4aq8 - Revision history

OCA at 11:32, 20 December 2023

OCA — Wed, 20 Dec 2023 11:32:54 GMT

←Older revision		Revision as of 11:32, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4aq8' size='340' side='right'caption='[[4aq8]], [[Resolution\|resolution]] 2.63Å' scene=''>		<StructureSection load='4aq8' size='340' side='right'caption='[[4aq8]], [[Resolution\|resolution]] 2.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4aq8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AQ8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4aq8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AQ8 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.63Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2wbx\|2wbx]], [[2wcp\|2wcp]], [[2wd0\|2wd0]], [[2whv\|2whv]], [[4apx\|4apx]], [[4aqa\|4aqa]], [[4aqe\|4aqe]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aq8 OCA], [https://pdbe.org/4aq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aq8 RCSB], [https://www.ebi.ac.uk/pdbsum/4aq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aq8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aq8 OCA], [https://pdbe.org/4aq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aq8 RCSB], [https://www.ebi.ac.uk/pdbsum/4aq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aq8 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Defects in Cdh23 are the cause of waltzer (v) phenotype. Waltzer mice are characterized by deafness and vestibular dysfunction due to degeneration of the neuroepithelium within the inner ear. [[https://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Defects in Pcdh15 are the cause of the Ames waltzer (av) phenotype. It is characterized by deafness and a balance disorder, associated with the degeneration of inner ear neuroepithelia.	+	[https://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE] Defects in Cdh23 are the cause of waltzer (v) phenotype. Waltzer mice are characterized by deafness and vestibular dysfunction due to degeneration of the neuroepithelium within the inner ear.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:11138008</ref> [[https://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function.	+	[https://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:11138008</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Corey~~, D P~~]]	+	[[Category: Corey DP]]
-	[[Category: Gaudet, R]]	+	[[Category: Gaudet R]]
-	[[Category: Sotomayor, M]]	+	[[Category: Sotomayor M]]
-	[[Category: Weihofen, W]]	+	[[Category: Weihofen W]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Deafness~~]]	+

OCA at 05:42, 25 August 2022

OCA — Thu, 25 Aug 2022 05:42:34 GMT

←Older revision		Revision as of 05:42, 25 August 2022
Line 3:		Line 3:
	<StructureSection load='4aq8' size='340' side='right'caption='[[4aq8]], [[Resolution\|resolution]] 2.63Å' scene=''>		<StructureSection load='4aq8' size='340' side='right'caption='[[4aq8]], [[Resolution\|resolution]] 2.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4aq8]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQ8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AQ8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4aq8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AQ8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wbx\|2wbx]], [[2wcp\|2wcp]], [[2wd0\|2wd0]], [[2whv\|2whv]], [[4apx\|4apx]], [[4aqa\|4aqa]], [[4aqe\|4aqe]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wbx\|2wbx]], [[2wcp\|2wcp]], [[2wd0\|2wd0]], [[2whv\|2whv]], [[4apx\|4apx]], [[4aqa\|4aqa]], [[4aqe\|4aqe]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4aq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aq8 OCA], [~~http~~://pdbe.org/4aq8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4aq8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4aq8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4aq8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aq8 OCA], [https://pdbe.org/4aq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aq8 RCSB], [https://www.ebi.ac.uk/pdbsum/4aq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aq8 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Defects in Cdh23 are the cause of waltzer (v) phenotype. Waltzer mice are characterized by deafness and vestibular dysfunction due to degeneration of the neuroepithelium within the inner ear. [[~~http~~://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Defects in Pcdh15 are the cause of the Ames waltzer (av) phenotype. It is characterized by deafness and a balance disorder, associated with the degeneration of inner ear neuroepithelia.	+	[[https://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Defects in Cdh23 are the cause of waltzer (v) phenotype. Waltzer mice are characterized by deafness and vestibular dysfunction due to degeneration of the neuroepithelium within the inner ear. [[https://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Defects in Pcdh15 are the cause of the Ames waltzer (av) phenotype. It is characterized by deafness and a balance disorder, associated with the degeneration of inner ear neuroepithelia.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:11138008</ref> [[~~http~~://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function.	+	[[https://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:11138008</ref> [[https://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Cadherin\|Cadherin]]	+	*[[Cadherin 3D structures\|Cadherin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Corey, D P]]		[[Category: Corey, D P]]

OCA at 08:52, 6 March 2019

OCA — Wed, 06 Mar 2019 08:52:18 GMT

←Older revision		Revision as of 08:52, 6 March 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCADHERIN-15 EC1- 2 FORM II==		==CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCADHERIN-15 EC1- 2 FORM II==
-	<StructureSection load='4aq8' size='340' side='right' caption='[[4aq8]], [[Resolution\|resolution]] 2.63Å' scene=''>	+	<StructureSection load='4aq8' size='340' side='right'caption='[[4aq8]], [[Resolution\|resolution]] 2.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4aq8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQ8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4aq8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQ8 FirstGlance]. <br>

OCA at 02:43, 11 December 2016

OCA — Sun, 11 Dec 2016 02:43:23 GMT

←Older revision		Revision as of 02:43, 11 December 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCADHERIN-15 EC1- 2 FORM II==		==CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCADHERIN-15 EC1- 2 FORM II==
	<StructureSection load='4aq8' size='340' side='right' caption='[[4aq8]], [[Resolution\|resolution]] 2.63Å' scene=''>		<StructureSection load='4aq8' size='340' side='right' caption='[[4aq8]], [[Resolution\|resolution]] 2.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4aq8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQ8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4aq8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQ8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wbx\|2wbx]], [[2wcp\|2wcp]], [[2wd0\|2wd0]], [[2whv\|2whv]], [[4apx\|4apx]], [[4aqa\|4aqa]], [[4aqe\|4aqe]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wbx\|2wbx]], [[2wcp\|2wcp]], [[2wd0\|2wd0]], [[2whv\|2whv]], [[4apx\|4apx]], [[4aqa\|4aqa]], [[4aqe\|4aqe]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aq8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aq8 RCSB], [http://www.ebi.ac.uk/pdbsum/4aq8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aq8 OCA], [http://pdbe.org/4aq8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4aq8 RCSB], [http://www.ebi.ac.uk/pdbsum/4aq8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4aq8 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[http://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Defects in Cdh23 are the cause of waltzer (v) phenotype. Waltzer mice are characterized by deafness and vestibular dysfunction due to degeneration of the neuroepithelium within the inner ear.	+	[[http://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Defects in Cdh23 are the cause of waltzer (v) phenotype. Waltzer mice are characterized by deafness and vestibular dysfunction due to degeneration of the neuroepithelium within the inner ear. [[http://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Defects in Pcdh15 are the cause of the Ames waltzer (av) phenotype. It is characterized by deafness and a balance disorder, associated with the degeneration of inner ear neuroepithelia.
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:11138008</ref>	+	[[http://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:11138008</ref> [[http://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4aq8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Corey, D P]]		[[Category: Corey, D P]]
	[[Category: Gaudet, R]]		[[Category: Gaudet, R]]

OCA at 14:40, 9 December 2014

OCA — Tue, 09 Dec 2014 14:40:19 GMT

←Older revision		Revision as of 14:40, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4aq8.~~png~~\|~~left~~\|~~200px~~]]	+	==CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCADHERIN-15 EC1- 2 FORM II==
		+	<StructureSection load='4aq8' size='340' side='right' caption='[[4aq8]], [[Resolution\|resolution]] 2.63Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4aq8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQ8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wbx\|2wbx]], [[2wcp\|2wcp]], [[2wd0\|2wd0]], [[2whv\|2whv]], [[4apx\|4apx]], [[4aqa\|4aqa]], [[4aqe\|4aqe]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aq8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aq8 RCSB], [http://www.ebi.ac.uk/pdbsum/4aq8 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Defects in Cdh23 are the cause of waltzer (v) phenotype. Waltzer mice are characterized by deafness and vestibular dysfunction due to degeneration of the neuroepithelium within the inner ear.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:11138008</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hearing and balance use hair cells in the inner ear to transform mechanical stimuli into electrical signals. Mechanical force from sound waves or head movements is conveyed to hair-cell transduction channels by tip links, fine filaments formed by two atypical cadherins known as protocadherin 15 and cadherin 23 (refs 4, 5). These two proteins are involved in inherited deafness and feature long extracellular domains that interact tip-to-tip in a Ca(2+)-dependent manner. However, the molecular architecture of this complex is unknown. Here we combine crystallography, molecular dynamics simulations and binding experiments to characterize the protocadherin 15-cadherin 23 bond. We find a unique cadherin interaction mechanism, in which the two most amino-terminal cadherin repeats (extracellular cadherin repeats 1 and 2) of each protein interact to form an overlapped, antiparallel heterodimer. Simulations predict that this tip-link bond is mechanically strong enough to resist forces in hair cells. In addition, the complex is shown to become unstable in response to Ca(2+) removal owing to increased flexure of Ca(2+)-free cadherin repeats. Finally, we use structures and biochemical measurements to study the molecular mechanisms by which deafness mutations disrupt tip-link function. Overall, our results shed light on the molecular mechanics of hair-cell sensory transduction and on new interaction mechanisms for cadherins, a large protein family implicated in tissue and organ morphogenesis, neural connectivity and cancer.

-	~~{{STRUCTURE_4aq8\| PDB=4aq8 \| SCENE= }}~~	+	Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction.,Sotomayor M, Weihofen WA, Gaudet R, Corey DP Nature. 2012 Nov 7. doi: 10.1038/nature11590. PMID:23135401<ref>PMID:23135401</ref>

-	~~===CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCADHERIN-15 EC1- 2 FORM II===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_23135401}}~~	+	==See Also==
-		+	*[[Cadherin\|Cadherin]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4aq8~~]] ~~is a 4 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQ8 OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Corey, D P.]]	+	[[Category: Corey, D P]]
-	[[Category: Gaudet, R.]]	+	[[Category: Gaudet, R]]
-	[[Category: Sotomayor, M.]]	+	[[Category: Sotomayor, M]]
-	[[Category: Weihofen, W.]]	+	[[Category: Weihofen, W]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Deafness]]		[[Category: Deafness]]

OCA at 09:37, 21 November 2012

OCA — Wed, 21 Nov 2012 09:37:19 GMT

←Older revision		Revision as of 09:37, 21 November 2012
Line 1:		Line 1:
-	[[Image:4aq8.~~jpg~~\|left\|200px]]	+	[[Image:4aq8.png\|left\|200px]]

	{{STRUCTURE_4aq8\| PDB=4aq8 \| SCENE= }}		{{STRUCTURE_4aq8\| PDB=4aq8 \| SCENE= }}
Line 5:		Line 5:
	===CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCADHERIN-15 EC1- 2 FORM II===		===CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCADHERIN-15 EC1- 2 FORM II===

		+	{{ABSTRACT_PUBMED_23135401}}

	==About this Structure==		==About this Structure==

OCA at 14:00, 8 November 2012

OCA — Thu, 08 Nov 2012 14:00:09 GMT

←Older revision		Revision as of 14:00, 8 November 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4aq8.jpg\|left\|200px]]

-	~~The entry~~ 4aq8 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4aq8\| PDB=4aq8 \| SCENE= }}

-	~~Authors: Sotomayor, M., Weihofen, W., Gaudet, R., Corey, D.P.~~	+	===CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCADHERIN-15 EC1- 2 FORM II===

-	~~Description~~: ~~CRYSTAL STRUCTURE OF MOUSE CADHERIN~~-~~23 EC1-2 AND PROTOCADHERIN-15 EC1-2 FORM II~~	+
		+	==About this Structure==
		+	[[4aq8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQ8 OCA].
		+	[[Category: Mus musculus]]
		+	[[Category: Corey, D P.]]
		+	[[Category: Gaudet, R.]]
		+	[[Category: Sotomayor, M.]]
		+	[[Category: Weihofen, W.]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Deafness]]

OCA at 07:15, 20 June 2012

OCA — Wed, 20 Jun 2012 07:15:44 GMT

←Older revision		Revision as of 07:15, 20 June 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4aq8 is ON HOLD	+	The entry 4aq8 is ON HOLD until Paper Publication

	Authors: Sotomayor, M., Weihofen, W., Gaudet, R., Corey, D.P.		Authors: Sotomayor, M., Weihofen, W., Gaudet, R., Corey, D.P.

	Description: CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCADHERIN-15 EC1-2 FORM II		Description: CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCADHERIN-15 EC1-2 FORM II

OCA: Protected "4aq8" [edit=sysop:move=sysop]

OCA — Wed, 25 Apr 2012 08:47:16 GMT

Protected "4aq8" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:47, 25 April 2012

OCA: New page: '''Unreleased structure''' The entry 4aq8 is ON HOLD Authors: Sotomayor, M., Weihofen, W., Gaudet, R., Corey, D.P. Description: CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCA...

OCA — Wed, 25 Apr 2012 08:47:15 GMT

New page: '''Unreleased structure''' The entry 4aq8 is ON HOLD Authors: Sotomayor, M., Weihofen, W., Gaudet, R., Corey, D.P. Description: CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCA...

New page

'''Unreleased structure'''

The entry 4aq8 is ON HOLD

Authors: Sotomayor, M., Weihofen, W., Gaudet, R., Corey, D.P.

Description: CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCADHERIN-15 EC1-2 FORM II