4a2m - Revision history

OCA at 07:13, 1 May 2024

OCA — Wed, 01 May 2024 07:13:43 GMT

←Older revision		Revision as of 07:13, 1 May 2024
Line 3:		Line 3:
	<StructureSection load='4a2m' size='340' side='right'caption='[[4a2m]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='4a2m' size='340' side='right'caption='[[4a2m]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a2m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bactn Bactn~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A2M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a2m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron_VPI-5482 Bacteroides thetaiotaomicron VPI-5482]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A2M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCD:4,5-DEHYDRO-D-GLUCURONIC+ACID'>GCD</scene>, <scene name='pdbligand=NGS:2-(ACETYLAMINO)-2-DEOXY-6-O-SULFO-BETA-D-GLUCOPYRANOSE'>NGS</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.4Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4a2l\|4a2l]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCD:4,5-DEHYDRO-D-GLUCURONIC+ACID'>GCD</scene>, <scene name='pdbligand=NGS:2-(ACETYLAMINO)-2-DEOXY-6-O-SULFO-BETA-D-GLUCOPYRANOSE'>NGS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a2m OCA], [https://pdbe.org/4a2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a2m RCSB], [https://www.ebi.ac.uk/pdbsum/4a2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a2m ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a2m OCA], [https://pdbe.org/4a2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a2m RCSB], [https://www.ebi.ac.uk/pdbsum/4a2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a2m ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/Q89YR8_BACTN Q89YR8_BACTN]
-	Signaling across the membrane in response to extracellular stimuli is essential for survival of all cells. In bacteria, responses to environmental changes are predominantly mediated by two-component systems, which are typically composed of a membrane-spanning sensor histidine kinase and a cytoplasmic response regulator. In the human gut symbiont Bacteroides thetaiotaomicron, hybrid two-component systems are a key part of the bacterium's ability to sense and degrade complex carbohydrates in the gut. Here, we identify the activating ligand of the hybrid two-component system, BT4663, which controls heparin and heparan sulfate acquisition and degradation in this prominent gut microbe, and report the crystal structure of the extracellular sensor domain in both apo and ligand-bound forms. Current models for signal transduction across the membrane involve either a piston-like or rotational displacement of the transmembrane helices to modulate activity of the linked cytoplasmic kinases. The structures of the BT4663 sensor domain reveal a significant conformational change in the homodimer on ligand binding, which results in a scissor-like closing of the C-termini of each protomer. We propose this movement activates the attached intracellular kinase domains and represents an allosteric mechanism for bacterial transmembrane signaling distinct from previously described models, thus expanding our understanding of signal transduction across the membrane, a fundamental requirement in many important biological processes.	+
-		+
-	A scissor blade-like closing mechanism implicated in transmembrane signaling in a Bacteroides hybrid two-component system.,Lowe EC, Basle A, Czjzek M, Firbank SJ, Bolam DN Proc Natl Acad Sci U S A. 2012 May 8;109(19):~~7298-303. Epub 2012 Apr 24. PMID:22532667<ref>PMID:22532667<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®~~/~~PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 4a2m" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bactn~~]]	+	[[Category: Bacteroides thetaiotaomicron VPI-5482]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Basle, A]]	+	[[Category: Basle A]]
-	[[Category: Bolam~~, D N~~]]	+	[[Category: Bolam DN]]
-	[[Category: Czjzek, M]]	+	[[Category: Czjzek M]]
-	[[Category: Firbank~~, S J~~]]	+	[[Category: Firbank SJ]]
-	[[Category: Lowe~~, E C]]~~	+	[[Category: Lowe EC]]
-	~~[[Category: Beta-propeller]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 07:41, 18 August 2022

OCA — Thu, 18 Aug 2022 07:41:00 GMT

←Older revision		Revision as of 07:41, 18 August 2022
Line 1:		Line 1:

	==Structure of the periplasmic domain of the heparin and heparan sulphate sensing hybrid two component system BT4663 in apo and ligand bound forms==		==Structure of the periplasmic domain of the heparin and heparan sulphate sensing hybrid two component system BT4663 in apo and ligand bound forms==
-	<StructureSection load='4a2m' size='340' side='right' caption='[[4a2m]], [[Resolution\|resolution]] 3.40Å' scene=''>	+	<StructureSection load='4a2m' size='340' side='right'caption='[[4a2m]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a2m]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bactn Bactn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A2M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4A2M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a2m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bactn Bactn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A2M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCD:4,5-DEHYDRO-D-GLUCURONIC+ACID'>GCD</scene>, <scene name='pdbligand=NGS:2-(ACETYLAMINO)-2-DEOXY-6-O-SULFO-BETA-D-GLUCOPYRANOSE'>NGS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCD:4,5-DEHYDRO-D-GLUCURONIC+ACID'>GCD</scene>, <scene name='pdbligand=NGS:2-(ACETYLAMINO)-2-DEOXY-6-O-SULFO-BETA-D-GLUCOPYRANOSE'>NGS</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a2l\|4a2l]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4a2l\|4a2l]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4a2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a2m OCA], [~~http~~://pdbe.org/4a2m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4a2m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4a2m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4a2m ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a2m OCA], [https://pdbe.org/4a2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a2m RCSB], [https://www.ebi.ac.uk/pdbsum/4a2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a2m ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Bactn]]		[[Category: Bactn]]
		+	[[Category: Large Structures]]
	[[Category: Basle, A]]		[[Category: Basle, A]]
	[[Category: Bolam, D N]]		[[Category: Bolam, D N]]

OCA at 18:56, 10 December 2016

OCA — Sat, 10 Dec 2016 18:56:20 GMT

←Older revision		Revision as of 18:56, 10 December 2016
Line 1:		Line 1:
		+
	==Structure of the periplasmic domain of the heparin and heparan sulphate sensing hybrid two component system BT4663 in apo and ligand bound forms==		==Structure of the periplasmic domain of the heparin and heparan sulphate sensing hybrid two component system BT4663 in apo and ligand bound forms==
	<StructureSection load='4a2m' size='340' side='right' caption='[[4a2m]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='4a2m' size='340' side='right' caption='[[4a2m]], [[Resolution\|resolution]] 3.40Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCD:4,5-DEHYDRO-D-GLUCURONIC+ACID'>GCD</scene>, <scene name='pdbligand=NGS:2-(ACETYLAMINO)-2-DEOXY-6-O-SULFO-BETA-D-GLUCOPYRANOSE'>NGS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCD:4,5-DEHYDRO-D-GLUCURONIC+ACID'>GCD</scene>, <scene name='pdbligand=NGS:2-(ACETYLAMINO)-2-DEOXY-6-O-SULFO-BETA-D-GLUCOPYRANOSE'>NGS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a2l\|4a2l]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a2l\|4a2l]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a2m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a2m RCSB], [http://www.ebi.ac.uk/pdbsum/4a2m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a2m OCA], [http://pdbe.org/4a2m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a2m RCSB], [http://www.ebi.ac.uk/pdbsum/4a2m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a2m ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4a2m" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:32, 3 December 2014

OCA — Wed, 03 Dec 2014 07:32:55 GMT

←Older revision		Revision as of 07:32, 3 December 2014
Line 2:		Line 2:
	<StructureSection load='4a2m' size='340' side='right' caption='[[4a2m]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='4a2m' size='340' side='right' caption='[[4a2m]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a2m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A2M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a2m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bactn Bactn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A2M FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCD:4,5-DEHYDRO-D-GLUCURONIC+ACID'>GCD</scene>, <scene name='pdbligand=NGS:2-(ACETYLAMINO)-2-DEOXY-6-O-SULFO-BETA-D-GLUCOPYRANOSE'>NGS</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCD:4,5-DEHYDRO-D-GLUCURONIC+ACID'>GCD</scene>, <scene name='pdbligand=NGS:2-(ACETYLAMINO)-2-DEOXY-6-O-SULFO-BETA-D-GLUCOPYRANOSE'>NGS</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a2l\|4a2l]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a2l\|4a2l]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a2m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a2m RCSB], [http://www.ebi.ac.uk/pdbsum/4a2m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a2m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a2m RCSB], [http://www.ebi.ac.uk/pdbsum/4a2m PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacteroides thetaiotaomicron~~]]	+	[[Category: Bactn]]
-	[[Category: Basle, A.]]	+	[[Category: Basle, A]]
-	[[Category: Bolam, D N.]]	+	[[Category: Bolam, D N]]
-	[[Category: Czjzek, M.]]	+	[[Category: Czjzek, M]]
-	[[Category: Firbank, S J.]]	+	[[Category: Firbank, S J]]
-	[[Category: Lowe, E C.]]	+	[[Category: Lowe, E C]]
	[[Category: Beta-propeller]]		[[Category: Beta-propeller]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 07:57, 5 June 2014

OCA — Thu, 05 Jun 2014 07:57:11 GMT

←Older revision		Revision as of 07:57, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~4a2m.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of the periplasmic domain of the heparin and heparan sulphate sensing hybrid two component system BT4663 in apo and ligand bound forms==
		+	<StructureSection load='4a2m' size='340' side='right' caption='[[4a2m]], [[Resolution\|resolution]] 3.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4a2m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A2M FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCD:4,5-DEHYDRO-D-GLUCURONIC+ACID'>GCD</scene>, <scene name='pdbligand=NGS:2-(ACETYLAMINO)-2-DEOXY-6-O-SULFO-BETA-D-GLUCOPYRANOSE'>NGS</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a2l\|4a2l]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a2m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a2m RCSB], [http://www.ebi.ac.uk/pdbsum/4a2m PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Signaling across the membrane in response to extracellular stimuli is essential for survival of all cells. In bacteria, responses to environmental changes are predominantly mediated by two-component systems, which are typically composed of a membrane-spanning sensor histidine kinase and a cytoplasmic response regulator. In the human gut symbiont Bacteroides thetaiotaomicron, hybrid two-component systems are a key part of the bacterium's ability to sense and degrade complex carbohydrates in the gut. Here, we identify the activating ligand of the hybrid two-component system, BT4663, which controls heparin and heparan sulfate acquisition and degradation in this prominent gut microbe, and report the crystal structure of the extracellular sensor domain in both apo and ligand-bound forms. Current models for signal transduction across the membrane involve either a piston-like or rotational displacement of the transmembrane helices to modulate activity of the linked cytoplasmic kinases. The structures of the BT4663 sensor domain reveal a significant conformational change in the homodimer on ligand binding, which results in a scissor-like closing of the C-termini of each protomer. We propose this movement activates the attached intracellular kinase domains and represents an allosteric mechanism for bacterial transmembrane signaling distinct from previously described models, thus expanding our understanding of signal transduction across the membrane, a fundamental requirement in many important biological processes.

-	<!--	+	A scissor blade-like closing mechanism implicated in transmembrane signaling in a Bacteroides hybrid two-component system.,Lowe EC, Basle A, Czjzek M, Firbank SJ, Bolam DN Proc Natl Acad Sci U S A. 2012 May 8;109(19):7298-303. Epub 2012 Apr 24. PMID:22532667<ref>PMID:22532667</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_4a2m"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_4a2m\| PDB=4a2m \| SCENE= }}~~	+

-	~~===Structure~~ of the ~~periplasmic domain of the heparin and heparan sulphate sensing hybrid two component system BT4663 in apo and ligand bound forms===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22532667}}, adds the Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22532667 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22532667}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[4a2m]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A2M OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022532667<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bacteroides thetaiotaomicron]]		[[Category: Bacteroides thetaiotaomicron]]
	[[Category: Basle, A.]]		[[Category: Basle, A.]]

OCA at 05:01, 23 May 2012

OCA — Wed, 23 May 2012 05:01:31 GMT

←Older revision		Revision as of 05:01, 23 May 2012
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-	[[Image:4a2m.~~jpg~~\|left\|200px]]	+	[[Image:4a2m.png\|left\|200px]]

	<!--		<!--
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	===Structure of the periplasmic domain of the heparin and heparan sulphate sensing hybrid two component system BT4663 in apo and ligand bound forms===		===Structure of the periplasmic domain of the heparin and heparan sulphate sensing hybrid two component system BT4663 in apo and ligand bound forms===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22532667}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22532667 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22532667}}

	==About this Structure==		==About this Structure==
	[[4a2m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A2M OCA].		[[4a2m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A2M OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022532667</ref><references group="xtra"/>
	[[Category: Bacteroides thetaiotaomicron]]		[[Category: Bacteroides thetaiotaomicron]]
	[[Category: Basle, A.]]		[[Category: Basle, A.]]

OCA at 19:27, 2 May 2012

OCA — Wed, 02 May 2012 19:27:21 GMT

←Older revision		Revision as of 19:27, 2 May 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4a2m.jpg\|left\|200px]]

-	The ~~entry 4a2m~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4a2m", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4a2m\| PDB=4a2m \| SCENE= }}

-	~~Authors: Lowe, E.C., Basle, A., Czjzek, M., Firbank, S.J., Bolam, D.N.~~	+	===Structure of the periplasmic domain of the heparin and heparan sulphate sensing hybrid two component system BT4663 in apo and ligand bound forms===

-	~~Description:~~ Structure ~~of the periplasmic domain of the heparin and heparan sulphate sensing hybrid two component system BT4663 in apo and ligand bound forms~~	+
		+	==About this Structure==
		+	[[4a2m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A2M OCA].
		+	[[Category: Bacteroides thetaiotaomicron]]
		+	[[Category: Basle, A.]]
		+	[[Category: Bolam, D N.]]
		+	[[Category: Czjzek, M.]]
		+	[[Category: Firbank, S J.]]
		+	[[Category: Lowe, E C.]]
		+	[[Category: Beta-propeller]]
		+	[[Category: Transcription]]

OCA at 09:00, 30 October 2011

OCA — Sun, 30 Oct 2011 09:00:55 GMT

←Older revision		Revision as of 09:00, 30 October 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4a2m is ON HOLD	+	The entry 4a2m is ON HOLD until Paper Publication

	Authors: Lowe, E.C., Basle, A., Czjzek, M., Firbank, S.J., Bolam, D.N.		Authors: Lowe, E.C., Basle, A., Czjzek, M., Firbank, S.J., Bolam, D.N.

	Description: Structure of the periplasmic domain of the heparin and heparan sulphate sensing hybrid two component system BT4663 in apo and ligand bound forms		Description: Structure of the periplasmic domain of the heparin and heparan sulphate sensing hybrid two component system BT4663 in apo and ligand bound forms

OCA: Protected "4a2m" [edit=sysop:move=sysop]

OCA — Wed, 05 Oct 2011 06:19:42 GMT

Protected "4a2m" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:19, 5 October 2011

OCA: New page: '''Unreleased structure''' The entry 4a2m is ON HOLD Authors: Lowe, E.C., Basle, A., Czjzek, M., Firbank, S.J., Bolam, D.N. Description: Structure of the periplasmic domain of the hepa...

OCA — Wed, 05 Oct 2011 06:19:41 GMT

New page: '''Unreleased structure''' The entry 4a2m is ON HOLD Authors: Lowe, E.C., Basle, A., Czjzek, M., Firbank, S.J., Bolam, D.N. Description: Structure of the periplasmic domain of the hepa...

New page

'''Unreleased structure'''

The entry 4a2m is ON HOLD

Authors: Lowe, E.C., Basle, A., Czjzek, M., Firbank, S.J., Bolam, D.N.

Description: Structure of the periplasmic domain of the heparin and heparan sulphate sensing hybrid two component system BT4663 in apo and ligand bound forms