3zxu - Revision history

OCA at 10:44, 9 May 2024

OCA — Thu, 09 May 2024 10:44:28 GMT

←Older revision		Revision as of 10:44, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='3zxu' size='340' side='right'caption='[[3zxu]], [[Resolution\|resolution]] 3.70Å' scene=''>		<StructureSection load='3zxu' size='340' side='right'caption='[[3zxu]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zxu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Candida_sphaerica Candida sphaerica~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zxu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Kluyveromyces_lactis_NRRL_Y-1140 Kluyveromyces lactis NRRL Y-1140]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.7Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~KLLA0B10142G ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=284590 Candida sphaerica]), KLLA0D07612G ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284590 Candida sphaerica])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxu OCA], [https://pdbe.org/3zxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxu RCSB], [https://www.ebi.ac.uk/pdbsum/3zxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxu OCA], [https://pdbe.org/3zxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxu RCSB], [https://www.ebi.ac.uk/pdbsum/3zxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~MCM21_KLULA MCM21_KLULA]~~] Component of the ~~central~~ kinetochore, ~~which mediates the attachment of the centromere~~ to ~~the mitotic~~ spindle ~~by forming essential interactions between the microtubule-associated outer kinetochore proteins~~ and ~~the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments~~ and ~~proper chromosome segregation~~ (By similarity). ~~[[https://www.uniprot.org/uniprot/CTF19_KLULA CTF19_KLULA]]~~ Component of the ~~central~~ kinetochore, which ~~mediates the attachment of the~~ centromere ~~to the mitotic spindle by forming essential interactions between the microtubule~~-associated outer kinetochore proteins ~~and~~ the centromere-associated ~~inner~~ kinetochore ~~proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation~~ (By similarity).	+	[https://www.uniprot.org/uniprot/CENPO_KLULA CENPO_KLULA] Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis (By similarity). Component of the inner kinetochore COMA subcomplex, which connects centromere-associated proteins and the outer kinetochore (PubMed:29046335). COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (By similarity).[UniProtKB:Q06675]<ref>PMID:29046335</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Candida sphaerica~~]]	+	[[Category: Kluyveromyces lactis NRRL Y-1140]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Harrison~~, S C~~]]	+	[[Category: Harrison SC]]
-	[[Category: Schmitzberger, F]]	+	[[Category: Schmitzberger F]]
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Cell division]]~~	+
-	~~[[Category: Coma complex]]~~	+
-	~~[[Category: Protein complex~~]]	+

OCA at 07:26, 18 August 2022

OCA — Thu, 18 Aug 2022 07:26:19 GMT

←Older revision		Revision as of 07:26, 18 August 2022
Line 1:		Line 1:

	==Crystal structure of the Ctf19-Mcm21 kinetochore heterodimer from yeast==		==Crystal structure of the Ctf19-Mcm21 kinetochore heterodimer from yeast==
-	<StructureSection load='3zxu' size='340' side='right' caption='[[3zxu]], [[Resolution\|resolution]] 3.70Å' scene=''>	+	<StructureSection load='3zxu' size='340' side='right'caption='[[3zxu]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zxu]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Candida_sphaerica Candida sphaerica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZXU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zxu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_sphaerica Candida sphaerica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KLLA0B10142G ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284590 Candida sphaerica]), KLLA0D07612G ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284590 Candida sphaerica])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KLLA0B10142G ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284590 Candida sphaerica]), KLLA0D07612G ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284590 Candida sphaerica])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxu OCA], [~~http~~://pdbe.org/3zxu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zxu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zxu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxu OCA], [https://pdbe.org/3zxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxu RCSB], [https://www.ebi.ac.uk/pdbsum/3zxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MCM21_KLULA MCM21_KLULA]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation (By similarity). [[~~http~~://www.uniprot.org/uniprot/CTF19_KLULA CTF19_KLULA]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation (By similarity).	+	[[https://www.uniprot.org/uniprot/MCM21_KLULA MCM21_KLULA]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation (By similarity). [[https://www.uniprot.org/uniprot/CTF19_KLULA CTF19_KLULA]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Candida sphaerica]]		[[Category: Candida sphaerica]]
		+	[[Category: Large Structures]]
	[[Category: Harrison, S C]]		[[Category: Harrison, S C]]
	[[Category: Schmitzberger, F]]		[[Category: Schmitzberger, F]]

OCA at 08:02, 6 March 2019

OCA — Wed, 06 Mar 2019 08:02:26 GMT

←Older revision		Revision as of 08:02, 6 March 2019
Line 1:		Line 1:

	==Crystal structure of the Ctf19-Mcm21 kinetochore heterodimer from yeast==		==Crystal structure of the Ctf19-Mcm21 kinetochore heterodimer from yeast==
-	<StructureSection load='3zxu' size='340' side='right' caption='[[3zxu]], [[Resolution\|resolution]] 3.70Å' scene=''>	+	<StructureSection load='3zxu' size='340' side='right' caption='[[3zxu]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_sphaerica Candida sphaerica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXU FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_sphaerica Candida sphaerica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXU FirstGlance]. <br>

OCA at 23:21, 4 August 2016

OCA — Thu, 04 Aug 2016 23:21:01 GMT

←Older revision		Revision as of 23:21, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the Ctf19-Mcm21 kinetochore heterodimer from yeast==		==Crystal structure of the Ctf19-Mcm21 kinetochore heterodimer from yeast==
	<StructureSection load='3zxu' size='340' side='right' caption='[[3zxu]], [[Resolution\|resolution]] 3.70Å' scene=''>		<StructureSection load='3zxu' size='340' side='right' caption='[[3zxu]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Kluyveromyces_lactis Kluyveromyces lactis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_sphaerica Candida sphaerica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KLLA0B10142G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~28985 Kluyveromyces lactis~~]), KLLA0D07612G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~28985 Kluyveromyces lactis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KLLA0B10142G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284590 Candida sphaerica]), KLLA0D07612G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284590 Candida sphaerica])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zxu RCSB], [http://www.ebi.ac.uk/pdbsum/3zxu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxu OCA], [http://pdbe.org/3zxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zxu RCSB], [http://www.ebi.ac.uk/pdbsum/3zxu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~Q6CVQ9_KLULA Q6CVQ9_KLULA~~]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation (By similarity). [[http://www.uniprot.org/uniprot/~~Q6CRN7_KLULA Q6CRN7_KLULA~~]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation (By similarity).	+	[[http://www.uniprot.org/uniprot/MCM21_KLULA MCM21_KLULA]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation (By similarity). [[http://www.uniprot.org/uniprot/CTF19_KLULA CTF19_KLULA]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zxu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Kluyveromyces lactis~~]]	+	[[Category: Candida sphaerica]]
	[[Category: Harrison, S C]]		[[Category: Harrison, S C]]
	[[Category: Schmitzberger, F]]		[[Category: Schmitzberger, F]]

OCA at 20:37, 24 December 2014

OCA — Wed, 24 Dec 2014 20:37:54 GMT

←Older revision		Revision as of 20:37, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXU FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KLLA0B10142G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28985 Kluyveromyces lactis]), KLLA0D07612G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28985 Kluyveromyces lactis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KLLA0B10142G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28985 Kluyveromyces lactis]), KLLA0D07612G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28985 Kluyveromyces lactis])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zxu RCSB], [http://www.ebi.ac.uk/pdbsum/3zxu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zxu RCSB], [http://www.ebi.ac.uk/pdbsum/3zxu PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q6CVQ9_KLULA Q6CVQ9_KLULA]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation (By similarity). [[http://www.uniprot.org/uniprot/Q6CRN7_KLULA Q6CRN7_KLULA]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Kluyveromyces lactis]]		[[Category: Kluyveromyces lactis]]
-	[[Category: Harrison, S C.]]	+	[[Category: Harrison, S C]]
-	[[Category: Schmitzberger, F.]]	+	[[Category: Schmitzberger, F]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Cell division]]		[[Category: Cell division]]
	[[Category: Coma complex]]		[[Category: Coma complex]]
	[[Category: Protein complex]]		[[Category: Protein complex]]

OCA at 07:57, 5 June 2014

OCA — Thu, 05 Jun 2014 07:57:52 GMT

←Older revision		Revision as of 07:57, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3zxu.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of the Ctf19-Mcm21 kinetochore heterodimer from yeast==
		+	<StructureSection load='3zxu' size='340' side='right' caption='[[3zxu]], [[Resolution\|resolution]] 3.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KLLA0B10142G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28985 Kluyveromyces lactis]), KLLA0D07612G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28985 Kluyveromyces lactis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zxu RCSB], [http://www.ebi.ac.uk/pdbsum/3zxu PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The proteins Ctf19, Okp1, Mcm21 and Ame1 are the components of COMA, a subassembly of budding-yeast kinetochores. We have determined the crystal structure of a conserved COMA subcomplex-the Ctf19-Mcm21 heterodimer-from Kluyveromyces lactis. Both proteins contain 'double-RWD' domains, which together form a Y-shaped framework with flexible N-terminal extensions. The kinetochore proteins Csm1, Spc24 and Spc25 have related single RWD domains, and Ctf19 and Mcm21 associate with pseudo-twofold symmetry analogous to that in the Csm1 homodimer and the Spc24-Spc25 heterodimer. The double-RWD domain core of the Ctf19-Mcm21 heterodimer is sufficient for association with Okp1-Ame1; the less conserved N-terminal regions may interact with components of a more extensive 'CTF19 complex'. Our structure shows the RWD domain to be a recurring module of kinetochore architecture that may be present in other kinetochore substructures. Like many eukaryotic molecular machines, kinetochores may have evolved from simpler assemblies by multiplication of a few ancestral modules.

-	<!--	+	RWD domain: a recurring module in kinetochore architecture shown by a Ctf19-Mcm21 complex structure.,Schmitzberger F, Harrison SC EMBO Rep. 2012 Mar 1;13(3):216-22. doi: 10.1038/embor.2012.1. PMID:22322944<ref>PMID:22322944</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3zxu"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3zxu\| PDB=3zxu \| SCENE= }}~~	+

-	~~===Crystal structure~~ of the ~~Ctf19-Mcm21 kinetochore heterodimer from yeast===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22322944}}, adds the Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22322944 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22322944}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3zxu]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXU OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022322944<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Kluyveromyces lactis]]		[[Category: Kluyveromyces lactis]]
	[[Category: Harrison, S C.]]		[[Category: Harrison, S C.]]

OCA at 06:31, 14 March 2012

OCA — Wed, 14 Mar 2012 06:31:34 GMT

←Older revision		Revision as of 06:31, 14 March 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3zxu.jpg\|left\|200px]]

-	The ~~entry 3zxu~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3zxu", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3zxu\| PDB=3zxu \| SCENE= }}

-	~~Authors: Schmitzberger, F., Harrison, S.C.~~	+	===Crystal structure of the Ctf19-Mcm21 kinetochore heterodimer from yeast===

-	~~Description~~: ~~Crystal structure of~~ the ~~Ctf19~~-~~Mcm21 kinetochore heterodimer~~ from ~~yeast~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22322944}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22322944 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22322944}}
		+
		+	==About this Structure==
		+	[[3zxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXU OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022322944</ref><references group="xtra"/>
		+	[[Category: Kluyveromyces lactis]]
		+	[[Category: Harrison, S C.]]
		+	[[Category: Schmitzberger, F.]]
		+	[[Category: Cell cycle]]
		+	[[Category: Cell division]]
		+	[[Category: Coma complex]]
		+	[[Category: Protein complex]]

OCA at 06:29, 31 August 2011

OCA — Wed, 31 Aug 2011 06:29:49 GMT

←Older revision		Revision as of 06:29, 31 August 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3zxu is ON HOLD	+	The entry 3zxu is ON HOLD until Paper Publication

	Authors: Schmitzberger, F., Harrison, S.C.		Authors: Schmitzberger, F., Harrison, S.C.

	Description: Crystal structure of the Ctf19-Mcm21 kinetochore heterodimer from yeast		Description: Crystal structure of the Ctf19-Mcm21 kinetochore heterodimer from yeast

OCA: Protected "3zxu" [edit=sysop:move=sysop]

OCA — Wed, 24 Aug 2011 07:15:56 GMT

Protected "3zxu" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:15, 24 August 2011

OCA: New page: '''Unreleased structure''' The entry 3zxu is ON HOLD Authors: Schmitzberger, F., Harrison, S.C. Description: Crystal structure of the Ctf19-Mcm21 kinetochore heterodimer from yeast

OCA — Wed, 24 Aug 2011 07:15:55 GMT

New page: '''Unreleased structure''' The entry 3zxu is ON HOLD Authors: Schmitzberger, F., Harrison, S.C. Description: Crystal structure of the Ctf19-Mcm21 kinetochore heterodimer from yeast

New page

'''Unreleased structure'''

The entry 3zxu is ON HOLD

Authors: Schmitzberger, F., Harrison, S.C.

Description: Crystal structure of the Ctf19-Mcm21 kinetochore heterodimer from yeast