4ain - Revision history

OCA at 09:10, 15 November 2023

OCA — Wed, 15 Nov 2023 09:10:07 GMT

←Older revision		Revision as of 09:10, 15 November 2023
Line 3:		Line 3:
	<StructureSection load='4ain' size='340' side='right'caption='[[4ain]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='4ain' size='340' side='right'caption='[[4ain]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ain]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AIN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ain]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AIN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BET:TRIMETHYL+GLYCINE'>BET</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wit\|2wit]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BET:TRIMETHYL+GLYCINE'>BET</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ain FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ain OCA], [https://pdbe.org/4ain PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ain RCSB], [https://www.ebi.ac.uk/pdbsum/4ain PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ain ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ain FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ain OCA], [https://pdbe.org/4ain PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ain RCSB], [https://www.ebi.ac.uk/pdbsum/4ain PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ain ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BETP_CORGL BETP_CORGL]] High-affinity uptake of glycine betaine (By similarity).	+	[https://www.uniprot.org/uniprot/BETP_CORGL BETP_CORGL] High-affinity uptake of glycine betaine (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Micrococcus glutamicus kinoshita et al. 1958~~]]	+	[[Category: Corynebacterium glutamicum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Koshy, C]]	+	[[Category: Koshy C]]
-	[[Category: Yildiz, O]]	+	[[Category: Yildiz O]]
-	[[Category: Ziegler, C]]	+	[[Category: Ziegler C]]
-	~~[[Category: Chemosensor and osmosensor]]~~	+
-	~~[[Category: Hyperosmotic stress]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Secondary transporter]]~~	+
-	~~[[Category: Sodium coupled transport]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 05:35, 25 August 2022

OCA — Thu, 25 Aug 2022 05:35:21 GMT

←Older revision		Revision as of 05:35, 25 August 2022
Line 3:		Line 3:
	<StructureSection load='4ain' size='340' side='right'caption='[[4ain]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='4ain' size='340' side='right'caption='[[4ain]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ain]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AIN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ain]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AIN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BET:TRIMETHYL+GLYCINE'>BET</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BET:TRIMETHYL+GLYCINE'>BET</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wit\|2wit]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wit\|2wit]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ain FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ain OCA], [~~http~~://pdbe.org/4ain PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ain RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ain PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ain ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ain FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ain OCA], [https://pdbe.org/4ain PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ain RCSB], [https://www.ebi.ac.uk/pdbsum/4ain PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ain ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BETP_CORGL BETP_CORGL]] High-affinity uptake of glycine betaine (By similarity).	+	[[https://www.uniprot.org/uniprot/BETP_CORGL BETP_CORGL]] High-affinity uptake of glycine betaine (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4ain" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ain" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Symporter 3D structures\|Symporter 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Micrococcus glutamicus kinoshita et al. 1958]]		[[Category: Micrococcus glutamicus kinoshita et al. 1958]]
		+	[[Category: Large Structures]]
	[[Category: Koshy, C]]		[[Category: Koshy, C]]
	[[Category: Yildiz, O]]		[[Category: Yildiz, O]]

OCA at 09:00, 6 March 2019

OCA — Wed, 06 Mar 2019 09:00:04 GMT

←Older revision		Revision as of 09:00, 6 March 2019
Line 1:		Line 1:

	==Crystal structure of BetP with asymmetric protomers.==		==Crystal structure of BetP with asymmetric protomers.==
-	<StructureSection load='4ain' size='340' side='right' caption='[[4ain]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='4ain' size='340' side='right'caption='[[4ain]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ain]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AIN FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ain]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AIN FirstGlance]. <br>

OCA at 17:02, 2 January 2017

OCA — Mon, 02 Jan 2017 17:02:07 GMT

←Older revision		Revision as of 17:02, 2 January 2017
Line 1:		Line 1:
		+
	==Crystal structure of BetP with asymmetric protomers.==		==Crystal structure of BetP with asymmetric protomers.==
	<StructureSection load='4ain' size='340' side='right' caption='[[4ain]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='4ain' size='340' side='right' caption='[[4ain]], [[Resolution\|resolution]] 3.10Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BET:TRIMETHYL+GLYCINE'>BET</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BET:TRIMETHYL+GLYCINE'>BET</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wit\|2wit]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wit\|2wit]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ain FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ain OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ain RCSB], [http://www.ebi.ac.uk/pdbsum/4ain PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ain FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ain OCA], [http://pdbe.org/4ain PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ain RCSB], [http://www.ebi.ac.uk/pdbsum/4ain PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ain ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ain" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:56, 26 March 2015

OCA — Thu, 26 Mar 2015 07:56:49 GMT

←Older revision		Revision as of 07:56, 26 March 2015
Line 2:		Line 2:
	<StructureSection load='4ain' size='340' side='right' caption='[[4ain]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='4ain' size='340' side='right' caption='[[4ain]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ain]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Corynebacterium_glutamicum Corynebacterium glutamicum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AIN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ain]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AIN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BET:TRIMETHYL+GLYCINE'>BET</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BET:TRIMETHYL+GLYCINE'>BET</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wit\|2wit]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wit\|2wit]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ain FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ain OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ain RCSB], [http://www.ebi.ac.uk/pdbsum/4ain PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ain FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ain OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ain RCSB], [http://www.ebi.ac.uk/pdbsum/4ain PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BETP_CORGL BETP_CORGL]] High-affinity uptake of glycine betaine (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Corynebacterium glutamicum~~]]	+	[[Category: Micrococcus glutamicus kinoshita et al. 1958]]
	[[Category: Koshy, C]]		[[Category: Koshy, C]]
	[[Category: Yildiz, O]]		[[Category: Yildiz, O]]

OCA at 09:12, 21 December 2014

OCA — Sun, 21 Dec 2014 09:12:33 GMT

←Older revision		Revision as of 09:12, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4ain\| PDB~~=4ain \| ~~SCENE~~= }}	+	==Crystal structure of BetP with asymmetric protomers.==
-	===~~Crystal~~ structure ~~of BetP~~ with ~~asymmetric protomers~~.===	+	<StructureSection load='4ain' size='340' side='right' caption='[[4ain]], [[Resolution\|resolution]] 3.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22940865}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ain]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AIN FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BET:TRIMETHYL+GLYCINE'>BET</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wit\|2wit]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ain FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ain OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ain RCSB], [http://www.ebi.ac.uk/pdbsum/4ain PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Betaine and Na(+) symport has been extensively studied in the osmotically regulated transporter BetP from Corynebacterium glutamicum, a member of the betaine/choline/carnitine transporter family, which shares the conserved LeuT-like fold of two inverted structural repeats. BetP adjusts its transport activity by sensing the cytoplasmic K(+) concentration as a measure for hyperosmotic stress via the osmosensing carboxy-terminal domain. BetP needs to be in a trimeric state for communication between individual protomers through several intratrimeric interaction sites. Recently, crystal structures of inward-facing BetP trimers have contributed to our understanding of activity regulation on a molecular level. Here we report new crystal structures, which reveal two conformationally asymmetric BetP trimers, capturing among them three distinct transport states. We observe a total of four new conformations at once: an outward-open apo and an outward-occluded apo state, and two closed transition states-one in complex with betaine and one substrate-free. On the basis of these new structures, we identified local and global conformational changes in BetP that underlie the molecular transport mechanism, which partially resemble structural changes observed in other sodium-coupled LeuT-like fold transporters, but show differences we attribute to the osmolytic nature of betaine, the exclusive substrate specificity and the regulatory properties of BetP.

-	~~==About this Structure==~~	+	Alternating-access mechanism in conformationally asymmetric trimers of the betaine transporter BetP.,Perez C, Koshy C, Yildiz O, Ziegler C Nature. 2012 Sep 2. doi: 10.1038/nature11403. PMID:22940865<ref>PMID:22940865</ref>
-	~~[[4ain]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki~~/~~Corynebacterium_glutamicum Corynebacterium glutamicum]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id~~=~~4AIN OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Corynebacterium glutamicum]]		[[Category: Corynebacterium glutamicum]]
-	[[Category: Koshy, C.]]	+	[[Category: Koshy, C]]
-	[[Category: Yildiz, O.]]	+	[[Category: Yildiz, O]]
-	[[Category: Ziegler, C.]]	+	[[Category: Ziegler, C]]
	[[Category: Chemosensor and osmosensor]]		[[Category: Chemosensor and osmosensor]]
	[[Category: Hyperosmotic stress]]		[[Category: Hyperosmotic stress]]

OCA at 07:32, 27 March 2013

OCA — Wed, 27 Mar 2013 07:32:15 GMT

←Older revision		Revision as of 07:32, 27 March 2013
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-	[[Image:4ain.png\|left\|200px]]
-
	{{STRUCTURE_4ain\| PDB=4ain \| SCENE= }}		{{STRUCTURE_4ain\| PDB=4ain \| SCENE= }}
-
	===Crystal structure of BetP with asymmetric protomers.===		===Crystal structure of BetP with asymmetric protomers.===
-
	{{ABSTRACT_PUBMED_22940865}}		{{ABSTRACT_PUBMED_22940865}}

OCA at 15:25, 28 November 2012

OCA — Wed, 28 Nov 2012 15:25:29 GMT

←Older revision		Revision as of 15:25, 28 November 2012
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	==About this Structure==		==About this Structure==
-	[[4ain]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIN OCA].	+	[[4ain]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIN OCA].
		+	[[Category: Corynebacterium glutamicum]]
	[[Category: Koshy, C.]]		[[Category: Koshy, C.]]
	[[Category: Yildiz, O.]]		[[Category: Yildiz, O.]]

OCA at 06:20, 10 October 2012

OCA — Wed, 10 Oct 2012 06:20:10 GMT

←Older revision		Revision as of 06:20, 10 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[4ain]] is a 3 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIN OCA].	+	[[4ain]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AIN OCA].
-	~~[[Category: Corynebacterium glutamicum]]~~	+
	[[Category: Koshy, C.]]		[[Category: Koshy, C.]]
	[[Category: Yildiz, O.]]		[[Category: Yildiz, O.]]

OCA at 05:11, 12 September 2012

OCA — Wed, 12 Sep 2012 05:11:53 GMT

←Older revision		Revision as of 05:11, 12 September 2012
Line 5:		Line 5:
	===Crystal structure of BetP with asymmetric protomers.===		===Crystal structure of BetP with asymmetric protomers.===

		+	{{ABSTRACT_PUBMED_22940865}}

	==About this Structure==		==About this Structure==