4adq - Revision history

OCA at 11:24, 20 December 2023

OCA — Wed, 20 Dec 2023 11:24:46 GMT

←Older revision		Revision as of 11:24, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4adq' size='340' side='right'caption='[[4adq]], [[Resolution\|resolution]] 4.50Å' scene=''>		<StructureSection load='4adq' size='340' side='right'caption='[[4adq]], [[Resolution\|resolution]] 4.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4adq]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ADQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ADQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4adq]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_4 Human gammaherpesvirus 4] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ADQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ADQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 4.5Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4adf\|4adf]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4adq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4adq OCA], [https://pdbe.org/4adq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4adq RCSB], [https://www.ebi.ac.uk/pdbsum/4adq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4adq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4adq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4adq OCA], [https://pdbe.org/4adq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4adq RCSB], [https://www.ebi.ac.uk/pdbsum/4adq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4adq ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[https://www.uniprot.org/uniprot/CSF1_MOUSE CSF1_MOUSE]] Note=A defect in Csf1 is the cause of osteopetrosis. Osteopetrotic mice (op/op) are severely deficient in mature macrophages and osteoclasts, display failed tooth eruption, and have a restricted capacity for bone remodeling.<ref>PMID:2188141</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~BARF1_EBVG BARF1_EBVG]~~] Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro ~~(By similarity)~~. ~~[[https~~://~~www.uniprot.org~~/uniprot/CSF1_MOUSE CSF1_MOUSE]] Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.	+	[https://www.uniprot.org/uniprot/BARF1_EBVB9 BARF1_EBVB9] Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro.<ref>PMID:15064715</ref> <ref>PMID:15778977</ref> <ref>PMID:16054293</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human gammaherpesvirus 4]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Bracke, N~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Elegheert, J]]~~	+	[[Category: Bracke N]]
-	~~[[Category: Savvides, S~~ N]]	+	[[Category: Elegheert J]]
-	[[Category: ~~Cytokine receptor-cytokine complex~~]]	+	[[Category: Savvides SN]]
-	[[Category: ~~Cytokine/signaling]]~~	+
-	~~[[Category: Extracellular]]~~	+
-	~~[[Category: Four-helix bundle]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Immune system-receptor complex]]~~	+
-	~~[[Category: Immunoglobulin domain]]~~	+
-	~~[[Category: Oncogene]]~~	+
-	~~[[Category: Rtkiii~~]]	+

OCA at 05:30, 25 August 2022

OCA — Thu, 25 Aug 2022 05:30:50 GMT

←Older revision		Revision as of 05:30, 25 August 2022
Line 3:		Line 3:
	<StructureSection load='4adq' size='340' side='right'caption='[[4adq]], [[Resolution\|resolution]] 4.50Å' scene=''>		<StructureSection load='4adq' size='340' side='right'caption='[[4adq]], [[Resolution\|resolution]] 4.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4adq]] is a 8 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Ebvg Ebvg] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ADQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ADQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4adq]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ADQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ADQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4adf\|4adf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4adf\|4adf]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4adq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4adq OCA], [~~http~~://pdbe.org/4adq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4adq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4adq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4adq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4adq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4adq OCA], [https://pdbe.org/4adq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4adq RCSB], [https://www.ebi.ac.uk/pdbsum/4adq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4adq ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/CSF1_MOUSE CSF1_MOUSE]] Note=A defect in Csf1 is the cause of osteopetrosis. Osteopetrotic mice (op/op) are severely deficient in mature macrophages and osteoclasts, display failed tooth eruption, and have a restricted capacity for bone remodeling.<ref>PMID:2188141</ref>	+	[[https://www.uniprot.org/uniprot/CSF1_MOUSE CSF1_MOUSE]] Note=A defect in Csf1 is the cause of osteopetrosis. Osteopetrotic mice (op/op) are severely deficient in mature macrophages and osteoclasts, display failed tooth eruption, and have a restricted capacity for bone remodeling.<ref>PMID:2188141</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BARF1_EBVG BARF1_EBVG]] Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro (By similarity). [[~~http~~://www.uniprot.org/uniprot/CSF1_MOUSE CSF1_MOUSE]] Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.	+	[[https://www.uniprot.org/uniprot/BARF1_EBVG BARF1_EBVG]] Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro (By similarity). [[https://www.uniprot.org/uniprot/CSF1_MOUSE CSF1_MOUSE]] Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Ebvg]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lk3 transgenic mice]]
	[[Category: Bracke, N]]		[[Category: Bracke, N]]
	[[Category: Elegheert, J]]		[[Category: Elegheert, J]]

OCA at 13:31, 1 January 2020

OCA — Wed, 01 Jan 2020 13:31:54 GMT

←Older revision		Revision as of 13:31, 1 January 2020
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF THE MOUSE COLONY-STIMULATING FACTOR 1 (MCSF-1) CYTOKINE IN COMPLEX WITH THE VIRAL RECEPTOR BARF1==		==CRYSTAL STRUCTURE OF THE MOUSE COLONY-STIMULATING FACTOR 1 (MCSF-1) CYTOKINE IN COMPLEX WITH THE VIRAL RECEPTOR BARF1==
-	<StructureSection load='4adq' size='340' side='right' caption='[[4adq]], [[Resolution\|resolution]] 4.50Å' scene=''>	+	<StructureSection load='4adq' size='340' side='right'caption='[[4adq]], [[Resolution\|resolution]] 4.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4adq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebvg Ebvg] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ADQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ADQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4adq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebvg Ebvg] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ADQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ADQ FirstGlance]. <br>
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4adq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4adq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Colony-stimulating factor 3D structures\|Colony-stimulating factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Ebvg]]		[[Category: Ebvg]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Bracke, N]]		[[Category: Bracke, N]]

OCA at 10:28, 5 August 2016

OCA — Fri, 05 Aug 2016 10:28:22 GMT

←Older revision		Revision as of 10:28, 5 August 2016
Line 1:		Line 1:
-	{{STRUCTURE_4adq\| PDB=4adq \| SCENE= }}
-	===CRYSTAL STRUCTURE OF THE MOUSE COLONY-STIMULATING FACTOR 1 (MCSF-1) CYTOKINE IN COMPLEX WITH THE VIRAL RECEPTOR BARF1===
-	{{ABSTRACT_PUBMED_22902366}}

-	==Disease==	+	==CRYSTAL STRUCTURE OF THE MOUSE COLONY-STIMULATING FACTOR 1 (MCSF-1) CYTOKINE IN COMPLEX WITH THE VIRAL RECEPTOR BARF1==
-	[[http://www.uniprot.org/uniprot/CSF1_MOUSE CSF1_MOUSE]] Note=A defect in Csf1 is the cause of osteopetrosis. Osteopetrotic mice (op/op) are severely deficient in mature macrophages and osteoclasts, display failed tooth eruption, and have a restricted capacity for bone remodeling.<ref>PMID:2188141</ref>	+	<StructureSection load='4adq' size='340' side='right' caption='[[4adq]], [[Resolution\|resolution]] 4.50Å' scene=''>
-		+	== Structural highlights ==
-	==Function==	+	<table><tr><td colspan='2'>[[4adq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebvg Ebvg] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ADQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ADQ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4adf\|4adf]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4adq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4adq OCA], [http://pdbe.org/4adq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4adq RCSB], [http://www.ebi.ac.uk/pdbsum/4adq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4adq ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CSF1_MOUSE CSF1_MOUSE]] Note=A defect in Csf1 is the cause of osteopetrosis. Osteopetrotic mice (op/op) are severely deficient in mature macrophages and osteoclasts, display failed tooth eruption, and have a restricted capacity for bone remodeling.<ref>PMID:2188141</ref>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/BARF1_EBVG BARF1_EBVG]] Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro (By similarity). [[http://www.uniprot.org/uniprot/CSF1_MOUSE CSF1_MOUSE]] Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.		[[http://www.uniprot.org/uniprot/BARF1_EBVG BARF1_EBVG]] Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro (By similarity). [[http://www.uniprot.org/uniprot/CSF1_MOUSE CSF1_MOUSE]] Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hematopoietic human colony-stimulating factor 1 (hCSF-1) is essential for innate and adaptive immunity against viral and microbial infections and cancer. The human pathogen Epstein-Barr virus secretes the lytic-cycle protein BARF1 that neutralizes hCSF-1 to achieve immunomodulation. Here we show that BARF1 binds the dimer interface of hCSF-1 with picomolar affinity, away from the cognate receptor-binding site, to establish a long-lived complex featuring three hCSF-1 at the periphery of the BARF1 toroid. BARF1 locks dimeric hCSF-1 into an inactive conformation, rendering it unable to signal via its cognate receptor on human monocytes. This reveals a new functional role for hCSF-1 cooperativity in signaling. We propose a new viral strategy paradigm featuring an allosteric decoy receptor of the competitive type, which couples efficient sequestration and inactivation of the host growth factor to abrogate cooperative assembly of the cognate signaling complex.

-	~~==About this Structure==~~	+	Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1.,Elegheert J, Bracke N, Pouliot P, Gutsche I, Shkumatov AV, Tarbouriech N, Verstraete K, Bekaert A, Burmeister WP, Svergun DI, Lambrecht BN, Vergauwen B, Savvides SN Nat Struct Mol Biol. 2012 Sep;19(9):938-47. doi: 10.1038/nsmb.2367. Epub 2012 Aug, 19. PMID:22902366<ref>PMID:22902366</ref>
-	~~[[4adq]] is a 8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human_herpesvirus_4 Human herpesvirus 4] and [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4ADQ OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: ~~Human herpesvirus 4~~]]	+	<div class="pdbe-citations 4adq" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Mus musculus~~]]	+	== References ==
-	[[Category: Bracke, N.]]	+	<references/>
-	[[Category: Elegheert, J.]]	+	__TOC__
-	[[Category: Savvides, S N.]]	+	</StructureSection>
		+	[[Category: Ebvg]]
		+	[[Category: Lk3 transgenic mice]]
		+	[[Category: Bracke, N]]
		+	[[Category: Elegheert, J]]
		+	[[Category: Savvides, S N]]
	[[Category: Cytokine receptor-cytokine complex]]		[[Category: Cytokine receptor-cytokine complex]]
	[[Category: Cytokine/signaling]]		[[Category: Cytokine/signaling]]

OCA at 20:23, 24 March 2013

OCA — Sun, 24 Mar 2013 20:23:26 GMT

←Older revision		Revision as of 20:23, 24 March 2013
Line 1:		Line 1:
-	[[Image:4adq.png\|left\|200px]]
-
	{{STRUCTURE_4adq\| PDB=4adq \| SCENE= }}		{{STRUCTURE_4adq\| PDB=4adq \| SCENE= }}
-
	===CRYSTAL STRUCTURE OF THE MOUSE COLONY-STIMULATING FACTOR 1 (MCSF-1) CYTOKINE IN COMPLEX WITH THE VIRAL RECEPTOR BARF1===		===CRYSTAL STRUCTURE OF THE MOUSE COLONY-STIMULATING FACTOR 1 (MCSF-1) CYTOKINE IN COMPLEX WITH THE VIRAL RECEPTOR BARF1===
-
	{{ABSTRACT_PUBMED_22902366}}		{{ABSTRACT_PUBMED_22902366}}
		+
		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/CSF1_MOUSE CSF1_MOUSE]] Note=A defect in Csf1 is the cause of osteopetrosis. Osteopetrotic mice (op/op) are severely deficient in mature macrophages and osteoclasts, display failed tooth eruption, and have a restricted capacity for bone remodeling.<ref>PMID:2188141</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/BARF1_EBVG BARF1_EBVG]] Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro (By similarity). [[http://www.uniprot.org/uniprot/CSF1_MOUSE CSF1_MOUSE]] Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.

	==About this Structure==		==About this Structure==
	[[4adq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ADQ OCA].		[[4adq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ADQ OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Human herpesvirus 4]]		[[Category: Human herpesvirus 4]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 20:42, 26 September 2012

OCA — Wed, 26 Sep 2012 20:42:09 GMT

←Older revision		Revision as of 20:42, 26 September 2012
Line 1:		Line 1:
-	[[Image:4adq.~~jpg~~\|left\|200px]]	+	[[Image:4adq.png\|left\|200px]]

	{{STRUCTURE_4adq\| PDB=4adq \| SCENE= }}		{{STRUCTURE_4adq\| PDB=4adq \| SCENE= }}
Line 5:		Line 5:
	===CRYSTAL STRUCTURE OF THE MOUSE COLONY-STIMULATING FACTOR 1 (MCSF-1) CYTOKINE IN COMPLEX WITH THE VIRAL RECEPTOR BARF1===		===CRYSTAL STRUCTURE OF THE MOUSE COLONY-STIMULATING FACTOR 1 (MCSF-1) CYTOKINE IN COMPLEX WITH THE VIRAL RECEPTOR BARF1===

		+	{{ABSTRACT_PUBMED_22902366}}

	==About this Structure==		==About this Structure==

OCA at 06:03, 22 August 2012

OCA — Wed, 22 Aug 2012 06:03:33 GMT

←Older revision		Revision as of 06:03, 22 August 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4adq.jpg\|left\|200px]]

-	~~The entry~~ 4adq ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4adq\| PDB=4adq \| SCENE= }}

-	~~Authors: Elegheert, J., Bracke, N., Savvides, S.N.~~	+	===CRYSTAL STRUCTURE OF THE MOUSE COLONY-STIMULATING FACTOR 1 (MCSF-1) CYTOKINE IN COMPLEX WITH THE VIRAL RECEPTOR BARF1===

-	~~Description~~: ~~CRYSTAL STRUCTURE OF THE MOUSE COLONY~~-~~STIMULATING FACTOR 1 (MCSF~~-~~1) CYTOKINE IN COMPLEX WITH THE VIRAL RECEPTOR BARF1~~	+
		+	==About this Structure==
		+	[[4adq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ADQ OCA].
		+	[[Category: Human herpesvirus 4]]
		+	[[Category: Mus musculus]]
		+	[[Category: Bracke, N.]]
		+	[[Category: Elegheert, J.]]
		+	[[Category: Savvides, S N.]]
		+	[[Category: Cytokine receptor-cytokine complex]]
		+	[[Category: Cytokine/signaling]]
		+	[[Category: Extracellular]]
		+	[[Category: Four-helix bundle]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Immune system-receptor complex]]
		+	[[Category: Immunoglobulin domain]]
		+	[[Category: Oncogene]]
		+	[[Category: Rtkiii]]

OCA: Protected "4adq" [edit=sysop:move=sysop]

OCA — Wed, 11 Jan 2012 06:05:18 GMT

Protected "4adq" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:05, 11 January 2012

OCA: New page: '''Unreleased structure''' The entry 4adq is ON HOLD until Paper Publication Authors: Elegheert, J., Bracke, N., Savvides, S.N. Description: CRYSTAL STRUCTURE OF THE MOUSE COLONY-STIMU...

OCA — Wed, 11 Jan 2012 06:05:17 GMT

New page: '''Unreleased structure''' The entry 4adq is ON HOLD until Paper Publication Authors: Elegheert, J., Bracke, N., Savvides, S.N. Description: CRYSTAL STRUCTURE OF THE MOUSE COLONY-STIMU...

New page

'''Unreleased structure'''

The entry 4adq is ON HOLD until Paper Publication

Authors: Elegheert, J., Bracke, N., Savvides, S.N.

Description: CRYSTAL STRUCTURE OF THE MOUSE COLONY-STIMULATING FACTOR 1 (MCSF-1) CYTOKINE IN COMPLEX WITH THE VIRAL RECEPTOR BARF1