3zzn - Revision history

OCA at 11:16, 20 December 2023

OCA — Wed, 20 Dec 2023 11:16:43 GMT

←Older revision		Revision as of 11:16, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='3zzn' size='340' side='right'caption='[[3zzn]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3zzn' size='340' side='right'caption='[[3zzn]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zzn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Thet8 Thet8~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZZN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zzn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZZN FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ADP:ADENOSINE~~-~~5-DIPHOSPHATE'>ADP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2v7p\|2v7p]], [[2xxb\|2xxb]], [[2xxe\|2xxe]], [[2xxj\|2xxj]], [[4a73\|4a73]], [[2v6m\|2v6m]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/L~~-~~lactate_dehydrogenase L~~-~~lactate dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zzn OCA], [https://pdbe.org/3zzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zzn RCSB], [https://www.ebi.ac.uk/pdbsum/3zzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zzn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zzn OCA], [https://pdbe.org/3zzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zzn RCSB], [https://www.ebi.ac.uk/pdbsum/3zzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zzn ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LDH_THET8 LDH_THET8]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: L-lactate dehydrogenase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Thet8~~]]	+	[[Category: Thermus thermophilus HB8]]
-	[[Category: Colletier~~, J P~~]]	+	[[Category: Colletier JP]]
-	[[Category: Madern, D]]	+	[[Category: Madern D]]
-	[[Category: Mraihi, S]]	+	[[Category: Mraihi S]]
-	~~[[Category: Conformational energy landscape]]~~	+
-	~~[[Category: Hyperthermophilic]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Protein adaptation~~]]	+

OCA at 07:30, 18 August 2022

OCA — Thu, 18 Aug 2022 07:30:36 GMT

←Older revision		Revision as of 07:30, 18 August 2022
Line 3:		Line 3:
	<StructureSection load='3zzn' size='340' side='right'caption='[[3zzn]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3zzn' size='340' side='right'caption='[[3zzn]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zzn]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ZZN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zzn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZZN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v7p\|2v7p]], [[2xxb\|2xxb]], [[2xxe\|2xxe]], [[2xxj\|2xxj]], [[4a73\|4a73]], [[2v6m\|2v6m]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2v7p\|2v7p]], [[2xxb\|2xxb]], [[2xxe\|2xxe]], [[2xxj\|2xxj]], [[4a73\|4a73]], [[2v6m\|2v6m]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3zzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zzn OCA], [~~http~~://pdbe.org/3zzn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3zzn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3zzn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3zzn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zzn OCA], [https://pdbe.org/3zzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zzn RCSB], [https://www.ebi.ac.uk/pdbsum/3zzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zzn ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Lactate ~~Dehydrogenase~~\|Lactate ~~Dehydrogenase~~]]	+	*[[Lactate dehydrogenase 3D structures\|Lactate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:40, 3 April 2019

OCA — Wed, 03 Apr 2019 07:40:59 GMT

←Older revision		Revision as of 07:40, 3 April 2019
Line 1:		Line 1:

	==5-Mutant (R79W, R151A, E279A, E299A,E313A) Lactate-Dehydrogenase from Thermus thermophillus==		==5-Mutant (R79W, R151A, E279A, E299A,E313A) Lactate-Dehydrogenase from Thermus thermophillus==
-	<StructureSection load='3zzn' size='340' side='right' caption='[[3zzn]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='3zzn' size='340' side='right'caption='[[3zzn]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3zzn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZZN FirstGlance]. <br>		<table><tr><td colspan='2'>[[3zzn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZZN FirstGlance]. <br>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 3zzn" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3zzn" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Lactate Dehydrogenase\|Lactate Dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
		+	[[Category: Large Structures]]
	[[Category: Thet8]]		[[Category: Thet8]]
	[[Category: Colletier, J P]]		[[Category: Colletier, J P]]

OCA at 07:01, 28 February 2018

OCA — Wed, 28 Feb 2018 07:01:47 GMT

←Older revision		Revision as of 07:01, 28 February 2018
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 3zzn" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3zzn" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Lactate Dehydrogenase\|Lactate Dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:03, 10 December 2016

OCA — Sat, 10 Dec 2016 19:03:20 GMT

←Older revision		Revision as of 19:03, 10 December 2016
Line 1:		Line 1:
		+
	==5-Mutant (R79W, R151A, E279A, E299A,E313A) Lactate-Dehydrogenase from Thermus thermophillus==		==5-Mutant (R79W, R151A, E279A, E299A,E313A) Lactate-Dehydrogenase from Thermus thermophillus==
	<StructureSection load='3zzn' size='340' side='right' caption='[[3zzn]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3zzn' size='340' side='right' caption='[[3zzn]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3zzn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermus_thermophilus Thermus thermophilus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZZN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3zzn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZZN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v7p\|2v7p]], [[2xxb\|2xxb]], [[2xxe\|2xxe]], [[2xxj\|2xxj]], [[4a73\|4a73]], [[2v6m\|2v6m]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v7p\|2v7p]], [[2xxb\|2xxb]], [[2xxe\|2xxe]], [[2xxj\|2xxj]], [[4a73\|4a73]], [[2v6m\|2v6m]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zzn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zzn RCSB], [http://www.ebi.ac.uk/pdbsum/3zzn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zzn OCA], [http://pdbe.org/3zzn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zzn RCSB], [http://www.ebi.ac.uk/pdbsum/3zzn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zzn ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3zzn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
-	[[Category: ~~Thermus thermophilus~~]]	+	[[Category: Thet8]]
	[[Category: Colletier, J P]]		[[Category: Colletier, J P]]
	[[Category: Madern, D]]		[[Category: Madern, D]]

OCA at 16:42, 9 December 2014

OCA — Tue, 09 Dec 2014 16:42:00 GMT

←Older revision		Revision as of 16:42, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3zzn.~~png~~\|~~left~~\|~~200px~~]]	+	==5-Mutant (R79W, R151A, E279A, E299A,E313A) Lactate-Dehydrogenase from Thermus thermophillus==
		+	<StructureSection load='3zzn' size='340' side='right' caption='[[3zzn]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3zzn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZZN FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v7p\|2v7p]], [[2xxb\|2xxb]], [[2xxe\|2xxe]], [[2xxj\|2xxj]], [[4a73\|4a73]], [[2v6m\|2v6m]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zzn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zzn RCSB], [http://www.ebi.ac.uk/pdbsum/3zzn PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Proteins exist as a dynamic ensemble of inter-converting substates which defines their conformational energy landscapes. Recent work has indicated that mutations that shift the balance between conformational substates (CS) are one of the main mechanisms by which proteins evolve new functions. In the present study we probe this assertion by examining phenotypic protein adaptation to extreme conditions, using the allosteric tetrameric lactate dehydrogenase (LDH) from the hyperthermophilic bacterium Thermus thermophilus (Tt) as a model enzyme. In the presence of fructose 1, 6 bis-phosphate (FBP), allosteric LDHs catalyse the conversion of pyruvate to lactate with concomitant oxidation of NADH. The catalysis involves a structural transition between a low-affinity, inactive "T-state" and a high-affinity, active "R-state" with bound FBP. During this structural transition, two important residues undergo changes in their side chain conformations. These are R171 and H188, which are involved in substrate and FBP binding, respectively. We designed two mutants of Tt-LDH with one ("1-Mut") and five ("5-Mut") mutations distant from the active site, and characterized their catalytic, dynamical and structural properties. In 1-Mut Tt-LDH, without FBP, the K(m)(Pyr) is reduced compared to that of the wild-type, which is consistent with a complete shifting of the CS equilibrium of H188 to that observed in the R-state. By contrast, the CS populations of R171, k(cat) and protein stability are little changed. In 5-Mut Tt-LDH, without FBP, K(m)(Pyr) approaches the values it has with FBP, and becomes almost temperature-independent, k(cat) increases substantially and the CS populations of R171 shift towards those of the R-state. These changes are accompanied by a decrease in protein stability at higher temperature, which is consistent with an increased flexibility at lower temperature. Together these results show that the thermal properties of an enzyme can be strongly modified by only a few, or even a single, mutation, which serve to alter the equilibrium and, hence, the relative populations of functionally-important native-state CSs, without changing the nature of the CSs themselves. They also provide insights into the types of mutational pathways by which protein adaptation to temperature is achieved.

-	~~{{STRUCTURE_3zzn\| PDB=3zzn \| SCENE= }}~~	+	Sampling the conformational energy landscape of a hyperthermophilic protein by engineering key substitutions.,Colletier JP, Aleksandrov A, Coquelle N, Mraihi S, Mendoza-Barbera E, Field M, Madern D Mol Biol Evol. 2012 Jan 19. PMID:22319152<ref>PMID:22319152</ref>

-	~~===5-Mutant (R79W~~, ~~R151A, E279A, E299A,E313A) Lactate-Dehydrogenase from Thermus thermophillus===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22319152}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3zzn]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thermus_thermophilus Thermus thermophilus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZN OCA].~~	+

	==See Also==		==See Also==
	*[[Lactate Dehydrogenase\|Lactate Dehydrogenase]]		*[[Lactate Dehydrogenase\|Lactate Dehydrogenase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022319152<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
-	[[Category: Colletier, J P.]]	+	[[Category: Colletier, J P]]
-	[[Category: Madern, D.]]	+	[[Category: Madern, D]]
-	[[Category: Mraihi, S.]]	+	[[Category: Mraihi, S]]
	[[Category: Conformational energy landscape]]		[[Category: Conformational energy landscape]]
	[[Category: Hyperthermophilic]]		[[Category: Hyperthermophilic]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Protein adaptation]]		[[Category: Protein adaptation]]

OCA at 19:34, 20 October 2012

OCA — Sat, 20 Oct 2012 19:34:18 GMT

←Older revision		Revision as of 19:34, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3zzn]] is a 4 chain structure ~~of [[Lactate Dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZN OCA].	+	[[3zzn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZN OCA].

	==See Also==		==See Also==

OCA at 07:47, 27 July 2012

OCA — Fri, 27 Jul 2012 07:47:42 GMT

←Older revision		Revision as of 07:47, 27 July 2012
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	[[Image:3zzn.png\|left\|200px]]		[[Image:3zzn.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3zzn", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3zzn\| PDB=3zzn \| SCENE= }}		{{STRUCTURE_3zzn\| PDB=3zzn \| SCENE= }}

	===5-Mutant (R79W, R151A, E279A, E299A,E313A) Lactate-Dehydrogenase from Thermus thermophillus===		===5-Mutant (R79W, R151A, E279A, E299A,E313A) Lactate-Dehydrogenase from Thermus thermophillus===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22319152}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22319152 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22319152}}		{{ABSTRACT_PUBMED_22319152}}

	==About this Structure==		==About this Structure==
-	[[3zzn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZN OCA].	+	[[3zzn]] is a 4 chain structure of [[Lactate Dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZN OCA].
		+
		+	==See Also==
		+	*[[Lactate Dehydrogenase\|Lactate Dehydrogenase]]

	==Reference==		==Reference==

OCA at 05:09, 8 March 2012

OCA — Thu, 08 Mar 2012 05:09:07 GMT

←Older revision		Revision as of 05:09, 8 March 2012
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-	[[Image:3zzn.~~jpg~~\|left\|200px]]	+	[[Image:3zzn.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===5-Mutant (R79W, R151A, E279A, E299A,E313A) Lactate-Dehydrogenase from Thermus thermophillus===		===5-Mutant (R79W, R151A, E279A, E299A,E313A) Lactate-Dehydrogenase from Thermus thermophillus===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22319152}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22319152 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22319152}}

	==About this Structure==		==About this Structure==
	[[3zzn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZN OCA].		[[3zzn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZN OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022319152</ref><references group="xtra"/>
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]

OCA at 06:44, 8 February 2012

OCA — Wed, 08 Feb 2012 06:44:02 GMT

←Older revision		Revision as of 06:44, 8 February 2012
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-	~~'''Unreleased structure'''~~	+	[[Image:3zzn.jpg\|left\|200px]]

-	The ~~entry 3zzn~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3zzn", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3zzn\| PDB=3zzn \| SCENE= }}

-	~~Authors: Colletier~~, ~~J.P.~~, ~~Mraihi~~, S., ~~Madern, D.~~	+	===5-Mutant (R79W, R151A, E279A, E299A,E313A) Lactate-Dehydrogenase from Thermus thermophillus===

-	~~Description~~: 5-~~Mutant (R79W~~, ~~R151A~~, ~~E279A~~, ~~E299A,E313A) Lactate-Dehydrogenase from Thermus thermophillus~~	+
		+	==About this Structure==
		+	[[3zzn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZN OCA].
		+	[[Category: L-lactate dehydrogenase]]
		+	[[Category: Thermus thermophilus]]
		+	[[Category: Colletier, J P.]]
		+	[[Category: Madern, D.]]
		+	[[Category: Mraihi, S.]]
		+	[[Category: Conformational energy landscape]]
		+	[[Category: Hyperthermophilic]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Protein adaptation]]