4a99 - Revision history

OCA at 11:22, 20 December 2023

OCA — Wed, 20 Dec 2023 11:22:20 GMT

←Older revision		Revision as of 11:22, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4a99' size='340' side='right'caption='[[4a99]], [[Resolution\|resolution]] 2.18Å' scene=''>		<StructureSection load='4a99' size='340' side='right'caption='[[4a99]], [[Resolution\|resolution]] 2.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a99]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_thetaiotaomicron"_distaso_1912 "bacillus~~ thetaiotaomicron~~" distaso 1912~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A99 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A99 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a99]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A99 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A99 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MIY:(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE'>MIY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.18Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xyo\|2xyo]], [[2xdo\|2xdo]], [[2y6q\|2y6q]], [[2y6r\|2y6r]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MIY:(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE'>MIY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a99 OCA], [https://pdbe.org/4a99 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a99 RCSB], [https://www.ebi.ac.uk/pdbsum/4a99 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a99 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a99 OCA], [https://pdbe.org/4a99 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a99 RCSB], [https://www.ebi.ac.uk/pdbsum/4a99 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a99 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TETX_BACT4 TETX_BACT4] An FAD-requiring monooxygenase active on tetracycline antibiotic derivatives, which leads to their inactivation (PubMed:15452119, PubMed:16128584). Hydroxylates carbon 11a of oxytetracycline and tigecycline (PubMed:15452119, PubMed:26097034). Acts on many tetracycline analogs (chlorotetracycline, demeclocycline, doxycycline, minocycline, oxytetracyclinee), probably by monooxygenization (PubMed:15452119, PubMed:16128584). Tigecycline, a new generation tetracycline antibiotic, is rendered less effective against E.coli by this monooxygenation, is much weaker at inhibiting translation in vitro and binds Mg(2+) considerably less well (PubMed:16128584, PubMed:26097034). Expression in E.coli BW25113 reduces its growth rate about 5%. The reaction probably proceeds by FAD reduction by NADPH and, second, hydroxylation of antibiotic in a ping-pong mechanism (PubMed:23236139). Degrades chlortetracycline, probably by monooxygenation (PubMed:15452119, PubMed:28481346). Slowly oxidizes anhydrotetracycline, the final substrate in tetracycline biosynthesis (PubMed:26097034).[HAMAP-Rule:MF_00845]<ref>PMID:15452119</ref> <ref>PMID:16128584</ref> <ref>PMID:23236139</ref> <ref>PMID:26097034</ref> <ref>PMID:28481346</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ thetaiotaomicron ~~distaso 1912~~]]	+	[[Category: Bacteroides thetaiotaomicron]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hinrichs, W]]	+	[[Category: Hinrichs W]]
-	[[Category: Palm~~, G J~~]]	+	[[Category: Palm GJ]]
-	[[Category: Volkers, G]]	+	[[Category: Volkers G]]
-	[[Category: Weiss~~, M S]]~~	+	[[Category: Weiss MS]]
-	~~[[Category: Flavin]]~~	+
-	~~[[Category: Flavoprotein]]~~	+
-	~~[[Category: Monooxygenase]]~~	+
-	~~[[Category: Tetracycline degradation~~]]	+

OCA at 07:53, 18 August 2022

OCA — Thu, 18 Aug 2022 07:53:39 GMT

←Older revision		Revision as of 07:53, 18 August 2022
Line 3:		Line 3:
	<StructureSection load='4a99' size='340' side='right'caption='[[4a99]], [[Resolution\|resolution]] 2.18Å' scene=''>		<StructureSection load='4a99' size='340' side='right'caption='[[4a99]], [[Resolution\|resolution]] 2.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a99]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_thetaiotaomicron"_distaso_1912 "bacillus thetaiotaomicron" distaso 1912]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A99 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4A99 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a99]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_thetaiotaomicron"_distaso_1912 "bacillus thetaiotaomicron" distaso 1912]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A99 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A99 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MIY:(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE'>MIY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MIY:(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE'>MIY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xyo\|2xyo]], [[2xdo\|2xdo]], [[2y6q\|2y6q]], [[2y6r\|2y6r]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xyo\|2xyo]], [[2xdo\|2xdo]], [[2y6q\|2y6q]], [[2y6r\|2y6r]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4a99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a99 OCA], [~~http~~://pdbe.org/4a99 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4a99 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4a99 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4a99 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a99 OCA], [https://pdbe.org/4a99 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a99 RCSB], [https://www.ebi.ac.uk/pdbsum/4a99 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a99 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus thetaiotaomicron distaso 1912]]		[[Category: Bacillus thetaiotaomicron distaso 1912]]
		+	[[Category: Large Structures]]
	[[Category: Hinrichs, W]]		[[Category: Hinrichs, W]]
	[[Category: Palm, G J]]		[[Category: Palm, G J]]

OCA at 09:39, 6 March 2019

OCA — Wed, 06 Mar 2019 09:39:29 GMT

←Older revision		Revision as of 09:39, 6 March 2019
Line 1:		Line 1:

	==STRUCTURE OF THE TETRACYCLINE DEGRADING MONOOXYGENASE TETX IN COMPLEX WITH MINOCYCLINE==		==STRUCTURE OF THE TETRACYCLINE DEGRADING MONOOXYGENASE TETX IN COMPLEX WITH MINOCYCLINE==
-	<StructureSection load='4a99' size='340' side='right' caption='[[4a99]], [[Resolution\|resolution]] 2.18Å' scene=''>	+	<StructureSection load='4a99' size='340' side='right'caption='[[4a99]], [[Resolution\|resolution]] 2.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4a99]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_thetaiotaomicron"_distaso_1912 "bacillus thetaiotaomicron" distaso 1912]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A99 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A99 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4a99]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_thetaiotaomicron"_distaso_1912 "bacillus thetaiotaomicron" distaso 1912]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A99 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A99 FirstGlance]. <br>

OCA at 08:02, 11 August 2016

OCA — Thu, 11 Aug 2016 08:02:28 GMT

←Older revision		Revision as of 08:02, 11 August 2016
Line 1:		Line 1:
		+
	==STRUCTURE OF THE TETRACYCLINE DEGRADING MONOOXYGENASE TETX IN COMPLEX WITH MINOCYCLINE==		==STRUCTURE OF THE TETRACYCLINE DEGRADING MONOOXYGENASE TETX IN COMPLEX WITH MINOCYCLINE==
	<StructureSection load='4a99' size='340' side='right' caption='[[4a99]], [[Resolution\|resolution]] 2.18Å' scene=''>		<StructureSection load='4a99' size='340' side='right' caption='[[4a99]], [[Resolution\|resolution]] 2.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4a99]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacteroides_thetaiotaomicron Bacteroides~~ thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A99 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A99 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4a99]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_thetaiotaomicron"_distaso_1912 "bacillus thetaiotaomicron" distaso 1912]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A99 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A99 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MIY:(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE'>MIY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MIY:(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE'>MIY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xyo\|2xyo]], [[2xdo\|2xdo]], [[2y6q\|2y6q]], [[2y6r\|2y6r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xyo\|2xyo]], [[2xdo\|2xdo]], [[2y6q\|2y6q]], [[2y6r\|2y6r]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a99 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a99 RCSB], [http://www.ebi.ac.uk/pdbsum/4a99 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a99 OCA], [http://pdbe.org/4a99 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a99 RCSB], [http://www.ebi.ac.uk/pdbsum/4a99 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a99 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4a99" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacteroides~~ thetaiotaomicron]]	+	[[Category: Bacillus thetaiotaomicron distaso 1912]]
	[[Category: Hinrichs, W]]		[[Category: Hinrichs, W]]
	[[Category: Palm, G J]]		[[Category: Palm, G J]]

OCA at 04:57, 27 January 2015

OCA — Tue, 27 Jan 2015 04:57:22 GMT

←Older revision		Revision as of 04:57, 27 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4a99\| PDB=4a99 \| SCENE= }}~~	+	==STRUCTURE OF THE TETRACYCLINE DEGRADING MONOOXYGENASE TETX IN COMPLEX WITH MINOCYCLINE==
-	===STRUCTURE OF THE TETRACYCLINE DEGRADING MONOOXYGENASE TETX IN COMPLEX WITH MINOCYCLINE===	+	<StructureSection load='4a99' size='340' side='right' caption='[[4a99]], [[Resolution\|resolution]] 2.18Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23999299}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4a99]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A99 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A99 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MIY:(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE'>MIY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xyo\|2xyo]], [[2xdo\|2xdo]], [[2y6q\|2y6q]], [[2y6r\|2y6r]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a99 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a99 RCSB], [http://www.ebi.ac.uk/pdbsum/4a99 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Expression of the aromatic hydroxylase TetX under aerobic conditions confers bacterial resistance against tetracycline antibiotics. Hydroxylation inactivates and degrades tetracyclines, preventing inhibition of the prokaryotic ribosome. X-ray crystal structure analyses of TetX in complex with the second-generation and third-generation tetracyclines minocycline and tigecycline at 2.18 and 2.30 A resolution, respectively, explain why both clinically potent antibiotics are suitable substrates. Both tetracyclines bind in a large tunnel-shaped active site in close contact to the cofactor FAD, pre-oriented for regioselective hydroxylation to 11a-hydroxytetracyclines. The characteristic bulky 9-tert-butylglycylamido substituent of tigecycline is solvent-exposed and does not interfere with TetX binding. In the TetX-minocycline complex a second binding site for a minocycline dimer is observed close to the active-site entrance. The pocket is formed by the crystal packing arrangement on the surface of two neighbouring TetX monomers. Crystal structure analysis at 2.73 A resolution of xenon-pressurized TetX identified two adjacent Xe-binding sites. These putative dioxygen-binding cavities are located in the substrate-binding domain next to the active site. Molecular-dynamics simulations were performed in order to characterize dioxygen-diffusion pathways to FADH2 at the active site.

-	~~==About this Structure==~~	+	Putative dioxygen-binding sites and recognition of tigecycline and minocycline in the tetracycline-degrading monooxygenase TetX.,Volkers G, Damas JM, Palm GJ, Panjikar S, Soares CM, Hinrichs W Acta Crystallogr D Biol Crystallogr. 2013 Sep 1;69(Pt 9):1758-67. doi:, 10.1107/S0907444913013802. Epub 2013 Aug 15. PMID:23999299<ref>PMID:23999299</ref>
-	~~[[4a99]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4A99 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023999299</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bacteroides thetaiotaomicron]]		[[Category: Bacteroides thetaiotaomicron]]
-	[[Category: Hinrichs, W.]]	+	[[Category: Hinrichs, W]]
-	[[Category: Palm, G J.]]	+	[[Category: Palm, G J]]
-	[[Category: Volkers, G.]]	+	[[Category: Volkers, G]]
-	[[Category: Weiss, M S.]]	+	[[Category: Weiss, M S]]
	[[Category: Flavin]]		[[Category: Flavin]]
	[[Category: Flavoprotein]]		[[Category: Flavoprotein]]
	[[Category: Monooxygenase]]		[[Category: Monooxygenase]]
	[[Category: Tetracycline degradation]]		[[Category: Tetracycline degradation]]

OCA at 04:14, 12 September 2013

OCA — Thu, 12 Sep 2013 04:14:10 GMT

←Older revision		Revision as of 04:14, 12 September 2013
Line 1:		Line 1:
	{{STRUCTURE_4a99\| PDB=4a99 \| SCENE= }}		{{STRUCTURE_4a99\| PDB=4a99 \| SCENE= }}
	===STRUCTURE OF THE TETRACYCLINE DEGRADING MONOOXYGENASE TETX IN COMPLEX WITH MINOCYCLINE===		===STRUCTURE OF THE TETRACYCLINE DEGRADING MONOOXYGENASE TETX IN COMPLEX WITH MINOCYCLINE===
		+	{{ABSTRACT_PUBMED_23999299}}

	==About this Structure==		==About this Structure==
	[[4a99]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A99 OCA].		[[4a99]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A99 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023999299</ref><references group="xtra"/><references/>
	[[Category: Bacteroides thetaiotaomicron]]		[[Category: Bacteroides thetaiotaomicron]]
	[[Category: Hinrichs, W.]]		[[Category: Hinrichs, W.]]

OCA at 05:53, 28 August 2013

OCA — Wed, 28 Aug 2013 05:53:47 GMT

←Older revision		Revision as of 05:53, 28 August 2013
Line 1:		Line 1:
-	[[Image:4a99.jpg\|left\|200px]]
-
	{{STRUCTURE_4a99\| PDB=4a99 \| SCENE= }}		{{STRUCTURE_4a99\| PDB=4a99 \| SCENE= }}
-
	===STRUCTURE OF THE TETRACYCLINE DEGRADING MONOOXYGENASE TETX IN COMPLEX WITH MINOCYCLINE===		===STRUCTURE OF THE TETRACYCLINE DEGRADING MONOOXYGENASE TETX IN COMPLEX WITH MINOCYCLINE===
-

	==About this Structure==		==About this Structure==
Line 10:		Line 6:
	[[Category: Bacteroides thetaiotaomicron]]		[[Category: Bacteroides thetaiotaomicron]]
	[[Category: Hinrichs, W.]]		[[Category: Hinrichs, W.]]
-	[[Category: Palm, G.]]	+	[[Category: Palm, G J.]]
	[[Category: Volkers, G.]]		[[Category: Volkers, G.]]
	[[Category: Weiss, M S.]]		[[Category: Weiss, M S.]]

OCA at 21:23, 12 December 2012

OCA — Wed, 12 Dec 2012 21:23:41 GMT

←Older revision		Revision as of 21:23, 12 December 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4a99.jpg\|left\|200px]]

-	~~The entry~~ 4a99 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4a99\| PDB=4a99 \| SCENE= }}

-	~~Authors: Volkers, G., Palm, G., Weiss, M.S., Hinrichs, W.~~	+	===STRUCTURE OF THE TETRACYCLINE DEGRADING MONOOXYGENASE TETX IN COMPLEX WITH MINOCYCLINE===

-	~~Description~~: ~~STRUCTURE OF THE TETRACYCLINE DEGRADING MONOOXYGENASE TETX IN COMPLEX WITH MINOCYCLINE~~	+
		+	==About this Structure==
		+	[[4a99]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A99 OCA].
		+	[[Category: Bacteroides thetaiotaomicron]]
		+	[[Category: Hinrichs, W.]]
		+	[[Category: Palm, G.]]
		+	[[Category: Volkers, G.]]
		+	[[Category: Weiss, M S.]]
		+	[[Category: Flavin]]
		+	[[Category: Flavoprotein]]
		+	[[Category: Monooxygenase]]
		+	[[Category: Tetracycline degradation]]

OCA at 06:59, 28 December 2011

OCA — Wed, 28 Dec 2011 06:59:38 GMT

←Older revision		Revision as of 06:59, 28 December 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4a99 is ON HOLD	+	The entry 4a99 is ON HOLD until Paper Publication

	Authors: Volkers, G., Palm, G., Weiss, M.S., Hinrichs, W.		Authors: Volkers, G., Palm, G., Weiss, M.S., Hinrichs, W.

	Description: STRUCTURE OF THE TETRACYCLINE DEGRADING MONOOXYGENASE TETX IN COMPLEX WITH MINOCYCLINE		Description: STRUCTURE OF THE TETRACYCLINE DEGRADING MONOOXYGENASE TETX IN COMPLEX WITH MINOCYCLINE

OCA at 07:44, 7 December 2011

OCA — Wed, 07 Dec 2011 07:44:53 GMT

←Older revision		Revision as of 07:44, 7 December 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4a99 is ON HOLD ~~until sometime in the future~~	+	The entry 4a99 is ON HOLD

	Authors: Volkers, G., Palm, G., Weiss, M.S., Hinrichs, W.		Authors: Volkers, G., Palm, G., Weiss, M.S., Hinrichs, W.

	Description: STRUCTURE OF THE TETRACYCLINE DEGRADING MONOOXYGENASE TETX IN COMPLEX WITH MINOCYCLINE		Description: STRUCTURE OF THE TETRACYCLINE DEGRADING MONOOXYGENASE TETX IN COMPLEX WITH MINOCYCLINE