4act - Revision history

OCA at 11:24, 20 December 2023

OCA — Wed, 20 Dec 2023 11:24:14 GMT

←Older revision		Revision as of 11:24, 20 December 2023
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	<StructureSection load='4act' size='340' side='right'caption='[[4act]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4act' size='340' side='right'caption='[[4act]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4act]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ACT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4act]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ACT FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FT0:3~~-~~HYDROXY-4-PHENOXYBENZALDEHYDE'>FT0</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>[[2g9k\|2g9k]], [[1dvy\|1dvy]], [[1eta\|1eta]], [[2b9a\|2b9a]], [[1ttr\|1ttr]], [[4ac2\|4ac2]], [[1iii\|1iii]], [[1dvt\|1dvt]], [[1bze\|1bze]], [[1ijn\|1ijn]], [[1bzd\|1bzd]], [[1tt6\|1tt6]], [[1e3f\|1e3f]], [[2b77\|2b77]], [[1tlm\|1tlm]], [[1f41\|1f41]], [[1e5a\|1e5a]], [[1tyr\|1tyr]], [[1sok\|1sok]], [[2pab\|2pab]], [[4abu\|4abu]], [[4abq\|4abq]], [[2wqa\|2wqa]], [[1e4h\|1e4h]], [[2rox\|2rox]], [[1fhn\|1fhn]], [[2b15\|2b15]], [[1fh2\|1fh2]], [[1g1o\|1g1o]], [[2f8i\|2f8i]], [[2b16\|2b16]], [[1iik\|1iik]], [[1tta\|1tta]], [[1dvs\|1dvs]], [[2b14\|2b14]], [[1bmz\|1bmz]], [[1gko\|1gko]], [[1z7j\|1z7j]], [[2flm\|2flm]], [[2fbr\|2fbr]], [[2try\|2try]], [[1dvu\|1dvu]], [[1bz8\|1bz8]], [[1ttb\|1ttb]], [[1thc\|1thc]], [[1qwh\|1qwh]], [[1dvz\|1dvz]], [[1tha\|1tha]], [[1dvq\|1dvq]], [[1y1d\|1y1d]], [[1qab\|1qab]], [[1u21\|1u21]], [[1f86\|1f86]], [[2f7i\|2f7i]], [[1soq\|1soq]], [[1x7s\|1x7s]], [[4abv\|4abv]], [[1zcr\|1zcr]], [[1ict\|1ict]], [[1dvx\|1dvx]], [[1ttc\|1ttc]], [[1bm7\|1bm7]], [[1tz8\|1tz8]], [[2roy\|2roy]], [[1rlb\|1rlb]], [[1etb\|1etb]], [[5ttr\|5ttr]], [[2g5u\|2g5u]], [[1f64\|1f64]], [[2gab\|2gab]], [[4ac4\|4ac4]], [[1x7t\|1x7t]], [[1tsh\|1tsh]], [[2trh\|2trh]], [[1zd6\|1zd6]], [[4abw\|4abw]]</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FT0:3-HYDROXY-4-PHENOXYBENZALDEHYDE'>FT0</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4act FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4act OCA], [https://pdbe.org/4act PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4act RCSB], [https://www.ebi.ac.uk/pdbsum/4act PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4act ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4act FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4act OCA], [https://pdbe.org/4act PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4act RCSB], [https://www.ebi.ac.uk/pdbsum/4act PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4act ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN]] Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR) [MIM:[https://omim.org/entry/105210 105210]]. A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor.<ref>PMID:11243784</ref> <ref>PMID:15735344</ref> <ref>PMID:19167329</ref> <ref>PMID:3818577</ref> <ref>PMID:3022108</ref> <ref>PMID:6651852</ref> <ref>PMID:6583672</ref> <ref>PMID:3135807</ref> <ref>PMID:1517749</ref> <ref>PMID:1932142</ref> <ref>PMID:7923855</ref> <ref>PMID:8382610</ref> <ref>PMID:8428915</ref> <ref>PMID:9733771</ref> <ref>PMID:12403615</ref> <ref>PMID:16185074</ref> <ref>PMID:16627944</ref> <ref>PMID:6487335</ref> <ref>PMID:3722385</ref> <ref>PMID:2891727</ref> <ref>PMID:2161654</ref> <ref>PMID:2363717</ref> <ref>PMID:1656975</ref> <ref>PMID:2046936</ref> <ref>PMID:1570831</ref> <ref>PMID:1734866</ref> <ref>PMID:1520326</ref> <ref>PMID:1520336</ref> <ref>PMID:1544214</ref> <ref>PMID:1351039</ref> <ref>PMID:1301926</ref> <ref>PMID:1362222</ref> <ref>PMID:1436517</ref> <ref>PMID:8352764</ref> <ref>PMID:8038017</ref> <ref>PMID:8257997</ref> <ref>PMID:8095302</ref> <ref>PMID:1997217</ref> <ref>PMID:8019560</ref> <ref>PMID:8081397</ref> <ref>PMID:7914929</ref> <ref>PMID:8133316</ref> <ref>PMID:7910950</ref> <ref>PMID:7655883</ref> <ref>PMID:7850982</ref> <ref>PMID:8579098</ref> <ref>PMID:9066351</ref> <ref>PMID:8990019</ref> <ref>PMID:9605286</ref> <ref>PMID:10036587</ref> <ref>PMID:10627135</ref> <ref>PMID:10694917</ref> <ref>PMID:10211412</ref> <ref>PMID:10439117</ref> <ref>PMID:10611950</ref> <ref>PMID:10071047</ref> <ref>PMID:10436378</ref> <ref>PMID:10842705</ref> <ref>PMID:10842718</ref> <ref>PMID:10882995</ref> <ref>PMID:11445644</ref> <ref>PMID:12557757</ref> <ref>PMID:11866053</ref> <ref>PMID:12050338</ref> <ref>PMID:12771253</ref> <ref>PMID:15214015</ref> <ref>PMID:15478468</ref> <ref>PMID:15217993</ref> <ref>PMID:17453626</ref> <ref>PMID:17577687</ref> <ref>PMID:17503405</ref> <ref>PMID:17635579</ref> Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) [MIM:[https://omim.org/entry/145680 145680]]. It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities.<ref>PMID:1979335</ref> Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1) [MIM:[https://omim.org/entry/115430 115430]]. It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.<ref>PMID:8309582</ref>	+	[https://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN] Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR) [MIM:[https://omim.org/entry/105210 105210]. A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor.<ref>PMID:11243784</ref> <ref>PMID:15735344</ref> <ref>PMID:19167329</ref> <ref>PMID:3818577</ref> <ref>PMID:3022108</ref> <ref>PMID:6651852</ref> <ref>PMID:6583672</ref> <ref>PMID:3135807</ref> <ref>PMID:1517749</ref> <ref>PMID:1932142</ref> <ref>PMID:7923855</ref> <ref>PMID:8382610</ref> <ref>PMID:8428915</ref> <ref>PMID:9733771</ref> <ref>PMID:12403615</ref> <ref>PMID:16185074</ref> <ref>PMID:16627944</ref> <ref>PMID:6487335</ref> <ref>PMID:3722385</ref> <ref>PMID:2891727</ref> <ref>PMID:2161654</ref> <ref>PMID:2363717</ref> <ref>PMID:1656975</ref> <ref>PMID:2046936</ref> <ref>PMID:1570831</ref> <ref>PMID:1734866</ref> <ref>PMID:1520326</ref> <ref>PMID:1520336</ref> <ref>PMID:1544214</ref> <ref>PMID:1351039</ref> <ref>PMID:1301926</ref> <ref>PMID:1362222</ref> <ref>PMID:1436517</ref> <ref>PMID:8352764</ref> <ref>PMID:8038017</ref> <ref>PMID:8257997</ref> <ref>PMID:8095302</ref> <ref>PMID:1997217</ref> <ref>PMID:8019560</ref> <ref>PMID:8081397</ref> <ref>PMID:7914929</ref> <ref>PMID:8133316</ref> <ref>PMID:7910950</ref> <ref>PMID:7655883</ref> <ref>PMID:7850982</ref> <ref>PMID:8579098</ref> <ref>PMID:9066351</ref> <ref>PMID:8990019</ref> <ref>PMID:9605286</ref> <ref>PMID:10036587</ref> <ref>PMID:10627135</ref> <ref>PMID:10694917</ref> <ref>PMID:10211412</ref> <ref>PMID:10439117</ref> <ref>PMID:10611950</ref> <ref>PMID:10071047</ref> <ref>PMID:10436378</ref> <ref>PMID:10842705</ref> <ref>PMID:10842718</ref> <ref>PMID:10882995</ref> <ref>PMID:11445644</ref> <ref>PMID:12557757</ref> <ref>PMID:11866053</ref> <ref>PMID:12050338</ref> <ref>PMID:12771253</ref> <ref>PMID:15214015</ref> <ref>PMID:15478468</ref> <ref>PMID:15217993</ref> <ref>PMID:17453626</ref> <ref>PMID:17577687</ref> <ref>PMID:17503405</ref> <ref>PMID:17635579</ref> Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) [MIM:[https://omim.org/entry/145680 145680]. It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities.<ref>PMID:1979335</ref> Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1) [MIM:[https://omim.org/entry/115430 115430]. It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.<ref>PMID:8309582</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN]] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:3714052</ref>	+	[https://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:3714052</ref>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gupta, S]]	+	[[Category: Gupta S]]
-	[[Category: Khan, T]]	+	[[Category: Khan T]]
-	[[Category: Mishra, S]]	+	[[Category: Mishra S]]
-	[[Category: Salunke~~, D M~~]]	+	[[Category: Salunke DM]]
-	[[Category: Singh~~, R R~~]]	+	[[Category: Singh RR]]
-	[[Category: Surolia, A]]	+	[[Category: Surolia A]]
-	[[Category: Tomar, D]]	+	[[Category: Tomar D]]
-	~~[[Category: Amyloidosis inhibition]]~~	+
-	~~[[Category: Hormone]]~~	+
-	~~[[Category: Thyroxine transport protein]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 05:29, 25 August 2022

OCA — Thu, 25 Aug 2022 05:29:42 GMT

←Older revision		Revision as of 05:29, 25 August 2022
Line 3:		Line 3:
	<StructureSection load='4act' size='340' side='right'caption='[[4act]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4act' size='340' side='right'caption='[[4act]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4act]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ACT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4act]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ACT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FT0:3-HYDROXY-4-PHENOXYBENZALDEHYDE'>FT0</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FT0:3-HYDROXY-4-PHENOXYBENZALDEHYDE'>FT0</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g9k\|2g9k]], [[1dvy\|1dvy]], [[1eta\|1eta]], [[2b9a\|2b9a]], [[1ttr\|1ttr]], [[4ac2\|4ac2]], [[1iii\|1iii]], [[1dvt\|1dvt]], [[1bze\|1bze]], [[1ijn\|1ijn]], [[1bzd\|1bzd]], [[1tt6\|1tt6]], [[1e3f\|1e3f]], [[2b77\|2b77]], [[1tlm\|1tlm]], [[1f41\|1f41]], [[1e5a\|1e5a]], [[1tyr\|1tyr]], [[1sok\|1sok]], [[2pab\|2pab]], [[4abu\|4abu]], [[4abq\|4abq]], [[2wqa\|2wqa]], [[1e4h\|1e4h]], [[2rox\|2rox]], [[1fhn\|1fhn]], [[2b15\|2b15]], [[1fh2\|1fh2]], [[1g1o\|1g1o]], [[2f8i\|2f8i]], [[2b16\|2b16]], [[1iik\|1iik]], [[1tta\|1tta]], [[1dvs\|1dvs]], [[2b14\|2b14]], [[1bmz\|1bmz]], [[1gko\|1gko]], [[1z7j\|1z7j]], [[2flm\|2flm]], [[2fbr\|2fbr]], [[2try\|2try]], [[1dvu\|1dvu]], [[1bz8\|1bz8]], [[1ttb\|1ttb]], [[1thc\|1thc]], [[1qwh\|1qwh]], [[1dvz\|1dvz]], [[1tha\|1tha]], [[1dvq\|1dvq]], [[1y1d\|1y1d]], [[1qab\|1qab]], [[1u21\|1u21]], [[1f86\|1f86]], [[2f7i\|2f7i]], [[1soq\|1soq]], [[1x7s\|1x7s]], [[4abv\|4abv]], [[1zcr\|1zcr]], [[1ict\|1ict]], [[1dvx\|1dvx]], [[1ttc\|1ttc]], [[1bm7\|1bm7]], [[1tz8\|1tz8]], [[2roy\|2roy]], [[1rlb\|1rlb]], [[1etb\|1etb]], [[5ttr\|5ttr]], [[2g5u\|2g5u]], [[1f64\|1f64]], [[2gab\|2gab]], [[4ac4\|4ac4]], [[1x7t\|1x7t]], [[1tsh\|1tsh]], [[2trh\|2trh]], [[1zd6\|1zd6]], [[4abw\|4abw]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2g9k\|2g9k]], [[1dvy\|1dvy]], [[1eta\|1eta]], [[2b9a\|2b9a]], [[1ttr\|1ttr]], [[4ac2\|4ac2]], [[1iii\|1iii]], [[1dvt\|1dvt]], [[1bze\|1bze]], [[1ijn\|1ijn]], [[1bzd\|1bzd]], [[1tt6\|1tt6]], [[1e3f\|1e3f]], [[2b77\|2b77]], [[1tlm\|1tlm]], [[1f41\|1f41]], [[1e5a\|1e5a]], [[1tyr\|1tyr]], [[1sok\|1sok]], [[2pab\|2pab]], [[4abu\|4abu]], [[4abq\|4abq]], [[2wqa\|2wqa]], [[1e4h\|1e4h]], [[2rox\|2rox]], [[1fhn\|1fhn]], [[2b15\|2b15]], [[1fh2\|1fh2]], [[1g1o\|1g1o]], [[2f8i\|2f8i]], [[2b16\|2b16]], [[1iik\|1iik]], [[1tta\|1tta]], [[1dvs\|1dvs]], [[2b14\|2b14]], [[1bmz\|1bmz]], [[1gko\|1gko]], [[1z7j\|1z7j]], [[2flm\|2flm]], [[2fbr\|2fbr]], [[2try\|2try]], [[1dvu\|1dvu]], [[1bz8\|1bz8]], [[1ttb\|1ttb]], [[1thc\|1thc]], [[1qwh\|1qwh]], [[1dvz\|1dvz]], [[1tha\|1tha]], [[1dvq\|1dvq]], [[1y1d\|1y1d]], [[1qab\|1qab]], [[1u21\|1u21]], [[1f86\|1f86]], [[2f7i\|2f7i]], [[1soq\|1soq]], [[1x7s\|1x7s]], [[4abv\|4abv]], [[1zcr\|1zcr]], [[1ict\|1ict]], [[1dvx\|1dvx]], [[1ttc\|1ttc]], [[1bm7\|1bm7]], [[1tz8\|1tz8]], [[2roy\|2roy]], [[1rlb\|1rlb]], [[1etb\|1etb]], [[5ttr\|5ttr]], [[2g5u\|2g5u]], [[1f64\|1f64]], [[2gab\|2gab]], [[4ac4\|4ac4]], [[1x7t\|1x7t]], [[1tsh\|1tsh]], [[2trh\|2trh]], [[1zd6\|1zd6]], [[4abw\|4abw]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4act FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4act OCA], [~~http~~://pdbe.org/4act PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4act RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4act PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4act ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4act FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4act OCA], [https://pdbe.org/4act PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4act RCSB], [https://www.ebi.ac.uk/pdbsum/4act PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4act ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN]] Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR) [MIM:[~~http~~://omim.org/entry/105210 105210]]. A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor.<ref>PMID:11243784</ref> <ref>PMID:15735344</ref> <ref>PMID:19167329</ref> <ref>PMID:3818577</ref> <ref>PMID:3022108</ref> <ref>PMID:6651852</ref> <ref>PMID:6583672</ref> <ref>PMID:3135807</ref> <ref>PMID:1517749</ref> <ref>PMID:1932142</ref> <ref>PMID:7923855</ref> <ref>PMID:8382610</ref> <ref>PMID:8428915</ref> <ref>PMID:9733771</ref> <ref>PMID:12403615</ref> <ref>PMID:16185074</ref> <ref>PMID:16627944</ref> <ref>PMID:6487335</ref> <ref>PMID:3722385</ref> <ref>PMID:2891727</ref> <ref>PMID:2161654</ref> <ref>PMID:2363717</ref> <ref>PMID:1656975</ref> <ref>PMID:2046936</ref> <ref>PMID:1570831</ref> <ref>PMID:1734866</ref> <ref>PMID:1520326</ref> <ref>PMID:1520336</ref> <ref>PMID:1544214</ref> <ref>PMID:1351039</ref> <ref>PMID:1301926</ref> <ref>PMID:1362222</ref> <ref>PMID:1436517</ref> <ref>PMID:8352764</ref> <ref>PMID:8038017</ref> <ref>PMID:8257997</ref> <ref>PMID:8095302</ref> <ref>PMID:1997217</ref> <ref>PMID:8019560</ref> <ref>PMID:8081397</ref> <ref>PMID:7914929</ref> <ref>PMID:8133316</ref> <ref>PMID:7910950</ref> <ref>PMID:7655883</ref> <ref>PMID:7850982</ref> <ref>PMID:8579098</ref> <ref>PMID:9066351</ref> <ref>PMID:8990019</ref> <ref>PMID:9605286</ref> <ref>PMID:10036587</ref> <ref>PMID:10627135</ref> <ref>PMID:10694917</ref> <ref>PMID:10211412</ref> <ref>PMID:10439117</ref> <ref>PMID:10611950</ref> <ref>PMID:10071047</ref> <ref>PMID:10436378</ref> <ref>PMID:10842705</ref> <ref>PMID:10842718</ref> <ref>PMID:10882995</ref> <ref>PMID:11445644</ref> <ref>PMID:12557757</ref> <ref>PMID:11866053</ref> <ref>PMID:12050338</ref> <ref>PMID:12771253</ref> <ref>PMID:15214015</ref> <ref>PMID:15478468</ref> <ref>PMID:15217993</ref> <ref>PMID:17453626</ref> <ref>PMID:17577687</ref> <ref>PMID:17503405</ref> <ref>PMID:17635579</ref> Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) [MIM:[~~http~~://omim.org/entry/145680 145680]]. It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities.<ref>PMID:1979335</ref> Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1) [MIM:[~~http~~://omim.org/entry/115430 115430]]. It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.<ref>PMID:8309582</ref>	+	[[https://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN]] Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR) [MIM:[https://omim.org/entry/105210 105210]]. A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor.<ref>PMID:11243784</ref> <ref>PMID:15735344</ref> <ref>PMID:19167329</ref> <ref>PMID:3818577</ref> <ref>PMID:3022108</ref> <ref>PMID:6651852</ref> <ref>PMID:6583672</ref> <ref>PMID:3135807</ref> <ref>PMID:1517749</ref> <ref>PMID:1932142</ref> <ref>PMID:7923855</ref> <ref>PMID:8382610</ref> <ref>PMID:8428915</ref> <ref>PMID:9733771</ref> <ref>PMID:12403615</ref> <ref>PMID:16185074</ref> <ref>PMID:16627944</ref> <ref>PMID:6487335</ref> <ref>PMID:3722385</ref> <ref>PMID:2891727</ref> <ref>PMID:2161654</ref> <ref>PMID:2363717</ref> <ref>PMID:1656975</ref> <ref>PMID:2046936</ref> <ref>PMID:1570831</ref> <ref>PMID:1734866</ref> <ref>PMID:1520326</ref> <ref>PMID:1520336</ref> <ref>PMID:1544214</ref> <ref>PMID:1351039</ref> <ref>PMID:1301926</ref> <ref>PMID:1362222</ref> <ref>PMID:1436517</ref> <ref>PMID:8352764</ref> <ref>PMID:8038017</ref> <ref>PMID:8257997</ref> <ref>PMID:8095302</ref> <ref>PMID:1997217</ref> <ref>PMID:8019560</ref> <ref>PMID:8081397</ref> <ref>PMID:7914929</ref> <ref>PMID:8133316</ref> <ref>PMID:7910950</ref> <ref>PMID:7655883</ref> <ref>PMID:7850982</ref> <ref>PMID:8579098</ref> <ref>PMID:9066351</ref> <ref>PMID:8990019</ref> <ref>PMID:9605286</ref> <ref>PMID:10036587</ref> <ref>PMID:10627135</ref> <ref>PMID:10694917</ref> <ref>PMID:10211412</ref> <ref>PMID:10439117</ref> <ref>PMID:10611950</ref> <ref>PMID:10071047</ref> <ref>PMID:10436378</ref> <ref>PMID:10842705</ref> <ref>PMID:10842718</ref> <ref>PMID:10882995</ref> <ref>PMID:11445644</ref> <ref>PMID:12557757</ref> <ref>PMID:11866053</ref> <ref>PMID:12050338</ref> <ref>PMID:12771253</ref> <ref>PMID:15214015</ref> <ref>PMID:15478468</ref> <ref>PMID:15217993</ref> <ref>PMID:17453626</ref> <ref>PMID:17577687</ref> <ref>PMID:17503405</ref> <ref>PMID:17635579</ref> Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) [MIM:[https://omim.org/entry/145680 145680]]. It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities.<ref>PMID:1979335</ref> Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1) [MIM:[https://omim.org/entry/115430 115430]]. It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.<ref>PMID:8309582</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN]] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:3714052</ref>	+	[[https://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN]] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:3714052</ref>

	==See Also==		==See Also==
-	*[[Transthyretin\|Transthyretin]]	+	*[[Transthyretin 3D structures\|Transthyretin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:47, 17 July 2019

OCA — Wed, 17 Jul 2019 11:47:31 GMT

←Older revision		Revision as of 11:47, 17 July 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-17==		==CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-17==
-	<StructureSection load='4act' size='340' side='right' caption='[[4act]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4act' size='340' side='right'caption='[[4act]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4act]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ACT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4act]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ACT FirstGlance]. <br>
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Gupta, S]]		[[Category: Gupta, S]]
	[[Category: Khan, T]]		[[Category: Khan, T]]

OCA at 20:03, 11 August 2016

OCA — Thu, 11 Aug 2016 20:03:10 GMT

←Older revision		Revision as of 20:03, 11 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-17==		==CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-17==
	<StructureSection load='4act' size='340' side='right' caption='[[4act]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4act' size='340' side='right' caption='[[4act]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4act]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ACT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4act]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ACT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FT0:3-HYDROXY-4-PHENOXYBENZALDEHYDE'>FT0</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FT0:3-HYDROXY-4-PHENOXYBENZALDEHYDE'>FT0</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g9k\|2g9k]], [[1dvy\|1dvy]], [[1eta\|1eta]], [[2b9a\|2b9a]], [[1ttr\|1ttr]], [[4ac2\|4ac2]], [[1iii\|1iii]], [[1dvt\|1dvt]], [[1bze\|1bze]], [[1ijn\|1ijn]], [[1bzd\|1bzd]], [[1tt6\|1tt6]], [[1e3f\|1e3f]], [[2b77\|2b77]], [[1tlm\|1tlm]], [[1f41\|1f41]], [[1e5a\|1e5a]], [[1tyr\|1tyr]], [[1sok\|1sok]], [[2pab\|2pab]], [[4abu\|4abu]], [[4abq\|4abq]], [[2wqa\|2wqa]], [[1e4h\|1e4h]], [[2rox\|2rox]], [[1fhn\|1fhn]], [[2b15\|2b15]], [[1fh2\|1fh2]], [[1g1o\|1g1o]], [[2f8i\|2f8i]], [[2b16\|2b16]], [[1iik\|1iik]], [[1tta\|1tta]], [[1dvs\|1dvs]], [[2b14\|2b14]], [[1bmz\|1bmz]], [[1gko\|1gko]], [[1z7j\|1z7j]], [[2flm\|2flm]], [[2fbr\|2fbr]], [[2try\|2try]], [[1dvu\|1dvu]], [[1bz8\|1bz8]], [[1ttb\|1ttb]], [[1thc\|1thc]], [[1qwh\|1qwh]], [[1dvz\|1dvz]], [[1tha\|1tha]], [[1dvq\|1dvq]], [[1y1d\|1y1d]], [[1qab\|1qab]], [[1u21\|1u21]], [[1f86\|1f86]], [[2f7i\|2f7i]], [[1soq\|1soq]], [[1x7s\|1x7s]], [[4abv\|4abv]], [[1zcr\|1zcr]], [[1ict\|1ict]], [[1dvx\|1dvx]], [[1ttc\|1ttc]], [[1bm7\|1bm7]], [[1tz8\|1tz8]], [[2roy\|2roy]], [[1rlb\|1rlb]], [[1etb\|1etb]], [[5ttr\|5ttr]], [[2g5u\|2g5u]], [[1f64\|1f64]], [[2gab\|2gab]], [[4ac4\|4ac4]], [[1x7t\|1x7t]], [[1tsh\|1tsh]], [[2trh\|2trh]], [[1zd6\|1zd6]], [[4abw\|4abw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g9k\|2g9k]], [[1dvy\|1dvy]], [[1eta\|1eta]], [[2b9a\|2b9a]], [[1ttr\|1ttr]], [[4ac2\|4ac2]], [[1iii\|1iii]], [[1dvt\|1dvt]], [[1bze\|1bze]], [[1ijn\|1ijn]], [[1bzd\|1bzd]], [[1tt6\|1tt6]], [[1e3f\|1e3f]], [[2b77\|2b77]], [[1tlm\|1tlm]], [[1f41\|1f41]], [[1e5a\|1e5a]], [[1tyr\|1tyr]], [[1sok\|1sok]], [[2pab\|2pab]], [[4abu\|4abu]], [[4abq\|4abq]], [[2wqa\|2wqa]], [[1e4h\|1e4h]], [[2rox\|2rox]], [[1fhn\|1fhn]], [[2b15\|2b15]], [[1fh2\|1fh2]], [[1g1o\|1g1o]], [[2f8i\|2f8i]], [[2b16\|2b16]], [[1iik\|1iik]], [[1tta\|1tta]], [[1dvs\|1dvs]], [[2b14\|2b14]], [[1bmz\|1bmz]], [[1gko\|1gko]], [[1z7j\|1z7j]], [[2flm\|2flm]], [[2fbr\|2fbr]], [[2try\|2try]], [[1dvu\|1dvu]], [[1bz8\|1bz8]], [[1ttb\|1ttb]], [[1thc\|1thc]], [[1qwh\|1qwh]], [[1dvz\|1dvz]], [[1tha\|1tha]], [[1dvq\|1dvq]], [[1y1d\|1y1d]], [[1qab\|1qab]], [[1u21\|1u21]], [[1f86\|1f86]], [[2f7i\|2f7i]], [[1soq\|1soq]], [[1x7s\|1x7s]], [[4abv\|4abv]], [[1zcr\|1zcr]], [[1ict\|1ict]], [[1dvx\|1dvx]], [[1ttc\|1ttc]], [[1bm7\|1bm7]], [[1tz8\|1tz8]], [[2roy\|2roy]], [[1rlb\|1rlb]], [[1etb\|1etb]], [[5ttr\|5ttr]], [[2g5u\|2g5u]], [[1f64\|1f64]], [[2gab\|2gab]], [[4ac4\|4ac4]], [[1x7t\|1x7t]], [[1tsh\|1tsh]], [[2trh\|2trh]], [[1zd6\|1zd6]], [[4abw\|4abw]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4act FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4act OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4act RCSB], [http://www.ebi.ac.uk/pdbsum/4act PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4act FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4act OCA], [http://pdbe.org/4act PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4act RCSB], [http://www.ebi.ac.uk/pdbsum/4act PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4act ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Gupta, S]]		[[Category: Gupta, S]]
	[[Category: Khan, T]]		[[Category: Khan, T]]

OCA at 10:30, 25 January 2015

OCA — Sun, 25 Jan 2015 10:30:37 GMT

←Older revision		Revision as of 10:30, 25 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4act\| PDB=4act \| SCENE= }}~~	+	==CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-17==
-	===CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-17===	+	<StructureSection load='4act' size='340' side='right' caption='[[4act]], [[Resolution\|resolution]] 1.80Å' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[4act]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ACT FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FT0:3-HYDROXY-4-PHENOXYBENZALDEHYDE'>FT0</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g9k\|2g9k]], [[1dvy\|1dvy]], [[1eta\|1eta]], [[2b9a\|2b9a]], [[1ttr\|1ttr]], [[4ac2\|4ac2]], [[1iii\|1iii]], [[1dvt\|1dvt]], [[1bze\|1bze]], [[1ijn\|1ijn]], [[1bzd\|1bzd]], [[1tt6\|1tt6]], [[1e3f\|1e3f]], [[2b77\|2b77]], [[1tlm\|1tlm]], [[1f41\|1f41]], [[1e5a\|1e5a]], [[1tyr\|1tyr]], [[1sok\|1sok]], [[2pab\|2pab]], [[4abu\|4abu]], [[4abq\|4abq]], [[2wqa\|2wqa]], [[1e4h\|1e4h]], [[2rox\|2rox]], [[1fhn\|1fhn]], [[2b15\|2b15]], [[1fh2\|1fh2]], [[1g1o\|1g1o]], [[2f8i\|2f8i]], [[2b16\|2b16]], [[1iik\|1iik]], [[1tta\|1tta]], [[1dvs\|1dvs]], [[2b14\|2b14]], [[1bmz\|1bmz]], [[1gko\|1gko]], [[1z7j\|1z7j]], [[2flm\|2flm]], [[2fbr\|2fbr]], [[2try\|2try]], [[1dvu\|1dvu]], [[1bz8\|1bz8]], [[1ttb\|1ttb]], [[1thc\|1thc]], [[1qwh\|1qwh]], [[1dvz\|1dvz]], [[1tha\|1tha]], [[1dvq\|1dvq]], [[1y1d\|1y1d]], [[1qab\|1qab]], [[1u21\|1u21]], [[1f86\|1f86]], [[2f7i\|2f7i]], [[1soq\|1soq]], [[1x7s\|1x7s]], [[4abv\|4abv]], [[1zcr\|1zcr]], [[1ict\|1ict]], [[1dvx\|1dvx]], [[1ttc\|1ttc]], [[1bm7\|1bm7]], [[1tz8\|1tz8]], [[2roy\|2roy]], [[1rlb\|1rlb]], [[1etb\|1etb]], [[5ttr\|5ttr]], [[2g5u\|2g5u]], [[1f64\|1f64]], [[2gab\|2gab]], [[4ac4\|4ac4]], [[1x7t\|1x7t]], [[1tsh\|1tsh]], [[2trh\|2trh]], [[1zd6\|1zd6]], [[4abw\|4abw]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4act FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4act OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4act RCSB], [http://www.ebi.ac.uk/pdbsum/4act PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN]] Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR) [MIM:[http://omim.org/entry/105210 105210]]. A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor.<ref>PMID:11243784</ref> <ref>PMID:15735344</ref> <ref>PMID:19167329</ref> <ref>PMID:3818577</ref> <ref>PMID:3022108</ref> <ref>PMID:6651852</ref> <ref>PMID:6583672</ref> <ref>PMID:3135807</ref> <ref>PMID:1517749</ref> <ref>PMID:1932142</ref> <ref>PMID:7923855</ref> <ref>PMID:8382610</ref> <ref>PMID:8428915</ref> <ref>PMID:9733771</ref> <ref>PMID:12403615</ref> <ref>PMID:16185074</ref> <ref>PMID:16627944</ref> <ref>PMID:6487335</ref> <ref>PMID:3722385</ref> <ref>PMID:2891727</ref> <ref>PMID:2161654</ref> <ref>PMID:2363717</ref> <ref>PMID:1656975</ref> <ref>PMID:2046936</ref> <ref>PMID:1570831</ref> <ref>PMID:1734866</ref> <ref>PMID:1520326</ref> <ref>PMID:1520336</ref> <ref>PMID:1544214</ref> <ref>PMID:1351039</ref> <ref>PMID:1301926</ref> <ref>PMID:1362222</ref> <ref>PMID:1436517</ref> <ref>PMID:8352764</ref> <ref>PMID:8038017</ref> <ref>PMID:8257997</ref> <ref>PMID:8095302</ref> <ref>PMID:1997217</ref> <ref>PMID:8019560</ref> <ref>PMID:8081397</ref> <ref>PMID:7914929</ref> <ref>PMID:8133316</ref> <ref>PMID:7910950</ref> <ref>PMID:7655883</ref> <ref>PMID:7850982</ref> <ref>PMID:8579098</ref> <ref>PMID:9066351</ref> <ref>PMID:8990019</ref> <ref>PMID:9605286</ref> <ref>PMID:10036587</ref> <ref>PMID:10627135</ref> <ref>PMID:10694917</ref> <ref>PMID:10211412</ref> <ref>PMID:10439117</ref> <ref>PMID:10611950</ref> <ref>PMID:10071047</ref> <ref>PMID:10436378</ref> <ref>PMID:10842705</ref> <ref>PMID:10842718</ref> <ref>PMID:10882995</ref> <ref>PMID:11445644</ref> <ref>PMID:12557757</ref> <ref>PMID:11866053</ref> <ref>PMID:12050338</ref> <ref>PMID:12771253</ref> <ref>PMID:15214015</ref> <ref>PMID:15478468</ref> <ref>PMID:15217993</ref> <ref>PMID:17453626</ref> <ref>PMID:17577687</ref> <ref>PMID:17503405</ref> <ref>PMID:17635579</ref> Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) [MIM:[http://omim.org/entry/145680 145680]]. It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities.<ref>PMID:1979335</ref> Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1) [MIM:[http://omim.org/entry/115430 115430]]. It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.<ref>PMID:8309582</ref>		[[http://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN]] Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR) [MIM:[http://omim.org/entry/105210 105210]]. A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor.<ref>PMID:11243784</ref> <ref>PMID:15735344</ref> <ref>PMID:19167329</ref> <ref>PMID:3818577</ref> <ref>PMID:3022108</ref> <ref>PMID:6651852</ref> <ref>PMID:6583672</ref> <ref>PMID:3135807</ref> <ref>PMID:1517749</ref> <ref>PMID:1932142</ref> <ref>PMID:7923855</ref> <ref>PMID:8382610</ref> <ref>PMID:8428915</ref> <ref>PMID:9733771</ref> <ref>PMID:12403615</ref> <ref>PMID:16185074</ref> <ref>PMID:16627944</ref> <ref>PMID:6487335</ref> <ref>PMID:3722385</ref> <ref>PMID:2891727</ref> <ref>PMID:2161654</ref> <ref>PMID:2363717</ref> <ref>PMID:1656975</ref> <ref>PMID:2046936</ref> <ref>PMID:1570831</ref> <ref>PMID:1734866</ref> <ref>PMID:1520326</ref> <ref>PMID:1520336</ref> <ref>PMID:1544214</ref> <ref>PMID:1351039</ref> <ref>PMID:1301926</ref> <ref>PMID:1362222</ref> <ref>PMID:1436517</ref> <ref>PMID:8352764</ref> <ref>PMID:8038017</ref> <ref>PMID:8257997</ref> <ref>PMID:8095302</ref> <ref>PMID:1997217</ref> <ref>PMID:8019560</ref> <ref>PMID:8081397</ref> <ref>PMID:7914929</ref> <ref>PMID:8133316</ref> <ref>PMID:7910950</ref> <ref>PMID:7655883</ref> <ref>PMID:7850982</ref> <ref>PMID:8579098</ref> <ref>PMID:9066351</ref> <ref>PMID:8990019</ref> <ref>PMID:9605286</ref> <ref>PMID:10036587</ref> <ref>PMID:10627135</ref> <ref>PMID:10694917</ref> <ref>PMID:10211412</ref> <ref>PMID:10439117</ref> <ref>PMID:10611950</ref> <ref>PMID:10071047</ref> <ref>PMID:10436378</ref> <ref>PMID:10842705</ref> <ref>PMID:10842718</ref> <ref>PMID:10882995</ref> <ref>PMID:11445644</ref> <ref>PMID:12557757</ref> <ref>PMID:11866053</ref> <ref>PMID:12050338</ref> <ref>PMID:12771253</ref> <ref>PMID:15214015</ref> <ref>PMID:15478468</ref> <ref>PMID:15217993</ref> <ref>PMID:17453626</ref> <ref>PMID:17577687</ref> <ref>PMID:17503405</ref> <ref>PMID:17635579</ref> Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) [MIM:[http://omim.org/entry/145680 145680]]. It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities.<ref>PMID:1979335</ref> Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1) [MIM:[http://omim.org/entry/115430 115430]]. It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.<ref>PMID:8309582</ref>
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN]] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:3714052</ref>		[[http://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN]] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:3714052</ref>
-
-	==About this Structure==
-	[[4act]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACT OCA].

	==See Also==		==See Also==
	*[[Transthyretin\|Transthyretin]]		*[[Transthyretin\|Transthyretin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Gupta, S.]]	+	[[Category: Gupta, S]]
-	[[Category: Khan, T.]]	+	[[Category: Khan, T]]
-	[[Category: Mishra, S.]]	+	[[Category: Mishra, S]]
-	[[Category: Salunke, D M.]]	+	[[Category: Salunke, D M]]
-	[[Category: Singh, R R.]]	+	[[Category: Singh, R R]]
-	[[Category: Surolia, A.]]	+	[[Category: Surolia, A]]
-	[[Category: Tomar, D.]]	+	[[Category: Tomar, D]]
	[[Category: Amyloidosis inhibition]]		[[Category: Amyloidosis inhibition]]
	[[Category: Hormone]]		[[Category: Hormone]]
	[[Category: Thyroxine transport protein]]		[[Category: Thyroxine transport protein]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 12:14, 31 March 2013

OCA — Sun, 31 Mar 2013 12:14:20 GMT

←Older revision		Revision as of 12:14, 31 March 2013
Line 3:		Line 3:

	==Disease==		==Disease==
-	[[http://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN]] Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR) [MIM:[http://omim.org/entry/105210 105210]]. A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor.<ref>PMID:11243784</ref><ref>PMID:15735344</ref><ref>PMID:19167329</ref><ref>PMID:3818577</ref><ref>PMID:3022108</ref><ref>PMID:6651852</ref><ref>PMID:6583672</ref><ref>PMID:3135807</ref><ref>PMID:1517749</ref><ref>PMID:1932142</ref><ref>PMID:7923855</ref><ref>PMID:8382610</ref><ref>PMID:8428915</ref><ref>PMID:9733771</ref><ref>PMID:12403615</ref><ref>PMID:16185074</ref><ref>PMID:16627944</ref><ref>PMID:6487335</ref><ref>PMID:3722385</ref><ref>PMID:2891727</ref><ref>PMID:2161654</ref><ref>PMID:2363717</ref><ref>PMID:1656975</ref><ref>PMID:2046936</ref><ref>PMID:1570831</ref><ref>PMID:1734866</ref><ref>PMID:1520326</ref><ref>PMID:1520336</ref><ref>PMID:1544214</ref><ref>PMID:1351039</ref><ref>PMID:1301926</ref><ref>PMID:1362222</ref><ref>PMID:1436517</ref><ref>PMID:8352764</ref><ref>PMID:8038017</ref><ref>PMID:8257997</ref><ref>PMID:8095302</ref><ref>PMID:1997217</ref><ref>PMID:8019560</ref><ref>PMID:8081397</ref><ref>PMID:7914929</ref><ref>PMID:8133316</ref><ref>PMID:7910950</ref><ref>PMID:7655883</ref><ref>PMID:7850982</ref><ref>PMID:8579098</ref><ref>PMID:9066351</ref><ref>PMID:8990019</ref><ref>PMID:9605286</ref><ref>PMID:10036587</ref><ref>PMID:10627135</ref><ref>PMID:10694917</ref><ref>PMID:10211412</ref><ref>PMID:10439117</ref><ref>PMID:10611950</ref><ref>PMID:10071047</ref><ref>PMID:10436378</ref><ref>PMID:10842705</ref><ref>PMID:10842718</ref><ref>PMID:10882995</ref><ref>PMID:11445644</ref><ref>PMID:12557757</ref><ref>PMID:11866053</ref><ref>PMID:12050338</ref><ref>PMID:12771253</ref><ref>PMID:15214015</ref><ref>PMID:15478468</ref><ref>PMID:15217993</ref><ref>PMID:17453626</ref><ref>PMID:17577687</ref><ref>PMID:17503405</ref><ref>PMID:17635579</ref> Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) [MIM:[http://omim.org/entry/145680 145680]]. It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities.<ref>PMID:1979335</ref> Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1) [MIM:[http://omim.org/entry/115430 115430]]. It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.<ref>PMID:8309582</ref>	+	[[http://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN]] Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR) [MIM:[http://omim.org/entry/105210 105210]]. A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor.<ref>PMID:11243784</ref> <ref>PMID:15735344</ref> <ref>PMID:19167329</ref> <ref>PMID:3818577</ref> <ref>PMID:3022108</ref> <ref>PMID:6651852</ref> <ref>PMID:6583672</ref> <ref>PMID:3135807</ref> <ref>PMID:1517749</ref> <ref>PMID:1932142</ref> <ref>PMID:7923855</ref> <ref>PMID:8382610</ref> <ref>PMID:8428915</ref> <ref>PMID:9733771</ref> <ref>PMID:12403615</ref> <ref>PMID:16185074</ref> <ref>PMID:16627944</ref> <ref>PMID:6487335</ref> <ref>PMID:3722385</ref> <ref>PMID:2891727</ref> <ref>PMID:2161654</ref> <ref>PMID:2363717</ref> <ref>PMID:1656975</ref> <ref>PMID:2046936</ref> <ref>PMID:1570831</ref> <ref>PMID:1734866</ref> <ref>PMID:1520326</ref> <ref>PMID:1520336</ref> <ref>PMID:1544214</ref> <ref>PMID:1351039</ref> <ref>PMID:1301926</ref> <ref>PMID:1362222</ref> <ref>PMID:1436517</ref> <ref>PMID:8352764</ref> <ref>PMID:8038017</ref> <ref>PMID:8257997</ref> <ref>PMID:8095302</ref> <ref>PMID:1997217</ref> <ref>PMID:8019560</ref> <ref>PMID:8081397</ref> <ref>PMID:7914929</ref> <ref>PMID:8133316</ref> <ref>PMID:7910950</ref> <ref>PMID:7655883</ref> <ref>PMID:7850982</ref> <ref>PMID:8579098</ref> <ref>PMID:9066351</ref> <ref>PMID:8990019</ref> <ref>PMID:9605286</ref> <ref>PMID:10036587</ref> <ref>PMID:10627135</ref> <ref>PMID:10694917</ref> <ref>PMID:10211412</ref> <ref>PMID:10439117</ref> <ref>PMID:10611950</ref> <ref>PMID:10071047</ref> <ref>PMID:10436378</ref> <ref>PMID:10842705</ref> <ref>PMID:10842718</ref> <ref>PMID:10882995</ref> <ref>PMID:11445644</ref> <ref>PMID:12557757</ref> <ref>PMID:11866053</ref> <ref>PMID:12050338</ref> <ref>PMID:12771253</ref> <ref>PMID:15214015</ref> <ref>PMID:15478468</ref> <ref>PMID:15217993</ref> <ref>PMID:17453626</ref> <ref>PMID:17577687</ref> <ref>PMID:17503405</ref> <ref>PMID:17635579</ref> Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) [MIM:[http://omim.org/entry/145680 145680]]. It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities.<ref>PMID:1979335</ref> Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1) [MIM:[http://omim.org/entry/115430 115430]]. It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.<ref>PMID:8309582</ref>

	==Function==		==Function==
-	[[http://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN]] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:3714052</ref>	+	[[http://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN]] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:3714052</ref>

	==About this Structure==		==About this Structure==

OCA at 05:54, 25 March 2013

OCA — Mon, 25 Mar 2013 05:54:19 GMT

←Older revision		Revision as of 05:54, 25 March 2013
Line 1:		Line 1:
-	[[Image:4act.jpg\|left\|200px]]
-
	{{STRUCTURE_4act\| PDB=4act \| SCENE= }}		{{STRUCTURE_4act\| PDB=4act \| SCENE= }}
-
	===CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-17===		===CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-17===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN]] Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR) [MIM:[http://omim.org/entry/105210 105210]]. A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor.<ref>PMID:11243784</ref><ref>PMID:15735344</ref><ref>PMID:19167329</ref><ref>PMID:3818577</ref><ref>PMID:3022108</ref><ref>PMID:6651852</ref><ref>PMID:6583672</ref><ref>PMID:3135807</ref><ref>PMID:1517749</ref><ref>PMID:1932142</ref><ref>PMID:7923855</ref><ref>PMID:8382610</ref><ref>PMID:8428915</ref><ref>PMID:9733771</ref><ref>PMID:12403615</ref><ref>PMID:16185074</ref><ref>PMID:16627944</ref><ref>PMID:6487335</ref><ref>PMID:3722385</ref><ref>PMID:2891727</ref><ref>PMID:2161654</ref><ref>PMID:2363717</ref><ref>PMID:1656975</ref><ref>PMID:2046936</ref><ref>PMID:1570831</ref><ref>PMID:1734866</ref><ref>PMID:1520326</ref><ref>PMID:1520336</ref><ref>PMID:1544214</ref><ref>PMID:1351039</ref><ref>PMID:1301926</ref><ref>PMID:1362222</ref><ref>PMID:1436517</ref><ref>PMID:8352764</ref><ref>PMID:8038017</ref><ref>PMID:8257997</ref><ref>PMID:8095302</ref><ref>PMID:1997217</ref><ref>PMID:8019560</ref><ref>PMID:8081397</ref><ref>PMID:7914929</ref><ref>PMID:8133316</ref><ref>PMID:7910950</ref><ref>PMID:7655883</ref><ref>PMID:7850982</ref><ref>PMID:8579098</ref><ref>PMID:9066351</ref><ref>PMID:8990019</ref><ref>PMID:9605286</ref><ref>PMID:10036587</ref><ref>PMID:10627135</ref><ref>PMID:10694917</ref><ref>PMID:10211412</ref><ref>PMID:10439117</ref><ref>PMID:10611950</ref><ref>PMID:10071047</ref><ref>PMID:10436378</ref><ref>PMID:10842705</ref><ref>PMID:10842718</ref><ref>PMID:10882995</ref><ref>PMID:11445644</ref><ref>PMID:12557757</ref><ref>PMID:11866053</ref><ref>PMID:12050338</ref><ref>PMID:12771253</ref><ref>PMID:15214015</ref><ref>PMID:15478468</ref><ref>PMID:15217993</ref><ref>PMID:17453626</ref><ref>PMID:17577687</ref><ref>PMID:17503405</ref><ref>PMID:17635579</ref> Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) [MIM:[http://omim.org/entry/145680 145680]]. It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities.<ref>PMID:1979335</ref> Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1) [MIM:[http://omim.org/entry/115430 115430]]. It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.<ref>PMID:8309582</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN]] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:3714052</ref>

	==About this Structure==		==About this Structure==
	[[4act]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACT OCA].		[[4act]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACT OCA].
		+
		+	==See Also==
		+	*[[Transthyretin\|Transthyretin]]
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Gupta, S.]]		[[Category: Gupta, S.]]

OCA at 10:57, 5 December 2012

OCA — Wed, 05 Dec 2012 10:57:51 GMT

←Older revision		Revision as of 10:57, 5 December 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4act.jpg\|left\|200px]]

-	~~The entry~~ 4act ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4act\| PDB=4act \| SCENE= }}

-	~~Authors: TOMAR, D., KHAN, T., SINGH, R.R., MISHRA, S., GUPTA, S., SUROLIA, A., SALUNKE, D.M.~~	+	===CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-17===

-	~~Description~~: ~~CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C~~-17	+
		+	==About this Structure==
		+	[[4act]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACT OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Gupta, S.]]
		+	[[Category: Khan, T.]]
		+	[[Category: Mishra, S.]]
		+	[[Category: Salunke, D M.]]
		+	[[Category: Singh, R R.]]
		+	[[Category: Surolia, A.]]
		+	[[Category: Tomar, D.]]
		+	[[Category: Amyloidosis inhibition]]
		+	[[Category: Hormone]]
		+	[[Category: Thyroxine transport protein]]
		+	[[Category: Transport protein]]

OCA at 06:04, 11 January 2012

OCA — Wed, 11 Jan 2012 06:04:57 GMT

←Older revision		Revision as of 06:04, 11 January 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4act is ON HOLD	+	The entry 4act is ON HOLD until Paper Publication

	Authors: TOMAR, D., KHAN, T., SINGH, R.R., MISHRA, S., GUPTA, S., SUROLIA, A., SALUNKE, D.M.		Authors: TOMAR, D., KHAN, T., SINGH, R.R., MISHRA, S., GUPTA, S., SUROLIA, A., SALUNKE, D.M.

	Description: CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-17		Description: CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-17

OCA at 05:51, 4 January 2012

OCA — Wed, 04 Jan 2012 05:51:11 GMT

←Older revision		Revision as of 05:51, 4 January 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4act is ON HOLD ~~until sometime in the future~~	+	The entry 4act is ON HOLD

	Authors: TOMAR, D., KHAN, T., SINGH, R.R., MISHRA, S., GUPTA, S., SUROLIA, A., SALUNKE, D.M.		Authors: TOMAR, D., KHAN, T., SINGH, R.R., MISHRA, S., GUPTA, S., SUROLIA, A., SALUNKE, D.M.

	Description: CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-17		Description: CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-17