4a68 - Revision history

OCA at 11:20, 20 December 2023

OCA — Wed, 20 Dec 2023 11:20:20 GMT

←Older revision		Revision as of 11:20, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4a68' size='340' side='right'caption='[[4a68]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4a68' size='340' side='right'caption='[[4a68]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"vibrio_subtilis"_ehrenberg_1835 "vibrio~~ subtilis~~" ehrenberg 1835~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A68 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A68 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1uvw\|1uvw]], [[1of0\|1of0]], [[1w6w\|1w6w]], [[2x88\|2x88]], [[4a67\|4a67]], [[4a66\|4a66]], [[1w8e\|1w8e]], [[1w6l\|1w6l]], [[1gsk\|1gsk]], [[2bhf\|2bhf]], [[2x87\|2x87]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Laccase Laccase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a68 OCA], [https://pdbe.org/4a68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a68 RCSB], [https://www.ebi.ac.uk/pdbsum/4a68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a68 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a68 OCA], [https://pdbe.org/4a68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a68 RCSB], [https://www.ebi.ac.uk/pdbsum/4a68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a68 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/COTA_BACSU COTA_BACSU]] Involved in brown pigmentation during sporogenesis.	+	[https://www.uniprot.org/uniprot/COTA_BACSU COTA_BACSU] Involved in brown pigmentation during sporogenesis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vibrio~~ subtilis ~~ehrenberg 1835]]~~	+	[[Category: Bacillus subtilis]]
-	~~[[Category: Laccase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bento, I]]	+	[[Category: Bento I]]
-	[[Category: Lindley~~, P F~~]]	+	[[Category: Lindley PF]]
-	[[Category: Silva~~, C S]]~~	+	[[Category: Silva CS]]
-	~~[[Category: Dioxygen reduction]]~~	+
-	~~[[Category: Multi-copper oxidase]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Oxidoreductase activity]]~~	+
-	~~[[Category: Trinuclear cluster~~]]	+

OCA at 07:47, 18 August 2022

OCA — Thu, 18 Aug 2022 07:47:54 GMT

←Older revision		Revision as of 07:47, 18 August 2022
Line 3:		Line 3:
	<StructureSection load='4a68' size='340' side='right'caption='[[4a68]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4a68' size='340' side='right'caption='[[4a68]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a68]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A68 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4A68 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A68 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uvw\|1uvw]], [[1of0\|1of0]], [[1w6w\|1w6w]], [[2x88\|2x88]], [[4a67\|4a67]], [[4a66\|4a66]], [[1w8e\|1w8e]], [[1w6l\|1w6l]], [[1gsk\|1gsk]], [[2bhf\|2bhf]], [[2x87\|2x87]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1uvw\|1uvw]], [[1of0\|1of0]], [[1w6w\|1w6w]], [[2x88\|2x88]], [[4a67\|4a67]], [[4a66\|4a66]], [[1w8e\|1w8e]], [[1w6l\|1w6l]], [[1gsk\|1gsk]], [[2bhf\|2bhf]], [[2x87\|2x87]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Laccase Laccase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Laccase Laccase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4a68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a68 OCA], [~~http~~://pdbe.org/4a68 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4a68 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4a68 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4a68 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a68 OCA], [https://pdbe.org/4a68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a68 RCSB], [https://www.ebi.ac.uk/pdbsum/4a68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a68 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/COTA_BACSU COTA_BACSU]] Involved in brown pigmentation during sporogenesis.	+	[[https://www.uniprot.org/uniprot/COTA_BACSU COTA_BACSU]] Involved in brown pigmentation during sporogenesis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[~~CotA laccase~~\|~~CotA laccase~~]]	+	*[[Laccase 3D structures\|Laccase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	[[Category: Vibrio subtilis ehrenberg 1835]]		[[Category: Vibrio subtilis ehrenberg 1835]]
	[[Category: Laccase]]		[[Category: Laccase]]
		+	[[Category: Large Structures]]
	[[Category: Bento, I]]		[[Category: Bento, I]]
	[[Category: Lindley, P F]]		[[Category: Lindley, P F]]

OCA at 09:20, 6 March 2019

OCA — Wed, 06 Mar 2019 09:20:01 GMT

←Older revision		Revision as of 09:20, 6 March 2019
Line 1:		Line 1:

	==Mutations in the neighbourhood of CotA-laccase trinuclear site: D116N mutant==		==Mutations in the neighbourhood of CotA-laccase trinuclear site: D116N mutant==
-	<StructureSection load='4a68' size='340' side='right' caption='[[4a68]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4a68' size='340' side='right'caption='[[4a68]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a68]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"~~bacillus_globigii~~"~~_migula_1900~~ "~~bacillus globigii~~" ~~migula 1900~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A68 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a68]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A68 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uvw\|1uvw]], [[1of0\|1of0]], [[1w6w\|1w6w]], [[2x88\|2x88]], [[4a67\|4a67]], [[4a66\|4a66]], [[1w8e\|1w8e]], [[1w6l\|1w6l]], [[1gsk\|1gsk]], [[2bhf\|2bhf]], [[2x87\|2x87]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uvw\|1uvw]], [[1of0\|1of0]], [[1w6w\|1w6w]], [[2x88\|2x88]], [[4a67\|4a67]], [[4a66\|4a66]], [[1w8e\|1w8e]], [[1w6l\|1w6l]], [[1gsk\|1gsk]], [[2bhf\|2bhf]], [[2x87\|2x87]]</td></tr>
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus globigii migula 1900~~]]	+	[[Category: Vibrio subtilis ehrenberg 1835]]
	[[Category: Laccase]]		[[Category: Laccase]]
	[[Category: Bento, I]]		[[Category: Bento, I]]

OCA at 18:33, 4 August 2016

OCA — Thu, 04 Aug 2016 18:33:45 GMT

←Older revision		Revision as of 18:33, 4 August 2016
Line 1:		Line 1:
		+
	==Mutations in the neighbourhood of CotA-laccase trinuclear site: D116N mutant==		==Mutations in the neighbourhood of CotA-laccase trinuclear site: D116N mutant==
	<StructureSection load='4a68' size='340' side='right' caption='[[4a68]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4a68' size='340' side='right' caption='[[4a68]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a68]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_subtilis Bacillus subtilis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A68 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a68]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A68 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uvw\|1uvw]], [[1of0\|1of0]], [[1w6w\|1w6w]], [[2x88\|2x88]], [[4a67\|4a67]], [[4a66\|4a66]], [[1w8e\|1w8e]], [[1w6l\|1w6l]], [[1gsk\|1gsk]], [[2bhf\|2bhf]], [[2x87\|2x87]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uvw\|1uvw]], [[1of0\|1of0]], [[1w6w\|1w6w]], [[2x88\|2x88]], [[4a67\|4a67]], [[4a66\|4a66]], [[1w8e\|1w8e]], [[1w6l\|1w6l]], [[1gsk\|1gsk]], [[2bhf\|2bhf]], [[2x87\|2x87]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Laccase Laccase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Laccase Laccase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a68 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a68 RCSB], [http://www.ebi.ac.uk/pdbsum/4a68 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a68 OCA], [http://pdbe.org/4a68 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a68 RCSB], [http://www.ebi.ac.uk/pdbsum/4a68 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a68 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4a68" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus ~~subtilis~~]]	+	[[Category: Bacillus globigii migula 1900]]
	[[Category: Laccase]]		[[Category: Laccase]]
	[[Category: Bento, I]]		[[Category: Bento, I]]

OCA at 11:57, 25 December 2014

OCA — Thu, 25 Dec 2014 11:57:01 GMT

←Older revision		Revision as of 11:57, 25 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4a68.~~png~~\|~~left~~\|~~200px~~]]	+	==Mutations in the neighbourhood of CotA-laccase trinuclear site: D116N mutant==
		+	<StructureSection load='4a68' size='340' side='right' caption='[[4a68]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4a68]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A68 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uvw\|1uvw]], [[1of0\|1of0]], [[1w6w\|1w6w]], [[2x88\|2x88]], [[4a67\|4a67]], [[4a66\|4a66]], [[1w8e\|1w8e]], [[1w6l\|1w6l]], [[1gsk\|1gsk]], [[2bhf\|2bhf]], [[2x87\|2x87]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Laccase Laccase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a68 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a68 RCSB], [http://www.ebi.ac.uk/pdbsum/4a68 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/COTA_BACSU COTA_BACSU]] Involved in brown pigmentation during sporogenesis.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Multi-copper oxidases constitute a family of proteins that are capable of coupling the one-electron oxidation of four substrate equivalents to the four-electron reduction of dioxygen to two molecules of water. The main catalytic stages occurring during the process have already been identified, but several questions remain, including the nature of the protonation events that take place during the reductive cleavage of dioxygen to water. The presence of a structurally conserved acidic residue (Glu498 in CotA laccase from Bacillus subtilis) at the dioxygen-entrance channel has been reported to play a decisive role in the protonation mechanisms, channelling protons during the reduction process and stabilizing the site as a whole. A second acidic residue that is sequentially conserved in multi-copper oxidases and sited within the exit channel (Asp116 in CotA) has also been identified as being important in the protonation process. In this study, CotA laccase has been used as a model system to assess the role of Asp116 in the reduction process of dioxygen to water. The crystal structures of three distinct mutants, D116E, D116N and D116A, produced by site-saturation mutagenesis have been determined. In addition, theoretical calculations have provided further support for a role of this residue in the protonation events.

-	~~{{STRUCTURE_4a68\| PDB=4a68 \| SCENE= }}~~	+	The role of Asp116 in the reductive cleavage of dioxygen to water in CotA laccase: assistance during the proton-transfer mechanism.,Silva CS, Damas JM, Chen Z, Brissos V, Martins LO, Soares CM, Lindley PF, Bento I Acta Crystallogr D Biol Crystallogr. 2012 Feb;68(Pt 2):186-93. Epub 2012 Jan 17. PMID:22281748<ref>PMID:22281748</ref>

-	~~===Mutations in~~ the ~~neighbourhood~~ of ~~CotA-laccase trinuclear site: D116N mutant===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_22281748}}~~	+	==See Also==
-		+	*[[CotA laccase\|CotA laccase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4a68~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A68 OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:022281748<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Laccase]]		[[Category: Laccase]]
-	[[Category: Bento, I.]]	+	[[Category: Bento, I]]
-	[[Category: Lindley, P F.]]	+	[[Category: Lindley, P F]]
-	[[Category: Silva, C S.]]	+	[[Category: Silva, C S]]
	[[Category: Dioxygen reduction]]		[[Category: Dioxygen reduction]]
	[[Category: Multi-copper oxidase]]		[[Category: Multi-copper oxidase]]

OCA at 09:51, 21 October 2012

OCA — Sun, 21 Oct 2012 09:51:22 GMT

←Older revision		Revision as of 09:51, 21 October 2012
Line 9:		Line 9:
	==About this Structure==		==About this Structure==
	[[4a68]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A68 OCA].		[[4a68]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A68 OCA].
-
-	==See Also==
-	*[[Spore coat protein\|Spore coat protein]]

	==Reference==		==Reference==

OCA at 16:25, 20 October 2012

OCA — Sat, 20 Oct 2012 16:25:03 GMT

←Older revision		Revision as of 16:25, 20 October 2012
Line 1:		Line 1:
	[[Image:4a68.png\|left\|200px]]		[[Image:4a68.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_4a68", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_4a68\| PDB=4a68 \| SCENE= }}		{{STRUCTURE_4a68\| PDB=4a68 \| SCENE= }}

	===Mutations in the neighbourhood of CotA-laccase trinuclear site: D116N mutant===		===Mutations in the neighbourhood of CotA-laccase trinuclear site: D116N mutant===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22281748}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22281748 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22281748}}		{{ABSTRACT_PUBMED_22281748}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[~~Ouabain~~]]	+	*[[Spore coat protein\|Spore coat protein]]

	==Reference==		==Reference==

OCA at 06:28, 28 March 2012

OCA — Wed, 28 Mar 2012 06:28:36 GMT

←Older revision		Revision as of 06:28, 28 March 2012
Line 11:		Line 11:
	===Mutations in the neighbourhood of CotA-laccase trinuclear site: D116N mutant===		===Mutations in the neighbourhood of CotA-laccase trinuclear site: D116N mutant===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22281748}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22281748 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22281748}}

	==About this Structure==		==About this Structure==
Line 17:		Line 23:
	==See Also==		==See Also==
	*[[Ouabain]]		*[[Ouabain]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022281748</ref><references group="xtra"/>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Laccase]]		[[Category: Laccase]]

OCA at 07:33, 1 February 2012

OCA — Wed, 01 Feb 2012 07:33:47 GMT

←Older revision		Revision as of 07:33, 1 February 2012
Line 1:		Line 1:
-	[[Image:4a68.~~jpg~~\|left\|200px]]	+	[[Image:4a68.png\|left\|200px]]

	<!--		<!--
Line 14:		Line 14:
	==About this Structure==		==About this Structure==
	[[4a68]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A68 OCA].		[[4a68]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A68 OCA].
		+
		+	==See Also==
		+	*[[Ouabain]]
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Laccase]]		[[Category: Laccase]]

OCA at 06:51, 25 January 2012

OCA — Wed, 25 Jan 2012 06:51:18 GMT

←Older revision		Revision as of 06:51, 25 January 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4a68.jpg\|left\|200px]]

-	The ~~entry 4a68~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4a68", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4a68\| PDB=4a68 \| SCENE= }}

-	~~Authors~~: ~~Silva, C.S., Lindley, P.F., Bento, I.~~	+	===Mutations in the neighbourhood of CotA-laccase trinuclear site: D116N mutant===

-	~~Description~~: ~~Mutations in the neighbourhood of CotA~~-~~laccase trinuclear site~~: ~~D116N mutant~~	+
		+	==About this Structure==
		+	[[4a68]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A68 OCA].
		+	[[Category: Bacillus subtilis]]
		+	[[Category: Laccase]]
		+	[[Category: Bento, I.]]
		+	[[Category: Lindley, P F.]]
		+	[[Category: Silva, C S.]]
		+	[[Category: Dioxygen reduction]]
		+	[[Category: Multi-copper oxidase]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Oxidoreductase activity]]
		+	[[Category: Trinuclear cluster]]