3zxv - Revision history

OCA at 11:15, 20 December 2023

OCA — Wed, 20 Dec 2023 11:15:39 GMT

←Older revision		Revision as of 11:15, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='3zxv' size='340' side='right'caption='[[3zxv]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='3zxv' size='340' side='right'caption='[[3zxv]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zxv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zxv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MXI:4-(2-TERT-BUTYL-4-(6-METHOXYNAPHTHALEN-2-YL)-3H-IMIDAZOL-4-YL)PYRIDIN-2-AMINE'>MXI</scene>, <scene name='pdbligand=P3S:L-METHIONINE-S-SULFOXIMINE+PHOSPHATE'>P3S</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.26Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hto\|1hto]], [[1htq\|1htq]], [[3zxr\|3zxr]], [[2whi\|2whi]], [[2bvc\|2bvc]], [[2wgs\|2wgs]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MXI:4-(2-TERT-BUTYL-4-(6-METHOXYNAPHTHALEN-2-YL)-3H-IMIDAZOL-4-YL)PYRIDIN-2-AMINE'>MXI</scene>, <scene name='pdbligand=P3S:L-METHIONINE-S-SULFOXIMINE+PHOSPHATE'>P3S</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutamate--ammonia_ligase Glutamate--ammonia ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.1.2 6.3.1.2] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxv OCA], [https://pdbe.org/3zxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxv RCSB], [https://www.ebi.ac.uk/pdbsum/3zxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxv OCA], [https://pdbe.org/3zxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxv RCSB], [https://www.ebi.ac.uk/pdbsum/3zxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxv ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GLN1B_MYCTU GLN1B_MYCTU] Involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia (PubMed:7937767, PubMed:12819079). Also able to use GTP (PubMed:7937767). D-glutamate is a poor substrate, and DL-glutamate shows about 50% of the standard specific activity (PubMed:7937767). Also plays a key role in controlling the ammonia levels within infected host cells and so contributes to the pathogens capacity to inhibit phagosome acidification and phagosome-lysosome fusion (PubMed:7937767, PubMed:12819079). Involved in cell wall biosynthesis via the production of the major component poly-L-glutamine (PLG) (PubMed:7937767, PubMed:10618433). PLG synthesis in the cell wall occurs only in nitrogen limiting conditions and on the contrary high nitrogen conditions inhibit PLG synthesis (Probable).<ref>PMID:10618433</ref> <ref>PMID:12819079</ref> <ref>PMID:7937767</ref> <ref>PMID:9278431</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Glutamate--ammonia ligase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Myctu~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: Mowbray~~, S L~~]]	+	[[Category: Mowbray SL]]
-	[[Category: Nilsson~~, M T]]~~	+	[[Category: Nilsson MT]]
-	~~[[Category: Glna1]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Mt2278]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Rv2220]]~~	+
-	~~[[Category: Taut state~~]]	+

OCA at 07:26, 18 August 2022

OCA — Thu, 18 Aug 2022 07:26:27 GMT

←Older revision		Revision as of 07:26, 18 August 2022
Line 3:		Line 3:
	<StructureSection load='3zxv' size='340' side='right'caption='[[3zxv]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='3zxv' size='340' side='right'caption='[[3zxv]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zxv]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZXV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zxv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MXI:4-(2-TERT-BUTYL-4-(6-METHOXYNAPHTHALEN-2-YL)-3H-IMIDAZOL-4-YL)PYRIDIN-2-AMINE'>MXI</scene>, <scene name='pdbligand=P3S:L-METHIONINE-S-SULFOXIMINE+PHOSPHATE'>P3S</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MXI:4-(2-TERT-BUTYL-4-(6-METHOXYNAPHTHALEN-2-YL)-3H-IMIDAZOL-4-YL)PYRIDIN-2-AMINE'>MXI</scene>, <scene name='pdbligand=P3S:L-METHIONINE-S-SULFOXIMINE+PHOSPHATE'>P3S</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hto\|1hto]], [[1htq\|1htq]], [[3zxr\|3zxr]], [[2whi\|2whi]], [[2bvc\|2bvc]], [[2wgs\|2wgs]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hto\|1hto]], [[1htq\|1htq]], [[3zxr\|3zxr]], [[2whi\|2whi]], [[2bvc\|2bvc]], [[2wgs\|2wgs]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glutamate--ammonia_ligase Glutamate--ammonia ligase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.1.2 6.3.1.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutamate--ammonia_ligase Glutamate--ammonia ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.1.2 6.3.1.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxv OCA], [~~http~~://pdbe.org/3zxv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zxv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zxv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxv OCA], [https://pdbe.org/3zxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxv RCSB], [https://www.ebi.ac.uk/pdbsum/3zxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxv ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Glutamine synthetase\|Glutamine synthetase]]	+	*[[Glutamine synthetase 3D structures\|Glutamine synthetase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:32, 10 May 2019

OCA — Fri, 10 May 2019 12:32:20 GMT

←Older revision		Revision as of 12:32, 10 May 2019
Line 1:		Line 1:

	==Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with tri-substituted imidazole inhibitor (4-(2-tert-butyl- 4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl)pyridin-2-amine) and L- methionine-S-sulfoximine phosphate==		==Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with tri-substituted imidazole inhibitor (4-(2-tert-butyl- 4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl)pyridin-2-amine) and L- methionine-S-sulfoximine phosphate==
-	<StructureSection load='3zxv' size='340' side='right' caption='[[3zxv]], [[Resolution\|resolution]] 2.26Å' scene=''>	+	<StructureSection load='3zxv' size='340' side='right'caption='[[3zxv]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zxv]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXV FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zxv]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXV FirstGlance]. <br>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Glutamate--ammonia ligase]]		[[Category: Glutamate--ammonia ligase]]
		+	[[Category: Large Structures]]
	[[Category: Myctu]]		[[Category: Myctu]]
	[[Category: Mowbray, S L]]		[[Category: Mowbray, S L]]

OCA at 16:55, 27 February 2019

OCA — Wed, 27 Feb 2019 16:55:17 GMT

←Older revision		Revision as of 16:55, 27 February 2019
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 3zxv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3zxv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glutamine synthetase\|Glutamine synthetase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:00, 11 August 2016

OCA — Thu, 11 Aug 2016 13:00:47 GMT

←Older revision		Revision as of 13:00, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with tri-substituted imidazole inhibitor (4-(2-tert-butyl- 4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl)pyridin-2-amine) and L- methionine-S-sulfoximine phosphate==		==Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with tri-substituted imidazole inhibitor (4-(2-tert-butyl- 4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl)pyridin-2-amine) and L- methionine-S-sulfoximine phosphate==
	<StructureSection load='3zxv' size='340' side='right' caption='[[3zxv]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='3zxv' size='340' side='right' caption='[[3zxv]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zxv]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium tuberculosis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zxv]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MXI:4-(2-TERT-BUTYL-4-(6-METHOXYNAPHTHALEN-2-YL)-3H-IMIDAZOL-4-YL)PYRIDIN-2-AMINE'>MXI</scene>, <scene name='pdbligand=P3S:L-METHIONINE-S-SULFOXIMINE+PHOSPHATE'>P3S</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MXI:4-(2-TERT-BUTYL-4-(6-METHOXYNAPHTHALEN-2-YL)-3H-IMIDAZOL-4-YL)PYRIDIN-2-AMINE'>MXI</scene>, <scene name='pdbligand=P3S:L-METHIONINE-S-SULFOXIMINE+PHOSPHATE'>P3S</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hto\|1hto]], [[1htq\|1htq]], [[3zxr\|3zxr]], [[2whi\|2whi]], [[2bvc\|2bvc]], [[2wgs\|2wgs]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hto\|1hto]], [[1htq\|1htq]], [[3zxr\|3zxr]], [[2whi\|2whi]], [[2bvc\|2bvc]], [[2wgs\|2wgs]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate--ammonia_ligase Glutamate--ammonia ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.1.2 6.3.1.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate--ammonia_ligase Glutamate--ammonia ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.1.2 6.3.1.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zxv RCSB], [http://www.ebi.ac.uk/pdbsum/3zxv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxv OCA], [http://pdbe.org/3zxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zxv RCSB], [http://www.ebi.ac.uk/pdbsum/3zxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxv ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zxv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Glutamate--ammonia ligase]]		[[Category: Glutamate--ammonia ligase]]
-	[[Category: ~~Mycobacterium tuberculosis~~]]	+	[[Category: Myctu]]
	[[Category: Mowbray, S L]]		[[Category: Mowbray, S L]]
	[[Category: Nilsson, M T]]		[[Category: Nilsson, M T]]

OCA at 09:55, 4 January 2015

OCA — Sun, 04 Jan 2015 09:55:18 GMT

←Older revision		Revision as of 09:55, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zxv]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXV FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zxv]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MXI:4-(2-TERT-BUTYL-4-(6-METHOXYNAPHTHALEN-2-YL)-3H-IMIDAZOL-4-YL)PYRIDIN-2-AMINE'>MXI</scene>, <scene name='pdbligand=P3S:L-METHIONINE-S-SULFOXIMINE+PHOSPHATE'>P3S</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MXI:4-(2-TERT-BUTYL-4-(6-METHOXYNAPHTHALEN-2-YL)-3H-IMIDAZOL-4-YL)PYRIDIN-2-AMINE'>MXI</scene>, <scene name='pdbligand=P3S:L-METHIONINE-S-SULFOXIMINE+PHOSPHATE'>P3S</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hto\|1hto]], [[1htq\|1htq]], [[3zxr\|3zxr]], [[2whi\|2whi]], [[2bvc\|2bvc]], [[2wgs\|2wgs]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hto\|1hto]], [[1htq\|1htq]], [[3zxr\|3zxr]], [[2whi\|2whi]], [[2bvc\|2bvc]], [[2wgs\|2wgs]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate--ammonia_ligase Glutamate--ammonia ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.1.2 6.3.1.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate--ammonia_ligase Glutamate--ammonia ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.1.2 6.3.1.2] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zxv RCSB], [http://www.ebi.ac.uk/pdbsum/3zxv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zxv RCSB], [http://www.ebi.ac.uk/pdbsum/3zxv PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	[[Category: Glutamate--ammonia ligase]]		[[Category: Glutamate--ammonia ligase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Mowbray, S L.]]	+	[[Category: Mowbray, S L]]
-	[[Category: Nilsson, M T.]]	+	[[Category: Nilsson, M T]]
	[[Category: Glna1]]		[[Category: Glna1]]
	[[Category: Ligase]]		[[Category: Ligase]]

OCA at 08:15, 5 June 2014

OCA — Thu, 05 Jun 2014 08:15:52 GMT

←Older revision		Revision as of 08:15, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3zxv.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with tri-substituted imidazole inhibitor (4-(2-tert-butyl- 4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl)pyridin-2-amine) and L- methionine-S-sulfoximine phosphate==
		+	<StructureSection load='3zxv' size='340' side='right' caption='[[3zxv]], [[Resolution\|resolution]] 2.26Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zxv]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXV FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MXI:4-(2-TERT-BUTYL-4-(6-METHOXYNAPHTHALEN-2-YL)-3H-IMIDAZOL-4-YL)PYRIDIN-2-AMINE'>MXI</scene>, <scene name='pdbligand=P3S:L-METHIONINE-S-SULFOXIMINE+PHOSPHATE'>P3S</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hto\|1hto]], [[1htq\|1htq]], [[3zxr\|3zxr]], [[2whi\|2whi]], [[2bvc\|2bvc]], [[2wgs\|2wgs]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate--ammonia_ligase Glutamate--ammonia ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.1.2 6.3.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zxv RCSB], [http://www.ebi.ac.uk/pdbsum/3zxv PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mycobacterium tuberculosis glutamine synthetase (MtGS) is a promising target for antituberculosis drug discovery. In a recent high-throughput screening study we identified several classes of MtGS inhibitors targeting the ATP-binding site. We now explore one of these classes, the 2-tert-butyl-4,5-diarylimidazoles, and present the design, synthesis, and X-ray crystallographic studies leading to the identification of MtGS inhibitors with submicromolar IC(50) values and promising antituberculosis MIC values.

-	~~<!--~~	+	Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors.,Gising J, Nilsson MT, Odell LR, Yahiaoui S, Lindh M, Iyer H, Sinha AM, Srinivasa BR, Larhed M, Mowbray SL, Karlen A J Med Chem. 2012 Mar 22;55(6):2894-8. Epub 2012 Mar 8. PMID:22369127<ref>PMID:22369127</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3zxv"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3zxv\| PDB=3zxv \| SCENE= }}~~	+

-	~~===Crystal structure~~ of Mycobacterium Tuberculosis Glutamine Synthetase in complex with tri-substituted imidazole inhibitor (4-(2-tert-butyl- 4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl)pyridin-2-amine) and L- methionine-S-sulfoximine phosphate===	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22369127}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22369127 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22369127}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3zxv]] is a 6 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXV OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022369127<~~/~~ref~~><~~ref group="xtra">PMID:016027359</ref><ref group="xtra">PMID:019695264</ref><references group="xtra"~~/>	+
	[[Category: Glutamate--ammonia ligase]]		[[Category: Glutamate--ammonia ligase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]

OCA at 06:08, 4 April 2012

OCA — Wed, 04 Apr 2012 06:08:19 GMT

←Older revision		Revision as of 06:08, 4 April 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3zxv.jpg\|left\|200px]]

-	The ~~entry 3zxv~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3zxv", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3zxv\| PDB=3zxv \| SCENE= }}

-	~~Authors: Nilsson, M.T., Mowbray, S.~~L.	+	===Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with tri-substituted imidazole inhibitor (4-(2-tert-butyl- 4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl)pyridin-2-amine) and L- methionine-S-sulfoximine phosphate===

-	~~Description: Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with tri~~-~~substituted imidazole inhibitor (4~~-(~~2-tert-butyl~~-4-(6-~~methoxynaphthalen~~-2-~~yl)-1H-imidazol-5-yl)pyridin-2-amine) and~~ L-~~methionine-S-sulfoximine phosphate~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22369127}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22369127 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22369127}}
		+
		+	==About this Structure==
		+	[[3zxv]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXV OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022369127</ref><ref group="xtra">PMID:016027359</ref><ref group="xtra">PMID:019695264</ref><references group="xtra"/>
		+	[[Category: Glutamate--ammonia ligase]]
		+	[[Category: Mycobacterium tuberculosis]]
		+	[[Category: Mowbray, S L.]]
		+	[[Category: Nilsson, M T.]]
		+	[[Category: Glna1]]
		+	[[Category: Ligase]]
		+	[[Category: Mt2278]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Rv2220]]
		+	[[Category: Taut state]]

OCA: Protected "3zxv" [edit=sysop:move=sysop]

OCA — Wed, 24 Aug 2011 07:15:59 GMT

Protected "3zxv" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:15, 24 August 2011

OCA: New page: '''Unreleased structure''' The entry 3zxv is ON HOLD until Paper Publication Authors: Nilsson, M.T., Mowbray, S.L. Description: Crystal structure of Mycobacterium Tuberculosis Glutamin...

OCA — Wed, 24 Aug 2011 07:15:58 GMT

New page: '''Unreleased structure''' The entry 3zxv is ON HOLD until Paper Publication Authors: Nilsson, M.T., Mowbray, S.L. Description: Crystal structure of Mycobacterium Tuberculosis Glutamin...

New page

'''Unreleased structure'''

The entry 3zxv is ON HOLD until Paper Publication

Authors: Nilsson, M.T., Mowbray, S.L.

Description: Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with tri-substituted imidazole inhibitor (4-(2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl)pyridin-2-amine) and L-methionine-S-sulfoximine phosphate