4amz - Revision history

OCA at 11:30, 20 December 2023

OCA — Wed, 20 Dec 2023 11:30:32 GMT

←Older revision		Revision as of 11:30, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4amz' size='340' side='right'caption='[[4amz]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4amz' size='340' side='right'caption='[[4amz]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4amz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AMZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4amz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AMZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2P4:(5R)-N-BENZYL-5-({(2S)-2-[(1R)-1,2-DIHYDROXYETHYL]PYRROLIDIN-1-YL}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXAMIDE'>2P4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e5t\|1e5t]], [[1e8m\|1e8m]], [[1e8n\|1e8n]], [[1h2w\|1h2w]], [[1h2x\|1h2x]], [[1h2y\|1h2y]], [[1h2z\|1h2z]], [[1o6f\|1o6f]], [[1o6g\|1o6g]], [[1qfm\|1qfm]], [[1qfs\|1qfs]], [[1uoo\|1uoo]], [[1uop\|1uop]], [[1uoq\|1uoq]], [[1vz2\|1vz2]], [[1vz3\|1vz3]], [[2xdw\|2xdw]], [[4amy\|4amy]], [[4an0\|4an0]], [[4an1\|4an1]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2P4:(5R)-N-BENZYL-5-({(2S)-2-[(1R)-1,2-DIHYDROXYETHYL]PYRROLIDIN-1-YL}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXAMIDE'>2P4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4amz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4amz OCA], [https://pdbe.org/4amz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4amz RCSB], [https://www.ebi.ac.uk/pdbsum/4amz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4amz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4amz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4amz OCA], [https://pdbe.org/4amz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4amz RCSB], [https://www.ebi.ac.uk/pdbsum/4amz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4amz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PPCE_PIG PPCE_PIG]] Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.	+	[https://www.uniprot.org/uniprot/PPCE_PIG PPCE_PIG] Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Prolyl oligopeptidase~~]]	+	[[Category: Sus scrofa]]
-	[[Category: Bunker, A]]	+	[[Category: Bunker A]]
-	[[Category: Canning, P]]	+	[[Category: Canning P]]
-	[[Category: Danne, R]]	+	[[Category: Danne R]]
-	[[Category: Fulop, V]]	+	[[Category: Fulop V]]
-	[[Category: Garcia-Horsman, A]]	+	[[Category: Garcia-Horsman A]]
-	[[Category: Hokkanen, J]]	+	[[Category: Hokkanen J]]
-	[[Category: Juhasz, T]]	+	[[Category: Juhasz T]]
-	[[Category: Karttunen, M]]	+	[[Category: Karttunen M]]
-	[[Category: Kaszuba, K]]	+	[[Category: Kaszuba K]]
-	[[Category: Mannisto~~, P T~~]]	+	[[Category: Mannisto PT]]
-	[[Category: Rog, T]]	+	[[Category: Rog T]]
-	[[Category: St-Pierre~~, J F~~]]	+	[[Category: St-Pierre JF]]
-	[[Category: Szeltner, Z]]	+	[[Category: Szeltner Z]]
-	~~[[Category: Alpha/beta-hydrolase]]~~	+
-	~~[[Category: Amnesia]]~~	+
-	~~[[Category: Beta-propeller]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 05:39, 25 August 2022

OCA — Thu, 25 Aug 2022 05:39:28 GMT

←Older revision		Revision as of 05:39, 25 August 2022
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	<StructureSection load='4amz' size='340' side='right'caption='[[4amz]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4amz' size='340' side='right'caption='[[4amz]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4amz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AMZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4amz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AMZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2P4:(5R)-N-BENZYL-5-({(2S)-2-[(1R)-1,2-DIHYDROXYETHYL]PYRROLIDIN-1-YL}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXAMIDE'>2P4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2P4:(5R)-N-BENZYL-5-({(2S)-2-[(1R)-1,2-DIHYDROXYETHYL]PYRROLIDIN-1-YL}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXAMIDE'>2P4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e5t\|1e5t]], [[1e8m\|1e8m]], [[1e8n\|1e8n]], [[1h2w\|1h2w]], [[1h2x\|1h2x]], [[1h2y\|1h2y]], [[1h2z\|1h2z]], [[1o6f\|1o6f]], [[1o6g\|1o6g]], [[1qfm\|1qfm]], [[1qfs\|1qfs]], [[1uoo\|1uoo]], [[1uop\|1uop]], [[1uoq\|1uoq]], [[1vz2\|1vz2]], [[1vz3\|1vz3]], [[2xdw\|2xdw]], [[4amy\|4amy]], [[4an0\|4an0]], [[4an1\|4an1]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e5t\|1e5t]], [[1e8m\|1e8m]], [[1e8n\|1e8n]], [[1h2w\|1h2w]], [[1h2x\|1h2x]], [[1h2y\|1h2y]], [[1h2z\|1h2z]], [[1o6f\|1o6f]], [[1o6g\|1o6g]], [[1qfm\|1qfm]], [[1qfs\|1qfs]], [[1uoo\|1uoo]], [[1uop\|1uop]], [[1uoq\|1uoq]], [[1vz2\|1vz2]], [[1vz3\|1vz3]], [[2xdw\|2xdw]], [[4amy\|4amy]], [[4an0\|4an0]], [[4an1\|4an1]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4amz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4amz OCA], [~~http~~://pdbe.org/4amz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4amz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4amz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4amz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4amz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4amz OCA], [https://pdbe.org/4amz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4amz RCSB], [https://www.ebi.ac.uk/pdbsum/4amz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4amz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PPCE_PIG PPCE_PIG]] Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.	+	[[https://www.uniprot.org/uniprot/PPCE_PIG PPCE_PIG]] Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:11, 7 August 2019

OCA — Wed, 07 Aug 2019 07:11:20 GMT

←Older revision		Revision as of 07:11, 7 August 2019
Line 1:		Line 1:

	==PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND INHIBITOR IC-2==		==PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND INHIBITOR IC-2==
-	<StructureSection load='4amz' size='340' side='right' caption='[[4amz]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4amz' size='340' side='right'caption='[[4amz]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4amz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AMZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4amz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AMZ FirstGlance]. <br>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4amz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4amz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Prolyl Endopeptidase\|Prolyl Endopeptidase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Prolyl oligopeptidase]]		[[Category: Prolyl oligopeptidase]]
	[[Category: Bunker, A]]		[[Category: Bunker, A]]

OCA at 12:29, 6 November 2017

OCA — Mon, 06 Nov 2017 12:29:11 GMT

←Older revision		Revision as of 12:29, 6 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4amz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4amz" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Prolyl Endopeptidase\|Prolyl Endopeptidase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:35, 3 August 2017

OCA — Thu, 03 Aug 2017 11:35:00 GMT

←Older revision		Revision as of 11:35, 3 August 2017
Line 3:		Line 3:
	<StructureSection load='4amz' size='340' side='right' caption='[[4amz]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4amz' size='340' side='right' caption='[[4amz]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4amz]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Pig Pig]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AMZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4amz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AMZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2P4:(5R)-N-BENZYL-5-({(2S)-2-[(1R)-1,2-DIHYDROXYETHYL]PYRROLIDIN-1-YL}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXAMIDE'>2P4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2P4:(5R)-N-BENZYL-5-({(2S)-2-[(1R)-1,2-DIHYDROXYETHYL]PYRROLIDIN-1-YL}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXAMIDE'>2P4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e5t\|1e5t]], [[1e8m\|1e8m]], [[1e8n\|1e8n]], [[1h2w\|1h2w]], [[1h2x\|1h2x]], [[1h2y\|1h2y]], [[1h2z\|1h2z]], [[1o6f\|1o6f]], [[1o6g\|1o6g]], [[1qfm\|1qfm]], [[1qfs\|1qfs]], [[1uoo\|1uoo]], [[1uop\|1uop]], [[1uoq\|1uoq]], [[1vz2\|1vz2]], [[1vz3\|1vz3]], [[2xdw\|2xdw]], [[4amy\|4amy]], [[4an0\|4an0]], [[4an1\|4an1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e5t\|1e5t]], [[1e8m\|1e8m]], [[1e8n\|1e8n]], [[1h2w\|1h2w]], [[1h2x\|1h2x]], [[1h2y\|1h2y]], [[1h2z\|1h2z]], [[1o6f\|1o6f]], [[1o6g\|1o6g]], [[1qfm\|1qfm]], [[1qfs\|1qfs]], [[1uoo\|1uoo]], [[1uop\|1uop]], [[1uoq\|1uoq]], [[1vz2\|1vz2]], [[1vz3\|1vz3]], [[2xdw\|2xdw]], [[4amy\|4amy]], [[4an0\|4an0]], [[4an1\|4an1]]</td></tr>
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Pig]]
	[[Category: Prolyl oligopeptidase]]		[[Category: Prolyl oligopeptidase]]
	[[Category: Bunker, A]]		[[Category: Bunker, A]]

OCA at 23:13, 5 August 2016

OCA — Fri, 05 Aug 2016 23:13:35 GMT

←Older revision		Revision as of 23:13, 5 August 2016
Line 1:		Line 1:
		+
	==PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND INHIBITOR IC-2==		==PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND INHIBITOR IC-2==
	<StructureSection load='4amz' size='340' side='right' caption='[[4amz]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4amz' size='340' side='right' caption='[[4amz]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4amz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sus_scrofa Sus scrofa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AMZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4amz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AMZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2P4:(5R)-N-BENZYL-5-({(2S)-2-[(1R)-1,2-DIHYDROXYETHYL]PYRROLIDIN-1-YL}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXAMIDE'>2P4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2P4:(5R)-N-BENZYL-5-({(2S)-2-[(1R)-1,2-DIHYDROXYETHYL]PYRROLIDIN-1-YL}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXAMIDE'>2P4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e5t\|1e5t]], [[1e8m\|1e8m]], [[1e8n\|1e8n]], [[1h2w\|1h2w]], [[1h2x\|1h2x]], [[1h2y\|1h2y]], [[1h2z\|1h2z]], [[1o6f\|1o6f]], [[1o6g\|1o6g]], [[1qfm\|1qfm]], [[1qfs\|1qfs]], [[1uoo\|1uoo]], [[1uop\|1uop]], [[1uoq\|1uoq]], [[1vz2\|1vz2]], [[1vz3\|1vz3]], [[2xdw\|2xdw]], [[4amy\|4amy]], [[4an0\|4an0]], [[4an1\|4an1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e5t\|1e5t]], [[1e8m\|1e8m]], [[1e8n\|1e8n]], [[1h2w\|1h2w]], [[1h2x\|1h2x]], [[1h2y\|1h2y]], [[1h2z\|1h2z]], [[1o6f\|1o6f]], [[1o6g\|1o6g]], [[1qfm\|1qfm]], [[1qfs\|1qfs]], [[1uoo\|1uoo]], [[1uop\|1uop]], [[1uoq\|1uoq]], [[1vz2\|1vz2]], [[1vz3\|1vz3]], [[2xdw\|2xdw]], [[4amy\|4amy]], [[4an0\|4an0]], [[4an1\|4an1]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4amz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4amz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4amz RCSB], [http://www.ebi.ac.uk/pdbsum/4amz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4amz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4amz OCA], [http://pdbe.org/4amz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4amz RCSB], [http://www.ebi.ac.uk/pdbsum/4amz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4amz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4amz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Pig]]
	[[Category: Prolyl oligopeptidase]]		[[Category: Prolyl oligopeptidase]]
-	[[Category: Sus scrofa]]
	[[Category: Bunker, A]]		[[Category: Bunker, A]]
	[[Category: Canning, P]]		[[Category: Canning, P]]

OCA at 06:42, 25 December 2014

OCA — Thu, 25 Dec 2014 06:42:22 GMT

←Older revision		Revision as of 06:42, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4amz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4amz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4amz RCSB], [http://www.ebi.ac.uk/pdbsum/4amz PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4amz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4amz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4amz RCSB], [http://www.ebi.ac.uk/pdbsum/4amz PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PPCE_PIG PPCE_PIG]] Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:41, 18 December 2014

OCA — Thu, 18 Dec 2014 08:41:10 GMT

←Older revision		Revision as of 08:41, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4amz\| PDB=4amz \| SCENE= }}~~	+	==PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND INHIBITOR IC-2==
-	===PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND INHIBITOR IC-2===	+	<StructureSection load='4amz' size='340' side='right' caption='[[4amz]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	{~~{ABSTRACT_PUBMED_22484394}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4amz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AMZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2P4:(5R)-N-BENZYL-5-({(2S)-2-[(1R)-1,2-DIHYDROXYETHYL]PYRROLIDIN-1-YL}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXAMIDE'>2P4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e5t\|1e5t]], [[1e8m\|1e8m]], [[1e8n\|1e8n]], [[1h2w\|1h2w]], [[1h2x\|1h2x]], [[1h2y\|1h2y]], [[1h2z\|1h2z]], [[1o6f\|1o6f]], [[1o6g\|1o6g]], [[1qfm\|1qfm]], [[1qfs\|1qfs]], [[1uoo\|1uoo]], [[1uop\|1uop]], [[1uoq\|1uoq]], [[1vz2\|1vz2]], [[1vz3\|1vz3]], [[2xdw\|2xdw]], [[4amy\|4amy]], [[4an0\|4an0]], [[4an1\|4an1]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4amz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4amz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4amz RCSB], [http://www.ebi.ac.uk/pdbsum/4amz PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Altered prolyl oligopeptidase (PREP) activity is found in many common neurological and other genetic disorders, and in some cases PREP inhibition may be a promising treatment. The active site of PREP resides in an internal cavity; in addition to the direct interaction between active site and substrate or inhibitor, the pathway to reach the active site (the gating mechanism) must be understood for more rational inhibitor design and understanding PREP function. The gating mechanism of PREP has been investigated through molecular dynamics (MD) simulation combined with crystallographic and mutagenesis studies. The MD results indicate the inter-domain loop structure, comprised of 3 loops at residues, 189-209 (loop A), 577-608 (loop B), and 636-646 (loop C) (porcine PREP numbering), are important components of the gating mechanism. The results from enzyme kinetics of PREP variants also support this hypothesis: When loop A is (1) locked to loop B through a disulphide bridge, all enzyme activity is halted, (2) nicked, enzyme activity is increased, and (3) removed, enzyme activity is only reduced. Limited proteolysis study also supports the hypothesis of a loop A driven gating mechanism. The MD results show a stable network of H-bonds that hold the two protein domains together. Crystallographic study indicates that a set of known PREP inhibitors inhabit a common binding conformation, and this H-bond network is not significantly altered. Thus the domain separation, seen to occur in lower taxa, is not involved in the gating mechanism for mammalian PREP. In two of the MD simulations we observed a conformational change that involved the breaking of the H-bond network holding loops A and B together. We also found that this network was more stable when the active site was occupied, thus decreasing the likelihood of this transition.

-	~~==About this Structure==~~	+	Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase.,Kaszuba K, Rog T, Danne R, Canning P, Fulop V, Juhasz T, Szeltner Z, St Pierre JF, Garcia-Horsman A, Mannisto PT, Karttunen M, Hokkanen J, Bunker A Biochimie. 2012 Jun;94(6):1398-411. Epub 2012 Mar 30. PMID:22484394<ref>PMID:22484394</ref>
-	~~[[4amz]] is a 1 chain structure with sequence from [http~~:~~//en~~.~~wikipedia.org/wiki/Sus_scrofa Sus scrofa]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4AMZ OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Prolyl Endopeptidase\|Prolyl Endopeptidase]]		*[[Prolyl Endopeptidase\|Prolyl Endopeptidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022484394<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Prolyl oligopeptidase]]		[[Category: Prolyl oligopeptidase]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
-	[[Category: Bunker, A.]]	+	[[Category: Bunker, A]]
-	[[Category: Canning, P.]]	+	[[Category: Canning, P]]
-	[[Category: Danne, R.]]	+	[[Category: Danne, R]]
-	[[Category: Fulop, V.]]	+	[[Category: Fulop, V]]
-	[[Category: Garcia-Horsman, A.]]	+	[[Category: Garcia-Horsman, A]]
-	[[Category: Hokkanen, J.]]	+	[[Category: Hokkanen, J]]
-	[[Category: Juhasz, T.]]	+	[[Category: Juhasz, T]]
-	[[Category: Karttunen, M.]]	+	[[Category: Karttunen, M]]
-	[[Category: Kaszuba, K.]]	+	[[Category: Kaszuba, K]]
-	[[Category: Mannisto, P T.]]	+	[[Category: Mannisto, P T]]
-	[[Category: Rog, T.]]	+	[[Category: Rog, T]]
-	[[Category: St-Pierre, J F.]]	+	[[Category: St-Pierre, J F]]
-	[[Category: Szeltner, Z.]]	+	[[Category: Szeltner, Z]]
	[[Category: Alpha/beta-hydrolase]]		[[Category: Alpha/beta-hydrolase]]
	[[Category: Amnesia]]		[[Category: Amnesia]]
	[[Category: Beta-propeller]]		[[Category: Beta-propeller]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 11:08, 11 March 2013

OCA — Mon, 11 Mar 2013 11:08:49 GMT

←Older revision		Revision as of 11:08, 11 March 2013
Line 1:		Line 1:
-	[[Image:4amz.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_4amz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_4amz\| PDB=4amz \| SCENE= }}		{{STRUCTURE_4amz\| PDB=4amz \| SCENE= }}
-
	===PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND INHIBITOR IC-2===		===PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND INHIBITOR IC-2===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22484394}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22484394 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22484394}}		{{ABSTRACT_PUBMED_22484394}}

	==About this Structure==		==About this Structure==
	[[4amz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMZ OCA].		[[4amz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMZ OCA].
		+
		+	==See Also==
		+	*[[Prolyl Endopeptidase\|Prolyl Endopeptidase]]

	==Reference==		==Reference==

OCA at 09:09, 16 May 2012

OCA — Wed, 16 May 2012 09:09:19 GMT

←Older revision		Revision as of 09:09, 16 May 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4amz.jpg\|left\|200px]]

-	The ~~entry 4amz~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4amz", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4amz\| PDB=4amz \| SCENE= }}

-	~~Authors: Kaszuba, K., Rog, T., Danne, R., Canning, P., Fulop, V., Juhasz, T., Szeltner, Z., St~~-~~Pierre, J.F., Garcia-Horsman, A., Mannisto, P.T., Karttunen, M., Hokkanen, J., Bunker, A.~~	+	===PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND INHIBITOR IC-2===

-	~~Description~~: ~~PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH~~ A ~~COVALENTLY BOUND INHIBITOR IC~~-2	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22484394}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22484394 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22484394}}
		+
		+	==About this Structure==
		+	[[4amz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMZ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022484394</ref><references group="xtra"/>
		+	[[Category: Prolyl oligopeptidase]]
		+	[[Category: Sus scrofa]]
		+	[[Category: Bunker, A.]]
		+	[[Category: Canning, P.]]
		+	[[Category: Danne, R.]]
		+	[[Category: Fulop, V.]]
		+	[[Category: Garcia-Horsman, A.]]
		+	[[Category: Hokkanen, J.]]
		+	[[Category: Juhasz, T.]]
		+	[[Category: Karttunen, M.]]
		+	[[Category: Kaszuba, K.]]
		+	[[Category: Mannisto, P T.]]
		+	[[Category: Rog, T.]]
		+	[[Category: St-Pierre, J F.]]
		+	[[Category: Szeltner, Z.]]
		+	[[Category: Alpha/beta-hydrolase]]
		+	[[Category: Amnesia]]
		+	[[Category: Beta-propeller]]
		+	[[Category: Hydrolase]]