3zwm - Revision history

OCA at 11:14, 20 December 2023

OCA — Wed, 20 Dec 2023 11:14:52 GMT

←Older revision		Revision as of 11:14, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='3zwm' size='340' side='right'caption='[[3zwm]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3zwm' size='340' side='right'caption='[[3zwm]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zwm]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Aplca Aplca~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZWM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zwm]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZWM FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CXR:CYCLIC+ADENOSINE+DIPHOSPHATE~~-~~RIBOSE'>CXR</scene>~~, ~~<scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3zwn\|3zwn]], [[1r0s\|1r0s]], [[3zwx\|3zwx]], [[1lbe\|1lbe]], [[1r16\|1r16]], [[3zwy\|3zwy]], [[3zwo\|3zwo]], [[3zwv\|3zwv]], [[3zwp\|3zwp]], [[1r15\|1r15]], [[1r12\|1r12]], [[3zww\|3zww]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CXR:CYCLIC+ADENOSINE+DIPHOSPHATE-RIBOSE'>CXR</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/~~NAD~~(+)_nucleosidase NAD(+) nucleosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zwm OCA], [https://pdbe.org/3zwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zwm RCSB], [https://www.ebi.ac.uk/pdbsum/3zwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zwm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zwm OCA], [https://pdbe.org/3zwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zwm RCSB], [https://www.ebi.ac.uk/pdbsum/3zwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zwm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NADA_APLCA NADA_APLCA]] Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for calcium mobilization from endoplasmic reticulum. Also has cADPr hydrolase activity.<ref>PMID:11829748</ref>	+	[https://www.uniprot.org/uniprot/NADA_APLCA NADA_APLCA] Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for calcium mobilization from endoplasmic reticulum. Also has cADPr hydrolase activity.<ref>PMID:11829748</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aplca~~]]	+	[[Category: Aplysia californica]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Graeff, R]]	+	[[Category: Graeff R]]
-	[[Category: Hao, Q]]	+	[[Category: Hao Q]]
-	[[Category: Kotaka, M]]	+	[[Category: Kotaka M]]
-	[[Category: Lee~~, H C~~]]	+	[[Category: Lee HC]]
-	[[Category: Zhang~~, L H]]~~	+	[[Category: Zhang LH]]
-	~~[[Category: Hydrolase~~]]	+

OCA at 07:23, 18 August 2022

OCA — Thu, 18 Aug 2022 07:23:46 GMT

←Older revision		Revision as of 07:23, 18 August 2022
Line 1:		Line 1:

	==Crystal structure of ADP ribosyl cyclase complexed with substrate NAD and product cADPR==		==Crystal structure of ADP ribosyl cyclase complexed with substrate NAD and product cADPR==
-	<StructureSection load='3zwm' size='340' side='right' caption='[[3zwm]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='3zwm' size='340' side='right'caption='[[3zwm]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zwm]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZWM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zwm]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZWM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CXR:CYCLIC+ADENOSINE+DIPHOSPHATE-RIBOSE'>CXR</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CXR:CYCLIC+ADENOSINE+DIPHOSPHATE-RIBOSE'>CXR</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zwn\|3zwn]], [[1r0s\|1r0s]], [[3zwx\|3zwx]], [[1lbe\|1lbe]], [[1r16\|1r16]], [[3zwy\|3zwy]], [[3zwo\|3zwo]], [[3zwv\|3zwv]], [[3zwp\|3zwp]], [[1r15\|1r15]], [[1r12\|1r12]], [[3zww\|3zww]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zwn\|3zwn]], [[1r0s\|1r0s]], [[3zwx\|3zwx]], [[1lbe\|1lbe]], [[1r16\|1r16]], [[3zwy\|3zwy]], [[3zwo\|3zwo]], [[3zwv\|3zwv]], [[3zwp\|3zwp]], [[1r15\|1r15]], [[1r12\|1r12]], [[3zww\|3zww]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zwm OCA], [~~http~~://pdbe.org/3zwm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zwm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zwm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zwm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zwm OCA], [https://pdbe.org/3zwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zwm RCSB], [https://www.ebi.ac.uk/pdbsum/3zwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zwm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NADA_APLCA NADA_APLCA]] Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for calcium mobilization from endoplasmic reticulum. Also has cADPr hydrolase activity.<ref>PMID:11829748</ref>	+	[[https://www.uniprot.org/uniprot/NADA_APLCA NADA_APLCA]] Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for calcium mobilization from endoplasmic reticulum. Also has cADPr hydrolase activity.<ref>PMID:11829748</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Aplca]]		[[Category: Aplca]]
		+	[[Category: Large Structures]]
	[[Category: Graeff, R]]		[[Category: Graeff, R]]
	[[Category: Hao, Q]]		[[Category: Hao, Q]]

OCA at 16:59, 27 February 2019

OCA — Wed, 27 Feb 2019 16:59:31 GMT

←Older revision		Revision as of 16:59, 27 February 2019
Line 1:		Line 1:
		+
	==Crystal structure of ADP ribosyl cyclase complexed with substrate NAD and product cADPR==		==Crystal structure of ADP ribosyl cyclase complexed with substrate NAD and product cADPR==
	<StructureSection load='3zwm' size='340' side='right' caption='[[3zwm]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3zwm' size='340' side='right' caption='[[3zwm]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zwm]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Aplysia_californica Aplysia californica~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZWM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zwm]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZWM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CXR:CYCLIC+ADENOSINE+DIPHOSPHATE-RIBOSE'>CXR</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CXR:CYCLIC+ADENOSINE+DIPHOSPHATE-RIBOSE'>CXR</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zwn\|3zwn]], [[1r0s\|1r0s]], [[3zwx\|3zwx]], [[1lbe\|1lbe]], [[1r16\|1r16]], [[3zwy\|3zwy]], [[3zwo\|3zwo]], [[3zwv\|3zwv]], [[3zwp\|3zwp]], [[1r15\|1r15]], [[1r12\|1r12]], [[3zww\|3zww]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zwn\|3zwn]], [[1r0s\|1r0s]], [[3zwx\|3zwx]], [[1lbe\|1lbe]], [[1r16\|1r16]], [[3zwy\|3zwy]], [[3zwo\|3zwo]], [[3zwv\|3zwv]], [[3zwp\|3zwp]], [[1r15\|1r15]], [[1r12\|1r12]], [[3zww\|3zww]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zwm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zwm RCSB], [http://www.ebi.ac.uk/pdbsum/3zwm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zwm OCA], [http://pdbe.org/3zwm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zwm RCSB], [http://www.ebi.ac.uk/pdbsum/3zwm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zwm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zwm" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[~~ADP-ribosyl cyclase~~\|~~ADP-ribosyl cyclase~~]]	+	*[[Cluster of Differentiation CD38\|Cluster of Differentiation CD38]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aplysia californica~~]]	+	[[Category: Aplca]]
	[[Category: Graeff, R]]		[[Category: Graeff, R]]
	[[Category: Hao, Q]]		[[Category: Hao, Q]]

OCA at 19:52, 25 December 2014

OCA — Thu, 25 Dec 2014 19:52:23 GMT

←Older revision		Revision as of 19:52, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zwm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zwm RCSB], [http://www.ebi.ac.uk/pdbsum/3zwm PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zwm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zwm RCSB], [http://www.ebi.ac.uk/pdbsum/3zwm PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NADA_APLCA NADA_APLCA]] Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for calcium mobilization from endoplasmic reticulum. Also has cADPr hydrolase activity.<ref>PMID:11829748</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:37, 9 December 2014

OCA — Tue, 09 Dec 2014 17:37:07 GMT

←Older revision		Revision as of 17:37, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3zwm.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of ADP ribosyl cyclase complexed with substrate NAD and product cADPR==
		+	<StructureSection load='3zwm' size='340' side='right' caption='[[3zwm]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zwm]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZWM FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CXR:CYCLIC+ADENOSINE+DIPHOSPHATE-RIBOSE'>CXR</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zwn\|3zwn]], [[1r0s\|1r0s]], [[3zwx\|3zwx]], [[1lbe\|1lbe]], [[1r16\|1r16]], [[3zwy\|3zwy]], [[3zwo\|3zwo]], [[3zwv\|3zwv]], [[3zwp\|3zwp]], [[1r15\|1r15]], [[1r12\|1r12]], [[3zww\|3zww]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zwm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zwm RCSB], [http://www.ebi.ac.uk/pdbsum/3zwm PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cyclic ADP-ribose (cADPR) is a calcium messenger that can mobilize intracellular Ca(2+) stores and activate Ca(2+) influx to regulate a wide range of physiological processes. Aplysia cyclase is the first member of the ADP-ribosyl cyclases identified to catalyze the cyclization of NAD(+) into cADPR. The catalysis involves a two-step reaction, the elimination of the nicotinamide ring and the cyclization of the intermediate resulting in the covalent attachment of the purine ring to the terminal ribose. Aplysia cyclase exhibits a high degree of leniency towards the purine base of its substrate, and the cyclization reaction takes place at either the N1- or the N7-position of the purine ring. To decipher the mechanism of cyclization in Aplysia cyclase, we used a crystallization setup with multiple Aplysia cyclase molecules present in the asymmetric unit. With the use of natural substrates and analogs, not only were we able to capture multiple snapshots during enzyme catalysis resulting in either N1 or N7 linkage of the purine ring to the terminal ribose, we were also able to observe, for the first time, the cyclized products of both N1 and N7 cyclization bound in the active site of Aplysia cyclase.

-	~~{{STRUCTURE_3zwm\| PDB=3zwm \| SCENE= }}~~	+	Structural Studies of Intermediates along the Cyclization Pathway of Aplysia ADP-Ribosyl Cyclase.,Kotaka M, Graeff R, Chen Z, Zhang LH, Lee HC, Hao Q J Mol Biol. 2011 Nov 18. PMID:22138343<ref>PMID:22138343</ref>

-	~~===Crystal structure~~ of ~~ADP ribosyl cyclase complexed with substrate NAD and product cADPR===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22138343}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3zwm]] is a 8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Aplysia_californica Aplysia californica]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWM OCA].~~	+

	==See Also==		==See Also==
	*[[ADP-ribosyl cyclase\|ADP-ribosyl cyclase]]		*[[ADP-ribosyl cyclase\|ADP-ribosyl cyclase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022138343<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Aplysia californica]]		[[Category: Aplysia californica]]
-	[[Category: Graeff, R.]]	+	[[Category: Graeff, R]]
-	[[Category: Hao, Q.]]	+	[[Category: Hao, Q]]
-	[[Category: Kotaka, M.]]	+	[[Category: Kotaka, M]]
-	[[Category: Lee, H C.]]	+	[[Category: Lee, H C]]
-	[[Category: Zhang, L H.]]	+	[[Category: Zhang, L H]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 20:46, 20 October 2012

OCA — Sat, 20 Oct 2012 20:46:56 GMT

←Older revision		Revision as of 20:46, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3zwm]] is a 8 chain structure ~~of [[ADP-ribosyl cyclase]]~~ with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWM OCA].	+	[[3zwm]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWM OCA].

	==See Also==		==See Also==

OCA at 11:36, 27 July 2012

OCA — Fri, 27 Jul 2012 11:36:16 GMT

←Older revision		Revision as of 11:36, 27 July 2012
Line 1:		Line 1:
	[[Image:3zwm.png\|left\|200px]]		[[Image:3zwm.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3zwm", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3zwm\| PDB=3zwm \| SCENE= }}		{{STRUCTURE_3zwm\| PDB=3zwm \| SCENE= }}

	===Crystal structure of ADP ribosyl cyclase complexed with substrate NAD and product cADPR===		===Crystal structure of ADP ribosyl cyclase complexed with substrate NAD and product cADPR===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22138343}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22138343 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22138343}}		{{ABSTRACT_PUBMED_22138343}}

	==About this Structure==		==About this Structure==
-	[[3zwm]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWM OCA].	+	[[3zwm]] is a 8 chain structure of [[ADP-ribosyl cyclase]] with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWM OCA].
		+
		+	==See Also==
		+	*[[ADP-ribosyl cyclase\|ADP-ribosyl cyclase]]

	==Reference==		==Reference==

OCA at 05:38, 25 January 2012

OCA — Wed, 25 Jan 2012 05:38:09 GMT

←Older revision		Revision as of 05:38, 25 January 2012
Line 9:		Line 9:
	{{STRUCTURE_3zwm\| PDB=3zwm \| SCENE= }}		{{STRUCTURE_3zwm\| PDB=3zwm \| SCENE= }}

-	===~~CRYSTAL STRUCTURE OF~~ ADP ~~RIBOSYL CYCLASE COMPLEXED WITH SUBSTRATE~~ NAD ~~AND PRODUCT CADPR~~===	+	===Crystal structure of ADP ribosyl cyclase complexed with substrate NAD and product cADPR===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22138343}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22138343 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22138343}}

	==About this Structure==		==About this Structure==
	[[3zwm]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWM OCA].		[[3zwm]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWM OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022138343</ref><references group="xtra"/>
	[[Category: Aplysia californica]]		[[Category: Aplysia californica]]
	[[Category: Graeff, R.]]		[[Category: Graeff, R.]]
Line 19:		Line 28:
	[[Category: Kotaka, M.]]		[[Category: Kotaka, M.]]
	[[Category: Lee, H C.]]		[[Category: Lee, H C.]]
-	[[Category: Zhang, L.]]	+	[[Category: Zhang, L H.]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 08:12, 7 December 2011

OCA — Wed, 07 Dec 2011 08:12:40 GMT

←Older revision		Revision as of 08:12, 7 December 2011
Line 1:		Line 1:
-	[[Image:3zwm.~~jpg~~\|left\|200px]]	+	[[Image:3zwm.png\|left\|200px]]

	<!--		<!--

OCA at 06:32, 30 November 2011

OCA — Wed, 30 Nov 2011 06:32:16 GMT

←Older revision		Revision as of 06:32, 30 November 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3zwm.jpg\|left\|200px]]

-	The ~~entry 3zwm~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3zwm", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3zwm\| PDB=3zwm \| SCENE= }}

-	~~Authors: Kotaka, M., Graeff, R., Zhang, L., Lee, H.C., Hao, Q.~~	+	===CRYSTAL STRUCTURE OF ADP RIBOSYL CYCLASE COMPLEXED WITH SUBSTRATE NAD AND PRODUCT CADPR===

-	~~Description: Crystal~~ structure ~~of ADP ribosyl cyclase complexed~~ with ~~substrate NAD and product cADPR~~	+
		+	==About this Structure==
		+	[[3zwm]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWM OCA].
		+	[[Category: Aplysia californica]]
		+	[[Category: Graeff, R.]]
		+	[[Category: Hao, Q.]]
		+	[[Category: Kotaka, M.]]
		+	[[Category: Lee, H C.]]
		+	[[Category: Zhang, L.]]
		+	[[Category: Hydrolase]]