3zys - Revision history

OCA at 10:44, 9 May 2024

OCA — Thu, 09 May 2024 10:44:34 GMT

←Older revision		Revision as of 10:44, 9 May 2024
Line 3:		Line 3:
	<SX load='3zys' size='340' side='right' viewer='molstar' caption='[[3zys]], [[Resolution\|resolution]] 12.20Å' scene=''>		<SX load='3zys' size='340' side='right' viewer='molstar' caption='[[3zys]], [[Resolution\|resolution]] 12.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zys]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZYS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zys]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZYS FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[3zyc\|3zyc]]~~, [[~~2x2f~~\|~~2x2f~~]]~~, [[2dyn\|2dyn]], [[2x2e\|2x2e]], [[1dyn\|1dyn]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 12.2Å</td></tr>
-	~~<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en~~.~~wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zys OCA], [https://pdbe.org/3zys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zys RCSB], [https://www.ebi.ac.uk/pdbsum/3zys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zys ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zys OCA], [https://pdbe.org/3zys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zys RCSB], [https://www.ebi.ac.uk/pdbsum/3zys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zys ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DYN1_HUMAN DYN1_HUMAN]] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. [[https://www.uniprot.org/uniprot/MX1_HUMAN MX1_HUMAN]] Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.<ref>PMID:20603636</ref> <ref>PMID:11880649</ref> <ref>PMID:15047845</ref> <ref>PMID:14752052</ref> <ref>PMID:15355513</ref> <ref>PMID:14687945</ref> <ref>PMID:15757897</ref> <ref>PMID:16413306</ref> <ref>PMID:16202617</ref> <ref>PMID:17374778</ref> <ref>PMID:18668195</ref> <ref>PMID:19109387</ref> <ref>PMID:21900240</ref> <ref>PMID:21992152</ref>	+	[https://www.uniprot.org/uniprot/DYN1_HUMAN DYN1_HUMAN] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: ~~Dynamin GTPase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chappie~~, J S~~]]	+	[[Category: Chappie JS]]
-	[[Category: Dyda, F]]	+	[[Category: Dyda F]]
-	[[Category: Fang, S]]	+	[[Category: Fang S]]
-	[[Category: Hinshaw~~, J E~~]]	+	[[Category: Hinshaw JE]]
-	[[Category: Leonard, M]]	+	[[Category: Leonard M]]
-	[[Category: Mears~~, J A~~]]	+	[[Category: Mears JA]]
-	[[Category: Milligan~~, R A~~]]	+	[[Category: Milligan RA]]
-	[[Category: Schmid~~, S L]]~~	+	[[Category: Schmid SL]]
-	~~[[Category: Endocytosis]]~~	+
-	~~[[Category: Gtp hydrolysis]]~~	+
-	~~[[Category: Hydrolase-gtp-binding protein complex]]~~	+
-	~~[[Category: Membrane remodeling~~]]	+

OCA at 07:28, 18 August 2022

OCA — Thu, 18 Aug 2022 07:28:46 GMT

←Older revision		Revision as of 07:28, 18 August 2022
Line 3:		Line 3:
	<SX load='3zys' size='340' side='right' viewer='molstar' caption='[[3zys]], [[Resolution\|resolution]] 12.20Å' scene=''>		<SX load='3zys' size='340' side='right' viewer='molstar' caption='[[3zys]], [[Resolution\|resolution]] 12.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zys]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3ZYS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zys]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZYS FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zyc\|3zyc]], [[2x2f\|2x2f]], [[2dyn\|2dyn]], [[2x2e\|2x2e]], [[1dyn\|1dyn]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zyc\|3zyc]], [[2x2f\|2x2f]], [[2dyn\|2dyn]], [[2x2e\|2x2e]], [[1dyn\|1dyn]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3zys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zys OCA], [~~http~~://pdbe.org/3zys PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zys RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zys PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zys ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zys OCA], [https://pdbe.org/3zys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zys RCSB], [https://www.ebi.ac.uk/pdbsum/3zys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zys ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DYN1_HUMAN DYN1_HUMAN]] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. [[~~http~~://www.uniprot.org/uniprot/MX1_HUMAN MX1_HUMAN]] Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.<ref>PMID:20603636</ref> <ref>PMID:11880649</ref> <ref>PMID:15047845</ref> <ref>PMID:14752052</ref> <ref>PMID:15355513</ref> <ref>PMID:14687945</ref> <ref>PMID:15757897</ref> <ref>PMID:16413306</ref> <ref>PMID:16202617</ref> <ref>PMID:17374778</ref> <ref>PMID:18668195</ref> <ref>PMID:19109387</ref> <ref>PMID:21900240</ref> <ref>PMID:21992152</ref>	+	[[https://www.uniprot.org/uniprot/DYN1_HUMAN DYN1_HUMAN]] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. [[https://www.uniprot.org/uniprot/MX1_HUMAN MX1_HUMAN]] Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.<ref>PMID:20603636</ref> <ref>PMID:11880649</ref> <ref>PMID:15047845</ref> <ref>PMID:14752052</ref> <ref>PMID:15355513</ref> <ref>PMID:14687945</ref> <ref>PMID:15757897</ref> <ref>PMID:16413306</ref> <ref>PMID:16202617</ref> <ref>PMID:17374778</ref> <ref>PMID:18668195</ref> <ref>PMID:19109387</ref> <ref>PMID:21900240</ref> <ref>PMID:21992152</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Dynamin 3D structures\|Dynamin 3D structures]]
	*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]		*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]
	== References ==		== References ==

OCA at 18:44, 10 April 2020

OCA — Fri, 10 Apr 2020 18:44:49 GMT

←Older revision		Revision as of 18:44, 10 April 2020
Line 3:		Line 3:
	<SX load='3zys' size='340' side='right' viewer='molstar' caption='[[3zys]], [[Resolution\|resolution]] 12.20Å' scene=''>		<SX load='3zys' size='340' side='right' viewer='molstar' caption='[[3zys]], [[Resolution\|resolution]] 12.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zys]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZYS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zys]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3ZYS FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zyc\|3zyc]], [[2x2f\|2x2f]], [[2dyn\|2dyn]], [[2x2e\|2x2e]], [[1dyn\|1dyn]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zyc\|3zyc]], [[2x2f\|2x2f]], [[2dyn\|2dyn]], [[2x2e\|2x2e]], [[1dyn\|1dyn]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zys OCA], [http://pdbe.org/3zys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zys RCSB], [http://www.ebi.ac.uk/pdbsum/3zys PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zys ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3zys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zys OCA], [http://pdbe.org/3zys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zys RCSB], [http://www.ebi.ac.uk/pdbsum/3zys PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zys ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 17:45, 6 March 2020

OCA — Fri, 06 Mar 2020 17:45:46 GMT

←Older revision		Revision as of 17:45, 6 March 2020
Line 1:		Line 1:

	==Human dynamin 1 deltaPRD polymer stabilized with GMPPCP==		==Human dynamin 1 deltaPRD polymer stabilized with GMPPCP==
-	<~~StructureSection~~ load='3zys' size='340' side='right'caption='[[3zys]], [[Resolution\|resolution]] 12.20Å' scene=''>	+	<SX load='3zys' size='340' side='right' viewer='molstar' caption='[[3zys]], [[Resolution\|resolution]] 12.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zys]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZYS FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zys]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZYS FirstGlance]. <br>
Line 26:		Line 26:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Dynamin GTPase]]		[[Category: Dynamin GTPase]]
	[[Category: Human]]		[[Category: Human]]

OCA at 16:56, 28 August 2019

OCA — Wed, 28 Aug 2019 16:56:57 GMT

←Older revision		Revision as of 16:56, 28 August 2019
Line 1:		Line 1:

	==Human dynamin 1 deltaPRD polymer stabilized with GMPPCP==		==Human dynamin 1 deltaPRD polymer stabilized with GMPPCP==
-	<StructureSection load='3zys' size='340' side='right' caption='[[3zys]], [[Resolution\|resolution]] 12.20Å' scene=''>	+	<StructureSection load='3zys' size='340' side='right'caption='[[3zys]], [[Resolution\|resolution]] 12.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zys]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZYS FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zys]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZYS FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 3zys" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3zys" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dynamin 3D structures\|Dynamin 3D structures]]
		+	*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 29:
	[[Category: Dynamin GTPase]]		[[Category: Dynamin GTPase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chappie, J S]]		[[Category: Chappie, J S]]
	[[Category: Dyda, F]]		[[Category: Dyda, F]]

OCA at 22:09, 15 November 2017

OCA — Wed, 15 Nov 2017 22:09:33 GMT

←Older revision		Revision as of 22:09, 15 November 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 3zys" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3zys" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[GTP-binding protein\|GTP-binding protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:27, 4 August 2016

OCA — Thu, 04 Aug 2016 14:27:25 GMT

←Older revision		Revision as of 14:27, 4 August 2016
Line 1:		Line 1:
		+
	==Human dynamin 1 deltaPRD polymer stabilized with GMPPCP==		==Human dynamin 1 deltaPRD polymer stabilized with GMPPCP==
	<StructureSection load='3zys' size='340' side='right' caption='[[3zys]], [[Resolution\|resolution]] 12.20Å' scene=''>		<StructureSection load='3zys' size='340' side='right' caption='[[3zys]], [[Resolution\|resolution]] 12.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zys]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZYS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zys]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZYS FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zyc\|3zyc]], [[2x2f\|2x2f]], [[2dyn\|2dyn]], [[2x2e\|2x2e]], [[1dyn\|1dyn]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zyc\|3zyc]], [[2x2f\|2x2f]], [[2dyn\|2dyn]], [[2x2e\|2x2e]], [[1dyn\|1dyn]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zys OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zys RCSB], [http://www.ebi.ac.uk/pdbsum/3zys PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zys OCA], [http://pdbe.org/3zys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zys RCSB], [http://www.ebi.ac.uk/pdbsum/3zys PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zys ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zys" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Dynamin GTPase]]		[[Category: Dynamin GTPase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chappie, J S]]		[[Category: Chappie, J S]]
	[[Category: Dyda, F]]		[[Category: Dyda, F]]

OCA at 15:46, 24 December 2014

OCA — Wed, 24 Dec 2014 15:46:17 GMT

←Older revision		Revision as of 15:46, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zys OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zys RCSB], [http://www.ebi.ac.uk/pdbsum/3zys PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zys OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zys RCSB], [http://www.ebi.ac.uk/pdbsum/3zys PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DYN1_HUMAN DYN1_HUMAN]] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. [[http://www.uniprot.org/uniprot/MX1_HUMAN MX1_HUMAN]] Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.<ref>PMID:20603636</ref> <ref>PMID:11880649</ref> <ref>PMID:15047845</ref> <ref>PMID:14752052</ref> <ref>PMID:15355513</ref> <ref>PMID:14687945</ref> <ref>PMID:15757897</ref> <ref>PMID:16413306</ref> <ref>PMID:16202617</ref> <ref>PMID:17374778</ref> <ref>PMID:18668195</ref> <ref>PMID:19109387</ref> <ref>PMID:21900240</ref> <ref>PMID:21992152</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:09, 21 December 2014

OCA — Sun, 21 Dec 2014 10:09:13 GMT

←Older revision		Revision as of 10:09, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3zys\| PDB=3zys \| SCENE= }}~~	+	==Human dynamin 1 deltaPRD polymer stabilized with GMPPCP==
-	===Human dynamin 1 deltaPRD polymer stabilized with GMPPCP===	+	<StructureSection load='3zys' size='340' side='right' caption='[[3zys]], [[Resolution\|resolution]] 12.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21962517}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zys]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZYS FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3zyc\|3zyc]], [[2x2f\|2x2f]], [[2dyn\|2dyn]], [[2x2e\|2x2e]], [[1dyn\|1dyn]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zys OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zys RCSB], [http://www.ebi.ac.uk/pdbsum/3zys PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The GTPase dynamin catalyzes membrane fission by forming a collar around the necks of clathrin-coated pits, but the specific structural interactions and conformational changes that drive this process remain a mystery. We present the GMPPCP-bound structures of the truncated human dynamin 1 helical polymer at 12.2 A and a fusion protein, GG, linking human dynamin 1's catalytic G domain to its GTPase effector domain (GED) at 2.2 A. The structures reveal the position and connectivity of dynamin fragments in the assembled structure, showing that G domain dimers only form between tetramers in sequential rungs of the dynamin helix. Using chemical crosslinking, we demonstrate that dynamin tetramers are made of two dimers, in which the G domain of one molecule interacts in trans with the GED of another. Structural comparison of GG(GMPPCP) to the GG transition-state complex identifies a hydrolysis-dependent powerstroke that may play a role in membrane-remodeling events necessary for fission.

-	~~==Function==~~	+	A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke.,Chappie JS, Mears JA, Fang S, Leonard M, Schmid SL, Milligan RA, Hinshaw JE, Dyda F Cell. 2011 Sep 30;147(1):209-22. PMID:21962517<ref>PMID:21962517</ref>
-	[[http://www.uniprot.org/uniprot/DYN1_HUMAN DYN1_HUMAN]] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. [[http://www.uniprot.org/uniprot/MX1_HUMAN MX1_HUMAN]] Interferon-induced dynamin~~-like GTPase with antiviral activity against~~ a ~~wide range of RNA viruses and some DNA viruses. Its target viruses include negative~~-~~stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid~~. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, ~~preventing genome amplification~~, ~~budding~~, ~~and egress~~. ~~Inhibits influenza A virus~~ (~~IAV~~) ~~replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress~~-~~mediated cell death after influenza virus infection~~. ~~May regulate the calcium channel activity of TRPCs.<ref>~~PMID:20603636</ref> <ref>PMID:11880649</ref> <ref>PMID:15047845</ref> <ref>PMID:14752052</ref> <ref>PMID:15355513</ref> <ref>PMID:14687945</ref> <ref>PMID:15757897</ref> <ref>PMID:16413306</ref> <ref>PMID:16202617</ref> <ref>PMID:17374778</ref> <ref>PMID:18668195</ref> <ref>PMID:19109387</ref> <ref>PMID:21900240</ref> <ref>PMID:~~21992152~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3zys]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYS OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:021962517</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[GTP-binding protein\|GTP-binding protein]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Dynamin GTPase]]		[[Category: Dynamin GTPase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chappie, J S.]]	+	[[Category: Chappie, J S]]
-	[[Category: Dyda, F.]]	+	[[Category: Dyda, F]]
-	[[Category: Fang, S.]]	+	[[Category: Fang, S]]
-	[[Category: Hinshaw, J E.]]	+	[[Category: Hinshaw, J E]]
-	[[Category: Leonard, M.]]	+	[[Category: Leonard, M]]
-	[[Category: Mears, J A.]]	+	[[Category: Mears, J A]]
-	[[Category: Milligan, R A.]]	+	[[Category: Milligan, R A]]
-	[[Category: Schmid, S L.]]	+	[[Category: Schmid, S L]]
	[[Category: Endocytosis]]		[[Category: Endocytosis]]
	[[Category: Gtp hydrolysis]]		[[Category: Gtp hydrolysis]]
	[[Category: Hydrolase-gtp-binding protein complex]]		[[Category: Hydrolase-gtp-binding protein complex]]
	[[Category: Membrane remodeling]]		[[Category: Membrane remodeling]]

OCA at 03:05, 20 September 2013

OCA — Fri, 20 Sep 2013 03:05:15 GMT

←Older revision		Revision as of 03:05, 20 September 2013
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-	[[Image:3zys.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3zys", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3zys\| PDB=3zys \| SCENE= }}		{{STRUCTURE_3zys\| PDB=3zys \| SCENE= }}
-
	===Human dynamin 1 deltaPRD polymer stabilized with GMPPCP===		===Human dynamin 1 deltaPRD polymer stabilized with GMPPCP===
		+	{{ABSTRACT_PUBMED_21962517}}

-		+	==Function==
-	<!--	+	[[http://www.uniprot.org/uniprot/DYN1_HUMAN DYN1_HUMAN]] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. [[http://www.uniprot.org/uniprot/MX1_HUMAN MX1_HUMAN]] Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.<ref>PMID:20603636</ref> <ref>PMID:11880649</ref> <ref>PMID:15047845</ref> <ref>PMID:14752052</ref> <ref>PMID:15355513</ref> <ref>PMID:14687945</ref> <ref>PMID:15757897</ref> <ref>PMID:16413306</ref> <ref>PMID:16202617</ref> <ref>PMID:17374778</ref> <ref>PMID:18668195</ref> <ref>PMID:19109387</ref> <ref>PMID:21900240</ref> <ref>PMID:21992152</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21962517}}, adds the Publication Abstract~~ to ~~the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~)~~, where 21962517 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_21962517}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021962517</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021962517</ref><references group="xtra"/><references/>
	[[Category: Dynamin GTPase]]		[[Category: Dynamin GTPase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]