3zx5 - Revision history

OCA at 11:15, 20 December 2023

OCA — Wed, 20 Dec 2023 11:15:15 GMT

←Older revision		Revision as of 11:15, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='3zx5' size='340' side='right'caption='[[3zx5]], [[Resolution\|resolution]] 1.81Å' scene=''>		<StructureSection load='3zx5' size='340' side='right'caption='[[3zx5]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zx5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Thet2 Thet2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZX5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zx5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZX5 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=2M8:2~~-~~O-ALPHA-MANNOSYL-D-GLYCERATE'>2M8</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VN4:OXIDO(DIOXO)VANADIUM'>VN4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.81Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3zwk\|3zwk]], [[3zup\|3zup]], [[3zty\|3zty]], [[3ztw\|3ztw]], [[3zu6\|3zu6]], [[3zw7\|3zw7]], [[3zwd\|3zwd]], [[3zx4\|3zx4]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2M8:2-O-ALPHA-MANNOSYL-D-GLYCERATE'>2M8</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VN4:OXIDO(DIOXO)VANADIUM'>VN4</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>[https://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zx5 OCA], [https://pdbe.org/3zx5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zx5 RCSB], [https://www.ebi.ac.uk/pdbsum/3zx5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zx5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zx5 OCA], [https://pdbe.org/3zx5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zx5 RCSB], [https://www.ebi.ac.uk/pdbsum/3zx5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zx5 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q72K29_THET2 Q72K29_THET2]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mannosyl-3-phosphoglycerate phosphatase]]~~	+	[[Category: Thermus thermophilus HB27]]
-	~~[[Category: Thet2~~]]	+	[[Category: Borges N]]
-	[[Category: Borges, N]]	+	[[Category: Esteves AM]]
-	[[Category: Esteves~~, A M~~]]	+	[[Category: Goncalves S]]
-	[[Category: Goncalves, S]]	+	[[Category: Matias PM]]
-	[[Category: Matias~~, P M~~]]	+	[[Category: Santos H]]
-	[[Category: Santos, H]]	+
-	~~[[Category: Crystallographic snapshot]]~~	+
-	~~[[Category: Had-like phosphatase]]~~	+
-	~~[[Category: Haloalkanoid acid dehalogenase-like phosphatase]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 07:24, 18 August 2022

OCA — Thu, 18 Aug 2022 07:24:56 GMT

←Older revision		Revision as of 07:24, 18 August 2022
Line 1:		Line 1:

	==The 3-dimensional structure of MpgP from Thermus thermophilus HB27, covalently bound to vanadate and in complex with alpha- mannosylglycerate and magnesium==		==The 3-dimensional structure of MpgP from Thermus thermophilus HB27, covalently bound to vanadate and in complex with alpha- mannosylglycerate and magnesium==
-	<StructureSection load='3zx5' size='340' side='right' caption='[[3zx5]], [[Resolution\|resolution]] 1.81Å' scene=''>	+	<StructureSection load='3zx5' size='340' side='right'caption='[[3zx5]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zx5]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Thet2 Thet2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZX5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZX5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zx5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thet2 Thet2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZX5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2M8:2-O-ALPHA-MANNOSYL-D-GLYCERATE'>2M8</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VN4:OXIDO(DIOXO)VANADIUM'>VN4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2M8:2-O-ALPHA-MANNOSYL-D-GLYCERATE'>2M8</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VN4:OXIDO(DIOXO)VANADIUM'>VN4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zwk\|3zwk]], [[3zup\|3zup]], [[3zty\|3zty]], [[3ztw\|3ztw]], [[3zu6\|3zu6]], [[3zw7\|3zw7]], [[3zwd\|3zwd]], [[3zx4\|3zx4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zwk\|3zwk]], [[3zup\|3zup]], [[3zty\|3zty]], [[3ztw\|3ztw]], [[3zu6\|3zu6]], [[3zw7\|3zw7]], [[3zwd\|3zwd]], [[3zx4\|3zx4]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zx5 OCA], [~~http~~://pdbe.org/3zx5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zx5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zx5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zx5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zx5 OCA], [https://pdbe.org/3zx5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zx5 RCSB], [https://www.ebi.ac.uk/pdbsum/3zx5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zx5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mannosyl-3-phosphoglycerate phosphatase]]		[[Category: Mannosyl-3-phosphoglycerate phosphatase]]
	[[Category: Thet2]]		[[Category: Thet2]]

OCA at 16:53, 27 February 2019

OCA — Wed, 27 Feb 2019 16:53:24 GMT

←Older revision		Revision as of 16:53, 27 February 2019
Line 1:		Line 1:

-	==~~THE~~ 3-~~DIMENSIONAL STRUCTURE OF MPGP FROM THERMUS THERMOPHILUS~~ HB27, ~~COVALENTLY BOUND TO VANADATE AND IN COMPLEX WITH ALPHA~~-~~MANNOSYLGLYCERATE AND MAGNESIUM~~==	+	==The 3-dimensional structure of MpgP from Thermus thermophilus HB27, covalently bound to vanadate and in complex with alpha- mannosylglycerate and magnesium==
	<StructureSection load='3zx5' size='340' side='right' caption='[[3zx5]], [[Resolution\|resolution]] 1.81Å' scene=''>		<StructureSection load='3zx5' size='340' side='right' caption='[[3zx5]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 07:49, 11 August 2016

OCA — Thu, 11 Aug 2016 07:49:18 GMT

←Older revision		Revision as of 07:49, 11 August 2016
Line 1:		Line 1:
		+
	==THE 3-DIMENSIONAL STRUCTURE OF MPGP FROM THERMUS THERMOPHILUS HB27, COVALENTLY BOUND TO VANADATE AND IN COMPLEX WITH ALPHA-MANNOSYLGLYCERATE AND MAGNESIUM==		==THE 3-DIMENSIONAL STRUCTURE OF MPGP FROM THERMUS THERMOPHILUS HB27, COVALENTLY BOUND TO VANADATE AND IN COMPLEX WITH ALPHA-MANNOSYLGLYCERATE AND MAGNESIUM==
	<StructureSection load='3zx5' size='340' side='right' caption='[[3zx5]], [[Resolution\|resolution]] 1.81Å' scene=''>		<StructureSection load='3zx5' size='340' side='right' caption='[[3zx5]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zx5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermus_thermophilus Thermus thermophilus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZX5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZX5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zx5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet2 Thet2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZX5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZX5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2M8:2-O-ALPHA-MANNOSYL-D-GLYCERATE'>2M8</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VN4:OXIDO(DIOXO)VANADIUM'>VN4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2M8:2-O-ALPHA-MANNOSYL-D-GLYCERATE'>2M8</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VN4:OXIDO(DIOXO)VANADIUM'>VN4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zwk\|3zwk]], [[3zup\|3zup]], [[3zty\|3zty]], [[3ztw\|3ztw]], [[3zu6\|3zu6]], [[3zw7\|3zw7]], [[3zwd\|3zwd]], [[3zx4\|3zx4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zwk\|3zwk]], [[3zup\|3zup]], [[3zty\|3zty]], [[3ztw\|3ztw]], [[3zu6\|3zu6]], [[3zw7\|3zw7]], [[3zwd\|3zwd]], [[3zx4\|3zx4]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zx5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zx5 RCSB], [http://www.ebi.ac.uk/pdbsum/3zx5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zx5 OCA], [http://pdbe.org/3zx5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zx5 RCSB], [http://www.ebi.ac.uk/pdbsum/3zx5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zx5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zx5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Mannosyl-3-phosphoglycerate phosphatase]]		[[Category: Mannosyl-3-phosphoglycerate phosphatase]]
-	[[Category: ~~Thermus thermophilus~~]]	+	[[Category: Thet2]]
	[[Category: Borges, N]]		[[Category: Borges, N]]
	[[Category: Esteves, A M]]		[[Category: Esteves, A M]]

OCA at 09:53, 4 January 2015

OCA — Sun, 04 Jan 2015 09:53:33 GMT

←Older revision		Revision as of 09:53, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zx5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZX5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZX5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zx5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZX5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZX5 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2M8:2-O-ALPHA-MANNOSYL-D-GLYCERATE'>2M8</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VN4:OXIDO(DIOXO)VANADIUM'>VN4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2M8:2-O-ALPHA-MANNOSYL-D-GLYCERATE'>2M8</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VN4:OXIDO(DIOXO)VANADIUM'>VN4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zwk\|3zwk]], [[3zup\|3zup]], [[3zty\|3zty]], [[3ztw\|3ztw]], [[3zu6\|3zu6]], [[3zw7\|3zw7]], [[3zwd\|3zwd]], [[3zx4\|3zx4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zwk\|3zwk]], [[3zup\|3zup]], [[3zty\|3zty]], [[3ztw\|3ztw]], [[3zu6\|3zu6]], [[3zw7\|3zw7]], [[3zwd\|3zwd]], [[3zx4\|3zx4]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zx5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zx5 RCSB], [http://www.ebi.ac.uk/pdbsum/3zx5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zx5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zx5 RCSB], [http://www.ebi.ac.uk/pdbsum/3zx5 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	[[Category: Mannosyl-3-phosphoglycerate phosphatase]]		[[Category: Mannosyl-3-phosphoglycerate phosphatase]]
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
-	[[Category: Borges, N.]]	+	[[Category: Borges, N]]
-	[[Category: Esteves, A M.]]	+	[[Category: Esteves, A M]]
-	[[Category: Goncalves, S.]]	+	[[Category: Goncalves, S]]
-	[[Category: Matias, P M.]]	+	[[Category: Matias, P M]]
-	[[Category: Santos, H.]]	+	[[Category: Santos, H]]
	[[Category: Crystallographic snapshot]]		[[Category: Crystallographic snapshot]]
	[[Category: Had-like phosphatase]]		[[Category: Had-like phosphatase]]
	[[Category: Haloalkanoid acid dehalogenase-like phosphatase]]		[[Category: Haloalkanoid acid dehalogenase-like phosphatase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 08:11, 5 June 2014

OCA — Thu, 05 Jun 2014 08:11:21 GMT

←Older revision		Revision as of 08:11, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3zx5.~~png~~\|~~left~~\|~~200px~~]]	+	==THE 3-DIMENSIONAL STRUCTURE OF MPGP FROM THERMUS THERMOPHILUS HB27, COVALENTLY BOUND TO VANADATE AND IN COMPLEX WITH ALPHA-MANNOSYLGLYCERATE AND MAGNESIUM==
		+	<StructureSection load='3zx5' size='340' side='right' caption='[[3zx5]], [[Resolution\|resolution]] 1.81Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zx5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZX5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZX5 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2M8:2-O-ALPHA-MANNOSYL-D-GLYCERATE'>2M8</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VN4:OXIDO(DIOXO)VANADIUM'>VN4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zwk\|3zwk]], [[3zup\|3zup]], [[3zty\|3zty]], [[3ztw\|3ztw]], [[3zu6\|3zu6]], [[3zw7\|3zw7]], [[3zwd\|3zwd]], [[3zx4\|3zx4]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zx5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zx5 RCSB], [http://www.ebi.ac.uk/pdbsum/3zx5 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mannosyl-3-phosphoglycerate phosphatase (MpgP) is a key mediator in the physiological response to thermal and osmotic stresses, catalyzing the hydrolysis of mannosyl-3-phosphoglycerate (MPG) to the final product, alpha-mannosylglycerate. MpgP is a metal-dependent haloalcanoic acid dehalogenase-like (HAD-like) phosphatase, preserving the catalytic motifs I-IV of the HAD core domain, and classified as a Cof-type MPGP (HAD-IIB-MPGP family; SCOP [117505]) on the basis of its C2B cap insertion module. Herein, the crystallographic structures of Thermus thermophilus HB27 MpgP in its apo form and in complex with substrates, substrate analogues, and inhibitors are reported. Two distinct enzyme conformations, open and closed, are catalytically relevant. Apo-MpgP is primarily found in the open state, while holo-MpgP, in complex with the reaction products, is found in the closed state. Enzyme activation entails a structural rearrangement of motifs I and IV with concomitant binding of the cocatalytic Mg(2+) ion. The closure motion of the C2B domain is subsequently triggered by the anchoring of the phosphoryl group to the cocatalytic metal center, and by Arg167 fixing the mannosyl moiety inside the catalytic pocket. The results led to the proposal that in T. thermophilus HB27 MpgP the phosphoryl transfer employs a concerted D(N)S(N) mechanism with assistance of proton transfer from the general acid Asp8, forming a short-lived PO(3)(-) intermediate that is attacked by a nucleophilic water molecule. These results provide new insights into a possible continuum of phosphoryl transfer mechanisms, ranging between those purely associative and dissociative, as well as a picture of the main mechanistic aspects of phosphoryl monoester transfer catalysis, common to other members of the HAD superfamily.

-	<!--	+	Three-Dimensional Structure of Mannosyl-3-phosphoglycerate Phosphatase from Thermus thermophilus HB27: A New Member of the Haloalcanoic Acid Dehalogenase Superfamily.,Goncalves S, Esteves AM, Santos H, Borges N, Matias PM Biochemistry. 2011 Oct 13. PMID:21961705<ref>PMID:21961705</ref>
-	~~The line below this paragraph, containing "STRUCTURE_3zx5", creates the "Structure Box" on~~ the ~~page~~.	+
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded)~~,	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3zx5\| PDB=3zx5 \| SCENE= }}~~	+

-	~~===THE 3-DIMENSIONAL STRUCTURE OF MPGP FROM THERMUS THERMOPHILUS HB27~~, ~~COVALENTLY BOUND TO VANADATE AND IN COMPLEX WITH ALPHA-MANNOSYLGLYCERATE AND MAGNESIUM===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21961705}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21961705 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21961705}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3zx5]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZX5 OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021961705<~~/~~ref~~><~~ref group="xtra">PMID:021393850</ref><references group="xtra"~~/>	+
	[[Category: Mannosyl-3-phosphoglycerate phosphatase]]		[[Category: Mannosyl-3-phosphoglycerate phosphatase]]
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]

OCA at 10:28, 30 October 2011

OCA — Sun, 30 Oct 2011 10:28:18 GMT

←Older revision		Revision as of 10:28, 30 October 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3zx5.png\|left\|200px]]

-	The ~~entry 3zx5~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3zx5", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3zx5\| PDB=3zx5 \| SCENE= }}

-	~~Authors: Goncalves~~, ~~S., Esteves, A.M., Santos, H., Borges, N., Matias, P.M.~~	+	===THE 3-DIMENSIONAL STRUCTURE OF MPGP FROM THERMUS THERMOPHILUS HB27, COVALENTLY BOUND TO VANADATE AND IN COMPLEX WITH ALPHA-MANNOSYLGLYCERATE AND MAGNESIUM===

-	~~Description:~~ The 3-~~dimensional~~ structure ~~of MpgP~~ from Thermus thermophilus ~~HB27~~, ~~covalently bound to vanadate and in complex with alpha~~-~~mannosylglycerate and magnesium~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21961705}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21961705 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21961705}}
		+
		+	==About this Structure==
		+	[[3zx5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZX5 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021961705</ref><ref group="xtra">PMID:021393850</ref><references group="xtra"/>
		+	[[Category: Mannosyl-3-phosphoglycerate phosphatase]]
		+	[[Category: Thermus thermophilus]]
		+	[[Category: Borges, N.]]
		+	[[Category: Esteves, A M.]]
		+	[[Category: Goncalves, S.]]
		+	[[Category: Matias, P M.]]
		+	[[Category: Santos, H.]]
		+	[[Category: Crystallographic snapshot]]
		+	[[Category: Had-like phosphatase]]
		+	[[Category: Haloalkanoid acid dehalogenase-like phosphatase]]
		+	[[Category: Hydrolase]]

OCA: Protected "3zx5" [edit=sysop:move=sysop]

OCA — Wed, 17 Aug 2011 06:00:12 GMT

Protected "3zx5" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:00, 17 August 2011

OCA: New page: '''Unreleased structure''' The entry 3zx5 is ON HOLD until Paper Publication Authors: Goncalves, S., Esteves, A.M., Santos, H., Borges, N., Matias, P.M. Description: The 3-dimensional ...

OCA — Wed, 17 Aug 2011 06:00:11 GMT

New page: '''Unreleased structure''' The entry 3zx5 is ON HOLD until Paper Publication Authors: Goncalves, S., Esteves, A.M., Santos, H., Borges, N., Matias, P.M. Description: The 3-dimensional ...

New page

'''Unreleased structure'''

The entry 3zx5 is ON HOLD until Paper Publication

Authors: Goncalves, S., Esteves, A.M., Santos, H., Borges, N., Matias, P.M.

Description: The 3-dimensional structure of MpgP from Thermus thermophilus HB27, covalently bound to vanadate and in complex with alpha-mannosylglycerate and magnesium