4ahl - Revision history

OCA at 11:27, 20 December 2023

OCA — Wed, 20 Dec 2023 11:27:13 GMT

←Older revision		Revision as of 11:27, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4ahl' size='340' side='right'caption='[[4ahl]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4ahl' size='340' side='right'caption='[[4ahl]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ahl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AHL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ahl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AHL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=TLA:L(+)~~-~~TARTARIC+ACID'>TLA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.053Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>[[1hby\|1hby]], [[1h53\|1h53]], [[2ang\|2ang]], [[1un3\|1un3]], [[4ahn\|4ahn]], [[1a4y\|1a4y]], [[4ahf\|4ahf]], [[1b1j\|1b1j]], [[4ahh\|4ahh]], [[1un4\|1un4]], [[4ahj\|4ahj]], [[1un5\|1un5]], [[4ahk\|4ahk]], [[1h0d\|1h0d]], [[4ahe\|4ahe]], [[1b1e\|1b1e]], [[1k59\|1k59]], [[1k5b\|1k5b]], [[1k58\|1k58]], [[4ahg\|4ahg]], [[4ahd\|4ahd]], [[1ang\|1ang]], [[4ahi\|4ahi]], [[1k5a\|1k5a]], [[1awz\|1awz]], [[1b1i\|1b1i]], [[1h52\|1h52]], [[4ahm\|4ahm]]</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ahl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ahl OCA], [https://pdbe.org/4ahl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ahl RCSB], [https://www.ebi.ac.uk/pdbsum/4ahl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ahl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ahl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ahl OCA], [https://pdbe.org/4ahl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ahl RCSB], [https://www.ebi.ac.uk/pdbsum/4ahl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ahl ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN]] Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:[https://omim.org/entry/611895 611895]]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.<ref>PMID:17886298</ref> <ref>PMID:15557516</ref> <ref>PMID:16501576</ref> <ref>PMID:17900154</ref> <ref>PMID:18087731</ref> <ref>PMID:17703939</ref>	+	[https://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN] Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:[https://omim.org/entry/611895 611895]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.<ref>PMID:17886298</ref> <ref>PMID:15557516</ref> <ref>PMID:16501576</ref> <ref>PMID:17900154</ref> <ref>PMID:18087731</ref> <ref>PMID:17703939</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN]] May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.<ref>PMID:1400510</ref> <ref>PMID:19354288</ref>	+	[https://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN] May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.<ref>PMID:1400510</ref> <ref>PMID:19354288</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Acharya~~, K R~~]]	+	[[Category: Acharya KR]]
-	[[Category: Ferguson, R]]	+	[[Category: Ferguson R]]
-	[[Category: Pham, T]]	+	[[Category: Pham T]]
-	[[Category: Saha, S]]	+	[[Category: Saha S]]
-	[[Category: Subramanian, V]]	+	[[Category: Subramanian V]]
-	[[Category: Thiyagarajan, N]]	+	[[Category: Thiyagarajan N]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Neovascularisation~~]]	+

OCA at 05:34, 25 August 2022

OCA — Thu, 25 Aug 2022 05:34:21 GMT

←Older revision		Revision as of 05:34, 25 August 2022
Line 3:		Line 3:
	<StructureSection load='4ahl' size='340' side='right'caption='[[4ahl]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4ahl' size='340' side='right'caption='[[4ahl]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ahl]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AHL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AHL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ahl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AHL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hby\|1hby]], [[1h53\|1h53]], [[2ang\|2ang]], [[1un3\|1un3]], [[4ahn\|4ahn]], [[1a4y\|1a4y]], [[4ahf\|4ahf]], [[1b1j\|1b1j]], [[4ahh\|4ahh]], [[1un4\|1un4]], [[4ahj\|4ahj]], [[1un5\|1un5]], [[4ahk\|4ahk]], [[1h0d\|1h0d]], [[4ahe\|4ahe]], [[1b1e\|1b1e]], [[1k59\|1k59]], [[1k5b\|1k5b]], [[1k58\|1k58]], [[4ahg\|4ahg]], [[4ahd\|4ahd]], [[1ang\|1ang]], [[4ahi\|4ahi]], [[1k5a\|1k5a]], [[1awz\|1awz]], [[1b1i\|1b1i]], [[1h52\|1h52]], [[4ahm\|4ahm]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hby\|1hby]], [[1h53\|1h53]], [[2ang\|2ang]], [[1un3\|1un3]], [[4ahn\|4ahn]], [[1a4y\|1a4y]], [[4ahf\|4ahf]], [[1b1j\|1b1j]], [[4ahh\|4ahh]], [[1un4\|1un4]], [[4ahj\|4ahj]], [[1un5\|1un5]], [[4ahk\|4ahk]], [[1h0d\|1h0d]], [[4ahe\|4ahe]], [[1b1e\|1b1e]], [[1k59\|1k59]], [[1k5b\|1k5b]], [[1k58\|1k58]], [[4ahg\|4ahg]], [[4ahd\|4ahd]], [[1ang\|1ang]], [[4ahi\|4ahi]], [[1k5a\|1k5a]], [[1awz\|1awz]], [[1b1i\|1b1i]], [[1h52\|1h52]], [[4ahm\|4ahm]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ahl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ahl OCA], [~~http~~://pdbe.org/4ahl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ahl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ahl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ahl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ahl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ahl OCA], [https://pdbe.org/4ahl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ahl RCSB], [https://www.ebi.ac.uk/pdbsum/4ahl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ahl ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN]] Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:[~~http~~://omim.org/entry/611895 611895]]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.<ref>PMID:17886298</ref> <ref>PMID:15557516</ref> <ref>PMID:16501576</ref> <ref>PMID:17900154</ref> <ref>PMID:18087731</ref> <ref>PMID:17703939</ref>	+	[[https://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN]] Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:[https://omim.org/entry/611895 611895]]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.<ref>PMID:17886298</ref> <ref>PMID:15557516</ref> <ref>PMID:16501576</ref> <ref>PMID:17900154</ref> <ref>PMID:18087731</ref> <ref>PMID:17703939</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN]] May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.<ref>PMID:1400510</ref> <ref>PMID:19354288</ref>	+	[[https://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN]] May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.<ref>PMID:1400510</ref> <ref>PMID:19354288</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Ribonuclease\|Ribonuclease]]	+	*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Acharya, K R]]		[[Category: Acharya, K R]]
	[[Category: Ferguson, R]]		[[Category: Ferguson, R]]

OCA at 09:21, 6 March 2019

OCA — Wed, 06 Mar 2019 09:21:20 GMT

←Older revision		Revision as of 09:21, 6 March 2019
Line 1:		Line 1:

	==P112L - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis==		==P112L - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis==
-	<StructureSection load='4ahl' size='340' side='right' caption='[[4ahl]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='4ahl' size='340' side='right'caption='[[4ahl]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ahl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AHL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ahl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AHL FirstGlance]. <br>

OCA at 21:43, 5 August 2016

OCA — Fri, 05 Aug 2016 21:43:22 GMT

←Older revision		Revision as of 21:43, 5 August 2016
Line 1:		Line 1:
		+
	==P112L - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis==		==P112L - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis==
	<StructureSection load='4ahl' size='340' side='right' caption='[[4ahl]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4ahl' size='340' side='right' caption='[[4ahl]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ahl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AHL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ahl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AHL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hby\|1hby]], [[1h53\|1h53]], [[2ang\|2ang]], [[1un3\|1un3]], [[4ahn\|4ahn]], [[1a4y\|1a4y]], [[4ahf\|4ahf]], [[1b1j\|1b1j]], [[4ahh\|4ahh]], [[1un4\|1un4]], [[4ahj\|4ahj]], [[1un5\|1un5]], [[4ahk\|4ahk]], [[1h0d\|1h0d]], [[4ahe\|4ahe]], [[1b1e\|1b1e]], [[1k59\|1k59]], [[1k5b\|1k5b]], [[1k58\|1k58]], [[4ahg\|4ahg]], [[4ahd\|4ahd]], [[1ang\|1ang]], [[4ahi\|4ahi]], [[1k5a\|1k5a]], [[1awz\|1awz]], [[1b1i\|1b1i]], [[1h52\|1h52]], [[4ahm\|4ahm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hby\|1hby]], [[1h53\|1h53]], [[2ang\|2ang]], [[1un3\|1un3]], [[4ahn\|4ahn]], [[1a4y\|1a4y]], [[4ahf\|4ahf]], [[1b1j\|1b1j]], [[4ahh\|4ahh]], [[1un4\|1un4]], [[4ahj\|4ahj]], [[1un5\|1un5]], [[4ahk\|4ahk]], [[1h0d\|1h0d]], [[4ahe\|4ahe]], [[1b1e\|1b1e]], [[1k59\|1k59]], [[1k5b\|1k5b]], [[1k58\|1k58]], [[4ahg\|4ahg]], [[4ahd\|4ahd]], [[1ang\|1ang]], [[4ahi\|4ahi]], [[1k5a\|1k5a]], [[1awz\|1awz]], [[1b1i\|1b1i]], [[1h52\|1h52]], [[4ahm\|4ahm]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ahl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ahl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ahl RCSB], [http://www.ebi.ac.uk/pdbsum/4ahl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ahl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ahl OCA], [http://pdbe.org/4ahl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ahl RCSB], [http://www.ebi.ac.uk/pdbsum/4ahl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ahl ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ahl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribonuclease\|Ribonuclease]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Acharya, K R]]		[[Category: Acharya, K R]]
	[[Category: Ferguson, R]]		[[Category: Ferguson, R]]

OCA at 09:41, 21 December 2014

OCA — Sun, 21 Dec 2014 09:41:55 GMT

←Older revision		Revision as of 09:41, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4ahl\| PDB=4ahl \| SCENE= }}~~	+	==P112L - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis==
-	===P112L - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis===	+	<StructureSection load='4ahl' size='340' side='right' caption='[[4ahl]], [[Resolution\|resolution]] 2.05Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23047679}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ahl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AHL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hby\|1hby]], [[1h53\|1h53]], [[2ang\|2ang]], [[1un3\|1un3]], [[4ahn\|4ahn]], [[1a4y\|1a4y]], [[4ahf\|4ahf]], [[1b1j\|1b1j]], [[4ahh\|4ahh]], [[1un4\|1un4]], [[4ahj\|4ahj]], [[1un5\|1un5]], [[4ahk\|4ahk]], [[1h0d\|1h0d]], [[4ahe\|4ahe]], [[1b1e\|1b1e]], [[1k59\|1k59]], [[1k5b\|1k5b]], [[1k58\|1k58]], [[4ahg\|4ahg]], [[4ahd\|4ahd]], [[1ang\|1ang]], [[4ahi\|4ahi]], [[1k5a\|1k5a]], [[1awz\|1awz]], [[1b1i\|1b1i]], [[1h52\|1h52]], [[4ahm\|4ahm]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ahl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ahl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ahl RCSB], [http://www.ebi.ac.uk/pdbsum/4ahl PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN]] Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:[http://omim.org/entry/611895 611895]]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.<ref>PMID:17886298</ref> <ref>PMID:15557516</ref> <ref>PMID:16501576</ref> <ref>PMID:17900154</ref> <ref>PMID:18087731</ref> <ref>PMID:17703939</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN]] May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.<ref>PMID:1400510</ref> <ref>PMID:19354288</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mutations in angiogenin (ANG), a member of the ribonuclease A superfamily, are associated with amyotrophic lateral sclerosis (ALS; sporadic and familial) and Parkinson's disease. We have previously shown that ANG is expressed in neurons during neuro-ectodermal differentiation, and that it has both neurotrophic and neuroprotective functions. Here we report the atomic resolution structure of native ANG and 11 ANG-ALS variants. We correlate the structural changes to the effects on neuronal survival and the ability to induce stress granules in neuronal cell lines. ANG-ALS variants that affect the structure of the catalytic site and either decrease or increase the RNase activity affect neuronal survival. Neuronal cell lines expressing the ANG-ALS variants also lack the ability to form stress granules. Our structure-function studies on these ANG-ALS variants are the first to provide insights into the cellular and molecular mechanisms underlying their role in ALS.

-	~~==Disease==~~	+	Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons.,Thiyagarajan N, Ferguson R, Subramanian V, Acharya KR Nat Commun. 2012 Oct 9;3:1121. doi: 10.1038/ncomms2126. PMID:23047679<ref>PMID:23047679</ref>
-	~~[[http://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN]] Defects in ANG are~~ the ~~cause~~ of ~~susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:[http://omim.org/entry/611895 611895]].~~ ALS ~~is a degenerative disorder of motor~~ neurons ~~in the cortex~~, ~~brain stem and spinal cord~~. ~~ALS is characterized by muscular weakness and atrophy~~.~~<ref>PMID~~:~~17886298<~~/~~ref><ref>~~PMID:~~15557516</ref><ref>PMID:16501576</ref><ref>PMID:17900154</ref><ref>PMID:18087731</ref>~~<ref>PMID:~~17703939~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN]] May function as~~ a ~~tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface~~ of ~~endothelial cells; once bound, angiogenin is endocytosed and translocated to~~ the ~~nucleus~~. ~~Angiogenin induces vascularization of normal and malignant tissues~~. ~~Angiogenic activity is regulated by interaction with RNH1 in vivo~~.<~~ref~~>~~PMID:1400510~~</~~ref~~>~~<ref>PMID:19354288</ref>~~	+	</div>
-		+	== References ==
-	==~~About this Structure==~~	+	<references/>
-	[[4ahl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AHL OCA].	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Acharya, K R.]]	+	[[Category: Acharya, K R]]
-	[[Category: Ferguson, R.]]	+	[[Category: Ferguson, R]]
-	[[Category: Pham, T.]]	+	[[Category: Pham, T]]
-	[[Category: Saha, S.]]	+	[[Category: Saha, S]]
-	[[Category: Subramanian, V.]]	+	[[Category: Subramanian, V]]
-	[[Category: Thiyagarajan, N.]]	+	[[Category: Thiyagarajan, N]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Neovascularisation]]		[[Category: Neovascularisation]]

OCA at 05:57, 25 March 2013

OCA — Mon, 25 Mar 2013 05:57:46 GMT

←Older revision		Revision as of 05:57, 25 March 2013
Line 1:		Line 1:
-	[[Image:4ahl.png\|left\|200px]]
-
	{{STRUCTURE_4ahl\| PDB=4ahl \| SCENE= }}		{{STRUCTURE_4ahl\| PDB=4ahl \| SCENE= }}
-
	===P112L - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis===		===P112L - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis===
-
	{{ABSTRACT_PUBMED_23047679}}		{{ABSTRACT_PUBMED_23047679}}
		+
		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN]] Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:[http://omim.org/entry/611895 611895]]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.<ref>PMID:17886298</ref><ref>PMID:15557516</ref><ref>PMID:16501576</ref><ref>PMID:17900154</ref><ref>PMID:18087731</ref><ref>PMID:17703939</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN]] May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.<ref>PMID:1400510</ref><ref>PMID:19354288</ref>

	==About this Structure==		==About this Structure==
	[[4ahl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AHL OCA].		[[4ahl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AHL OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Acharya, K R.]]		[[Category: Acharya, K R.]]

OCA at 06:29, 24 October 2012

OCA — Wed, 24 Oct 2012 06:29:39 GMT

←Older revision		Revision as of 06:29, 24 October 2012
Line 1:		Line 1:
-	[[Image:4ahl.~~jpg~~\|left\|200px]]	+	[[Image:4ahl.png\|left\|200px]]

	{{STRUCTURE_4ahl\| PDB=4ahl \| SCENE= }}		{{STRUCTURE_4ahl\| PDB=4ahl \| SCENE= }}
Line 5:		Line 5:
	===P112L - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis===		===P112L - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis===

		+	{{ABSTRACT_PUBMED_23047679}}

	==About this Structure==		==About this Structure==
-	[[4ahl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AHL OCA].	+	[[4ahl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AHL OCA].
		+	[[Category: Homo sapiens]]
	[[Category: Acharya, K R.]]		[[Category: Acharya, K R.]]
	[[Category: Ferguson, R.]]		[[Category: Ferguson, R.]]

OCA at 07:25, 10 October 2012

OCA — Wed, 10 Oct 2012 07:25:13 GMT

←Older revision		Revision as of 07:25, 10 October 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4ahl.jpg\|left\|200px]]

-	~~The entry~~ 4ahl ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4ahl\| PDB=4ahl \| SCENE= }}

-	~~Authors: Thiyagarajan, N., Ferguson, R., Saha, S., Pham, T., Subramanian, V., Acharya, K.R.~~	+	===P112L - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis===

-	~~Description~~: ~~P112L~~ -~~Angiogenin mutants and amyotrophic lateral sclerosis -a biochemical and biological analysis~~	+
		+	==About this Structure==
		+	[[4ahl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AHL OCA].
		+	[[Category: Acharya, K R.]]
		+	[[Category: Ferguson, R.]]
		+	[[Category: Pham, T.]]
		+	[[Category: Saha, S.]]
		+	[[Category: Subramanian, V.]]
		+	[[Category: Thiyagarajan, N.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Neovascularisation]]

OCA: Protected "4ahl" [edit=sysop:move=sysop]

OCA — Wed, 15 Feb 2012 06:18:18 GMT

Protected "4ahl" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:18, 15 February 2012

OCA: New page: '''Unreleased structure''' The entry 4ahl is ON HOLD until Paper Publication Authors: Thiyagarajan, N., Ferguson, R., Saha, S., Pham, T., Subramanian, V., Acharya, K.R. Description: P1...

OCA — Wed, 15 Feb 2012 06:18:17 GMT

New page: '''Unreleased structure''' The entry 4ahl is ON HOLD until Paper Publication Authors: Thiyagarajan, N., Ferguson, R., Saha, S., Pham, T., Subramanian, V., Acharya, K.R. Description: P1...

New page

'''Unreleased structure'''

The entry 4ahl is ON HOLD until Paper Publication

Authors: Thiyagarajan, N., Ferguson, R., Saha, S., Pham, T., Subramanian, V., Acharya, K.R.

Description: P112L -Angiogenin mutants and amyotrophic lateral sclerosis -a biochemical and biological analysis