4acm - Revision history

OCA at 07:14, 1 May 2024

OCA — Wed, 01 May 2024 07:14:08 GMT

←Older revision		Revision as of 07:14, 1 May 2024
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	<StructureSection load='4acm' size='340' side='right'caption='[[4acm]], [[Resolution\|resolution]] 1.63Å' scene=''>		<StructureSection load='4acm' size='340' side='right'caption='[[4acm]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4acm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ACM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4acm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ACM FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=7YG:3~~-~~AMINO-6-(4-{~~[~~2-(DIMETHYLAMINO)ETHYL~~]~~SULFAMOYL}PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE'>7YG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.63Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~ACE~~:~~ACETYL+GROUP~~'>~~ACE~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7YG:3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE'>7YG</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td>~~<td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1h08\|1h08]]~~, [[1pye\|1pye]], [[2vth\|2vth]], [[1v1k\|1v1k]], [[2b53\|2b53]], [[1h25\|1h25]], [[1okv\|1okv]], [[1ke7\|1ke7]], [[1pxk\|1pxk]], [[2wih\|2wih]], [[2bhh\|2bhh]], [[2vta\|2vta]], [[2uue\|2uue]], [[1gz8\|1gz8]], [[1e1v\|1e1v]], [[1ol2\|1ol2]], [[1h27\|1h27]], [[1jsv\|1jsv]], [[2b52\|2b52]], [[1ke5\|1ke5]], [[1fin\|1fin]], [[2c5o\|2c5o]], [[2c68\|2c68]], [[1p2a\|1p2a]], [[2x1n\|2x1n]], [[2vtt\|2vtt]], [[2vtq\|2vtq]], [[2c4g\|2c4g]], [[1h1q\|1h1q]], [[1w0x\|1w0x]], [[2w05\|2w05]], [[1pxo\|1pxo]], [[1ke9\|1ke9]], [[1hck\|1hck]], [[2a0c\|2a0c]], [[1jsu\|1jsu]], [[1pxn\|1pxn]], [[2uze\|2uze]], [[2vtm\|2vtm]], [[2v0d\|2v0d]], [[1oiq\|1oiq]], [[1h1r\|1h1r]], [[2iw8\|2iw8]], [[1gih\|1gih]], [[1hcl\|1hcl]], [[1pw2\|1pw2]], [[2whb\|2whb]], [[2w06\|2w06]], [[2vtn\|2vtn]], [[1jst\|1jst]], [[1oiu\|1oiu]], [[1pxm\|1pxm]], [[1b38\|1b38]], [[1fq1\|1fq1]], [[1vyw\|1vyw]], [[1h1p\|1h1p]], [[2wma\|2wma]], [[2c69\|2c69]], [[1urc\|1urc]], [[1pxi\|1pxi]], [[2c6i\|2c6i]], [[1ykr\|1ykr]], [[2wxv\|2wxv]], [[2w17\|2w17]], [[2uzd\|2uzd]], [[2c6k\|2c6k]], [[2c5y\|2c5y]], [[1wcc\|1wcc]], [[2j9m\|2j9m]], [[1vyz\|1vyz]], [[2vti\|2vti]], [[1jvp\|1jvp]], [[1w98\|1w98]], [[2wip\|2wip]], [[1pkd\|1pkd]], [[1p5e\|1p5e]], [[2vts\|2vts]], [[2uzn\|2uzn]], [[2b54\|2b54]], [[1ke6\|1ke6]], [[1pxj\|1pxj]], [[2uzl\|2uzl]], [[2cci\|2cci]], [[2bkz\|2bkz]], [[2g9x\|2g9x]], [[1y91\|1y91]], [[2iw6\|2iw6]], [[1gij\|1gij]], [[1r78\|1r78]], [[1h0v\|1h0v]], [[2iw9\|2iw9]], [[1w8c\|1w8c]], [[1buh\|1buh]], [[2bpm\|2bpm]], [[2bts\|2bts]], [[1fvv\|1fvv]], [[1okw\|1okw]], [[2a4l\|2a4l]], [[2vtp\|2vtp]], [[2c6t\|2c6t]], [[1fvt\|1fvt]], [[1qmz\|1qmz]], [[2w1h\|2w1h]], [[2vu3\|2vu3]], [[2xmy\|2xmy]], [[2b55\|2b55]], [[1ogu\|1ogu]], [[1pf8\|1pf8]], [[1h1s\|1h1s]], [[2c5v\|2c5v]], [[2jgz\|2jgz]], [[2bhe\|2bhe]], [[1urw\|1urw]], [[1oiy\|1oiy]], [[2c6l\|2c6l]], [[1f5q\|1f5q]], [[2c6o\|2c6o]], [[2vtl\|2vtl]], [[1ol1\|1ol1]], [[2wfy\|2wfy]], [[1h01\|1h01]], [[2uzb\|2uzb]], [[1oir\|1oir]], [[1oi9\|1oi9]], [[2vtj\|2vtj]], [[2cjm\|2cjm]], [[2c5n\|2c5n]], [[2wev\|2wev]], [[2c5x\|2c5x]], [[2c6m\|2c6m]], [[1oit\|1oit]], [[2v22\|2v22]], [[1gy3\|1gy3]], [[1gii\|1gii]], [[2vv9\|2vv9]], [[1di8\|1di8]], [[2wpa\|2wpa]], [[2wmb\|2wmb]], [[1e9h\|1e9h]], [[2vto\|2vto]], [[1dm2\|1dm2]], [[2uzo\|2uzo]], [[1h24\|1h24]], [[2exm\|2exm]], [[1h00\|1h00]], [[2clx\|2clx]], [[1pxp\|1pxp]], [[2cch\|2cch]], [[1b39\|1b39]], [[2xnb\|2xnb]], [[2btr\|2btr]], [[1aq1\|1aq1]], [[1h0w\|1h0w]], [[1g5s\|1g5s]], [[1ckp\|1ckp]], [[1ke8\|1ke8]], [[1pxl\|1pxl]], [[1h28\|1h28]], [[2vtr\|2vtr]], [[1h26\|1h26]], [[1e1x\|1e1x]], [[1h07\|1h07]], [[1y8y\|1y8y]]<~~/div></td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4acm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4acm OCA], [https://pdbe.org/4acm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4acm RCSB], [https://www.ebi.ac.uk/pdbsum/4acm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4acm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4acm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4acm OCA], [https://pdbe.org/4acm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4acm RCSB], [https://www.ebi.ac.uk/pdbsum/4acm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4acm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CDK2_HUMAN CDK2_HUMAN]] Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization.<ref>PMID:10499802</ref> <ref>PMID:11051553</ref> <ref>PMID:10995386</ref> <ref>PMID:10995387</ref> <ref>PMID:10884347</ref> <ref>PMID:11113184</ref> <ref>PMID:15800615</ref> <ref>PMID:18372919</ref> <ref>PMID:20147522</ref> <ref>PMID:20079829</ref> <ref>PMID:20935635</ref> <ref>PMID:20195506</ref> <ref>PMID:19966300</ref> <ref>PMID:21262353</ref> <ref>PMID:21596315</ref> <ref>PMID:21319273</ref> <ref>PMID:17495531</ref>	+	[https://www.uniprot.org/uniprot/CDK2_HUMAN CDK2_HUMAN] Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization.<ref>PMID:10499802</ref> <ref>PMID:11051553</ref> <ref>PMID:10995386</ref> <ref>PMID:10995387</ref> <ref>PMID:10884347</ref> <ref>PMID:11113184</ref> <ref>PMID:15800615</ref> <ref>PMID:18372919</ref> <ref>PMID:20147522</ref> <ref>PMID:20079829</ref> <ref>PMID:20935635</ref> <ref>PMID:20195506</ref> <ref>PMID:19966300</ref> <ref>PMID:21262353</ref> <ref>PMID:21596315</ref> <ref>PMID:21319273</ref> <ref>PMID:17495531</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Glycogen synthase kinase-3beta, also called tau phosphorylating kinase, is a proline-directed serine/threonine kinase which was originally identified due to its role in glycogen metabolism. Active forms of GSK3beta localize to pretangle pathology including dystrophic neuritis and neurofibrillary tangles in Alzheimer's disease (AD) brain. By using a high throughput screening (HTS) approach to search for new chemical series and cocrystallization of key analogues to guide the optimization and synthesis of our pyrazine series, we have developed highly potent and selective inhibitors showing cellular efficacy and blood-brain barrier penetrance. The inhibitors are suitable for in vivo efficacy testing and may serve as a new treatment strategy for Alzheimer's disease.	+
-		+
-	Discovery of Novel Potent and Highly Selective Glycogen Synthase Kinase-3beta (GSK3beta) Inhibitors for Alzheimer's Disease: Design, Synthesis, and Characterization of Pyrazines.,Berg S, Bergh M, Hellberg S, Hogdin K, Lo-Alfredsson Y, Soderman P, von Berg S, Weigelt T, Ormo M, Xue Y, Tucker J, Neelissen J, Jerning E, Nilsson Y, Bhat R J Med Chem. 2012 Apr 27. PMID:22489897<ref>PMID:22489897</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4acm" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cyclin-dependent kinase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Anderson, M]]	+	[[Category: Anderson M]]
-	[[Category: Berg, S]]	+	[[Category: Berg S]]
-	~~[[Category: Berg, S von~~]]	+	[[Category: Bergh M]]
-	[[Category: Bergh, M]]	+	[[Category: Bhat R]]
-	[[Category: Bhat, R]]	+	[[Category: Brassington C]]
-	[[Category: Brassington, C]]	+	[[Category: Hellberg S]]
-	[[Category: Hellberg, S]]	+	[[Category: Hogdin K]]
-	[[Category: Hogdin, K]]	+	[[Category: Jerning E]]
-	[[Category: Jerning, E]]	+	[[Category: Lo-Alfredsson Y]]
-	[[Category: Lo-Alfredsson, Y]]	+	[[Category: Neelissen J]]
-	[[Category: Neelissen, J]]	+	[[Category: Nilsson Y]]
-	[[Category: Nilsson, Y]]	+	[[Category: Ormo M]]
-	[[Category: Ormo, M]]	+	[[Category: Soderman P]]
-	[[Category: Soderman, P]]	+	[[Category: Stanway J]]
-	[[Category: Stanway, J]]	+	[[Category: Tucker J]]
-	[[Category: Tucker, J]]	+	[[Category: Weigelt T]]
-	[[Category: Weigelt, T]]	+	[[Category: Xue Y]]
-	[[Category: Xue, Y]]	+	[[Category: Von Berg S]]
-	[[Category: ~~Atp-binding]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Cell division]]~~	+
-	~~[[Category: Mitosis]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Serine/threonine- protein kinase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 05:29, 25 August 2022

OCA — Thu, 25 Aug 2022 05:29:33 GMT

OCA at 05:09, 19 November 2020

OCA — Thu, 19 Nov 2020 05:09:08 GMT

←Older revision		Revision as of 05:09, 19 November 2020
Line 3:		Line 3:
	<StructureSection load='4acm' size='340' side='right'caption='[[4acm]], [[Resolution\|resolution]] 1.63Å' scene=''>		<StructureSection load='4acm' size='340' side='right'caption='[[4acm]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4acm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACM OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ACM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4acm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4ACM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7YG:3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE'>7YG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7YG:3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE'>7YG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h08\|1h08]], [[1pye\|1pye]], [[2vth\|2vth]], [[1v1k\|1v1k]], [[2b53\|2b53]], [[1h25\|1h25]], [[1okv\|1okv]], [[1ke7\|1ke7]], [[1pxk\|1pxk]], [[2wih\|2wih]], [[2bhh\|2bhh]], [[2vta\|2vta]], [[2uue\|2uue]], [[1gz8\|1gz8]], [[1e1v\|1e1v]], [[1ol2\|1ol2]], [[1h27\|1h27]], [[1jsv\|1jsv]], [[2b52\|2b52]], [[1ke5\|1ke5]], [[1fin\|1fin]], [[2c5o\|2c5o]], [[2c68\|2c68]], [[1p2a\|1p2a]], [[2x1n\|2x1n]], [[2vtt\|2vtt]], [[2vtq\|2vtq]], [[2c4g\|2c4g]], [[1h1q\|1h1q]], [[1w0x\|1w0x]], [[2w05\|2w05]], [[1pxo\|1pxo]], [[1ke9\|1ke9]], [[1hck\|1hck]], [[2a0c\|2a0c]], [[1jsu\|1jsu]], [[1pxn\|1pxn]], [[2uze\|2uze]], [[2vtm\|2vtm]], [[2v0d\|2v0d]], [[1oiq\|1oiq]], [[1h1r\|1h1r]], [[2iw8\|2iw8]], [[1gih\|1gih]], [[1hcl\|1hcl]], [[1pw2\|1pw2]], [[2whb\|2whb]], [[2w06\|2w06]], [[2vtn\|2vtn]], [[1jst\|1jst]], [[1oiu\|1oiu]], [[1pxm\|1pxm]], [[1b38\|1b38]], [[1fq1\|1fq1]], [[1vyw\|1vyw]], [[1h1p\|1h1p]], [[2wma\|2wma]], [[2c69\|2c69]], [[1urc\|1urc]], [[1pxi\|1pxi]], [[2c6i\|2c6i]], [[1ykr\|1ykr]], [[2wxv\|2wxv]], [[2w17\|2w17]], [[2uzd\|2uzd]], [[2c6k\|2c6k]], [[2c5y\|2c5y]], [[1wcc\|1wcc]], [[2j9m\|2j9m]], [[1vyz\|1vyz]], [[2vti\|2vti]], [[1jvp\|1jvp]], [[1w98\|1w98]], [[2wip\|2wip]], [[1pkd\|1pkd]], [[1p5e\|1p5e]], [[2vts\|2vts]], [[2uzn\|2uzn]], [[2b54\|2b54]], [[1ke6\|1ke6]], [[1pxj\|1pxj]], [[2uzl\|2uzl]], [[2cci\|2cci]], [[2bkz\|2bkz]], [[2g9x\|2g9x]], [[1y91\|1y91]], [[2iw6\|2iw6]], [[1gij\|1gij]], [[1r78\|1r78]], [[1h0v\|1h0v]], [[2iw9\|2iw9]], [[1w8c\|1w8c]], [[1buh\|1buh]], [[2bpm\|2bpm]], [[2bts\|2bts]], [[1fvv\|1fvv]], [[1okw\|1okw]], [[2a4l\|2a4l]], [[2vtp\|2vtp]], [[2c6t\|2c6t]], [[1fvt\|1fvt]], [[1qmz\|1qmz]], [[2w1h\|2w1h]], [[2vu3\|2vu3]], [[2xmy\|2xmy]], [[2b55\|2b55]], [[1ogu\|1ogu]], [[1pf8\|1pf8]], [[1h1s\|1h1s]], [[2c5v\|2c5v]], [[2jgz\|2jgz]], [[2bhe\|2bhe]], [[1urw\|1urw]], [[1oiy\|1oiy]], [[2c6l\|2c6l]], [[1f5q\|1f5q]], [[2c6o\|2c6o]], [[2vtl\|2vtl]], [[1ol1\|1ol1]], [[2wfy\|2wfy]], [[1h01\|1h01]], [[2uzb\|2uzb]], [[1oir\|1oir]], [[1oi9\|1oi9]], [[2vtj\|2vtj]], [[2cjm\|2cjm]], [[2c5n\|2c5n]], [[2wev\|2wev]], [[2c5x\|2c5x]], [[2c6m\|2c6m]], [[1oit\|1oit]], [[2v22\|2v22]], [[1gy3\|1gy3]], [[1gii\|1gii]], [[2vv9\|2vv9]], [[1di8\|1di8]], [[2wpa\|2wpa]], [[2wmb\|2wmb]], [[1e9h\|1e9h]], [[2vto\|2vto]], [[1dm2\|1dm2]], [[2uzo\|2uzo]], [[1h24\|1h24]], [[2exm\|2exm]], [[1h00\|1h00]], [[2clx\|2clx]], [[1pxp\|1pxp]], [[2cch\|2cch]], [[1b39\|1b39]], [[2xnb\|2xnb]], [[2btr\|2btr]], [[1aq1\|1aq1]], [[1h0w\|1h0w]], [[1g5s\|1g5s]], [[1ckp\|1ckp]], [[1ke8\|1ke8]], [[1pxl\|1pxl]], [[1h28\|1h28]], [[2vtr\|2vtr]], [[1h26\|1h26]], [[1e1x\|1e1x]], [[1h07\|1h07]], [[1y8y\|1y8y]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1h08\|1h08]], [[1pye\|1pye]], [[2vth\|2vth]], [[1v1k\|1v1k]], [[2b53\|2b53]], [[1h25\|1h25]], [[1okv\|1okv]], [[1ke7\|1ke7]], [[1pxk\|1pxk]], [[2wih\|2wih]], [[2bhh\|2bhh]], [[2vta\|2vta]], [[2uue\|2uue]], [[1gz8\|1gz8]], [[1e1v\|1e1v]], [[1ol2\|1ol2]], [[1h27\|1h27]], [[1jsv\|1jsv]], [[2b52\|2b52]], [[1ke5\|1ke5]], [[1fin\|1fin]], [[2c5o\|2c5o]], [[2c68\|2c68]], [[1p2a\|1p2a]], [[2x1n\|2x1n]], [[2vtt\|2vtt]], [[2vtq\|2vtq]], [[2c4g\|2c4g]], [[1h1q\|1h1q]], [[1w0x\|1w0x]], [[2w05\|2w05]], [[1pxo\|1pxo]], [[1ke9\|1ke9]], [[1hck\|1hck]], [[2a0c\|2a0c]], [[1jsu\|1jsu]], [[1pxn\|1pxn]], [[2uze\|2uze]], [[2vtm\|2vtm]], [[2v0d\|2v0d]], [[1oiq\|1oiq]], [[1h1r\|1h1r]], [[2iw8\|2iw8]], [[1gih\|1gih]], [[1hcl\|1hcl]], [[1pw2\|1pw2]], [[2whb\|2whb]], [[2w06\|2w06]], [[2vtn\|2vtn]], [[1jst\|1jst]], [[1oiu\|1oiu]], [[1pxm\|1pxm]], [[1b38\|1b38]], [[1fq1\|1fq1]], [[1vyw\|1vyw]], [[1h1p\|1h1p]], [[2wma\|2wma]], [[2c69\|2c69]], [[1urc\|1urc]], [[1pxi\|1pxi]], [[2c6i\|2c6i]], [[1ykr\|1ykr]], [[2wxv\|2wxv]], [[2w17\|2w17]], [[2uzd\|2uzd]], [[2c6k\|2c6k]], [[2c5y\|2c5y]], [[1wcc\|1wcc]], [[2j9m\|2j9m]], [[1vyz\|1vyz]], [[2vti\|2vti]], [[1jvp\|1jvp]], [[1w98\|1w98]], [[2wip\|2wip]], [[1pkd\|1pkd]], [[1p5e\|1p5e]], [[2vts\|2vts]], [[2uzn\|2uzn]], [[2b54\|2b54]], [[1ke6\|1ke6]], [[1pxj\|1pxj]], [[2uzl\|2uzl]], [[2cci\|2cci]], [[2bkz\|2bkz]], [[2g9x\|2g9x]], [[1y91\|1y91]], [[2iw6\|2iw6]], [[1gij\|1gij]], [[1r78\|1r78]], [[1h0v\|1h0v]], [[2iw9\|2iw9]], [[1w8c\|1w8c]], [[1buh\|1buh]], [[2bpm\|2bpm]], [[2bts\|2bts]], [[1fvv\|1fvv]], [[1okw\|1okw]], [[2a4l\|2a4l]], [[2vtp\|2vtp]], [[2c6t\|2c6t]], [[1fvt\|1fvt]], [[1qmz\|1qmz]], [[2w1h\|2w1h]], [[2vu3\|2vu3]], [[2xmy\|2xmy]], [[2b55\|2b55]], [[1ogu\|1ogu]], [[1pf8\|1pf8]], [[1h1s\|1h1s]], [[2c5v\|2c5v]], [[2jgz\|2jgz]], [[2bhe\|2bhe]], [[1urw\|1urw]], [[1oiy\|1oiy]], [[2c6l\|2c6l]], [[1f5q\|1f5q]], [[2c6o\|2c6o]], [[2vtl\|2vtl]], [[1ol1\|1ol1]], [[2wfy\|2wfy]], [[1h01\|1h01]], [[2uzb\|2uzb]], [[1oir\|1oir]], [[1oi9\|1oi9]], [[2vtj\|2vtj]], [[2cjm\|2cjm]], [[2c5n\|2c5n]], [[2wev\|2wev]], [[2c5x\|2c5x]], [[2c6m\|2c6m]], [[1oit\|1oit]], [[2v22\|2v22]], [[1gy3\|1gy3]], [[1gii\|1gii]], [[2vv9\|2vv9]], [[1di8\|1di8]], [[2wpa\|2wpa]], [[2wmb\|2wmb]], [[1e9h\|1e9h]], [[2vto\|2vto]], [[1dm2\|1dm2]], [[2uzo\|2uzo]], [[1h24\|1h24]], [[2exm\|2exm]], [[1h00\|1h00]], [[2clx\|2clx]], [[1pxp\|1pxp]], [[2cch\|2cch]], [[1b39\|1b39]], [[2xnb\|2xnb]], [[2btr\|2btr]], [[1aq1\|1aq1]], [[1h0w\|1h0w]], [[1g5s\|1g5s]], [[1ckp\|1ckp]], [[1ke8\|1ke8]], [[1pxl\|1pxl]], [[1h28\|1h28]], [[2vtr\|2vtr]], [[1h26\|1h26]], [[1e1x\|1e1x]], [[1h07\|1h07]], [[1y8y\|1y8y]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4acm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4acm OCA], [http://pdbe.org/4acm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4acm RCSB], [http://www.ebi.ac.uk/pdbsum/4acm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4acm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4acm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4acm OCA], [http://pdbe.org/4acm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4acm RCSB], [http://www.ebi.ac.uk/pdbsum/4acm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4acm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 12:51, 1 January 2020

OCA — Wed, 01 Jan 2020 12:51:25 GMT

←Older revision		Revision as of 12:51, 1 January 2020
Line 1:		Line 1:

	==CDK2 IN COMPLEX WITH 3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}-PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE==		==CDK2 IN COMPLEX WITH 3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}-PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE==
-	<StructureSection load='4acm' size='340' side='right' caption='[[4acm]], [[Resolution\|resolution]] 1.63Å' scene=''>	+	<StructureSection load='4acm' size='340' side='right'caption='[[4acm]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4acm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ACM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4acm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ACM FirstGlance]. <br>
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4acm" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4acm" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cyclin-dependent kinase 3D structures\|Cyclin-dependent kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 30:
	[[Category: Cyclin-dependent kinase]]		[[Category: Cyclin-dependent kinase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Anderson, M]]		[[Category: Anderson, M]]
	[[Category: Berg, S]]		[[Category: Berg, S]]

OCA at 06:49, 15 February 2018

OCA — Thu, 15 Feb 2018 06:49:29 GMT

←Older revision		Revision as of 06:49, 15 February 2018
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4acm" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4acm" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cyclin-dependent kinase\|Cyclin-dependent kinase]]
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 29:
	[[Category: Anderson, M]]		[[Category: Anderson, M]]
	[[Category: Berg, S]]		[[Category: Berg, S]]
-	[[Category: ~~Berga~~, S ~~Von~~]]	+	[[Category: Berg, S von]]
	[[Category: Bergh, M]]		[[Category: Bergh, M]]
	[[Category: Bhat, R]]		[[Category: Bhat, R]]

OCA at 21:15, 5 August 2016

OCA — Fri, 05 Aug 2016 21:15:24 GMT

←Older revision		Revision as of 21:15, 5 August 2016
Line 1:		Line 1:
		+
	==CDK2 IN COMPLEX WITH 3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}-PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE==		==CDK2 IN COMPLEX WITH 3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}-PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE==
	<StructureSection load='4acm' size='340' side='right' caption='[[4acm]], [[Resolution\|resolution]] 1.63Å' scene=''>		<StructureSection load='4acm' size='340' side='right' caption='[[4acm]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4acm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ACM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4acm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ACM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7YG:3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE'>7YG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7YG:3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE'>7YG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h08\|1h08]], [[1pye\|1pye]], [[2vth\|2vth]], [[1v1k\|1v1k]], [[2b53\|2b53]], [[1h25\|1h25]], [[1okv\|1okv]], [[1ke7\|1ke7]], [[1pxk\|1pxk]], [[2wih\|2wih]], [[2bhh\|2bhh]], [[2vta\|2vta]], [[2uue\|2uue]], [[1gz8\|1gz8]], [[1e1v\|1e1v]], [[1ol2\|1ol2]], [[1h27\|1h27]], [[1jsv\|1jsv]], [[2b52\|2b52]], [[1ke5\|1ke5]], [[1fin\|1fin]], [[2c5o\|2c5o]], [[2c68\|2c68]], [[1p2a\|1p2a]], [[2x1n\|2x1n]], [[2vtt\|2vtt]], [[2vtq\|2vtq]], [[2c4g\|2c4g]], [[1h1q\|1h1q]], [[1w0x\|1w0x]], [[2w05\|2w05]], [[1pxo\|1pxo]], [[1ke9\|1ke9]], [[1hck\|1hck]], [[2a0c\|2a0c]], [[1jsu\|1jsu]], [[1pxn\|1pxn]], [[2uze\|2uze]], [[2vtm\|2vtm]], [[2v0d\|2v0d]], [[1oiq\|1oiq]], [[1h1r\|1h1r]], [[2iw8\|2iw8]], [[1gih\|1gih]], [[1hcl\|1hcl]], [[1pw2\|1pw2]], [[2whb\|2whb]], [[2w06\|2w06]], [[2vtn\|2vtn]], [[1jst\|1jst]], [[1oiu\|1oiu]], [[1pxm\|1pxm]], [[1b38\|1b38]], [[1fq1\|1fq1]], [[1vyw\|1vyw]], [[1h1p\|1h1p]], [[2wma\|2wma]], [[2c69\|2c69]], [[1urc\|1urc]], [[1pxi\|1pxi]], [[2c6i\|2c6i]], [[1ykr\|1ykr]], [[2wxv\|2wxv]], [[2w17\|2w17]], [[2uzd\|2uzd]], [[2c6k\|2c6k]], [[2c5y\|2c5y]], [[1wcc\|1wcc]], [[2j9m\|2j9m]], [[1vyz\|1vyz]], [[2vti\|2vti]], [[1jvp\|1jvp]], [[1w98\|1w98]], [[2wip\|2wip]], [[1pkd\|1pkd]], [[1p5e\|1p5e]], [[2vts\|2vts]], [[2uzn\|2uzn]], [[2b54\|2b54]], [[1ke6\|1ke6]], [[1pxj\|1pxj]], [[2uzl\|2uzl]], [[2cci\|2cci]], [[2bkz\|2bkz]], [[2g9x\|2g9x]], [[1y91\|1y91]], [[2iw6\|2iw6]], [[1gij\|1gij]], [[1r78\|1r78]], [[1h0v\|1h0v]], [[2iw9\|2iw9]], [[1w8c\|1w8c]], [[1buh\|1buh]], [[2bpm\|2bpm]], [[2bts\|2bts]], [[1fvv\|1fvv]], [[1okw\|1okw]], [[2a4l\|2a4l]], [[2vtp\|2vtp]], [[2c6t\|2c6t]], [[1fvt\|1fvt]], [[1qmz\|1qmz]], [[2w1h\|2w1h]], [[2vu3\|2vu3]], [[2xmy\|2xmy]], [[2b55\|2b55]], [[1ogu\|1ogu]], [[1pf8\|1pf8]], [[1h1s\|1h1s]], [[2c5v\|2c5v]], [[2jgz\|2jgz]], [[2bhe\|2bhe]], [[1urw\|1urw]], [[1oiy\|1oiy]], [[2c6l\|2c6l]], [[1f5q\|1f5q]], [[2c6o\|2c6o]], [[2vtl\|2vtl]], [[1ol1\|1ol1]], [[2wfy\|2wfy]], [[1h01\|1h01]], [[2uzb\|2uzb]], [[1oir\|1oir]], [[1oi9\|1oi9]], [[2vtj\|2vtj]], [[2cjm\|2cjm]], [[2c5n\|2c5n]], [[2wev\|2wev]], [[2c5x\|2c5x]], [[2c6m\|2c6m]], [[1oit\|1oit]], [[2v22\|2v22]], [[1gy3\|1gy3]], [[1gii\|1gii]], [[2vv9\|2vv9]], [[1di8\|1di8]], [[2wpa\|2wpa]], [[2wmb\|2wmb]], [[1e9h\|1e9h]], [[2vto\|2vto]], [[1dm2\|1dm2]], [[2uzo\|2uzo]], [[1h24\|1h24]], [[2exm\|2exm]], [[1h00\|1h00]], [[2clx\|2clx]], [[1pxp\|1pxp]], [[2cch\|2cch]], [[1b39\|1b39]], [[2xnb\|2xnb]], [[2btr\|2btr]], [[1aq1\|1aq1]], [[1h0w\|1h0w]], [[1g5s\|1g5s]], [[1ckp\|1ckp]], [[1ke8\|1ke8]], [[1pxl\|1pxl]], [[1h28\|1h28]], [[2vtr\|2vtr]], [[1h26\|1h26]], [[1e1x\|1e1x]], [[1h07\|1h07]], [[1y8y\|1y8y]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h08\|1h08]], [[1pye\|1pye]], [[2vth\|2vth]], [[1v1k\|1v1k]], [[2b53\|2b53]], [[1h25\|1h25]], [[1okv\|1okv]], [[1ke7\|1ke7]], [[1pxk\|1pxk]], [[2wih\|2wih]], [[2bhh\|2bhh]], [[2vta\|2vta]], [[2uue\|2uue]], [[1gz8\|1gz8]], [[1e1v\|1e1v]], [[1ol2\|1ol2]], [[1h27\|1h27]], [[1jsv\|1jsv]], [[2b52\|2b52]], [[1ke5\|1ke5]], [[1fin\|1fin]], [[2c5o\|2c5o]], [[2c68\|2c68]], [[1p2a\|1p2a]], [[2x1n\|2x1n]], [[2vtt\|2vtt]], [[2vtq\|2vtq]], [[2c4g\|2c4g]], [[1h1q\|1h1q]], [[1w0x\|1w0x]], [[2w05\|2w05]], [[1pxo\|1pxo]], [[1ke9\|1ke9]], [[1hck\|1hck]], [[2a0c\|2a0c]], [[1jsu\|1jsu]], [[1pxn\|1pxn]], [[2uze\|2uze]], [[2vtm\|2vtm]], [[2v0d\|2v0d]], [[1oiq\|1oiq]], [[1h1r\|1h1r]], [[2iw8\|2iw8]], [[1gih\|1gih]], [[1hcl\|1hcl]], [[1pw2\|1pw2]], [[2whb\|2whb]], [[2w06\|2w06]], [[2vtn\|2vtn]], [[1jst\|1jst]], [[1oiu\|1oiu]], [[1pxm\|1pxm]], [[1b38\|1b38]], [[1fq1\|1fq1]], [[1vyw\|1vyw]], [[1h1p\|1h1p]], [[2wma\|2wma]], [[2c69\|2c69]], [[1urc\|1urc]], [[1pxi\|1pxi]], [[2c6i\|2c6i]], [[1ykr\|1ykr]], [[2wxv\|2wxv]], [[2w17\|2w17]], [[2uzd\|2uzd]], [[2c6k\|2c6k]], [[2c5y\|2c5y]], [[1wcc\|1wcc]], [[2j9m\|2j9m]], [[1vyz\|1vyz]], [[2vti\|2vti]], [[1jvp\|1jvp]], [[1w98\|1w98]], [[2wip\|2wip]], [[1pkd\|1pkd]], [[1p5e\|1p5e]], [[2vts\|2vts]], [[2uzn\|2uzn]], [[2b54\|2b54]], [[1ke6\|1ke6]], [[1pxj\|1pxj]], [[2uzl\|2uzl]], [[2cci\|2cci]], [[2bkz\|2bkz]], [[2g9x\|2g9x]], [[1y91\|1y91]], [[2iw6\|2iw6]], [[1gij\|1gij]], [[1r78\|1r78]], [[1h0v\|1h0v]], [[2iw9\|2iw9]], [[1w8c\|1w8c]], [[1buh\|1buh]], [[2bpm\|2bpm]], [[2bts\|2bts]], [[1fvv\|1fvv]], [[1okw\|1okw]], [[2a4l\|2a4l]], [[2vtp\|2vtp]], [[2c6t\|2c6t]], [[1fvt\|1fvt]], [[1qmz\|1qmz]], [[2w1h\|2w1h]], [[2vu3\|2vu3]], [[2xmy\|2xmy]], [[2b55\|2b55]], [[1ogu\|1ogu]], [[1pf8\|1pf8]], [[1h1s\|1h1s]], [[2c5v\|2c5v]], [[2jgz\|2jgz]], [[2bhe\|2bhe]], [[1urw\|1urw]], [[1oiy\|1oiy]], [[2c6l\|2c6l]], [[1f5q\|1f5q]], [[2c6o\|2c6o]], [[2vtl\|2vtl]], [[1ol1\|1ol1]], [[2wfy\|2wfy]], [[1h01\|1h01]], [[2uzb\|2uzb]], [[1oir\|1oir]], [[1oi9\|1oi9]], [[2vtj\|2vtj]], [[2cjm\|2cjm]], [[2c5n\|2c5n]], [[2wev\|2wev]], [[2c5x\|2c5x]], [[2c6m\|2c6m]], [[1oit\|1oit]], [[2v22\|2v22]], [[1gy3\|1gy3]], [[1gii\|1gii]], [[2vv9\|2vv9]], [[1di8\|1di8]], [[2wpa\|2wpa]], [[2wmb\|2wmb]], [[1e9h\|1e9h]], [[2vto\|2vto]], [[1dm2\|1dm2]], [[2uzo\|2uzo]], [[1h24\|1h24]], [[2exm\|2exm]], [[1h00\|1h00]], [[2clx\|2clx]], [[1pxp\|1pxp]], [[2cch\|2cch]], [[1b39\|1b39]], [[2xnb\|2xnb]], [[2btr\|2btr]], [[1aq1\|1aq1]], [[1h0w\|1h0w]], [[1g5s\|1g5s]], [[1ckp\|1ckp]], [[1ke8\|1ke8]], [[1pxl\|1pxl]], [[1h28\|1h28]], [[2vtr\|2vtr]], [[1h26\|1h26]], [[1e1x\|1e1x]], [[1h07\|1h07]], [[1y8y\|1y8y]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4acm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4acm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4acm RCSB], [http://www.ebi.ac.uk/pdbsum/4acm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4acm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4acm OCA], [http://pdbe.org/4acm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4acm RCSB], [http://www.ebi.ac.uk/pdbsum/4acm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4acm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4acm" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[~~Cell division protein~~ kinase 2\|~~Cell division protein~~ kinase 2]]	+	*[[Cyclin-dependent kinase\|Cyclin-dependent kinase]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Cyclin-dependent kinase]]		[[Category: Cyclin-dependent kinase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Anderson, M]]		[[Category: Anderson, M]]
	[[Category: Berg, S]]		[[Category: Berg, S]]

OCA at 21:57, 25 December 2014

OCA — Thu, 25 Dec 2014 21:57:26 GMT

←Older revision		Revision as of 21:57, 25 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4acm.~~png~~\|~~left~~\|~~200px~~]]	+	==CDK2 IN COMPLEX WITH 3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}-PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE==
		+	<StructureSection load='4acm' size='340' side='right' caption='[[4acm]], [[Resolution\|resolution]] 1.63Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4acm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ACM FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7YG:3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE'>7YG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h08\|1h08]], [[1pye\|1pye]], [[2vth\|2vth]], [[1v1k\|1v1k]], [[2b53\|2b53]], [[1h25\|1h25]], [[1okv\|1okv]], [[1ke7\|1ke7]], [[1pxk\|1pxk]], [[2wih\|2wih]], [[2bhh\|2bhh]], [[2vta\|2vta]], [[2uue\|2uue]], [[1gz8\|1gz8]], [[1e1v\|1e1v]], [[1ol2\|1ol2]], [[1h27\|1h27]], [[1jsv\|1jsv]], [[2b52\|2b52]], [[1ke5\|1ke5]], [[1fin\|1fin]], [[2c5o\|2c5o]], [[2c68\|2c68]], [[1p2a\|1p2a]], [[2x1n\|2x1n]], [[2vtt\|2vtt]], [[2vtq\|2vtq]], [[2c4g\|2c4g]], [[1h1q\|1h1q]], [[1w0x\|1w0x]], [[2w05\|2w05]], [[1pxo\|1pxo]], [[1ke9\|1ke9]], [[1hck\|1hck]], [[2a0c\|2a0c]], [[1jsu\|1jsu]], [[1pxn\|1pxn]], [[2uze\|2uze]], [[2vtm\|2vtm]], [[2v0d\|2v0d]], [[1oiq\|1oiq]], [[1h1r\|1h1r]], [[2iw8\|2iw8]], [[1gih\|1gih]], [[1hcl\|1hcl]], [[1pw2\|1pw2]], [[2whb\|2whb]], [[2w06\|2w06]], [[2vtn\|2vtn]], [[1jst\|1jst]], [[1oiu\|1oiu]], [[1pxm\|1pxm]], [[1b38\|1b38]], [[1fq1\|1fq1]], [[1vyw\|1vyw]], [[1h1p\|1h1p]], [[2wma\|2wma]], [[2c69\|2c69]], [[1urc\|1urc]], [[1pxi\|1pxi]], [[2c6i\|2c6i]], [[1ykr\|1ykr]], [[2wxv\|2wxv]], [[2w17\|2w17]], [[2uzd\|2uzd]], [[2c6k\|2c6k]], [[2c5y\|2c5y]], [[1wcc\|1wcc]], [[2j9m\|2j9m]], [[1vyz\|1vyz]], [[2vti\|2vti]], [[1jvp\|1jvp]], [[1w98\|1w98]], [[2wip\|2wip]], [[1pkd\|1pkd]], [[1p5e\|1p5e]], [[2vts\|2vts]], [[2uzn\|2uzn]], [[2b54\|2b54]], [[1ke6\|1ke6]], [[1pxj\|1pxj]], [[2uzl\|2uzl]], [[2cci\|2cci]], [[2bkz\|2bkz]], [[2g9x\|2g9x]], [[1y91\|1y91]], [[2iw6\|2iw6]], [[1gij\|1gij]], [[1r78\|1r78]], [[1h0v\|1h0v]], [[2iw9\|2iw9]], [[1w8c\|1w8c]], [[1buh\|1buh]], [[2bpm\|2bpm]], [[2bts\|2bts]], [[1fvv\|1fvv]], [[1okw\|1okw]], [[2a4l\|2a4l]], [[2vtp\|2vtp]], [[2c6t\|2c6t]], [[1fvt\|1fvt]], [[1qmz\|1qmz]], [[2w1h\|2w1h]], [[2vu3\|2vu3]], [[2xmy\|2xmy]], [[2b55\|2b55]], [[1ogu\|1ogu]], [[1pf8\|1pf8]], [[1h1s\|1h1s]], [[2c5v\|2c5v]], [[2jgz\|2jgz]], [[2bhe\|2bhe]], [[1urw\|1urw]], [[1oiy\|1oiy]], [[2c6l\|2c6l]], [[1f5q\|1f5q]], [[2c6o\|2c6o]], [[2vtl\|2vtl]], [[1ol1\|1ol1]], [[2wfy\|2wfy]], [[1h01\|1h01]], [[2uzb\|2uzb]], [[1oir\|1oir]], [[1oi9\|1oi9]], [[2vtj\|2vtj]], [[2cjm\|2cjm]], [[2c5n\|2c5n]], [[2wev\|2wev]], [[2c5x\|2c5x]], [[2c6m\|2c6m]], [[1oit\|1oit]], [[2v22\|2v22]], [[1gy3\|1gy3]], [[1gii\|1gii]], [[2vv9\|2vv9]], [[1di8\|1di8]], [[2wpa\|2wpa]], [[2wmb\|2wmb]], [[1e9h\|1e9h]], [[2vto\|2vto]], [[1dm2\|1dm2]], [[2uzo\|2uzo]], [[1h24\|1h24]], [[2exm\|2exm]], [[1h00\|1h00]], [[2clx\|2clx]], [[1pxp\|1pxp]], [[2cch\|2cch]], [[1b39\|1b39]], [[2xnb\|2xnb]], [[2btr\|2btr]], [[1aq1\|1aq1]], [[1h0w\|1h0w]], [[1g5s\|1g5s]], [[1ckp\|1ckp]], [[1ke8\|1ke8]], [[1pxl\|1pxl]], [[1h28\|1h28]], [[2vtr\|2vtr]], [[1h26\|1h26]], [[1e1x\|1e1x]], [[1h07\|1h07]], [[1y8y\|1y8y]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4acm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4acm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4acm RCSB], [http://www.ebi.ac.uk/pdbsum/4acm PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CDK2_HUMAN CDK2_HUMAN]] Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization.<ref>PMID:10499802</ref> <ref>PMID:11051553</ref> <ref>PMID:10995386</ref> <ref>PMID:10995387</ref> <ref>PMID:10884347</ref> <ref>PMID:11113184</ref> <ref>PMID:15800615</ref> <ref>PMID:18372919</ref> <ref>PMID:20147522</ref> <ref>PMID:20079829</ref> <ref>PMID:20935635</ref> <ref>PMID:20195506</ref> <ref>PMID:19966300</ref> <ref>PMID:21262353</ref> <ref>PMID:21596315</ref> <ref>PMID:21319273</ref> <ref>PMID:17495531</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glycogen synthase kinase-3beta, also called tau phosphorylating kinase, is a proline-directed serine/threonine kinase which was originally identified due to its role in glycogen metabolism. Active forms of GSK3beta localize to pretangle pathology including dystrophic neuritis and neurofibrillary tangles in Alzheimer's disease (AD) brain. By using a high throughput screening (HTS) approach to search for new chemical series and cocrystallization of key analogues to guide the optimization and synthesis of our pyrazine series, we have developed highly potent and selective inhibitors showing cellular efficacy and blood-brain barrier penetrance. The inhibitors are suitable for in vivo efficacy testing and may serve as a new treatment strategy for Alzheimer's disease.

-	~~{{STRUCTURE_4acm\| PDB=4acm \| SCENE= }}~~	+	Discovery of Novel Potent and Highly Selective Glycogen Synthase Kinase-3beta (GSK3beta) Inhibitors for Alzheimer's Disease: Design, Synthesis, and Characterization of Pyrazines.,Berg S, Bergh M, Hellberg S, Hogdin K, Lo-Alfredsson Y, Soderman P, von Berg S, Weigelt T, Ormo M, Xue Y, Tucker J, Neelissen J, Jerning E, Nilsson Y, Bhat R J Med Chem. 2012 Apr 27. PMID:22489897<ref>PMID:22489897</ref>

-	~~===CDK2 IN COMPLEX WITH 3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}-PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_22489897}}~~	+	==See Also==
-		+	*[[Cell division protein kinase 2\|Cell division protein kinase 2]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4acm~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACM OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:022489897<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Cyclin-dependent kinase]]		[[Category: Cyclin-dependent kinase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Anderson, M.]]	+	[[Category: Anderson, M]]
-	[[Category: Berg, S.]]	+	[[Category: Berg, S]]
-	[[Category: Berga, S Von.]]	+	[[Category: Berga, S Von]]
-	[[Category: Bergh, M.]]	+	[[Category: Bergh, M]]
-	[[Category: Bhat, R.]]	+	[[Category: Bhat, R]]
-	[[Category: Brassington, C.]]	+	[[Category: Brassington, C]]
-	[[Category: Hellberg, S.]]	+	[[Category: Hellberg, S]]
-	[[Category: Hogdin, K.]]	+	[[Category: Hogdin, K]]
-	[[Category: Jerning, E.]]	+	[[Category: Jerning, E]]
-	[[Category: Lo-Alfredsson, Y.]]	+	[[Category: Lo-Alfredsson, Y]]
-	[[Category: Neelissen, J.]]	+	[[Category: Neelissen, J]]
-	[[Category: Nilsson, Y.]]	+	[[Category: Nilsson, Y]]
-	[[Category: Ormo, M.]]	+	[[Category: Ormo, M]]
-	[[Category: Soderman, P.]]	+	[[Category: Soderman, P]]
-	[[Category: Stanway, J.]]	+	[[Category: Stanway, J]]
-	[[Category: Tucker, J.]]	+	[[Category: Tucker, J]]
-	[[Category: Weigelt, T.]]	+	[[Category: Weigelt, T]]
-	[[Category: Xue, Y.]]	+	[[Category: Xue, Y]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]

OCA at 09:53, 21 November 2012

OCA — Wed, 21 Nov 2012 09:53:09 GMT

←Older revision		Revision as of 09:53, 21 November 2012
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-	[[Image:4acm.~~jpg~~\|left\|200px]]	+	[[Image:4acm.png\|left\|200px]]

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-	-->
	{{STRUCTURE_4acm\| PDB=4acm \| SCENE= }}		{{STRUCTURE_4acm\| PDB=4acm \| SCENE= }}

	===CDK2 IN COMPLEX WITH 3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}-PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE===		===CDK2 IN COMPLEX WITH 3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}-PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22489897}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22489897 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22489897}}		{{ABSTRACT_PUBMED_22489897}}

OCA at 09:15, 16 May 2012

OCA — Wed, 16 May 2012 09:15:39 GMT

←Older revision		Revision as of 09:15, 16 May 2012
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-	~~'''Unreleased structure'''~~	+	[[Image:4acm.jpg\|left\|200px]]

-	The ~~entry 4acm~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4acm", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4acm\| PDB=4acm \| SCENE= }}

-	~~Authors: Berg, S., Bhat, R., Anderson, M., Bergh, M., Brassington, C., Hellberg, S., Jerning, E., Hogdin, K., Lo~~-~~Alfredsson, Y., Neelissen, J., Nilsson, Y., Ormo, M., Soderman, P., Stanway, J., Tucker, J., von Berga, S., Weigelt, T., Xue, Y.~~	+	===CDK2 IN COMPLEX WITH 3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}-PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE===

-	~~Description: CDK2 IN COMPLEX WITH 3~~-~~AMINO-6~~-(4-{[2-~~(DIMETHYLAMINO)ETHYL~~]~~SULFAMOYL}~~-~~PHENYL)~~-N-~~PYRIDIN~~-3-~~YLPYRAZINE-2-CARBOXAMIDE~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22489897}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22489897 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22489897}}
		+
		+	==About this Structure==
		+	[[4acm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACM OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022489897</ref><references group="xtra"/>
		+	[[Category: Cyclin-dependent kinase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Anderson, M.]]
		+	[[Category: Berg, S.]]
		+	[[Category: Berga, S Von.]]
		+	[[Category: Bergh, M.]]
		+	[[Category: Bhat, R.]]
		+	[[Category: Brassington, C.]]
		+	[[Category: Hellberg, S.]]
		+	[[Category: Hogdin, K.]]
		+	[[Category: Jerning, E.]]
		+	[[Category: Lo-Alfredsson, Y.]]
		+	[[Category: Neelissen, J.]]
		+	[[Category: Nilsson, Y.]]
		+	[[Category: Ormo, M.]]
		+	[[Category: Soderman, P.]]
		+	[[Category: Stanway, J.]]
		+	[[Category: Tucker, J.]]
		+	[[Category: Weigelt, T.]]
		+	[[Category: Xue, Y.]]
		+	[[Category: Atp-binding]]
		+	[[Category: Cell cycle]]
		+	[[Category: Cell division]]
		+	[[Category: Mitosis]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Serine/threonine- protein kinase]]
		+	[[Category: Transferase]]

OCA: Protected "4acm" [edit=sysop:move=sysop]

OCA — Wed, 28 Dec 2011 07:01:55 GMT

Protected "4acm" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:01, 28 December 2011

←Older revision		Revision as of 05:29, 25 August 2022
Line 3:		Line 3:
	<StructureSection load='4acm' size='340' side='right'caption='[[4acm]], [[Resolution\|resolution]] 1.63Å' scene=''>		<StructureSection load='4acm' size='340' side='right'caption='[[4acm]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4acm]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=4ACM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4acm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ACM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7YG:3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE'>7YG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7YG:3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE'>7YG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1h08\|1h08]], [[1pye\|1pye]], [[2vth\|2vth]], [[1v1k\|1v1k]], [[2b53\|2b53]], [[1h25\|1h25]], [[1okv\|1okv]], [[1ke7\|1ke7]], [[1pxk\|1pxk]], [[2wih\|2wih]], [[2bhh\|2bhh]], [[2vta\|2vta]], [[2uue\|2uue]], [[1gz8\|1gz8]], [[1e1v\|1e1v]], [[1ol2\|1ol2]], [[1h27\|1h27]], [[1jsv\|1jsv]], [[2b52\|2b52]], [[1ke5\|1ke5]], [[1fin\|1fin]], [[2c5o\|2c5o]], [[2c68\|2c68]], [[1p2a\|1p2a]], [[2x1n\|2x1n]], [[2vtt\|2vtt]], [[2vtq\|2vtq]], [[2c4g\|2c4g]], [[1h1q\|1h1q]], [[1w0x\|1w0x]], [[2w05\|2w05]], [[1pxo\|1pxo]], [[1ke9\|1ke9]], [[1hck\|1hck]], [[2a0c\|2a0c]], [[1jsu\|1jsu]], [[1pxn\|1pxn]], [[2uze\|2uze]], [[2vtm\|2vtm]], [[2v0d\|2v0d]], [[1oiq\|1oiq]], [[1h1r\|1h1r]], [[2iw8\|2iw8]], [[1gih\|1gih]], [[1hcl\|1hcl]], [[1pw2\|1pw2]], [[2whb\|2whb]], [[2w06\|2w06]], [[2vtn\|2vtn]], [[1jst\|1jst]], [[1oiu\|1oiu]], [[1pxm\|1pxm]], [[1b38\|1b38]], [[1fq1\|1fq1]], [[1vyw\|1vyw]], [[1h1p\|1h1p]], [[2wma\|2wma]], [[2c69\|2c69]], [[1urc\|1urc]], [[1pxi\|1pxi]], [[2c6i\|2c6i]], [[1ykr\|1ykr]], [[2wxv\|2wxv]], [[2w17\|2w17]], [[2uzd\|2uzd]], [[2c6k\|2c6k]], [[2c5y\|2c5y]], [[1wcc\|1wcc]], [[2j9m\|2j9m]], [[1vyz\|1vyz]], [[2vti\|2vti]], [[1jvp\|1jvp]], [[1w98\|1w98]], [[2wip\|2wip]], [[1pkd\|1pkd]], [[1p5e\|1p5e]], [[2vts\|2vts]], [[2uzn\|2uzn]], [[2b54\|2b54]], [[1ke6\|1ke6]], [[1pxj\|1pxj]], [[2uzl\|2uzl]], [[2cci\|2cci]], [[2bkz\|2bkz]], [[2g9x\|2g9x]], [[1y91\|1y91]], [[2iw6\|2iw6]], [[1gij\|1gij]], [[1r78\|1r78]], [[1h0v\|1h0v]], [[2iw9\|2iw9]], [[1w8c\|1w8c]], [[1buh\|1buh]], [[2bpm\|2bpm]], [[2bts\|2bts]], [[1fvv\|1fvv]], [[1okw\|1okw]], [[2a4l\|2a4l]], [[2vtp\|2vtp]], [[2c6t\|2c6t]], [[1fvt\|1fvt]], [[1qmz\|1qmz]], [[2w1h\|2w1h]], [[2vu3\|2vu3]], [[2xmy\|2xmy]], [[2b55\|2b55]], [[1ogu\|1ogu]], [[1pf8\|1pf8]], [[1h1s\|1h1s]], [[2c5v\|2c5v]], [[2jgz\|2jgz]], [[2bhe\|2bhe]], [[1urw\|1urw]], [[1oiy\|1oiy]], [[2c6l\|2c6l]], [[1f5q\|1f5q]], [[2c6o\|2c6o]], [[2vtl\|2vtl]], [[1ol1\|1ol1]], [[2wfy\|2wfy]], [[1h01\|1h01]], [[2uzb\|2uzb]], [[1oir\|1oir]], [[1oi9\|1oi9]], [[2vtj\|2vtj]], [[2cjm\|2cjm]], [[2c5n\|2c5n]], [[2wev\|2wev]], [[2c5x\|2c5x]], [[2c6m\|2c6m]], [[1oit\|1oit]], [[2v22\|2v22]], [[1gy3\|1gy3]], [[1gii\|1gii]], [[2vv9\|2vv9]], [[1di8\|1di8]], [[2wpa\|2wpa]], [[2wmb\|2wmb]], [[1e9h\|1e9h]], [[2vto\|2vto]], [[1dm2\|1dm2]], [[2uzo\|2uzo]], [[1h24\|1h24]], [[2exm\|2exm]], [[1h00\|1h00]], [[2clx\|2clx]], [[1pxp\|1pxp]], [[2cch\|2cch]], [[1b39\|1b39]], [[2xnb\|2xnb]], [[2btr\|2btr]], [[1aq1\|1aq1]], [[1h0w\|1h0w]], [[1g5s\|1g5s]], [[1ckp\|1ckp]], [[1ke8\|1ke8]], [[1pxl\|1pxl]], [[1h28\|1h28]], [[2vtr\|2vtr]], [[1h26\|1h26]], [[1e1x\|1e1x]], [[1h07\|1h07]], [[1y8y\|1y8y]]</div></td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1h08\|1h08]], [[1pye\|1pye]], [[2vth\|2vth]], [[1v1k\|1v1k]], [[2b53\|2b53]], [[1h25\|1h25]], [[1okv\|1okv]], [[1ke7\|1ke7]], [[1pxk\|1pxk]], [[2wih\|2wih]], [[2bhh\|2bhh]], [[2vta\|2vta]], [[2uue\|2uue]], [[1gz8\|1gz8]], [[1e1v\|1e1v]], [[1ol2\|1ol2]], [[1h27\|1h27]], [[1jsv\|1jsv]], [[2b52\|2b52]], [[1ke5\|1ke5]], [[1fin\|1fin]], [[2c5o\|2c5o]], [[2c68\|2c68]], [[1p2a\|1p2a]], [[2x1n\|2x1n]], [[2vtt\|2vtt]], [[2vtq\|2vtq]], [[2c4g\|2c4g]], [[1h1q\|1h1q]], [[1w0x\|1w0x]], [[2w05\|2w05]], [[1pxo\|1pxo]], [[1ke9\|1ke9]], [[1hck\|1hck]], [[2a0c\|2a0c]], [[1jsu\|1jsu]], [[1pxn\|1pxn]], [[2uze\|2uze]], [[2vtm\|2vtm]], [[2v0d\|2v0d]], [[1oiq\|1oiq]], [[1h1r\|1h1r]], [[2iw8\|2iw8]], [[1gih\|1gih]], [[1hcl\|1hcl]], [[1pw2\|1pw2]], [[2whb\|2whb]], [[2w06\|2w06]], [[2vtn\|2vtn]], [[1jst\|1jst]], [[1oiu\|1oiu]], [[1pxm\|1pxm]], [[1b38\|1b38]], [[1fq1\|1fq1]], [[1vyw\|1vyw]], [[1h1p\|1h1p]], [[2wma\|2wma]], [[2c69\|2c69]], [[1urc\|1urc]], [[1pxi\|1pxi]], [[2c6i\|2c6i]], [[1ykr\|1ykr]], [[2wxv\|2wxv]], [[2w17\|2w17]], [[2uzd\|2uzd]], [[2c6k\|2c6k]], [[2c5y\|2c5y]], [[1wcc\|1wcc]], [[2j9m\|2j9m]], [[1vyz\|1vyz]], [[2vti\|2vti]], [[1jvp\|1jvp]], [[1w98\|1w98]], [[2wip\|2wip]], [[1pkd\|1pkd]], [[1p5e\|1p5e]], [[2vts\|2vts]], [[2uzn\|2uzn]], [[2b54\|2b54]], [[1ke6\|1ke6]], [[1pxj\|1pxj]], [[2uzl\|2uzl]], [[2cci\|2cci]], [[2bkz\|2bkz]], [[2g9x\|2g9x]], [[1y91\|1y91]], [[2iw6\|2iw6]], [[1gij\|1gij]], [[1r78\|1r78]], [[1h0v\|1h0v]], [[2iw9\|2iw9]], [[1w8c\|1w8c]], [[1buh\|1buh]], [[2bpm\|2bpm]], [[2bts\|2bts]], [[1fvv\|1fvv]], [[1okw\|1okw]], [[2a4l\|2a4l]], [[2vtp\|2vtp]], [[2c6t\|2c6t]], [[1fvt\|1fvt]], [[1qmz\|1qmz]], [[2w1h\|2w1h]], [[2vu3\|2vu3]], [[2xmy\|2xmy]], [[2b55\|2b55]], [[1ogu\|1ogu]], [[1pf8\|1pf8]], [[1h1s\|1h1s]], [[2c5v\|2c5v]], [[2jgz\|2jgz]], [[2bhe\|2bhe]], [[1urw\|1urw]], [[1oiy\|1oiy]], [[2c6l\|2c6l]], [[1f5q\|1f5q]], [[2c6o\|2c6o]], [[2vtl\|2vtl]], [[1ol1\|1ol1]], [[2wfy\|2wfy]], [[1h01\|1h01]], [[2uzb\|2uzb]], [[1oir\|1oir]], [[1oi9\|1oi9]], [[2vtj\|2vtj]], [[2cjm\|2cjm]], [[2c5n\|2c5n]], [[2wev\|2wev]], [[2c5x\|2c5x]], [[2c6m\|2c6m]], [[1oit\|1oit]], [[2v22\|2v22]], [[1gy3\|1gy3]], [[1gii\|1gii]], [[2vv9\|2vv9]], [[1di8\|1di8]], [[2wpa\|2wpa]], [[2wmb\|2wmb]], [[1e9h\|1e9h]], [[2vto\|2vto]], [[1dm2\|1dm2]], [[2uzo\|2uzo]], [[1h24\|1h24]], [[2exm\|2exm]], [[1h00\|1h00]], [[2clx\|2clx]], [[1pxp\|1pxp]], [[2cch\|2cch]], [[1b39\|1b39]], [[2xnb\|2xnb]], [[2btr\|2btr]], [[1aq1\|1aq1]], [[1h0w\|1h0w]], [[1g5s\|1g5s]], [[1ckp\|1ckp]], [[1ke8\|1ke8]], [[1pxl\|1pxl]], [[1h28\|1h28]], [[2vtr\|2vtr]], [[1h26\|1h26]], [[1e1x\|1e1x]], [[1h07\|1h07]], [[1y8y\|1y8y]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=4acm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4acm OCA], [~~http~~://pdbe.org/4acm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4acm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4acm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4acm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4acm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4acm OCA], [https://pdbe.org/4acm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4acm RCSB], [https://www.ebi.ac.uk/pdbsum/4acm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4acm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CDK2_HUMAN CDK2_HUMAN]] Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization.<ref>PMID:10499802</ref> <ref>PMID:11051553</ref> <ref>PMID:10995386</ref> <ref>PMID:10995387</ref> <ref>PMID:10884347</ref> <ref>PMID:11113184</ref> <ref>PMID:15800615</ref> <ref>PMID:18372919</ref> <ref>PMID:20147522</ref> <ref>PMID:20079829</ref> <ref>PMID:20935635</ref> <ref>PMID:20195506</ref> <ref>PMID:19966300</ref> <ref>PMID:21262353</ref> <ref>PMID:21596315</ref> <ref>PMID:21319273</ref> <ref>PMID:17495531</ref>	+	[[https://www.uniprot.org/uniprot/CDK2_HUMAN CDK2_HUMAN]] Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization.<ref>PMID:10499802</ref> <ref>PMID:11051553</ref> <ref>PMID:10995386</ref> <ref>PMID:10995387</ref> <ref>PMID:10884347</ref> <ref>PMID:11113184</ref> <ref>PMID:15800615</ref> <ref>PMID:18372919</ref> <ref>PMID:20147522</ref> <ref>PMID:20079829</ref> <ref>PMID:20935635</ref> <ref>PMID:20195506</ref> <ref>PMID:19966300</ref> <ref>PMID:21262353</ref> <ref>PMID:21596315</ref> <ref>PMID:21319273</ref> <ref>PMID:17495531</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==