4a0i - Revision history

OCA at 11:17, 20 December 2023

OCA — Wed, 20 Dec 2023 11:17:29 GMT

←Older revision		Revision as of 11:17, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4a0i]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A0I FirstGlance]. <br>		<table><tr><td colspan='2'>[[4a0i]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A0I FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.605Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1f3h\|1f3h]], [[1e31\|1e31]], [[1xox\|1xox]], [[4a0j\|4a0j]], [[4a0n\|4a0n]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0i OCA], [https://pdbe.org/4a0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a0i RCSB], [https://www.ebi.ac.uk/pdbsum/4a0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a0i ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0i OCA], [https://pdbe.org/4a0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a0i RCSB], [https://www.ebi.ac.uk/pdbsum/4a0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a0i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BIRC5_HUMAN BIRC5_HUMAN]] Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.<ref>PMID:10626797</ref> <ref>PMID:9859993</ref> <ref>PMID:12773388</ref> <ref>PMID:16322459</ref> <ref>PMID:16291752</ref> <ref>PMID:18591255</ref> <ref>PMID:20826784</ref> <ref>PMID:21536684</ref> [[https://www.uniprot.org/uniprot/SGOL1_HUMAN SGOL1_HUMAN]] Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.<ref>PMID:15737064</ref> <ref>PMID:15723797</ref> <ref>PMID:15604152</ref> <ref>PMID:16580887</ref> <ref>PMID:17617734</ref> <ref>PMID:17621308</ref> <ref>PMID:18331714</ref>	+	[https://www.uniprot.org/uniprot/BIRC5_HUMAN BIRC5_HUMAN] Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.<ref>PMID:10626797</ref> <ref>PMID:9859993</ref> <ref>PMID:12773388</ref> <ref>PMID:16322459</ref> <ref>PMID:16291752</ref> <ref>PMID:18591255</ref> <ref>PMID:20826784</ref> <ref>PMID:21536684</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 28:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Basquin, C]]	+	[[Category: Basquin C]]
-	[[Category: Conti, E]]	+	[[Category: Conti E]]
-	[[Category: Jayachandran, U]]	+	[[Category: Jayachandran U]]
-	[[Category: Jeyaprakash~~, A A]]~~	+	[[Category: Jeyaprakash AA]]
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Cell division]]~~	+
-	~~[[Category: Centromere]]~~	+
-	~~[[Category: Chromatin]]~~	+
-	~~[[Category: Chromosomal passenger complex]]~~	+
-	~~[[Category: Mitosis~~]]	+

OCA at 07:36, 18 August 2022

OCA — Thu, 18 Aug 2022 07:36:52 GMT

←Older revision		Revision as of 07:36, 18 August 2022
Line 1:		Line 1:

	==Crystal structure of Survivin bound to the N-terminal tail of hSgo1==		==Crystal structure of Survivin bound to the N-terminal tail of hSgo1==
-	<StructureSection load='4a0i' size='340' side='right' caption='[[4a0i]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='4a0i' size='340' side='right'caption='[[4a0i]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a0i]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4A0I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a0i]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A0I FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f3h\|1f3h]], [[1e31\|1e31]], [[1xox\|1xox]], [[4a0j\|4a0j]], [[4a0n\|4a0n]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1f3h\|1f3h]], [[1e31\|1e31]], [[1xox\|1xox]], [[4a0j\|4a0j]], [[4a0n\|4a0n]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4a0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0i OCA], [~~http~~://pdbe.org/4a0i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4a0i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4a0i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4a0i ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0i OCA], [https://pdbe.org/4a0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a0i RCSB], [https://www.ebi.ac.uk/pdbsum/4a0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a0i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BIRC5_HUMAN BIRC5_HUMAN]] Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.<ref>PMID:10626797</ref> <ref>PMID:9859993</ref> <ref>PMID:12773388</ref> <ref>PMID:16322459</ref> <ref>PMID:16291752</ref> <ref>PMID:18591255</ref> <ref>PMID:20826784</ref> <ref>PMID:21536684</ref> [[~~http~~://www.uniprot.org/uniprot/SGOL1_HUMAN SGOL1_HUMAN]] Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.<ref>PMID:15737064</ref> <ref>PMID:15723797</ref> <ref>PMID:15604152</ref> <ref>PMID:16580887</ref> <ref>PMID:17617734</ref> <ref>PMID:17621308</ref> <ref>PMID:18331714</ref>	+	[[https://www.uniprot.org/uniprot/BIRC5_HUMAN BIRC5_HUMAN]] Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.<ref>PMID:10626797</ref> <ref>PMID:9859993</ref> <ref>PMID:12773388</ref> <ref>PMID:16322459</ref> <ref>PMID:16291752</ref> <ref>PMID:18591255</ref> <ref>PMID:20826784</ref> <ref>PMID:21536684</ref> [[https://www.uniprot.org/uniprot/SGOL1_HUMAN SGOL1_HUMAN]] Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.<ref>PMID:15737064</ref> <ref>PMID:15723797</ref> <ref>PMID:15604152</ref> <ref>PMID:16580887</ref> <ref>PMID:17617734</ref> <ref>PMID:17621308</ref> <ref>PMID:18331714</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Basquin, C]]		[[Category: Basquin, C]]
	[[Category: Conti, E]]		[[Category: Conti, E]]

OCA at 16:52, 27 February 2019

OCA — Wed, 27 Feb 2019 16:52:17 GMT

←Older revision		Revision as of 16:52, 27 February 2019
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF SURVIVIN BOUND TO THE~~ N-~~TERMINAL TAIL OF HSGO1~~==	+	==Crystal structure of Survivin bound to the N-terminal tail of hSgo1==
	<StructureSection load='4a0i' size='340' side='right' caption='[[4a0i]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4a0i' size='340' side='right' caption='[[4a0i]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 11:37, 4 August 2016

OCA — Thu, 04 Aug 2016 11:37:51 GMT

←Older revision		Revision as of 11:37, 4 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF SURVIVIN BOUND TO THE N-TERMINAL TAIL OF HSGO1==		==CRYSTAL STRUCTURE OF SURVIVIN BOUND TO THE N-TERMINAL TAIL OF HSGO1==
	<StructureSection load='4a0i' size='340' side='right' caption='[[4a0i]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4a0i' size='340' side='right' caption='[[4a0i]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f3h\|1f3h]], [[1e31\|1e31]], [[1xox\|1xox]], [[4a0j\|4a0j]], [[4a0n\|4a0n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f3h\|1f3h]], [[1e31\|1e31]], [[1xox\|1xox]], [[4a0j\|4a0j]], [[4a0n\|4a0n]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a0i RCSB], [http://www.ebi.ac.uk/pdbsum/4a0i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0i OCA], [http://pdbe.org/4a0i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a0i RCSB], [http://www.ebi.ac.uk/pdbsum/4a0i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a0i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4a0i" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 14:00, 24 December 2014

OCA — Wed, 24 Dec 2014 14:00:21 GMT

←Older revision		Revision as of 14:00, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4a0i]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A0I FirstGlance]. <br>		<table><tr><td colspan='2'>[[4a0i]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A0I FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f3h\|1f3h]], [[1e31\|1e31]], [[1xox\|1xox]], [[4a0j\|4a0j]], [[4a0n\|4a0n]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f3h\|1f3h]], [[1e31\|1e31]], [[1xox\|1xox]], [[4a0j\|4a0j]], [[4a0n\|4a0n]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a0i RCSB], [http://www.ebi.ac.uk/pdbsum/4a0i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a0i RCSB], [http://www.ebi.ac.uk/pdbsum/4a0i PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BIRC5_HUMAN BIRC5_HUMAN]] Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.<ref>PMID:10626797</ref> <ref>PMID:9859993</ref> <ref>PMID:12773388</ref> <ref>PMID:16322459</ref> <ref>PMID:16291752</ref> <ref>PMID:18591255</ref> <ref>PMID:20826784</ref> <ref>PMID:21536684</ref> [[http://www.uniprot.org/uniprot/SGOL1_HUMAN SGOL1_HUMAN]] Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.<ref>PMID:15737064</ref> <ref>PMID:15723797</ref> <ref>PMID:15604152</ref> <ref>PMID:16580887</ref> <ref>PMID:17617734</ref> <ref>PMID:17621308</ref> <ref>PMID:18331714</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Survivin\|Survivin]]
	== References ==		== References ==
	<references/>		<references/>
Line 20:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Basquin, C.]]	+	[[Category: Basquin, C]]
-	[[Category: Conti, E.]]	+	[[Category: Conti, E]]
-	[[Category: Jayachandran, U.]]	+	[[Category: Jayachandran, U]]
-	[[Category: Jeyaprakash, A A.]]	+	[[Category: Jeyaprakash, A A]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Cell division]]		[[Category: Cell division]]

OCA at 08:09, 5 June 2014

OCA — Thu, 05 Jun 2014 08:09:48 GMT

←Older revision		Revision as of 08:09, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~4a0i.~~png~~\|~~left~~\|~~200px~~]]	+	==CRYSTAL STRUCTURE OF SURVIVIN BOUND TO THE N-TERMINAL TAIL OF HSGO1==
		+	<StructureSection load='4a0i' size='340' side='right' caption='[[4a0i]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4a0i]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A0I FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f3h\|1f3h]], [[1e31\|1e31]], [[1xox\|1xox]], [[4a0j\|4a0j]], [[4a0n\|4a0n]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a0i RCSB], [http://www.ebi.ac.uk/pdbsum/4a0i PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Localization of the chromosomal passenger complex (CPC) at centromeres during early mitosis is essential for accurate chromosome segregation and is dependent on the phosphorylation of histone H3. We report the 2.7 A resolution structure of the CPC subunit Survivin bound to the N-terminal tail of histone H3 carrying the Thr3 phosphorylation mark (Thr3ph). The BIR domain of Survivin recognizes the Ala1-Arg2-Thr3ph-Lys4 sequence, decoding the modification state and the free N terminus of histone H3 by a strategy similar to that used by PHD fingers. The structural analysis permitted the identification of putative Survivin-binding epitopes in other mitotic proteins, including human Shugoshin 1. Using biophysical and structural data, we show that a phospho-mimic N-terminal sequence such as that of hSgo1 (Ala1-Lys2-Glu3-Arg4) contains the specificity determinants to bind Survivin. Our findings suggest that the CPC engages in mutually exclusive interactions with other constituents of the mitotic machinery and a histone mark in chromatin.

-	~~<!--~~	+	Structural Basis for the Recognition of Phosphorylated Histone H3 by the Survivin Subunit of the Chromosomal Passenger Complex.,Jeyaprakash AA, Basquin C, Jayachandran U, Conti E Structure. 2011 Oct 25. PMID:22032967<ref>PMID:22032967</ref>
-	~~The line below this paragraph, containing "STRUCTURE_4a0i", creates~~ the ~~"Structure Box" on~~ the ~~page~~.	+
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded)~~,	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_4a0i\| PDB=4a0i \| SCENE= }}~~	+

-	~~===CRYSTAL STRUCTURE OF SURVIVIN BOUND TO THE N-TERMINAL TAIL OF HSGO1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_22032967}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22032967 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22032967}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[4a0i]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0I OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022032967<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Basquin, C.]]		[[Category: Basquin, C.]]

OCA at 18:11, 23 November 2011

OCA — Wed, 23 Nov 2011 18:11:37 GMT

←Older revision		Revision as of 18:11, 23 November 2011
Line 1:		Line 1:
-	[[Image:4a0i.~~jpg~~\|left\|200px]]	+	[[Image:4a0i.png\|left\|200px]]

	<!--		<!--

OCA at 11:40, 9 November 2011

OCA — Wed, 09 Nov 2011 11:40:39 GMT

←Older revision		Revision as of 11:40, 9 November 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:4a0i.jpg\|left\|200px]]

-	The ~~entry 4a0i~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4a0i", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4a0i\| PDB=4a0i \| SCENE= }}

-	~~Authors: Jeyaprakash, A.A., Basquin, C., Jayachandran, U., Conti, E.~~	+	===CRYSTAL STRUCTURE OF SURVIVIN BOUND TO THE N-TERMINAL TAIL OF HSGO1===

-	~~Description: Crystal structure of Survivin bound~~ to the N-~~terminal tail of hSgo1~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22032967}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22032967 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22032967}}
		+
		+	==About this Structure==
		+	[[4a0i]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0I OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022032967</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Basquin, C.]]
		+	[[Category: Conti, E.]]
		+	[[Category: Jayachandran, U.]]
		+	[[Category: Jeyaprakash, A A.]]
		+	[[Category: Cell cycle]]
		+	[[Category: Cell division]]
		+	[[Category: Centromere]]
		+	[[Category: Chromatin]]
		+	[[Category: Chromosomal passenger complex]]
		+	[[Category: Mitosis]]

OCA at 05:21, 28 September 2011

OCA — Wed, 28 Sep 2011 05:21:53 GMT

←Older revision		Revision as of 05:21, 28 September 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4a0i is ON HOLD	+	The entry 4a0i is ON HOLD until Paper Publication

	Authors: Jeyaprakash, A.A., Basquin, C., Jayachandran, U., Conti, E.		Authors: Jeyaprakash, A.A., Basquin, C., Jayachandran, U., Conti, E.

	Description: Crystal structure of Survivin bound to the N-terminal tail of hSgo1		Description: Crystal structure of Survivin bound to the N-terminal tail of hSgo1

OCA: Protected "4a0i" [edit=sysop:move=sysop]

OCA — Wed, 21 Sep 2011 05:37:50 GMT

Protected "4a0i" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:37, 21 September 2011