqr]], [[2va9\|2va9]], [[2ace\|2ace]], [[1vxr\|1vxr]], [[4ace\|4ace]], [[2c58\|2c58]], [[1hbj\|1hbj]], [[1w75\|1w75]], [[1vot\|1vot]], [[2c5g\|2c5g]], [[2v98\|2v98]], [[1jgb\|1jgb]], [[2xi4\|2xi4]], [[1gpn\|1gpn]], [[1qih\|1qih]], [[1h23\|1h23]], [[1fss\|1fss]], [[1acj\|1acj]], [[2v97\|2v97]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zgb\|1zgb]], [[1qti\|1qti]], [[1amn\|1amn]], [[1e66\|1e66]], [[2vq6\|2vq6]], [[2ack\|2ack]], [[2j3d\|2j3d]], [[1qii\|1qii]], [[2ckm\|2ckm]], [[1dx6\|1dx6]], [[1qie\|1qie]], [[1qij\|1qij]], [[1acl\|1acl]], [[1odc\|1odc]], [[1w4l\|1w4l]], [[2cmf\|2cmf]], [[2wg0\|2wg0]], [[2j3q\|2j3q]], [[1gqs\|1gqs]], [[2j4f\|2j4f]], [[1e3q\|1e3q]], [[1qik\|1qik]], [[2dfp\|2dfp]], [[2c5f\|2c5f]], [[1ea5\|1ea5]], [[1qif\|1qif]], [[2vjc\|2vjc]], [[1eea\|1eea]], [[2vjb\|2vjb]], [[1qig\|1qig]], [[1qid\|1qid]], [[1zgc\|1zgc]], [[2wfz\|2wfz]], [[2vjd\|2vjd]], [[1jjb\|1jjb]], [[2wg1\|2wg1]], [[1ut6\|1ut6]], [[2vt6\|2vt6]], [[2wg2\|2wg2]], [[2w9i\|2w9i]], [[2vt7\|2vt7]], [[2cek\|2cek]], [[1qim\|1qim]], [[1jga\|1jga]], [[1gpk\|1gpk]], [[3ace\|3ace]], [[1oce\|1oce]], [[1w6r\|1w6r]], [[1som\|1som]], [[1vxo\|1vxo]], [[2vja\|2vja]], [[2w6c\|2w6c]], [[1cfj\|1cfj]], [[2v96\|2v96]], [[1ax9\|1ax9]], [[1w76\|1w76]], [[1u65\|1u65]], [[1h22\|1h22]], [[1eve\|1eve]], [[2c4h\|2c4h]], [[1gqr\|1gqr]], [[2va9\|2va9]], [[2ace\|2ace]], [[1vxr\|1vxr]], [[4ace\|4ace]], [[2c58\|2c58]], [[1hbj\|1hbj]], [[1w75\|1w75]], [[1vot\|1vot]], [[2c5g\|2c5g]], [[2v98\|2v98]], [[1jgb\|1jgb]], [[2xi4\|2xi4]], [[1gpn\|1gpn]], [[1qih\|1qih]], [[1h23\|1h23]], [[1fss\|1fss]], [[1acj\|1acj]], [[2v97\|2v97]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv7 OCA], [http://pdbe.org/3zv7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zv7 RCSB], [http://www.ebi.ac.uk/pdbsum/3zv7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zv7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3zv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv7 OCA], [http://pdbe.org/3zv7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zv7 RCSB], [http://www.ebi.ac.uk/pdbsum/3zv7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zv7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
		+	[[Category: Large Structures]]
	[[Category: Torpedo californica]]		[[Category: Torpedo californica]]
	[[Category: Bartolucci, C]]		[[Category: Bartolucci, C]]

OCA at 09:02, 30 January 2019

OCA — Wed, 30 Jan 2019 09:02:07 GMT

←Older revision		Revision as of 09:02, 30 January 2019
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Acetylcholinesterase~~\|Acetylcholinesterase]]~~	+	*[[Acetylcholinesterase 3D structures\|Acetylcholinesterase 3D structures]]
-	*[[3D structures ~~of acetylcholinesterase~~\|3D structures ~~of acetylcholinesterase~~]]	+
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:42, 5 August 2016

OCA — Fri, 05 Aug 2016 15:42:49 GMT

←Older revision		Revision as of 15:42, 5 August 2016
Line 1:		Line 1:
		+
	==Torpedo californica Acetylcholinesterase Inhibition by Bisnorcymserine==		==Torpedo californica Acetylcholinesterase Inhibition by Bisnorcymserine==
	<StructureSection load='3zv7' size='340' side='right' caption='[[3zv7]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='3zv7' size='340' side='right' caption='[[3zv7]], [[Resolution\|resolution]] 2.26Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zgb\|1zgb]], [[1qti\|1qti]], [[1amn\|1amn]], [[1e66\|1e66]], [[2vq6\|2vq6]], [[2ack\|2ack]], [[2j3d\|2j3d]], [[1qii\|1qii]], [[2ckm\|2ckm]], [[1dx6\|1dx6]], [[1qie\|1qie]], [[1qij\|1qij]], [[1acl\|1acl]], [[1odc\|1odc]], [[1w4l\|1w4l]], [[2cmf\|2cmf]], [[2wg0\|2wg0]], [[2j3q\|2j3q]], [[1gqs\|1gqs]], [[2j4f\|2j4f]], [[1e3q\|1e3q]], [[1qik\|1qik]], [[2dfp\|2dfp]], [[2c5f\|2c5f]], [[1ea5\|1ea5]], [[1qif\|1qif]], [[2vjc\|2vjc]], [[1eea\|1eea]], [[2vjb\|2vjb]], [[1qig\|1qig]], [[1qid\|1qid]], [[1zgc\|1zgc]], [[2wfz\|2wfz]], [[2vjd\|2vjd]], [[1jjb\|1jjb]], [[2wg1\|2wg1]], [[1ut6\|1ut6]], [[2vt6\|2vt6]], [[2wg2\|2wg2]], [[2w9i\|2w9i]], [[2vt7\|2vt7]], [[2cek\|2cek]], [[1qim\|1qim]], [[1jga\|1jga]], [[1gpk\|1gpk]], [[3ace\|3ace]], [[1oce\|1oce]], [[1w6r\|1w6r]], [[1som\|1som]], [[1vxo\|1vxo]], [[2vja\|2vja]], [[2w6c\|2w6c]], [[1cfj\|1cfj]], [[2v96\|2v96]], [[1ax9\|1ax9]], [[1w76\|1w76]], [[1u65\|1u65]], [[1h22\|1h22]], [[1eve\|1eve]], [[2c4h\|2c4h]], [[1gqr\|1gqr]], [[2va9\|2va9]], [[2ace\|2ace]], [[1vxr\|1vxr]], [[4ace\|4ace]], [[2c58\|2c58]], [[1hbj\|1hbj]], [[1w75\|1w75]], [[1vot\|1vot]], [[2c5g\|2c5g]], [[2v98\|2v98]], [[1jgb\|1jgb]], [[2xi4\|2xi4]], [[1gpn\|1gpn]], [[1qih\|1qih]], [[1h23\|1h23]], [[1fss\|1fss]], [[1acj\|1acj]], [[2v97\|2v97]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zgb\|1zgb]], [[1qti\|1qti]], [[1amn\|1amn]], [[1e66\|1e66]], [[2vq6\|2vq6]], [[2ack\|2ack]], [[2j3d\|2j3d]], [[1qii\|1qii]], [[2ckm\|2ckm]], [[1dx6\|1dx6]], [[1qie\|1qie]], [[1qij\|1qij]], [[1acl\|1acl]], [[1odc\|1odc]], [[1w4l\|1w4l]], [[2cmf\|2cmf]], [[2wg0\|2wg0]], [[2j3q\|2j3q]], [[1gqs\|1gqs]], [[2j4f\|2j4f]], [[1e3q\|1e3q]], [[1qik\|1qik]], [[2dfp\|2dfp]], [[2c5f\|2c5f]], [[1ea5\|1ea5]], [[1qif\|1qif]], [[2vjc\|2vjc]], [[1eea\|1eea]], [[2vjb\|2vjb]], [[1qig\|1qig]], [[1qid\|1qid]], [[1zgc\|1zgc]], [[2wfz\|2wfz]], [[2vjd\|2vjd]], [[1jjb\|1jjb]], [[2wg1\|2wg1]], [[1ut6\|1ut6]], [[2vt6\|2vt6]], [[2wg2\|2wg2]], [[2w9i\|2w9i]], [[2vt7\|2vt7]], [[2cek\|2cek]], [[1qim\|1qim]], [[1jga\|1jga]], [[1gpk\|1gpk]], [[3ace\|3ace]], [[1oce\|1oce]], [[1w6r\|1w6r]], [[1som\|1som]], [[1vxo\|1vxo]], [[2vja\|2vja]], [[2w6c\|2w6c]], [[1cfj\|1cfj]], [[2v96\|2v96]], [[1ax9\|1ax9]], [[1w76\|1w76]], [[1u65\|1u65]], [[1h22\|1h22]], [[1eve\|1eve]], [[2c4h\|2c4h]], [[1gqr\|1gqr]], [[2va9\|2va9]], [[2ace\|2ace]], [[1vxr\|1vxr]], [[4ace\|4ace]], [[2c58\|2c58]], [[1hbj\|1hbj]], [[1w75\|1w75]], [[1vot\|1vot]], [[2c5g\|2c5g]], [[2v98\|2v98]], [[1jgb\|1jgb]], [[2xi4\|2xi4]], [[1gpn\|1gpn]], [[1qih\|1qih]], [[1h23\|1h23]], [[1fss\|1fss]], [[1acj\|1acj]], [[2v97\|2v97]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zv7 RCSB], [http://www.ebi.ac.uk/pdbsum/3zv7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv7 OCA], [http://pdbe.org/3zv7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zv7 RCSB], [http://www.ebi.ac.uk/pdbsum/3zv7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zv7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zv7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Acetylcholinesterase\|Acetylcholinesterase]]		*[[Acetylcholinesterase\|Acetylcholinesterase]]
		+	*[[3D structures of acetylcholinesterase\|3D structures of acetylcholinesterase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:59, 25 December 2014

OCA — Thu, 25 Dec 2014 19:59:43 GMT

←Older revision		Revision as of 19:59, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zv7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZV7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zv7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZV7 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NHG:BIS-NORESEROLINE'>NHG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NHG:BIS-NORESEROLINE'>NHG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zgb\|1zgb]], [[1qti\|1qti]], [[1amn\|1amn]], [[1e66\|1e66]], [[2vq6\|2vq6]], [[2ack\|2ack]], [[2j3d\|2j3d]], [[1qii\|1qii]], [[2ckm\|2ckm]], [[1dx6\|1dx6]], [[1qie\|1qie]], [[1qij\|1qij]], [[1acl\|1acl]], [[1odc\|1odc]], [[1w4l\|1w4l]], [[2cmf\|2cmf]], [[2wg0\|2wg0]], [[2j3q\|2j3q]], [[1gqs\|1gqs]], [[2j4f\|2j4f]], [[1e3q\|1e3q]], [[1qik\|1qik]], [[2dfp\|2dfp]], [[2c5f\|2c5f]], [[1ea5\|1ea5]], [[1qif\|1qif]], [[2vjc\|2vjc]], [[1eea\|1eea]], [[2vjb\|2vjb]], [[1qig\|1qig]], [[1qid\|1qid]], [[1zgc\|1zgc]], [[2wfz\|2wfz]], [[2vjd\|2vjd]], [[1jjb\|1jjb]], [[2wg1\|2wg1]], [[1ut6\|1ut6]], [[2vt6\|2vt6]], [[2wg2\|2wg2]], [[2w9i\|2w9i]], [[2vt7\|2vt7]], [[2cek\|2cek]], [[1qim\|1qim]], [[1jga\|1jga]], [[1gpk\|1gpk]], [[3ace\|3ace]], [[1oce\|1oce]], [[1w6r\|1w6r]], [[1som\|1som]], [[1vxo\|1vxo]], [[2vja\|2vja]], [[2w6c\|2w6c]], [[1cfj\|1cfj]], [[2v96\|2v96]], [[1ax9\|1ax9]], [[1w76\|1w76]], [[1u65\|1u65]], [[1h22\|1h22]], [[1eve\|1eve]], [[2c4h\|2c4h]], [[1gqr\|1gqr]], [[2va9\|2va9]], [[2ace\|2ace]], [[1vxr\|1vxr]], [[4ace\|4ace]], [[2c58\|2c58]], [[1hbj\|1hbj]], [[1w75\|1w75]], [[1vot\|1vot]], [[2c5g\|2c5g]], [[2v98\|2v98]], [[1jgb\|1jgb]], [[2xi4\|2xi4]], [[1gpn\|1gpn]], [[1qih\|1qih]], [[1h23\|1h23]], [[1fss\|1fss]], [[1acj\|1acj]], [[2v97\|2v97]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zgb\|1zgb]], [[1qti\|1qti]], [[1amn\|1amn]], [[1e66\|1e66]], [[2vq6\|2vq6]], [[2ack\|2ack]], [[2j3d\|2j3d]], [[1qii\|1qii]], [[2ckm\|2ckm]], [[1dx6\|1dx6]], [[1qie\|1qie]], [[1qij\|1qij]], [[1acl\|1acl]], [[1odc\|1odc]], [[1w4l\|1w4l]], [[2cmf\|2cmf]], [[2wg0\|2wg0]], [[2j3q\|2j3q]], [[1gqs\|1gqs]], [[2j4f\|2j4f]], [[1e3q\|1e3q]], [[1qik\|1qik]], [[2dfp\|2dfp]], [[2c5f\|2c5f]], [[1ea5\|1ea5]], [[1qif\|1qif]], [[2vjc\|2vjc]], [[1eea\|1eea]], [[2vjb\|2vjb]], [[1qig\|1qig]], [[1qid\|1qid]], [[1zgc\|1zgc]], [[2wfz\|2wfz]], [[2vjd\|2vjd]], [[1jjb\|1jjb]], [[2wg1\|2wg1]], [[1ut6\|1ut6]], [[2vt6\|2vt6]], [[2wg2\|2wg2]], [[2w9i\|2w9i]], [[2vt7\|2vt7]], [[2cek\|2cek]], [[1qim\|1qim]], [[1jga\|1jga]], [[1gpk\|1gpk]], [[3ace\|3ace]], [[1oce\|1oce]], [[1w6r\|1w6r]], [[1som\|1som]], [[1vxo\|1vxo]], [[2vja\|2vja]], [[2w6c\|2w6c]], [[1cfj\|1cfj]], [[2v96\|2v96]], [[1ax9\|1ax9]], [[1w76\|1w76]], [[1u65\|1u65]], [[1h22\|1h22]], [[1eve\|1eve]], [[2c4h\|2c4h]], [[1gqr\|1gqr]], [[2va9\|2va9]], [[2ace\|2ace]], [[1vxr\|1vxr]], [[4ace\|4ace]], [[2c58\|2c58]], [[1hbj\|1hbj]], [[1w75\|1w75]], [[1vot\|1vot]], [[2c5g\|2c5g]], [[2v98\|2v98]], [[1jgb\|1jgb]], [[2xi4\|2xi4]], [[1gpn\|1gpn]], [[1qih\|1qih]], [[1h23\|1h23]], [[1fss\|1fss]], [[1acj\|1acj]], [[2v97\|2v97]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zv7 RCSB], [http://www.ebi.ac.uk/pdbsum/3zv7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zv7 RCSB], [http://www.ebi.ac.uk/pdbsum/3zv7 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACES_TORCA ACES_TORCA]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 16:
	Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group.,Bartolucci C, Stojan J, Yu QS, Greig NH, Lamba D Biochem J. 2012 Jun 1;444(2):269-77. PMID:22390827<ref>PMID:22390827</ref>		Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group.,Bartolucci C, Stojan J, Yu QS, Greig NH, Lamba D Biochem J. 2012 Jun 1;444(2):269-77. PMID:22390827<ref>PMID:22390827</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>

Line 25:		Line 27:
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Torpedo californica]]		[[Category: Torpedo californica]]
-	[[Category: Bartolucci, C.]]	+	[[Category: Bartolucci, C]]
-	[[Category: Greig, N H.]]	+	[[Category: Greig, N H]]
-	[[Category: Lamba, D.]]	+	[[Category: Lamba, D]]
-	[[Category: Stojan, J.]]	+	[[Category: Stojan, J]]
	[[Category: Anti-alzheimer drug]]		[[Category: Anti-alzheimer drug]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Neurotransmitter cleavage]]		[[Category: Neurotransmitter cleavage]]

OCA at 07:16, 5 June 2014

OCA — Thu, 05 Jun 2014 07:16:29 GMT

←Older revision		Revision as of 07:16, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3zv7.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Torpedo californica Acetylcholinesterase Inhibition by Bisnorcymserine==
		+	<StructureSection load='3zv7' size='340' side='right' caption='[[3zv7]], [[Resolution\|resolution]] 2.26Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zv7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZV7 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NHG:BIS-NORESEROLINE'>NHG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zgb\|1zgb]], [[1qti\|1qti]], [[1amn\|1amn]], [[1e66\|1e66]], [[2vq6\|2vq6]], [[2ack\|2ack]], [[2j3d\|2j3d]], [[1qii\|1qii]], [[2ckm\|2ckm]], [[1dx6\|1dx6]], [[1qie\|1qie]], [[1qij\|1qij]], [[1acl\|1acl]], [[1odc\|1odc]], [[1w4l\|1w4l]], [[2cmf\|2cmf]], [[2wg0\|2wg0]], [[2j3q\|2j3q]], [[1gqs\|1gqs]], [[2j4f\|2j4f]], [[1e3q\|1e3q]], [[1qik\|1qik]], [[2dfp\|2dfp]], [[2c5f\|2c5f]], [[1ea5\|1ea5]], [[1qif\|1qif]], [[2vjc\|2vjc]], [[1eea\|1eea]], [[2vjb\|2vjb]], [[1qig\|1qig]], [[1qid\|1qid]], [[1zgc\|1zgc]], [[2wfz\|2wfz]], [[2vjd\|2vjd]], [[1jjb\|1jjb]], [[2wg1\|2wg1]], [[1ut6\|1ut6]], [[2vt6\|2vt6]], [[2wg2\|2wg2]], [[2w9i\|2w9i]], [[2vt7\|2vt7]], [[2cek\|2cek]], [[1qim\|1qim]], [[1jga\|1jga]], [[1gpk\|1gpk]], [[3ace\|3ace]], [[1oce\|1oce]], [[1w6r\|1w6r]], [[1som\|1som]], [[1vxo\|1vxo]], [[2vja\|2vja]], [[2w6c\|2w6c]], [[1cfj\|1cfj]], [[2v96\|2v96]], [[1ax9\|1ax9]], [[1w76\|1w76]], [[1u65\|1u65]], [[1h22\|1h22]], [[1eve\|1eve]], [[2c4h\|2c4h]], [[1gqr\|1gqr]], [[2va9\|2va9]], [[2ace\|2ace]], [[1vxr\|1vxr]], [[4ace\|4ace]], [[2c58\|2c58]], [[1hbj\|1hbj]], [[1w75\|1w75]], [[1vot\|1vot]], [[2c5g\|2c5g]], [[2v98\|2v98]], [[1jgb\|1jgb]], [[2xi4\|2xi4]], [[1gpn\|1gpn]], [[1qih\|1qih]], [[1h23\|1h23]], [[1fss\|1fss]], [[1acj\|1acj]], [[2v97\|2v97]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zv7 RCSB], [http://www.ebi.ac.uk/pdbsum/3zv7 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Natural and synthetic carbamates act as pseudo-irreversible inhibitors of AChE (acetylcholinesterase) as well as BChE (butyrylcholinesterase), two enzymes involved in neuronal function as well as in the development and progression of AD (Alzheimer's disease). The AChE mode of action is characterized by a rapid carbamoylation of the active-site Ser200 with release of a leaving group followed by a slow regeneration of enzyme action due to subsequent decarbamoylation. The experimental AD therapeutic bisnorcymserine, a synthetic carbamate, shows an interesting activity and selectivity for BChE, and its clinical development is currently being pursued. We undertook detailed kinetic studies on the activity of the carbamate bisnorcymserine with Tc (Torpedo californica) AChE and, on the basis of the results, crystallized the complex between TcAChE and bisnorcymserine. The X-ray crystal structure showed only the leaving group, bisnoreseroline, trapped at the bottom of the aromatic enzyme gorge. Specifically, bisnoreseroline interacts in a non-covalent way with Ser200 and His440, disrupting the existing interactions within the catalytic triad, and it stacks with Trp84 at the bottom of the gorge, giving rise to an unprecedented hydrogen-bonding contact. These interactions point to a dominant reversible inhibition mechanism attributable to the leaving group, bisnoreseroline, as revealed by kinetic analysis.

-	~~<!--~~	+	Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group.,Bartolucci C, Stojan J, Yu QS, Greig NH, Lamba D Biochem J. 2012 Jun 1;444(2):269-77. PMID:22390827<ref>PMID:22390827</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3zv7"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3zv7\| PDB=3zv7 \| SCENE= }}~~	+

-	~~===Torpedo californica Acetylcholinesterase Inhibition by Bisnorcymserine===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-		+	==See Also==
-	~~<!--~~	+	*[[Acetylcholinesterase\|Acetylcholinesterase]]
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22390827}}, adds the Publication Abstract to the page~~	+	== References ==
-	~~(as it appears on PubMed at http://www.pubmed.gov), where 22390827 is the PubMed ID number.~~	+	<references/>
-	~~-->~~	+	__TOC__
-	~~{{ABSTRACT_PUBMED_22390827}}~~	+	</StructureSection>
-		+
-	==~~About this Structure~~==	+
-	[[~~3zv7~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV7 OCA].	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022390827<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Torpedo californica]]		[[Category: Torpedo californica]]

OCA at 06:02, 23 May 2012

OCA — Wed, 23 May 2012 06:02:00 GMT

←Older revision		Revision as of 06:02, 23 May 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3zv7.jpg\|left\|200px]]

-	The ~~entry 3zv7~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3zv7", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3zv7\| PDB=3zv7 \| SCENE= }}

-	~~Authors: Bartolucci, C., Stojan, J., Greig, N.H., Lamba, D.~~	+	===Torpedo californica Acetylcholinesterase Inhibition by Bisnorcymserine===

-	~~Description~~: Torpedo californica Acetylcholinesterase ~~Inhibition by Bisnorcymserine~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22390827}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22390827 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22390827}}
		+
		+	==About this Structure==
		+	[[3zv7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV7 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022390827</ref><references group="xtra"/>
		+	[[Category: Acetylcholinesterase]]
		+	[[Category: Torpedo californica]]
		+	[[Category: Bartolucci, C.]]
		+	[[Category: Greig, N H.]]
		+	[[Category: Lamba, D.]]
		+	[[Category: Stojan, J.]]
		+	[[Category: Anti-alzheimer drug]]
		+	[[Category: Hydrolase]]
		+	[[Category: Neurotransmitter cleavage]]

OCA at 05:40, 10 August 2011

OCA — Wed, 10 Aug 2011 05:40:51 GMT

←Older revision		Revision as of 05:40, 10 August 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3zv7 is ON HOLD	+	The entry 3zv7 is ON HOLD until Paper Publication

	Authors: Bartolucci, C., Stojan, J., Greig, N.H., Lamba, D.		Authors: Bartolucci, C., Stojan, J., Greig, N.H., Lamba, D.

	Description: Torpedo californica Acetylcholinesterase Inhibition by Bisnorcymserine		Description: Torpedo californica Acetylcholinesterase Inhibition by Bisnorcymserine

OCA: Protected "3zv7" [edit=sysop:move=sysop]

OCA — Wed, 03 Aug 2011 08:30:09 GMT

Protected "3zv7" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:30, 3 August 2011