4akn - Revision history

OCA at 10:51, 9 May 2024

OCA — Thu, 09 May 2024 10:51:30 GMT

←Older revision		Revision as of 10:51, 9 May 2024
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	<StructureSection load='4akn' size='340' side='right'caption='[[4akn]], [[Resolution\|resolution]] 1.82Å' scene=''>		<StructureSection load='4akn' size='340' side='right'caption='[[4akn]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4akn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AKN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4akn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AKN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=S5B:4-[(2-TERT-BUTYLPHENYL)AMINO]-7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)QUINOLINE-3-CARBOXYLIC+ACID'>S5B</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.82Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1x0j\|1x0j]], [[2ydw\|2ydw]], [[2yek\|2yek]], [[4a9e\|4a9e]], [[4a9f\|4a9f]], [[4a9h\|4a9h]], [[4a9i\|4a9i]], [[4a9j\|4a9j]], [[4a9m\|4a9m]], [[4a9n\|4a9n]], [[4a9o\|4a9o]], [[4a9p\|4a9p]], [[4alg\|4alg]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=S5B:4-[(2-TERT-BUTYLPHENYL)AMINO]-7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)QUINOLINE-3-CARBOXYLIC+ACID'>S5B</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4akn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4akn OCA], [https://pdbe.org/4akn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4akn RCSB], [https://www.ebi.ac.uk/pdbsum/4akn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4akn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4akn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4akn OCA], [https://pdbe.org/4akn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4akn RCSB], [https://www.ebi.ac.uk/pdbsum/4akn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4akn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>	+	[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bouillot, A]]	+	[[Category: Bouillot A]]
-	[[Category: Chung, C]]	+	[[Category: Chung C]]
-	[[Category: Donche, F]]	+	[[Category: Donche F]]
-	[[Category: Lamotte, Y]]	+	[[Category: Lamotte Y]]
-	[[Category: Mirguet, O]]	+	[[Category: Mirguet O]]
-	~~[[Category: Epigenetic reader]]~~	+
-	~~[[Category: Histone]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Protein binding~~]]	+

OCA at 05:37, 25 August 2022

OCA — Thu, 25 Aug 2022 05:37:18 GMT

←Older revision		Revision as of 05:37, 25 August 2022
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	<StructureSection load='4akn' size='340' side='right'caption='[[4akn]], [[Resolution\|resolution]] 1.82Å' scene=''>		<StructureSection load='4akn' size='340' side='right'caption='[[4akn]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4akn]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AKN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AKN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4akn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AKN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=S5B:4-[(2-TERT-BUTYLPHENYL)AMINO]-7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)QUINOLINE-3-CARBOXYLIC+ACID'>S5B</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=S5B:4-[(2-TERT-BUTYLPHENYL)AMINO]-7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)QUINOLINE-3-CARBOXYLIC+ACID'>S5B</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1x0j\|1x0j]], [[2ydw\|2ydw]], [[2yek\|2yek]], [[4a9e\|4a9e]], [[4a9f\|4a9f]], [[4a9h\|4a9h]], [[4a9i\|4a9i]], [[4a9j\|4a9j]], [[4a9m\|4a9m]], [[4a9n\|4a9n]], [[4a9o\|4a9o]], [[4a9p\|4a9p]], [[4alg\|4alg]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1x0j\|1x0j]], [[2ydw\|2ydw]], [[2yek\|2yek]], [[4a9e\|4a9e]], [[4a9f\|4a9f]], [[4a9h\|4a9h]], [[4a9i\|4a9i]], [[4a9j\|4a9j]], [[4a9m\|4a9m]], [[4a9n\|4a9n]], [[4a9o\|4a9o]], [[4a9p\|4a9p]], [[4alg\|4alg]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4akn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4akn OCA], [~~http~~://pdbe.org/4akn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4akn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4akn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4akn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4akn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4akn OCA], [https://pdbe.org/4akn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4akn RCSB], [https://www.ebi.ac.uk/pdbsum/4akn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4akn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>	+	[[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:55, 21 May 2019

OCA — Tue, 21 May 2019 07:55:25 GMT

←Older revision		Revision as of 07:55, 21 May 2019
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]	+	*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bouillot, A]]		[[Category: Bouillot, A]]
	[[Category: Chung, C]]		[[Category: Chung, C]]

OCA at 09:12, 6 March 2019

OCA — Wed, 06 Mar 2019 09:12:05 GMT

←Older revision		Revision as of 09:12, 6 March 2019
Line 1:		Line 1:

	==N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid==		==N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid==
-	<StructureSection load='4akn' size='340' side='right' caption='[[4akn]], [[Resolution\|resolution]] 1.82Å' scene=''>	+	<StructureSection load='4akn' size='340' side='right'caption='[[4akn]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4akn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AKN FirstGlance]. <br>		<table><tr><td colspan='2'>[[4akn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AKN FirstGlance]. <br>

OCA at 12:18, 5 August 2016

OCA — Fri, 05 Aug 2016 12:18:53 GMT

←Older revision		Revision as of 12:18, 5 August 2016
Line 1:		Line 1:
		+
	==N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid==		==N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid==
	<StructureSection load='4akn' size='340' side='right' caption='[[4akn]], [[Resolution\|resolution]] 1.82Å' scene=''>		<StructureSection load='4akn' size='340' side='right' caption='[[4akn]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4akn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AKN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4akn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AKN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=S5B:4-[(2-TERT-BUTYLPHENYL)AMINO]-7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)QUINOLINE-3-CARBOXYLIC+ACID'>S5B</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=S5B:4-[(2-TERT-BUTYLPHENYL)AMINO]-7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)QUINOLINE-3-CARBOXYLIC+ACID'>S5B</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1x0j\|1x0j]], [[2ydw\|2ydw]], [[2yek\|2yek]], [[4a9e\|4a9e]], [[4a9f\|4a9f]], [[4a9h\|4a9h]], [[4a9i\|4a9i]], [[4a9j\|4a9j]], [[4a9m\|4a9m]], [[4a9n\|4a9n]], [[4a9o\|4a9o]], [[4a9p\|4a9p]], [[4alg\|4alg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1x0j\|1x0j]], [[2ydw\|2ydw]], [[2yek\|2yek]], [[4a9e\|4a9e]], [[4a9f\|4a9f]], [[4a9h\|4a9h]], [[4a9i\|4a9i]], [[4a9j\|4a9j]], [[4a9m\|4a9m]], [[4a9n\|4a9n]], [[4a9o\|4a9o]], [[4a9p\|4a9p]], [[4alg\|4alg]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4akn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4akn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4akn RCSB], [http://www.ebi.ac.uk/pdbsum/4akn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4akn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4akn OCA], [http://pdbe.org/4akn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4akn RCSB], [http://www.ebi.ac.uk/pdbsum/4akn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4akn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4akn" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bouillot, A]]		[[Category: Bouillot, A]]
	[[Category: Chung, C]]		[[Category: Chung, C]]

OCA at 18:46, 25 December 2014

OCA — Thu, 25 Dec 2014 18:46:58 GMT

←Older revision		Revision as of 18:46, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4akn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4akn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4akn RCSB], [http://www.ebi.ac.uk/pdbsum/4akn PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4akn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4akn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4akn RCSB], [http://www.ebi.ac.uk/pdbsum/4akn PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:06, 9 December 2014

OCA — Tue, 09 Dec 2014 17:06:14 GMT

←Older revision		Revision as of 17:06, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4akn.~~png~~\|~~left~~\|~~200px~~]]	+	==N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid==
		+	<StructureSection load='4akn' size='340' side='right' caption='[[4akn]], [[Resolution\|resolution]] 1.82Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4akn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AKN FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=S5B:4-[(2-TERT-BUTYLPHENYL)AMINO]-7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)QUINOLINE-3-CARBOXYLIC+ACID'>S5B</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1x0j\|1x0j]], [[2ydw\|2ydw]], [[2yek\|2yek]], [[4a9e\|4a9e]], [[4a9f\|4a9f]], [[4a9h\|4a9h]], [[4a9i\|4a9i]], [[4a9j\|4a9j]], [[4a9m\|4a9m]], [[4a9n\|4a9n]], [[4a9o\|4a9o]], [[4a9p\|4a9p]], [[4alg\|4alg]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4akn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4akn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4akn RCSB], [http://www.ebi.ac.uk/pdbsum/4akn PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A novel series of quinoline isoxazole BET family bromodomain inhibitors are discussed. Crystallography is used to illustrate binding modes and rationalize their SAR. One member, I-BET151 (GSK1210151A), shows good oral bioavailability in both the rat and minipig as well as demonstrating efficient suppression of bacterial induced inflammation and sepsis in a murine in vivo endotoxaemia model.

-	~~{{STRUCTURE_4akn\| PDB=4akn \| SCENE= }}~~	+	Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A).,Seal J, Lamotte Y, Donche F, Bouillot A, Mirguet O, Gellibert F, Nicodeme E, Krysa G, Kirilovsky J, Beinke S, McCleary S, Rioja I, Bamborough P, Chung CW, Gordon L, Lewis T, Walker AL, Cutler L, Lugo D, Wilson DM, Witherington J, Lee K, Prinjha RK Bioorg Med Chem Lett. 2012 Apr 15;22(8):2968-72. Epub 2012 Feb 24. PMID:22437115<ref>PMID:22437115</ref>

-	~~===N-Terminal Bromodomain~~ of ~~Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22437115}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[4akn]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4AKN OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022437115<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bouillot, A.]]	+	[[Category: Bouillot, A]]
-	[[Category: Chung, C.]]	+	[[Category: Chung, C]]
-	[[Category: Donche, F.]]	+	[[Category: Donche, F]]
-	[[Category: Lamotte, Y.]]	+	[[Category: Lamotte, Y]]
-	[[Category: Mirguet, O.]]	+	[[Category: Mirguet, O]]
	[[Category: Epigenetic reader]]		[[Category: Epigenetic reader]]
	[[Category: Histone]]		[[Category: Histone]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 10:44, 14 November 2012

OCA — Wed, 14 Nov 2012 10:44:17 GMT

←Older revision		Revision as of 10:44, 14 November 2012
Line 5:		Line 5:
	===N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid===		===N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid===

		+	{{ABSTRACT_PUBMED_22437115}}

	==About this Structure==		==About this Structure==

OCA at 07:08, 14 November 2012

OCA — Wed, 14 Nov 2012 07:08:32 GMT

←Older revision		Revision as of 07:08, 14 November 2012
Line 1:		Line 1:
-	[[Image:4akn.~~jpg~~\|left\|200px]]	+	[[Image:4akn.png\|left\|200px]]

	{{STRUCTURE_4akn\| PDB=4akn \| SCENE= }}		{{STRUCTURE_4akn\| PDB=4akn \| SCENE= }}
Line 5:		Line 5:
	===N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid===		===N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid===

-	{{ABSTRACT_PUBMED_22437115}}

	==About this Structure==		==About this Structure==

OCA at 07:40, 4 July 2012

OCA — Wed, 04 Jul 2012 07:40:46 GMT

←Older revision		Revision as of 07:40, 4 July 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4akn.jpg\|left\|200px]]

-	~~The entry~~ 4akn ~~is ON HOLD~~	+	{{STRUCTURE_4akn\| PDB=4akn \| SCENE= }}

-	~~Authors: Chung, C., Lamotte, Y., Donche, F., Bouillot, A., Mirguet, O.~~	+	===N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid===

-	~~Description~~: N-~~Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino-dimethyl-oxazolyl-quinoline-carboxylic acid~~	+	{{ABSTRACT_PUBMED_22437115}}
		+
		+	==About this Structure==
		+	[[4akn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AKN OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022437115</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Bouillot, A.]]
		+	[[Category: Chung, C.]]
		+	[[Category: Donche, F.]]
		+	[[Category: Lamotte, Y.]]
		+	[[Category: Mirguet, O.]]
		+	[[Category: Epigenetic reader]]
		+	[[Category: Histone]]
		+	[[Category: Inhibitor]]
		+	[[Category: Protein binding]]