4aig - Revision history

OCA at 06:49, 9 August 2023

OCA — Wed, 09 Aug 2023 06:49:46 GMT

←Older revision		Revision as of 06:49, 9 August 2023
Line 3:		Line 3:
	<StructureSection load='4aig' size='340' side='right'caption='[[4aig]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4aig' size='340' side='right'caption='[[4aig]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4aig]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Crotalus_adamanteus Crotalus adamanteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AIG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4aig]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Crotalus_adamanteus Crotalus adamanteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AIG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLX:N-[(FURAN-2-YL)CARBONYL]-(S)-LEUCYL-(R)-[1-AMINO-2(1H-INDOL-3-YL)ETHYL]-PHOSPHONIC+ACID'>FLX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adamalysin Adamalysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.46 3.4.24.46] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLX:N-[(FURAN-2-YL)CARBONYL]-(S)-LEUCYL-(R)-[1-AMINO-2(1H-INDOL-3-YL)ETHYL]-PHOSPHONIC+ACID'>FLX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4aig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aig OCA], [~~http~~://pdbe.org/4aig PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4aig RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4aig PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4aig ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aig OCA], [https://pdbe.org/4aig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aig RCSB], [https://www.ebi.ac.uk/pdbsum/4aig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aig ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/VM12_CROAD VM12_CROAD]] Has no significant hemorrhagic activity, but inactivates serpins by limited proteolysis of their reactive-site loops.	+	[https://www.uniprot.org/uniprot/VM12_CROAD VM12_CROAD] Has no significant hemorrhagic activity, but inactivates serpins by limited proteolysis of their reactive-site loops.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Adamalysin]]
	[[Category: Crotalus adamanteus]]		[[Category: Crotalus adamanteus]]
-	[[Category: Cirilli, M]]	+	[[Category: Large Structures]]
-	[[Category: Gavuzzo, E]]	+	[[Category: Cirilli M]]
-	[[Category: Mazza, F]]	+	[[Category: Gavuzzo E]]
-	[[Category: Pochetti, G]]	+	[[Category: Mazza F]]
-	~~[[Category: Metalloendopeptidase]]~~	+	[[Category: Pochetti G]]
-	~~[[Category: Snake venom metalloendopeptidase]]~~	+
-	~~[[Category: Zinc protease~~]]	+

OCA at 09:12, 6 March 2019

OCA — Wed, 06 Mar 2019 09:12:44 GMT

←Older revision		Revision as of 09:12, 6 March 2019
Line 1:		Line 1:
		+
	==ADAMALYSIN II WITH PHOSPHONATE INHIBITOR==		==ADAMALYSIN II WITH PHOSPHONATE INHIBITOR==
-	<StructureSection load='4aig' size='340' side='right' caption='[[4aig]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4aig' size='340' side='right'caption='[[4aig]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4aig]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Crotalus_adamanteus Crotalus adamanteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AIG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4aig]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Crotalus_adamanteus Crotalus adamanteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AIG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLX:N-[(FURAN-2-YL)CARBONYL]-(S)-LEUCYL-(R)-[1-AMINO-2(1H-INDOL-3-YL)ETHYL]-PHOSPHONIC+ACID'>FLX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLX:N-[(FURAN-2-YL)CARBONYL]-(S)-LEUCYL-(R)-[1-AMINO-2(1H-INDOL-3-YL)ETHYL]-PHOSPHONIC+ACID'>FLX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adamalysin Adamalysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.46 3.4.24.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adamalysin Adamalysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.46 3.4.24.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aig OCA], [http://pdbe.org/4aig PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4aig RCSB], [http://www.ebi.ac.uk/pdbsum/4aig PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aig OCA], [http://pdbe.org/4aig PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4aig RCSB], [http://www.ebi.ac.uk/pdbsum/4aig PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4aig ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ai/4aig_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ai/4aig_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 08:08, 10 February 2016

OCA — Wed, 10 Feb 2016 08:08:02 GMT

←Older revision		Revision as of 08:08, 10 February 2016
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLX:N-[(FURAN-2-YL)CARBONYL]-(S)-LEUCYL-(R)-[1-AMINO-2(1H-INDOL-3-YL)ETHYL]-PHOSPHONIC+ACID'>FLX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLX:N-[(FURAN-2-YL)CARBONYL]-(S)-LEUCYL-(R)-[1-AMINO-2(1H-INDOL-3-YL)ETHYL]-PHOSPHONIC+ACID'>FLX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adamalysin Adamalysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.46 3.4.24.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adamalysin Adamalysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.46 3.4.24.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aig OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aig RCSB], [http://www.ebi.ac.uk/pdbsum/4aig PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aig OCA], [http://pdbe.org/4aig PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4aig RCSB], [http://www.ebi.ac.uk/pdbsum/4aig PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~ADAM_CROAD ADAM_CROAD~~]] Has no significant hemorrhagic activity, but inactivates serpins by limited proteolysis of their reactive-site loops.	+	[[http://www.uniprot.org/uniprot/VM12_CROAD VM12_CROAD]] Has no significant hemorrhagic activity, but inactivates serpins by limited proteolysis of their reactive-site loops.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=4aig ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4aig" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:55, 25 December 2014

OCA — Thu, 25 Dec 2014 12:55:03 GMT

←Older revision		Revision as of 12:55, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4aig]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Crotalus_adamanteus Crotalus adamanteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AIG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4aig]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Crotalus_adamanteus Crotalus adamanteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AIG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLX:N-[(FURAN-2-YL)CARBONYL]-(S)-LEUCYL-(R)-[1-AMINO-2(1H-INDOL-3-YL)ETHYL]-PHOSPHONIC+ACID'>FLX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLX:N-[(FURAN-2-YL)CARBONYL]-(S)-LEUCYL-(R)-[1-AMINO-2(1H-INDOL-3-YL)ETHYL]-PHOSPHONIC+ACID'>FLX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adamalysin Adamalysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.46 3.4.24.46] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adamalysin Adamalysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.46 3.4.24.46] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aig OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aig RCSB], [http://www.ebi.ac.uk/pdbsum/4aig PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aig OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aig RCSB], [http://www.ebi.ac.uk/pdbsum/4aig PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ADAM_CROAD ADAM_CROAD]] Has no significant hemorrhagic activity, but inactivates serpins by limited proteolysis of their reactive-site loops.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	[[Category: Adamalysin]]		[[Category: Adamalysin]]
	[[Category: Crotalus adamanteus]]		[[Category: Crotalus adamanteus]]
-	[[Category: Cirilli, M.]]	+	[[Category: Cirilli, M]]
-	[[Category: Gavuzzo, E.]]	+	[[Category: Gavuzzo, E]]
-	[[Category: Mazza, F.]]	+	[[Category: Mazza, F]]
-	[[Category: Pochetti, G.]]	+	[[Category: Pochetti, G]]
	[[Category: Metalloendopeptidase]]		[[Category: Metalloendopeptidase]]
	[[Category: Snake venom metalloendopeptidase]]		[[Category: Snake venom metalloendopeptidase]]
	[[Category: Zinc protease]]		[[Category: Zinc protease]]

OCA: Protected "4aig" [edit=sysop:move=sysop]

OCA — Thu, 05 Jun 2014 07:48:12 GMT

Protected "4aig" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:48, 5 June 2014

OCA at 07:48, 5 June 2014

OCA — Thu, 05 Jun 2014 07:48:10 GMT

←Older revision		Revision as of 07:48, 5 June 2014
Line 1:		Line 1:
-	~~{{Seed}}~~	+	==ADAMALYSIN II WITH PHOSPHONATE INHIBITOR==
-	[[~~Image~~:4aig.~~png\|left~~\|200px]]	+	<StructureSection load='4aig' size='340' side='right' caption='[[4aig]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4aig]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Crotalus_adamanteus Crotalus adamanteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AIG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLX:N-[(FURAN-2-YL)CARBONYL]-(S)-LEUCYL-(R)-[1-AMINO-2(1H-INDOL-3-YL)ETHYL]-PHOSPHONIC+ACID'>FLX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adamalysin Adamalysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.46 3.4.24.46] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aig OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aig RCSB], [http://www.ebi.ac.uk/pdbsum/4aig PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ai/4aig_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The search of reprolysin inhibitors offers the possibility of intervention against both matrixins and ADAMs. Here we report the crystal structure of the complex between adamalysin II, a member of the reprolysin family, and a phosphonate inhibitor modeled on an endogenous venom tripeptide. The inhibitor occupies the primed region of the cleavage site adopting a retro-binding mode. The phosphonate group ligates the zinc ion in an asymmetric bidentate mode and the adjacent Trp indole system partly fills the primary specificity subsite S1'. An adamalysin-based model of tumor necrosis factor-alpha-converting enzyme (TACE) reveals a smaller S1' pocket for this enzyme.

-	<!--	+	2 angstrom X-ray structure of adamalysin II complexed with a peptide phosphonate inhibitor adopting a retro-binding mode.,Cirilli M, Gallina C, Gavuzzo E, Giordano C, Gomis-Ruth FX, Gorini B, Kress LF, Mazza F, Paradisi MP, Pochetti G, Politi V FEBS Lett. 1997 Dec 1;418(3):319-22. PMID:9428736<ref>PMID:9428736</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_4aig"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_4aig\| PDB=4aig \| SCENE= }}~~	+

-	~~===ADAMALYSIN II WITH PHOSPHONATE INHIBITOR===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_9428736}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 9428736 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_9428736}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~4AIG is a 1 chain structure of sequence from [http:~~/~~/en.wikipedia.org/wiki/Crotalus_adamanteus Crotalus adamanteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIG OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:9428736<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Adamalysin]]		[[Category: Adamalysin]]
	[[Category: Crotalus adamanteus]]		[[Category: Crotalus adamanteus]]
Line 30:		Line 35:
	[[Category: Mazza, F.]]		[[Category: Mazza, F.]]
	[[Category: Pochetti, G.]]		[[Category: Pochetti, G.]]
		+	[[Category: Metalloendopeptidase]]
	[[Category: Snake venom metalloendopeptidase]]		[[Category: Snake venom metalloendopeptidase]]
	[[Category: Zinc protease]]		[[Category: Zinc protease]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:44:02 2009''

OCA at 14:44, 17 February 2009

OCA — Tue, 17 Feb 2009 14:44:04 GMT

←Older revision		Revision as of 14:44, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	4AIG is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Crotalus_adamanteus Crotalus adamanteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIG OCA].	+	4AIG is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Crotalus_adamanteus Crotalus adamanteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIG OCA].

	==Reference==		==Reference==
-	2 angstrom X-ray structure of adamalysin II complexed with a peptide phosphonate inhibitor adopting a retro-binding mode., Cirilli M, Gallina C, Gavuzzo E, Giordano C, Gomis-Ruth FX, Gorini B, Kress LF, Mazza F, Paradisi MP, Pochetti G, Politi V, FEBS Lett. 1997 Dec 1;418(3):319-22. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/9428736 9428736]~~	+	<ref group="xtra">PMID:9428736</ref><references group="xtra"/>
	[[Category: Adamalysin]]		[[Category: Adamalysin]]
	[[Category: Crotalus adamanteus]]		[[Category: Crotalus adamanteus]]
-	[[Category: Single protein]]
	[[Category: Cirilli, M.]]		[[Category: Cirilli, M.]]
	[[Category: Gavuzzo, E.]]		[[Category: Gavuzzo, E.]]
Line 34:		Line 33:
	[[Category: Zinc protease]]		[[Category: Zinc protease]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jul 3 13~~:27:~~24 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:44:02 2009''

OCA at 10:27, 3 July 2008

OCA — Thu, 03 Jul 2008 10:27:25 GMT

←Older revision		Revision as of 10:27, 3 July 2008
Line 1:		Line 1:
-	[[Image:4aig.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:4aig.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_4aig\| PDB=4aig \| SCENE= }}		{{STRUCTURE_4aig\| PDB=4aig \| SCENE= }}

-	~~'''~~ADAMALYSIN II WITH PHOSPHONATE INHIBITOR~~'''~~	+	===ADAMALYSIN II WITH PHOSPHONATE INHIBITOR===


-	~~==Overview==~~	+	<!--
-	The ~~search of reprolysin inhibitors offers the possibility of intervention against both matrixins and ADAMs. Here we report the crystal structure of the complex between adamalysin II~~, ~~a member of the reprolysin family~~, ~~and a phosphonate inhibitor modeled on an endogenous venom tripeptide. The inhibitor occupies~~ the ~~primed region of~~ the ~~cleavage site adopting a retro-binding mode~~. ~~The phosphonate group ligates~~ the ~~zinc ion in an asymmetric bidentate mode and the adjacent Trp indole system partly fills the primary specificity subsite S1'~~. ~~An adamalysin~~-~~based model of tumor necrosis factor~~-~~alpha-converting enzyme (TACE) reveals a smaller S1' pocket for this enzyme.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_9428736}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 9428736 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_9428736}}

	==About this Structure==		==About this Structure==
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	[[Category: Snake venom metalloendopeptidase]]		[[Category: Snake venom metalloendopeptidase]]
	[[Category: Zinc protease]]		[[Category: Zinc protease]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May~~ ~~4 22~~:20:29 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:27:24 2008''

OCA at 19:20, 4 May 2008

OCA — Sun, 04 May 2008 19:20:31 GMT

←Older revision		Revision as of 19:20, 4 May 2008
Line 1:		Line 1:
	[[Image:4aig.gif\|left\|200px]]		[[Image:4aig.gif\|left\|200px]]

-	~~{{Structure~~	+	<!--
-	~~\|PDB= 4aig \|SIZE=350\|CAPTION= <scene name='initialview01'>4aig</scene>~~, ~~resolution 2~~.~~00Å~~	+	The line below this paragraph, containing "STRUCTURE_4aig", creates the "Structure Box" on the page.
-	~~\|SITE=~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	~~\|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLX:N-[~~(~~FURAN-2-YL~~)~~CARBONYL]-~~(S)~~-LEUCYL-(R)-[1-AMINO-2(1H-INDOL-3-YL)ETHYL]-PHOSPHONIC+ACID'>FLX</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	~~\|ACTIVITY= <span class='plainlinks'>[http://en~~.~~wikipedia.org/wiki/Adamalysin Adamalysin], with EC number [http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.4.24.46 3.4.24.46] </span~~>	+	or leave the SCENE parameter empty for the default display.
-	\|~~GENE~~=	+	-->
-	\|~~DOMAIN~~=	+	{{STRUCTURE_4aig\| PDB=4aig \| SCENE= }}
-	~~\|RELATEDENTRY=~~	+
-	\|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aig OCA], [http://www.ebi.ac.uk/pdbsum/4aig PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=4aig RCSB]</span>	+
-	}}	+

	'''ADAMALYSIN II WITH PHOSPHONATE INHIBITOR'''		'''ADAMALYSIN II WITH PHOSPHONATE INHIBITOR'''
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	[[Category: Mazza, F.]]		[[Category: Mazza, F.]]
	[[Category: Pochetti, G.]]		[[Category: Pochetti, G.]]
-	[[Category: ~~snake~~ venom metalloendopeptidase]]	+	[[Category: Snake venom metalloendopeptidase]]
-	[[Category: ~~zinc~~ protease]]	+	[[Category: Zinc protease]]
-		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:20:29 2008''
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Mar 31 05~~:37:51 2008''	+

OCA at 02:37, 31 March 2008

OCA — Mon, 31 Mar 2008 02:37:54 GMT

←Older revision		Revision as of 02:37, 31 March 2008
Line 4:		Line 4:
	\|PDB= 4aig \|SIZE=350\|CAPTION= <scene name='initialview01'>4aig</scene>, resolution 2.00Å		\|PDB= 4aig \|SIZE=350\|CAPTION= <scene name='initialview01'>4aig</scene>, resolution 2.00Å
	\|SITE=		\|SITE=
-	\|LIGAND= ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>,~~ <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> ~~and~~ <scene name='pdbligand=FLX:N-[(FURAN-2-YL)CARBONYL]-(S)-LEUCYL-(R)-[1-AMINO-2(1H-INDOL-3-YL)ETHYL]-PHOSPHONIC ACID'>FLX</scene>	+	\|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLX:N-[(FURAN-2-YL)CARBONYL]-(S)-LEUCYL-(R)-[1-AMINO-2(1H-INDOL-3-YL)ETHYL]-PHOSPHONIC+ACID'>FLX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
-	\|ACTIVITY= [http://en.wikipedia.org/wiki/Adamalysin Adamalysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.46 3.4.24.46]	+	\|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Adamalysin Adamalysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.46 3.4.24.46] </span>
	\|GENE=		\|GENE=
		+	\|DOMAIN=
		+	\|RELATEDENTRY=
		+	\|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aig OCA], [http://www.ebi.ac.uk/pdbsum/4aig PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=4aig RCSB]</span>
	}}		}}

Line 27:		Line 30:
	[[Category: Mazza, F.]]		[[Category: Mazza, F.]]
	[[Category: Pochetti, G.]]		[[Category: Pochetti, G.]]
-	[[Category: CA]]
-	[[Category: FLX]]
-	[[Category: ZN]]
	[[Category: snake venom metalloendopeptidase]]		[[Category: snake venom metalloendopeptidase]]
	[[Category: zinc protease]]		[[Category: zinc protease]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu~~ Mar ~~20 19~~:08:49 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:37:51 2008''