3zvn - Revision history

OCA at 11:14, 20 December 2023

OCA — Wed, 20 Dec 2023 11:14:14 GMT

←Older revision		Revision as of 11:14, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='3zvn' size='340' side='right'caption='[[3zvn]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='3zvn' size='340' side='right'caption='[[3zvn]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zvn]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZVN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zvn]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZVN FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ADP:ADENOSINE~~-~~5-DIPHOSPHATE'>ADP</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class~~=~~"sblockDat"><div style~~=~~'overflow~~: ~~auto; max-height: 3em;~~'>~~[[3zvl\|3zvl]], [[1ujx\|1ujx]], [[1yj5\|1yj5]], [[1yjm\|1yjm]], [[3zvm\|3zvm]]~~</~~div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zvn OCA], [https://pdbe.org/3zvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zvn RCSB], [https://www.ebi.ac.uk/pdbsum/3zvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zvn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zvn OCA], [https://pdbe.org/3zvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zvn RCSB], [https://www.ebi.ac.uk/pdbsum/3zvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zvn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PNKP_MOUSE PNKP_MOUSE]] Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.	+	[https://www.uniprot.org/uniprot/PNKP_MOUSE PNKP_MOUSE] Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Garces, F~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Oliver, A W~~]]	+	[[Category: Garces F]]
-	[[Category: ~~Pearl, L H~~]]	+	[[Category: Oliver AW]]
-	[[Category: ~~Base excision repair]]~~	+	[[Category: Pearl LH]]
-	~~[[Category: Ber]]~~	+
-	~~[[Category: Cancer]]~~	+
-	~~[[Category: Dna repair]]~~	+
-	~~[[Category: Hydrolase-transferase-dna complex]]~~	+
-	~~[[Category: Nhej]]~~	+
-	~~[[Category: Non-homologous end-joining~~]]	+

OCA at 07:21, 18 August 2022

OCA — Thu, 18 Aug 2022 07:21:28 GMT

←Older revision		Revision as of 07:21, 18 August 2022
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	<StructureSection load='3zvn' size='340' side='right'caption='[[3zvn]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='3zvn' size='340' side='right'caption='[[3zvn]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zvn]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZVN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZVN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zvn]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZVN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zvl\|3zvl]], [[1ujx\|1ujx]], [[1yj5\|1yj5]], [[1yjm\|1yjm]], [[3zvm\|3zvm]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zvl\|3zvl]], [[1ujx\|1ujx]], [[1yj5\|1yj5]], [[1yjm\|1yjm]], [[3zvm\|3zvm]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zvn OCA], [~~http~~://pdbe.org/3zvn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zvn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zvn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zvn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zvn OCA], [https://pdbe.org/3zvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zvn RCSB], [https://www.ebi.ac.uk/pdbsum/3zvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zvn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PNKP_MOUSE PNKP_MOUSE]] Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.	+	[[https://www.uniprot.org/uniprot/PNKP_MOUSE PNKP_MOUSE]] Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:24, 1 January 2020

OCA — Wed, 01 Jan 2020 13:24:43 GMT

←Older revision		Revision as of 13:24, 1 January 2020
Line 1:		Line 1:

	==The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase==		==The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase==
-	<StructureSection load='3zvn' size='340' side='right' caption='[[3zvn]], [[Resolution\|resolution]] 2.15Å' scene=''>	+	<StructureSection load='3zvn' size='340' side='right'caption='[[3zvn]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zvn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZVN FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zvn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZVN FirstGlance]. <br>
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Garces, F]]		[[Category: Garces, F]]

OCA at 05:46, 8 March 2018

OCA — Thu, 08 Mar 2018 05:46:10 GMT

←Older revision		Revision as of 05:46, 8 March 2018
Line 1:		Line 1:

-	==~~THE STRUCTURAL BASIS FOR SUBSTRATE RECOGNITION BY MAMMALIAN POLYNUCLEOTIDE KINASE~~ 3' ~~PHOSPHATASE~~==	+	==The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase==
	<StructureSection load='3zvn' size='340' side='right' caption='[[3zvn]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='3zvn' size='340' side='right' caption='[[3zvn]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 23:44, 4 August 2016

OCA — Thu, 04 Aug 2016 23:44:39 GMT

←Older revision		Revision as of 23:44, 4 August 2016
Line 1:		Line 1:
		+
	==THE STRUCTURAL BASIS FOR SUBSTRATE RECOGNITION BY MAMMALIAN POLYNUCLEOTIDE KINASE 3' PHOSPHATASE==		==THE STRUCTURAL BASIS FOR SUBSTRATE RECOGNITION BY MAMMALIAN POLYNUCLEOTIDE KINASE 3' PHOSPHATASE==
	<StructureSection load='3zvn' size='340' side='right' caption='[[3zvn]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='3zvn' size='340' side='right' caption='[[3zvn]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zvn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZVN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zvn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZVN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zvl\|3zvl]], [[1ujx\|1ujx]], [[1yj5\|1yj5]], [[1yjm\|1yjm]], [[3zvm\|3zvm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zvl\|3zvl]], [[1ujx\|1ujx]], [[1yj5\|1yj5]], [[1yjm\|1yjm]], [[3zvm\|3zvm]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zvn RCSB], [http://www.ebi.ac.uk/pdbsum/3zvn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zvn OCA], [http://pdbe.org/3zvn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zvn RCSB], [http://www.ebi.ac.uk/pdbsum/3zvn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zvn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zvn" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Garces, F]]		[[Category: Garces, F]]
	[[Category: Oliver, A W]]		[[Category: Oliver, A W]]

OCA at 14:05, 25 December 2014

OCA — Thu, 25 Dec 2014 14:05:39 GMT

←Older revision		Revision as of 14:05, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zvn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZVN FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zvn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZVN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zvl\|3zvl]], [[1ujx\|1ujx]], [[1yj5\|1yj5]], [[1yjm\|1yjm]], [[3zvm\|3zvm]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zvl\|3zvl]], [[1ujx\|1ujx]], [[1yj5\|1yj5]], [[1yjm\|1yjm]], [[3zvm\|3zvm]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zvn RCSB], [http://www.ebi.ac.uk/pdbsum/3zvn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zvn RCSB], [http://www.ebi.ac.uk/pdbsum/3zvn PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PNKP_MOUSE PNKP_MOUSE]] Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Garces, F.]]	+	[[Category: Garces, F]]
-	[[Category: Oliver, A W.]]	+	[[Category: Oliver, A W]]
-	[[Category: Pearl, L H.]]	+	[[Category: Pearl, L H]]
	[[Category: Base excision repair]]		[[Category: Base excision repair]]
	[[Category: Ber]]		[[Category: Ber]]

OCA at 08:29, 5 June 2014

OCA — Thu, 05 Jun 2014 08:29:16 GMT

←Older revision		Revision as of 08:29, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3zvn.~~jpg~~\|~~left~~\|~~200px~~]]	+	==THE STRUCTURAL BASIS FOR SUBSTRATE RECOGNITION BY MAMMALIAN POLYNUCLEOTIDE KINASE 3' PHOSPHATASE==
		+	<StructureSection load='3zvn' size='340' side='right' caption='[[3zvn]], [[Resolution\|resolution]] 2.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zvn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZVN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zvl\|3zvl]], [[1ujx\|1ujx]], [[1yj5\|1yj5]], [[1yjm\|1yjm]], [[3zvm\|3zvm]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zvn RCSB], [http://www.ebi.ac.uk/pdbsum/3zvn PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mammalian polynucleotide kinase 3' phosphatase (PNK) plays a key role in the repair of DNA damage, functioning as part of both the nonhomologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. We have now determined crystal structures of murine PNK with DNA molecules bound to both of its active sites. The structure of ssDNA engaged with the 3'-phosphatase domain suggests a mechanism of substrate interaction that assists DNA end seeking. The structure of dsDNA bound to the 5'-kinase domain reveals a mechanism of DNA bending that facilitates recognition of DNA ends in the context of single-strand and double-strand breaks and suggests a close functional cooperation in substrate recognition between the kinase and phosphatase active sites.

-	~~<!--~~	+	The structural basis for substrate recognition by Mammalian polynucleotide kinase 3' phosphatase.,Garces F, Pearl LH, Oliver AW Mol Cell. 2011 Nov 4;44(3):385-96. PMID:22055185<ref>PMID:22055185</ref>
-	The ~~line below this paragraph~~, ~~containing "STRUCTURE_3zvn"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3zvn\| PDB=3zvn \| SCENE= }}~~	+

-	~~===THE STRUCTURAL BASIS FOR SUBSTRATE RECOGNITION BY MAMMALIAN POLYNUCLEOTIDE KINASE 3' PHOSPHATASE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_22055185}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22055185 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22055185}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3zvn]] is a 6 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZVN OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022055185<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Garces, F.]]		[[Category: Garces, F.]]

OCA at 12:19, 16 November 2011

OCA — Wed, 16 Nov 2011 12:19:02 GMT

←Older revision		Revision as of 12:19, 16 November 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3zvn.jpg\|left\|200px]]

-	The ~~entry 3zvn~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3zvn", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3zvn\| PDB=3zvn \| SCENE= }}

-	~~Authors: Garces, F., Pearl, L.H., Oliver, A.W.~~	+	===THE STRUCTURAL BASIS FOR SUBSTRATE RECOGNITION BY MAMMALIAN POLYNUCLEOTIDE KINASE 3' PHOSPHATASE===

-	~~Description:~~ The ~~structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22055185}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22055185 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22055185}}
		+
		+	==About this Structure==
		+	[[3zvn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZVN OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022055185</ref><references group="xtra"/>
		+	[[Category: Mus musculus]]
		+	[[Category: Garces, F.]]
		+	[[Category: Oliver, A W.]]
		+	[[Category: Pearl, L H.]]
		+	[[Category: Base excision repair]]
		+	[[Category: Ber]]
		+	[[Category: Cancer]]
		+	[[Category: Dna repair]]
		+	[[Category: Hydrolase-transferase-dna complex]]
		+	[[Category: Nhej]]
		+	[[Category: Non-homologous end-joining]]

OCA at 05:41, 10 August 2011

OCA — Wed, 10 Aug 2011 05:41:10 GMT

←Older revision		Revision as of 05:41, 10 August 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3zvn is ON HOLD	+	The entry 3zvn is ON HOLD until Paper Publication

	Authors: Garces, F., Pearl, L.H., Oliver, A.W.		Authors: Garces, F., Pearl, L.H., Oliver, A.W.

	Description: The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase		Description: The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase

OCA: Protected "3zvn" [edit=sysop:move=sysop]

OCA — Wed, 03 Aug 2011 08:30:39 GMT

Protected "3zvn" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:30, 3 August 2011