4ajg - Revision history

OCA at 05:36, 25 August 2022

OCA — Thu, 25 Aug 2022 05:36:04 GMT

←Older revision		Revision as of 05:36, 25 August 2022
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	<StructureSection load='4ajg' size='340' side='right'caption='[[4ajg]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4ajg' size='340' side='right'caption='[[4ajg]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ajg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AJG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ajg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AJG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F07:THIENO[3,2-C][1,6]NAPHTHYRIDINE'>F07</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F07:THIENO[3,2-C][1,6]NAPHTHYRIDINE'>F07</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lrb\|1lrb]], [[2wey\|2wey]], [[2y0j\|2y0j]], [[4ael\|4ael]], [[4ajd\|4ajd]], [[4ajf\|4ajf]], [[4ajm\|4ajm]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lrb\|1lrb]], [[2wey\|2wey]], [[2y0j\|2y0j]], [[4ael\|4ael]], [[4ajd\|4ajd]], [[4ajf\|4ajf]], [[4ajm\|4ajm]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ajg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ajg OCA], [~~http~~://pdbe.org/4ajg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ajg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ajg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ajg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ajg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ajg OCA], [https://pdbe.org/4ajg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ajg RCSB], [https://www.ebi.ac.uk/pdbsum/4ajg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ajg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>	+	[[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>

	==See Also==		==See Also==
-	*[[Phosphodiesterase\|Phosphodiesterase]]	+	*[[Phosphodiesterase 3D structures\|Phosphodiesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 18:		Line 18:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Aharony, D]]		[[Category: Aharony, D]]
	[[Category: Akerud, T]]		[[Category: Akerud, T]]

OCA at 08:40, 6 March 2019

OCA — Wed, 06 Mar 2019 08:40:45 GMT

←Older revision		Revision as of 08:40, 6 March 2019
Line 1:		Line 1:

	==Identification and structural characterization of PDE10 fragment inhibitors==		==Identification and structural characterization of PDE10 fragment inhibitors==
-	<StructureSection load='4ajg' size='340' side='right' caption='[[4ajg]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4ajg' size='340' side='right'caption='[[4ajg]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ajg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AJG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ajg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AJG FirstGlance]. <br>

OCA at 16:53, 5 August 2016

OCA — Fri, 05 Aug 2016 16:53:59 GMT

←Older revision		Revision as of 16:53, 5 August 2016
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		+
	==Identification and structural characterization of PDE10 fragment inhibitors==		==Identification and structural characterization of PDE10 fragment inhibitors==
	<StructureSection load='4ajg' size='340' side='right' caption='[[4ajg]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4ajg' size='340' side='right' caption='[[4ajg]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ajg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AJG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ajg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AJG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F07:THIENO[3,2-C][1,6]NAPHTHYRIDINE'>F07</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F07:THIENO[3,2-C][1,6]NAPHTHYRIDINE'>F07</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lrb\|1lrb]], [[2wey\|2wey]], [[2y0j\|2y0j]], [[4ael\|4ael]], [[4ajd\|4ajd]], [[4ajf\|4ajf]], [[4ajm\|4ajm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lrb\|1lrb]], [[2wey\|2wey]], [[2y0j\|2y0j]], [[4ael\|4ael]], [[4ajd\|4ajd]], [[4ajf\|4ajf]], [[4ajm\|4ajm]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ajg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ajg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ajg RCSB], [http://www.ebi.ac.uk/pdbsum/4ajg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ajg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ajg OCA], [http://pdbe.org/4ajg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ajg RCSB], [http://www.ebi.ac.uk/pdbsum/4ajg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ajg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Aharony, D]]		[[Category: Aharony, D]]
	[[Category: Akerud, T]]		[[Category: Akerud, T]]

OCA at 20:27, 25 December 2014

OCA — Thu, 25 Dec 2014 20:27:20 GMT

←Older revision		Revision as of 20:27, 25 December 2014
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-	[[~~Image:~~4ajg.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Identification and structural characterization of PDE10 fragment inhibitors==
		+	<StructureSection load='4ajg' size='340' side='right' caption='[[4ajg]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ajg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AJG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F07:THIENO[3,2-C][1,6]NAPHTHYRIDINE'>F07</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lrb\|1lrb]], [[2wey\|2wey]], [[2y0j\|2y0j]], [[4ael\|4ael]], [[4ajd\|4ajd]], [[4ajf\|4ajf]], [[4ajm\|4ajm]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ajg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ajg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ajg RCSB], [http://www.ebi.ac.uk/pdbsum/4ajg PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>

-	~~{{STRUCTURE_4ajg\| PDB~~=~~4ajg \| SCENE= }}~~	+	==See Also==
-		+	*[[Phosphodiesterase\|Phosphodiesterase]]
-	~~===Identification and structural characterization of PDE10 fragment inhibitors~~===	+	== References ==
-		+	<references/>
-		+	__TOC__
-	==~~About this Structure~~==	+	</StructureSection>
-	~~[[4ajg]] is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJG OCA].~~	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Aharony, D.]]	+	[[Category: Aharony, D]]
-	[[Category: Akerud, T.]]	+	[[Category: Akerud, T]]
-	[[Category: Albert, J S.]]	+	[[Category: Albert, J S]]
-	[[Category: Back, E.]]	+	[[Category: Back, E]]
-	[[Category: Geschwindner, S.]]	+	[[Category: Geschwindner, S]]
-	[[Category: Hillertz, P.]]	+	[[Category: Hillertz, P]]
-	[[Category: Horsefeld, R.]]	+	[[Category: Horsefeld, R]]
-	[[Category: Johansson, P.]]	+	[[Category: Johansson, P]]
-	[[Category: Scott, C.]]	+	[[Category: Scott, C]]
-	[[Category: Spadola, L.]]	+	[[Category: Spadola, L]]
-	[[Category: Spear, N.]]	+	[[Category: Spear, N]]
-	[[Category: Tian, G.]]	+	[[Category: Tian, G]]
-	[[Category: Tigerstrom, A.]]	+	[[Category: Tigerstrom, A]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 14:22, 6 March 2013

OCA — Wed, 06 Mar 2013 14:22:21 GMT

←Older revision		Revision as of 14:22, 6 March 2013
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-	~~'''Unreleased structure'''~~	+	[[Image:4ajg.jpg\|left\|200px]]

-	~~The entry~~ 4ajg ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4ajg\| PDB=4ajg \| SCENE= }}

-	~~Authors: Johansson, P., Albert, J.S., Spadola, L., Akerud, T., Back, E., Hillertz, P., Horsefeld, R., Scott, C., Spear, N., Tian, G., Tigerstrom, A., Aharony, D., Geschwindner, S.~~	+	===Identification and structural characterization of PDE10 fragment inhibitors===

-	~~Description~~: ~~Identification and structural characterization of PDE10 fragment inhibitors~~	+
		+	==About this Structure==
		+	[[4ajg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJG OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Aharony, D.]]
		+	[[Category: Akerud, T.]]
		+	[[Category: Albert, J S.]]
		+	[[Category: Back, E.]]
		+	[[Category: Geschwindner, S.]]
		+	[[Category: Hillertz, P.]]
		+	[[Category: Horsefeld, R.]]
		+	[[Category: Johansson, P.]]
		+	[[Category: Scott, C.]]
		+	[[Category: Spadola, L.]]
		+	[[Category: Spear, N.]]
		+	[[Category: Tian, G.]]
		+	[[Category: Tigerstrom, A.]]
		+	[[Category: Hydrolase]]

OCA at 08:19, 29 February 2012

OCA — Wed, 29 Feb 2012 08:19:45 GMT

←Older revision		Revision as of 08:19, 29 February 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ajg is ON HOLD	+	The entry 4ajg is ON HOLD until Paper Publication

	Authors: Johansson, P., Albert, J.S., Spadola, L., Akerud, T., Back, E., Hillertz, P., Horsefeld, R., Scott, C., Spear, N., Tian, G., Tigerstrom, A., Aharony, D., Geschwindner, S.		Authors: Johansson, P., Albert, J.S., Spadola, L., Akerud, T., Back, E., Hillertz, P., Horsefeld, R., Scott, C., Spear, N., Tian, G., Tigerstrom, A., Aharony, D., Geschwindner, S.

	Description: Identification and structural characterization of PDE10 fragment inhibitors		Description: Identification and structural characterization of PDE10 fragment inhibitors

OCA: Protected "4ajg" [edit=sysop:move=sysop]

OCA — Wed, 22 Feb 2012 07:26:33 GMT

Protected "4ajg" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:26, 22 February 2012

OCA: New page: '''Unreleased structure''' The entry 4ajg is ON HOLD Authors: Johansson, P., Albert, J.S., Spadola, L., Akerud, T., Back, E., Hillertz, P., Horsefeld, R., Scott, C., Spear, N., Tian, G....

OCA — Wed, 22 Feb 2012 07:26:32 GMT

New page: '''Unreleased structure''' The entry 4ajg is ON HOLD Authors: Johansson, P., Albert, J.S., Spadola, L., Akerud, T., Back, E., Hillertz, P., Horsefeld, R., Scott, C., Spear, N., Tian, G....

New page

'''Unreleased structure'''

The entry 4ajg is ON HOLD

Authors: Johansson, P., Albert, J.S., Spadola, L., Akerud, T., Back, E., Hillertz, P., Horsefeld, R., Scott, C., Spear, N., Tian, G., Tigerstrom, A., Aharony, D., Geschwindner, S.

Description: Identification and structural characterization of PDE10 fragment inhibitors