4an8 - Revision history

OCA at 05:39, 25 August 2022

OCA — Thu, 25 Aug 2022 05:39:51 GMT

←Older revision		Revision as of 05:39, 25 August 2022
Line 1:		Line 1:

	==Structure of Thermus thermophilus CasA (Cse1)==		==Structure of Thermus thermophilus CasA (Cse1)==
-	<StructureSection load='4an8' size='340' side='right' caption='[[4an8]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4an8' size='340' side='right'caption='[[4an8]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4an8]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AN8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AN8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4an8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AN8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TTHB188 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4an8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4an8 OCA], [https://pdbe.org/4an8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4an8 RCSB], [https://www.ebi.ac.uk/pdbsum/4an8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4an8 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4an8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4an8 OCA], [~~http~~://pdbe.org/4an8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4an8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4an8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4an8 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CSE1_THET8 CSE1_THET8]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity). A component of Cascade, which participates in CRISPR interference, the third stage of CRISPR immunity. Cascade binds both crRNA and in a sequence-specific manner negatively supercoiled dsDNA target. This leads to the formation of an R-loop in which the crRNA binds the target DNA, displacing the noncomplementary strand. Cas3 is recruited to Cascade, probably via interactions with CasA, nicks target DNA and then unwinds and cleaves the target, leading to DNA degradation and invader neutralization. CasA is not required for formation of Cascade, but probably enhances binding to and subsequent recognition of both target dsDNA and ssDNA (By similarity).	+	[[https://www.uniprot.org/uniprot/CSE1_THET8 CSE1_THET8]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity). A component of Cascade, which participates in CRISPR interference, the third stage of CRISPR immunity. Cascade binds both crRNA and in a sequence-specific manner negatively supercoiled dsDNA target. This leads to the formation of an R-loop in which the crRNA binds the target DNA, displacing the noncomplementary strand. Cas3 is recruited to Cascade, probably via interactions with CasA, nicks target DNA and then unwinds and cleaves the target, leading to DNA degradation and invader neutralization. CasA is not required for formation of Cascade, but probably enhances binding to and subsequent recognition of both target dsDNA and ssDNA (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:

	==See Also==		==See Also==
-	*[[Endonuclease\|Endonuclease]]	+	*[[Endonuclease 3D structures\|Endonuclease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Thet8~~]]	+	[[Category: Large Structures]]
	[[Category: Doudna, J A]]		[[Category: Doudna, J A]]
	[[Category: Sashital, D G]]		[[Category: Sashital, D G]]

OCA at 22:30, 5 August 2016

OCA — Fri, 05 Aug 2016 22:30:39 GMT

←Older revision		Revision as of 22:30, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of Thermus thermophilus CasA (Cse1)==		==Structure of Thermus thermophilus CasA (Cse1)==
	<StructureSection load='4an8' size='340' side='right' caption='[[4an8]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4an8' size='340' side='right' caption='[[4an8]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4an8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermus_thermophilus Thermus thermophilus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AN8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AN8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4an8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AN8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AN8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TTHB188 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~274 Thermus thermophilus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TTHB188 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4an8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4an8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4an8 RCSB], [http://www.ebi.ac.uk/pdbsum/4an8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4an8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4an8 OCA], [http://pdbe.org/4an8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4an8 RCSB], [http://www.ebi.ac.uk/pdbsum/4an8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4an8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~Q53VY1_THET8 Q53VY1_THET8~~]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity). A component of Cascade, which participates in CRISPR interference, the third stage of CRISPR immunity. Cascade binds both crRNA and in a sequence-specific manner negatively supercoiled dsDNA target. This leads to the formation of an R-loop in which the crRNA binds the target DNA, displacing the noncomplementary strand. Cas3 is recruited to Cascade, probably via interactions with CasA, nicks target DNA and then unwinds and cleaves the target, leading to DNA degradation and invader neutralization. CasA is not required for formation of Cascade, but probably enhances binding to and subsequent recognition of both target dsDNA and ssDNA (By similarity).	+	[[http://www.uniprot.org/uniprot/CSE1_THET8 CSE1_THET8]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity). A component of Cascade, which participates in CRISPR interference, the third stage of CRISPR immunity. Cascade binds both crRNA and in a sequence-specific manner negatively supercoiled dsDNA target. This leads to the formation of an R-loop in which the crRNA binds the target DNA, displacing the noncomplementary strand. Cas3 is recruited to Cascade, probably via interactions with CasA, nicks target DNA and then unwinds and cleaves the target, leading to DNA degradation and invader neutralization. CasA is not required for formation of Cascade, but probably enhances binding to and subsequent recognition of both target dsDNA and ssDNA (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4an8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Thermus thermophilus~~]]	+	[[Category: Thet8]]
	[[Category: Doudna, J A]]		[[Category: Doudna, J A]]
	[[Category: Sashital, D G]]		[[Category: Sashital, D G]]

OCA at 22:28, 25 December 2014

OCA — Thu, 25 Dec 2014 22:28:50 GMT

←Older revision		Revision as of 22:28, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4an8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AN8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AN8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4an8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AN8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AN8 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TTHB188 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TTHB188 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4an8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4an8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4an8 RCSB], [http://www.ebi.ac.uk/pdbsum/4an8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4an8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4an8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4an8 RCSB], [http://www.ebi.ac.uk/pdbsum/4an8 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q53VY1_THET8 Q53VY1_THET8]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity). A component of Cascade, which participates in CRISPR interference, the third stage of CRISPR immunity. Cascade binds both crRNA and in a sequence-specific manner negatively supercoiled dsDNA target. This leads to the formation of an R-loop in which the crRNA binds the target DNA, displacing the noncomplementary strand. Cas3 is recruited to Cascade, probably via interactions with CasA, nicks target DNA and then unwinds and cleaves the target, leading to DNA degradation and invader neutralization. CasA is not required for formation of Cascade, but probably enhances binding to and subsequent recognition of both target dsDNA and ssDNA (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 15:
	Mechanism of Foreign DNA Selection in a Bacterial Adaptive Immune System.,Sashital DG, Wiedenheft B, Doudna JA Mol Cell. 2012 Apr 17. PMID:22521690<ref>PMID:22521690</ref>		Mechanism of Foreign DNA Selection in a Bacterial Adaptive Immune System.,Sashital DG, Wiedenheft B, Doudna JA Mol Cell. 2012 Apr 17. PMID:22521690<ref>PMID:22521690</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Endonuclease\|Endonuclease]]
	== References ==		== References ==
	<references/>		<references/>
Line 20:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
-	[[Category: Doudna, J A.]]	+	[[Category: Doudna, J A]]
-	[[Category: Sashital, D G.]]	+	[[Category: Sashital, D G]]
-	[[Category: Wiedenheft, B.]]	+	[[Category: Wiedenheft, B]]
	[[Category: Casa]]		[[Category: Casa]]
	[[Category: Cascade]]		[[Category: Cascade]]
	[[Category: Crispr]]		[[Category: Crispr]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 07:24, 5 June 2014

OCA — Thu, 05 Jun 2014 07:24:35 GMT

←Older revision		Revision as of 07:24, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~4an8.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of Thermus thermophilus CasA (Cse1)==
		+	<StructureSection load='4an8' size='340' side='right' caption='[[4an8]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4an8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AN8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AN8 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TTHB188 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4an8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4an8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4an8 RCSB], [http://www.ebi.ac.uk/pdbsum/4an8 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In bacterial and archaeal CRISPR immune pathways, DNA sequences from invading bacteriophage or plasmids are integrated into CRISPR loci within the host genome, conferring immunity against subsequent infections. The ribonucleoprotein complex Cascade utilizes RNAs generated from these loci to target complementary "nonself" DNA sequences for destruction, while avoiding binding to "self" sequences within the CRISPR locus. Here we show that CasA, the largest protein subunit of Cascade, is required for nonself target recognition and binding. Combining a 2.3 A crystal structure of CasA with cryo-EM structures of Cascade, we have identified a loop that is required for viral defense. This loop contacts a conserved three base pair motif that is required for nonself target selection. Our data suggest a model in which the CasA loop scans DNA for this short motif prior to target destabilization and binding, maximizing the efficiency of DNA surveillance by Cascade.

-	~~{{STRUCTURE_4an8\| PDB=4an8 \| SCENE= }}~~	+	Mechanism of Foreign DNA Selection in a Bacterial Adaptive Immune System.,Sashital DG, Wiedenheft B, Doudna JA Mol Cell. 2012 Apr 17. PMID:22521690<ref>PMID:22521690</ref>

-	~~===Structure~~ of ~~Thermus thermophilus CasA (Cse1)===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22521690}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[4an8]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thermus_thermophilus Thermus thermophilus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4AN8 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022521690<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
	[[Category: Doudna, J A.]]		[[Category: Doudna, J A.]]

OCA at 08:05, 20 June 2012

OCA — Wed, 20 Jun 2012 08:05:10 GMT

←Older revision		Revision as of 08:05, 20 June 2012
Line 1:		Line 1:
	[[Image:4an8.png\|left\|200px]]		[[Image:4an8.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_4an8", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_4an8\| PDB=4an8 \| SCENE= }}		{{STRUCTURE_4an8\| PDB=4an8 \| SCENE= }}

	===Structure of Thermus thermophilus CasA (Cse1)===		===Structure of Thermus thermophilus CasA (Cse1)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22521690}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22521690 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22521690}}		{{ABSTRACT_PUBMED_22521690}}

OCA at 07:04, 20 June 2012

OCA — Wed, 20 Jun 2012 07:04:17 GMT

←Older revision		Revision as of 07:04, 20 June 2012
Line 1:		Line 1:
-	[[Image:4an8.~~jpg~~\|left\|200px]]	+	[[Image:4an8.png\|left\|200px]]

	<!--		<!--

OCA at 19:20, 2 May 2012

OCA — Wed, 02 May 2012 19:20:30 GMT

←Older revision		Revision as of 19:20, 2 May 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4an8.jpg\|left\|200px]]

-	The ~~entry 4an8~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4an8", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4an8\| PDB=4an8 \| SCENE= }}

-	~~Authors: Sashital, D.G., Wiedenheft, B., Doudna, J.A.~~	+	===Structure of Thermus thermophilus CasA (Cse1)===

-	~~Description~~: Structure of Thermus thermophilus ~~CasA (Cse1)~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22521690}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22521690 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22521690}}
		+
		+	==About this Structure==
		+	[[4an8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AN8 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022521690</ref><references group="xtra"/>
		+	[[Category: Thermus thermophilus]]
		+	[[Category: Doudna, J A.]]
		+	[[Category: Sashital, D G.]]
		+	[[Category: Wiedenheft, B.]]
		+	[[Category: Casa]]
		+	[[Category: Cascade]]
		+	[[Category: Crispr]]
		+	[[Category: Immune system]]

OCA at 07:17, 28 March 2012

OCA — Wed, 28 Mar 2012 07:17:08 GMT

←Older revision		Revision as of 07:17, 28 March 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4an8 is ON HOLD	+	The entry 4an8 is ON HOLD until Paper Publication

	Authors: Sashital, D.G., Wiedenheft, B., Doudna, J.A.		Authors: Sashital, D.G., Wiedenheft, B., Doudna, J.A.

	Description: Structure of Thermus thermophilus CasA (Cse1)		Description: Structure of Thermus thermophilus CasA (Cse1)

OCA: Protected "4an8" [edit=sysop:move=sysop]

OCA — Wed, 21 Mar 2012 07:10:16 GMT

Protected "4an8" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:10, 21 March 2012

OCA: New page: '''Unreleased structure''' The entry 4an8 is ON HOLD Authors: Sashital, D.G., Wiedenheft, B., Doudna, J.A. Description: Structure of Thermus thermophilus CasA (Cse1)

OCA — Wed, 21 Mar 2012 07:10:15 GMT

New page: '''Unreleased structure''' The entry 4an8 is ON HOLD Authors: Sashital, D.G., Wiedenheft, B., Doudna, J.A. Description: Structure of Thermus thermophilus CasA (Cse1)

New page

'''Unreleased structure'''

The entry 4an8 is ON HOLD

Authors: Sashital, D.G., Wiedenheft, B., Doudna, J.A.

Description: Structure of Thermus thermophilus CasA (Cse1)