3zxg - Revision history

OCA at 11:15, 20 December 2023

OCA — Wed, 20 Dec 2023 11:15:22 GMT

←Older revision		Revision as of 11:15, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='3zxg' size='340' side='right'caption='[[3zxg]], [[Resolution\|resolution]] 3.12Å' scene=''>		<StructureSection load='3zxg' size='340' side='right'caption='[[3zxg]], [[Resolution\|resolution]] 3.12Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zxg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Eisfe Eisfe~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zxg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Eisenia_fetida Eisenia fetida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0SM:TRIMETHYL-[2-[[(2S,3S)-2-(OCTADECANOYLAMINO)-3-OXIDANYL-BUTOXY]-OXIDANYL-PHOSPHORYL]OXYETHYL]AZANIUM'>0SM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.12Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zx7\|3zx7]], [[3zxd\|3zxd]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0SM:TRIMETHYL-[2-[[(2S,3S)-2-(OCTADECANOYLAMINO)-3-OXIDANYL-BUTOXY]-OXIDANYL-PHOSPHORYL]OXYETHYL]AZANIUM'>0SM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxg OCA], [https://pdbe.org/3zxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxg RCSB], [https://www.ebi.ac.uk/pdbsum/3zxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxg OCA], [https://pdbe.org/3zxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxg RCSB], [https://www.ebi.ac.uk/pdbsum/3zxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~TXL_EISFO TXL_EISFO]~~] Pore-forming toxin that specifically binds sphingomyelin in the plasma membrane of various cells. Has hemolytic activity. Is also cytotoxic to spermatozoa of some species of invertebrates and many species of vertebrates and to amphibian larvae, guinea pig polymorphonuclear leukocytes, chicken fibroblasts, normal spleen cells and various tumor cells. Is lethal for various species of reptiles, amphibian, birds and mammals. Induces smooth muscle contraction. It binds sphingomyelin and induces hemolysis in the same manner as lysenin-related protein 2, and is 10 times more effective than lysenin-related protein 1.<ref>PMID:10684578</ref> <ref>PMID:12676961</ref> <ref>PMID:15274631</ref> <ref>PMID:16971770</ref> <ref>PMID:9210594</ref> <ref>PMID:9478988</ref>	+	[https://www.uniprot.org/uniprot/TXL_EISFE TXL_EISFE] Pore-forming toxin that specifically binds sphingomyelin in the plasma membrane of various cells. Has hemolytic activity. Is also cytotoxic to spermatozoa of some species of invertebrates and many species of vertebrates and to amphibian larvae, guinea pig polymorphonuclear leukocytes, chicken fibroblasts, normal spleen cells and various tumor cells. Is lethal for various species of reptiles, amphibian, birds and mammals. Induces smooth muscle contraction. It binds sphingomyelin and induces hemolysis in the same manner as lysenin-related protein 2, and is 10 times more effective than lysenin-related protein 1.<ref>PMID:10684578</ref> <ref>PMID:12676961</ref> <ref>PMID:15274631</ref> <ref>PMID:16971770</ref> <ref>PMID:9210594</ref> <ref>PMID:9478988</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Eisfe~~]]	+	[[Category: Eisenia fetida]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Abrusci, P]]	+	[[Category: Abrusci P]]
-	[[Category: Anderluh, G]]	+	[[Category: Anderluh G]]
-	[[Category: Colibus, L De]]	+	[[Category: De Colibus L]]
-	[[Category: Gilbert~~, R J.C~~]]	+	[[Category: Gilbert RJC]]
-	[[Category: Hodnik, V]]	+	[[Category: Hodnik V]]
-	[[Category: Leippe, M]]	+	[[Category: Leippe M]]
-	[[Category: Morris~~, K J~~]]	+	[[Category: Morris KJ]]
-	[[Category: Plitzko, J]]	+	[[Category: Plitzko J]]
-	[[Category: Siebert~~, C A~~]]	+	[[Category: Siebert CA]]
-	[[Category: Sonnen~~, A F.P~~]]	+	[[Category: Sonnen AFP]]
-	[[Category: Volpi, E]]	+	[[Category: Volpi E]]
-	~~[[Category: Earthworm]]~~	+
-	~~[[Category: Pore-forming toxin]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 07:25, 18 August 2022

OCA — Thu, 18 Aug 2022 07:25:32 GMT

←Older revision		Revision as of 07:25, 18 August 2022
Line 1:		Line 1:

	==lysenin sphingomyelin complex==		==lysenin sphingomyelin complex==
-	<StructureSection load='3zxg' size='340' side='right' caption='[[3zxg]], [[Resolution\|resolution]] 3.12Å' scene=''>	+	<StructureSection load='3zxg' size='340' side='right'caption='[[3zxg]], [[Resolution\|resolution]] 3.12Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zxg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Eisfe Eisfe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZXG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zxg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Eisfe Eisfe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0SM:TRIMETHYL-[2-[[(2S,3S)-2-(OCTADECANOYLAMINO)-3-OXIDANYL-BUTOXY]-OXIDANYL-PHOSPHORYL]OXYETHYL]AZANIUM'>0SM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0SM:TRIMETHYL-[2-[[(2S,3S)-2-(OCTADECANOYLAMINO)-3-OXIDANYL-BUTOXY]-OXIDANYL-PHOSPHORYL]OXYETHYL]AZANIUM'>0SM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zx7\|3zx7]], [[3zxd\|3zxd]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zx7\|3zx7]], [[3zxd\|3zxd]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxg OCA], [~~http~~://pdbe.org/3zxg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zxg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zxg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxg OCA], [https://pdbe.org/3zxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxg RCSB], [https://www.ebi.ac.uk/pdbsum/3zxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TXL_EISFO TXL_EISFO]] Pore-forming toxin that specifically binds sphingomyelin in the plasma membrane of various cells. Has hemolytic activity. Is also cytotoxic to spermatozoa of some species of invertebrates and many species of vertebrates and to amphibian larvae, guinea pig polymorphonuclear leukocytes, chicken fibroblasts, normal spleen cells and various tumor cells. Is lethal for various species of reptiles, amphibian, birds and mammals. Induces smooth muscle contraction. It binds sphingomyelin and induces hemolysis in the same manner as lysenin-related protein 2, and is 10 times more effective than lysenin-related protein 1.<ref>PMID:10684578</ref> <ref>PMID:12676961</ref> <ref>PMID:15274631</ref> <ref>PMID:16971770</ref> <ref>PMID:9210594</ref> <ref>PMID:9478988</ref>	+	[[https://www.uniprot.org/uniprot/TXL_EISFO TXL_EISFO]] Pore-forming toxin that specifically binds sphingomyelin in the plasma membrane of various cells. Has hemolytic activity. Is also cytotoxic to spermatozoa of some species of invertebrates and many species of vertebrates and to amphibian larvae, guinea pig polymorphonuclear leukocytes, chicken fibroblasts, normal spleen cells and various tumor cells. Is lethal for various species of reptiles, amphibian, birds and mammals. Induces smooth muscle contraction. It binds sphingomyelin and induces hemolysis in the same manner as lysenin-related protein 2, and is 10 times more effective than lysenin-related protein 1.<ref>PMID:10684578</ref> <ref>PMID:12676961</ref> <ref>PMID:15274631</ref> <ref>PMID:16971770</ref> <ref>PMID:9210594</ref> <ref>PMID:9478988</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 3zxg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3zxg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cytolysin 3D structures\|Cytolysin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Eisfe]]		[[Category: Eisfe]]
		+	[[Category: Large Structures]]
	[[Category: Abrusci, P]]		[[Category: Abrusci, P]]
	[[Category: Anderluh, G]]		[[Category: Anderluh, G]]

OCA at 16:54, 27 February 2019

OCA — Wed, 27 Feb 2019 16:54:32 GMT

←Older revision		Revision as of 16:54, 27 February 2019
Line 3:		Line 3:
	<StructureSection load='3zxg' size='340' side='right' caption='[[3zxg]], [[Resolution\|resolution]] 3.12Å' scene=''>		<StructureSection load='3zxg' size='340' side='right' caption='[[3zxg]], [[Resolution\|resolution]] 3.12Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zxg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Common_brandling_worm Common brandling worm~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zxg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Eisfe Eisfe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0SM:TRIMETHYL-[2-[[(2S,3S)-2-(OCTADECANOYLAMINO)-3-OXIDANYL-BUTOXY]-OXIDANYL-PHOSPHORYL]OXYETHYL]AZANIUM'>0SM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0SM:TRIMETHYL-[2-[[(2S,3S)-2-(OCTADECANOYLAMINO)-3-OXIDANYL-BUTOXY]-OXIDANYL-PHOSPHORYL]OXYETHYL]AZANIUM'>0SM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zx7\|3zx7]], [[3zxd\|3zxd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zx7\|3zx7]], [[3zxd\|3zxd]]</td></tr>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Common brandling worm~~]]	+	[[Category: Eisfe]]
	[[Category: Abrusci, P]]		[[Category: Abrusci, P]]
	[[Category: Anderluh, G]]		[[Category: Anderluh, G]]

OCA at 10:05, 5 August 2016

OCA — Fri, 05 Aug 2016 10:05:00 GMT

←Older revision		Revision as of 10:05, 5 August 2016
Line 1:		Line 1:
		+
	==lysenin sphingomyelin complex==		==lysenin sphingomyelin complex==
	<StructureSection load='3zxg' size='340' side='right' caption='[[3zxg]], [[Resolution\|resolution]] 3.12Å' scene=''>		<StructureSection load='3zxg' size='340' side='right' caption='[[3zxg]], [[Resolution\|resolution]] 3.12Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zxg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Eisenia_fetida Eisenia fetida~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zxg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Common_brandling_worm Common brandling worm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0SM:TRIMETHYL-[2-[[(2S,3S)-2-(OCTADECANOYLAMINO)-3-OXIDANYL-BUTOXY]-OXIDANYL-PHOSPHORYL]OXYETHYL]AZANIUM'>0SM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0SM:TRIMETHYL-[2-[[(2S,3S)-2-(OCTADECANOYLAMINO)-3-OXIDANYL-BUTOXY]-OXIDANYL-PHOSPHORYL]OXYETHYL]AZANIUM'>0SM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zx7\|3zx7]], [[3zxd\|3zxd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zx7\|3zx7]], [[3zxd\|3zxd]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zxg RCSB], [http://www.ebi.ac.uk/pdbsum/3zxg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxg OCA], [http://pdbe.org/3zxg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zxg RCSB], [http://www.ebi.ac.uk/pdbsum/3zxg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zxg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Eisenia fetida~~]]	+	[[Category: Common brandling worm]]
	[[Category: Abrusci, P]]		[[Category: Abrusci, P]]
	[[Category: Anderluh, G]]		[[Category: Anderluh, G]]

OCA at 01:26, 25 December 2014

OCA — Thu, 25 Dec 2014 01:26:38 GMT

←Older revision		Revision as of 01:26, 25 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3zxg.~~png~~\|~~left~~\|~~200px~~]]	+	==lysenin sphingomyelin complex==
		+	<StructureSection load='3zxg' size='340' side='right' caption='[[3zxg]], [[Resolution\|resolution]] 3.12Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zxg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Eisenia_fetida Eisenia fetida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0SM:TRIMETHYL-[2-[[(2S,3S)-2-(OCTADECANOYLAMINO)-3-OXIDANYL-BUTOXY]-OXIDANYL-PHOSPHORYL]OXYETHYL]AZANIUM'>0SM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zx7\|3zx7]], [[3zxd\|3zxd]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zxg RCSB], [http://www.ebi.ac.uk/pdbsum/3zxg PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TXL_EISFO TXL_EISFO]] Pore-forming toxin that specifically binds sphingomyelin in the plasma membrane of various cells. Has hemolytic activity. Is also cytotoxic to spermatozoa of some species of invertebrates and many species of vertebrates and to amphibian larvae, guinea pig polymorphonuclear leukocytes, chicken fibroblasts, normal spleen cells and various tumor cells. Is lethal for various species of reptiles, amphibian, birds and mammals. Induces smooth muscle contraction. It binds sphingomyelin and induces hemolysis in the same manner as lysenin-related protein 2, and is 10 times more effective than lysenin-related protein 1.<ref>PMID:10684578</ref> <ref>PMID:12676961</ref> <ref>PMID:15274631</ref> <ref>PMID:16971770</ref> <ref>PMID:9210594</ref> <ref>PMID:9478988</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pore-forming proteins insert from solution into membranes to create lesions, undergoing a structural rearrangement often accompanied by oligomerization. Lysenin, a pore-forming toxin from the earthworm Eisenia fetida, specifically interacts with sphingomyelin (SM) and may confer innate immunity against parasites by attacking their membranes to form pores. SM has important roles in cell membranes and lysenin is a popular SM-labeling reagent. The structure of lysenin suggests common ancestry with other pore-forming proteins from a diverse set of eukaryotes and prokaryotes. The complex with SM shows the mode of its recognition by a protein in which both the phosphocholine headgroup and one acyl tail are specifically bound. Lipid interaction studies and assays using viable target cells confirm the functional reliance of lysenin on this form of SM recognition.

-	~~{{STRUCTURE_3zxg\| PDB=3zxg \| SCENE= }}~~	+	Structures of lysenin reveal a shared evolutionary origin for pore-forming proteins and its mode of sphingomyelin recognition.,De Colibus L, Sonnen AF, Morris KJ, Siebert CA, Abrusci P, Plitzko J, Hodnik V, Leippe M, Volpi E, Anderluh G, Gilbert RJ Structure. 2012 Sep 5;20(9):1498-507. Epub 2012 Jul 19. PMID:22819216<ref>PMID:22819216</ref>

-	~~===lysenin sphingomyelin complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22819216}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[3zxg]] is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Eisenia_fetida Eisenia fetida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXG OCA].~~	+	</StructureSection>
	[[Category: Eisenia fetida]]		[[Category: Eisenia fetida]]
-	[[Category: Abrusci, P.]]	+	[[Category: Abrusci, P]]
-	[[Category: Anderluh, G.]]	+	[[Category: Anderluh, G]]
-	[[Category: Colibus, L De.]]	+	[[Category: Colibus, L De]]
-	[[Category: Gilbert, R J.C.]]	+	[[Category: Gilbert, R J.C]]
-	[[Category: Hodnik, V.]]	+	[[Category: Hodnik, V]]
-	[[Category: Leippe, M.]]	+	[[Category: Leippe, M]]
-	[[Category: Morris, K J.]]	+	[[Category: Morris, K J]]
-	[[Category: Plitzko, J.]]	+	[[Category: Plitzko, J]]
-	[[Category: Siebert, C A.]]	+	[[Category: Siebert, C A]]
-	[[Category: Sonnen, A F.P.]]	+	[[Category: Sonnen, A F.P]]
-	[[Category: Volpi, E.]]	+	[[Category: Volpi, E]]
	[[Category: Earthworm]]		[[Category: Earthworm]]
	[[Category: Pore-forming toxin]]		[[Category: Pore-forming toxin]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 06:15, 3 October 2012

OCA — Wed, 03 Oct 2012 06:15:30 GMT

←Older revision		Revision as of 06:15, 3 October 2012
Line 5:		Line 5:
	===lysenin sphingomyelin complex===		===lysenin sphingomyelin complex===

		+	{{ABSTRACT_PUBMED_22819216}}

	==About this Structure==		==About this Structure==

OCA at 20:55, 26 September 2012

OCA — Wed, 26 Sep 2012 20:55:16 GMT

←Older revision		Revision as of 20:55, 26 September 2012
Line 1:		Line 1:
-	[[Image:3zxg.~~jpg~~\|left\|200px]]	+	[[Image:3zxg.png\|left\|200px]]

	{{STRUCTURE_3zxg\| PDB=3zxg \| SCENE= }}		{{STRUCTURE_3zxg\| PDB=3zxg \| SCENE= }}

OCA at 07:19, 19 September 2012

OCA — Wed, 19 Sep 2012 07:19:07 GMT

←Older revision		Revision as of 07:19, 19 September 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3zxg.jpg\|left\|200px]]

-	~~The entry~~ 3zxg ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_3zxg\| PDB=3zxg \| SCENE= }}

-	~~Authors: De Colibus, L., Sonnen, A.F.P., Morris, K.J., Siebert, C.A., Abrusci, P., Plitzko, J., Hodnik, V., Leippe, M., Volpi, E., Anderluh, G., Gilbert, R.J.C.~~	+	===lysenin sphingomyelin complex===

-	~~Description~~: ~~lysenin sphingomyelin complex~~	+
		+	==About this Structure==
		+	[[3zxg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Eisenia_fetida Eisenia fetida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXG OCA].
		+	[[Category: Eisenia fetida]]
		+	[[Category: Abrusci, P.]]
		+	[[Category: Anderluh, G.]]
		+	[[Category: Colibus, L De.]]
		+	[[Category: Gilbert, R J.C.]]
		+	[[Category: Hodnik, V.]]
		+	[[Category: Leippe, M.]]
		+	[[Category: Morris, K J.]]
		+	[[Category: Plitzko, J.]]
		+	[[Category: Siebert, C A.]]
		+	[[Category: Sonnen, A F.P.]]
		+	[[Category: Volpi, E.]]
		+	[[Category: Earthworm]]
		+	[[Category: Pore-forming toxin]]
		+	[[Category: Toxin]]

OCA at 07:14, 20 June 2012

OCA — Wed, 20 Jun 2012 07:14:21 GMT

←Older revision		Revision as of 07:14, 20 June 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3zxg is ON HOLD	+	The entry 3zxg is ON HOLD until Paper Publication

	Authors: De Colibus, L., Sonnen, A.F.P., Morris, K.J., Siebert, C.A., Abrusci, P., Plitzko, J., Hodnik, V., Leippe, M., Volpi, E., Anderluh, G., Gilbert, R.J.C.		Authors: De Colibus, L., Sonnen, A.F.P., Morris, K.J., Siebert, C.A., Abrusci, P., Plitzko, J., Hodnik, V., Leippe, M., Volpi, E., Anderluh, G., Gilbert, R.J.C.

	Description: lysenin sphingomyelin complex		Description: lysenin sphingomyelin complex

OCA: Protected "3zxg" [edit=sysop:move=sysop]

OCA — Wed, 17 Aug 2011 06:00:28 GMT

Protected "3zxg" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:00, 17 August 2011