4aqb - Revision history

OCA at 11:32, 20 December 2023

OCA — Wed, 20 Dec 2023 11:32:57 GMT

←Older revision		Revision as of 11:32, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4aqb' size='340' side='right'caption='[[4aqb]], [[Resolution\|resolution]] 4.20Å' scene=''>		<StructureSection load='4aqb' size='340' side='right'caption='[[4aqb]], [[Resolution\|resolution]] 4.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4aqb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AQB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4aqb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AQB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 4.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqb OCA], [https://pdbe.org/4aqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aqb RCSB], [https://www.ebi.ac.uk/pdbsum/4aqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqb OCA], [https://pdbe.org/4aqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aqb RCSB], [https://www.ebi.ac.uk/pdbsum/4aqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/MASP1_HUMAN MASP1_HUMAN]] Defects in MASP1 are the cause of 3MC syndrome type 1 (3MC1) [MIM:[https://omim.org/entry/257920 257920]]. 3MC1 is a disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly arched eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes.<ref>PMID:21258343</ref>	+	[https://www.uniprot.org/uniprot/MASP1_HUMAN MASP1_HUMAN] Defects in MASP1 are the cause of 3MC syndrome type 1 (3MC1) [MIM:[https://omim.org/entry/257920 257920]. 3MC1 is a disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly arched eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes.<ref>PMID:21258343</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MASP1_HUMAN MASP1_HUMAN]] Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.<ref>PMID:11485744</ref> <ref>PMID:17182967</ref>	+	[https://www.uniprot.org/uniprot/MASP1_HUMAN MASP1_HUMAN] Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.<ref>PMID:11485744</ref> <ref>PMID:17182967</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Garred, P]]	+	[[Category: Garred P]]
-	[[Category: Hummelshoj, T]]	+	[[Category: Hummelshoj T]]
-	[[Category: Johnson, S]]	+	[[Category: Johnson S]]
-	[[Category: Lea~~, S M~~]]	+	[[Category: Lea SM]]
-	[[Category: Palarasah, Y]]	+	[[Category: Palarasah Y]]
-	[[Category: Roversi, P]]	+	[[Category: Roversi P]]
-	[[Category: Skjoedt~~, M O]]~~	+	[[Category: Skjoedt MO]]
-	~~[[Category: Blood clotting]]~~	+
-	~~[[Category: Complement]]~~	+
-	~~[[Category: Ficolin]]~~	+
-	~~[[Category: Lectin complement pathway]]~~	+
-	~~[[Category: Mannan-binding protein]]~~	+
-	~~[[Category: Mannose- binding lectin]]~~	+
-	~~[[Category: Map1]]~~	+
-	~~[[Category: Map44]]~~	+
-	~~[[Category: Mbl/ficolin associated protein-1]]~~	+
-	~~[[Category: Mbl/ficolin associated serine protease~~]]	+

OCA at 05:42, 25 August 2022

OCA — Thu, 25 Aug 2022 05:42:40 GMT

←Older revision		Revision as of 05:42, 25 August 2022
Line 3:		Line 3:
	<StructureSection load='4aqb' size='340' side='right'caption='[[4aqb]], [[Resolution\|resolution]] 4.20Å' scene=''>		<StructureSection load='4aqb' size='340' side='right'caption='[[4aqb]], [[Resolution\|resolution]] 4.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4aqb]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AQB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4aqb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AQB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4aqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqb OCA], [~~http~~://pdbe.org/4aqb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4aqb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4aqb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqb OCA], [https://pdbe.org/4aqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aqb RCSB], [https://www.ebi.ac.uk/pdbsum/4aqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/MASP1_HUMAN MASP1_HUMAN]] Defects in MASP1 are the cause of 3MC syndrome type 1 (3MC1) [MIM:[~~http~~://omim.org/entry/257920 257920]]. 3MC1 is a disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly arched eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes.<ref>PMID:21258343</ref>	+	[[https://www.uniprot.org/uniprot/MASP1_HUMAN MASP1_HUMAN]] Defects in MASP1 are the cause of 3MC syndrome type 1 (3MC1) [MIM:[https://omim.org/entry/257920 257920]]. 3MC1 is a disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly arched eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes.<ref>PMID:21258343</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MASP1_HUMAN MASP1_HUMAN]] Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.<ref>PMID:11485744</ref> <ref>PMID:17182967</ref>	+	[[https://www.uniprot.org/uniprot/MASP1_HUMAN MASP1_HUMAN]] Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.<ref>PMID:11485744</ref> <ref>PMID:17182967</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
	[[Category: Garred, P]]		[[Category: Garred, P]]
	[[Category: Hummelshoj, T]]		[[Category: Hummelshoj, T]]

OCA at 09:03, 6 March 2019

OCA — Wed, 06 Mar 2019 09:03:25 GMT

←Older revision		Revision as of 09:03, 6 March 2019
Line 1:		Line 1:

	==MBL-Ficolin Associated Protein-1, MAP-1 aka MAP44==		==MBL-Ficolin Associated Protein-1, MAP-1 aka MAP44==
-	<StructureSection load='4aqb' size='340' side='right' caption='[[4aqb]], [[Resolution\|resolution]] 4.20Å' scene=''>	+	<StructureSection load='4aqb' size='340' side='right'caption='[[4aqb]], [[Resolution\|resolution]] 4.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4aqb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4aqb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQB FirstGlance]. <br>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4aqb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4aqb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Mannan-binding lectin serine protease\|Mannan-binding lectin serine protease]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:40, 4 August 2016

OCA — Thu, 04 Aug 2016 21:40:10 GMT

←Older revision		Revision as of 21:40, 4 August 2016
Line 1:		Line 1:
		+
	==MBL-Ficolin Associated Protein-1, MAP-1 aka MAP44==		==MBL-Ficolin Associated Protein-1, MAP-1 aka MAP44==
	<StructureSection load='4aqb' size='340' side='right' caption='[[4aqb]], [[Resolution\|resolution]] 4.20Å' scene=''>		<StructureSection load='4aqb' size='340' side='right' caption='[[4aqb]], [[Resolution\|resolution]] 4.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4aqb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4aqb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aqb RCSB], [http://www.ebi.ac.uk/pdbsum/4aqb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqb OCA], [http://pdbe.org/4aqb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4aqb RCSB], [http://www.ebi.ac.uk/pdbsum/4aqb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4aqb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Garred, P]]		[[Category: Garred, P]]
	[[Category: Hummelshoj, T]]		[[Category: Hummelshoj, T]]

OCA at 09:16, 21 December 2014

OCA — Sun, 21 Dec 2014 09:16:52 GMT

←Older revision		Revision as of 09:16, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4aqb\| PDB=4aqb \| SCENE= }}~~	+	==MBL-Ficolin Associated Protein-1, MAP-1 aka MAP44==
-	===MBL-Ficolin Associated Protein-1, MAP-1 aka MAP44===	+	<StructureSection load='4aqb' size='340' side='right' caption='[[4aqb]], [[Resolution\|resolution]] 4.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22854970}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4aqb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQB FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aqb RCSB], [http://www.ebi.ac.uk/pdbsum/4aqb PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/MASP1_HUMAN MASP1_HUMAN]] Defects in MASP1 are the cause of 3MC syndrome type 1 (3MC1) [MIM:[http://omim.org/entry/257920 257920]]. 3MC1 is a disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly arched eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes.<ref>PMID:21258343</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MASP1_HUMAN MASP1_HUMAN]] Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.<ref>PMID:11485744</ref> <ref>PMID:17182967</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The human lectin complement pathway activation molecules comprise mannose-binding lectin (MBL) and ficolin-1, -2, and -3 in complex with associated serine proteases MASP-1, -2, and -3 and the non-enzymatic small MBL associated protein or sMAP. Recently, a novel plasma protein named MBL/ficolin-associated protein-1 (MAP-1) was identified in humans. This protein is the result of a differential splicing of the MASP1 gene and includes the major part of the heavy chain but lacks the serine protease domain. We investigated the direct interactions of MAP-1 and MASP-3 with ficolin-3 and MBL using surface plasmon resonance and found affinities around 5 nm and 2.5 nm, respectively. We studied structural aspects of MAP-1 and could show by multi-angle laser light scattering that MAP-1 forms a calcium-dependent homodimer in solution. We were able to determine the crystal structure of MAP-1, which also contains a head-to-tail dimer approximately 146 A long. This structure of MAP-1 also enables modeling and assembly of the MASP-1 molecule in its entirety. Finally we found that MAP-1 competes with all three MASPs for ligand binding and is able to mediate a strong dose-dependent inhibitory effect on the lectin pathway activation, as measured by levels of C3 and C9.

-	~~==Disease==~~	+	Crystal Structure and Functional Characterization of the Complement Regulator Mannose-binding Lectin (MBL)/Ficolin-associated Protein-1 (MAP-1).,Skjoedt MO, Roversi P, Hummelshoj T, Palarasah Y, Rosbjerg A, Johnson S, Lea SM, Garred P J Biol Chem. 2012 Sep 21;287(39):32913-21. Epub 2012 Aug 1. PMID:22854970<ref>PMID:22854970</ref>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/MASP1_HUMAN MASP1_HUMAN]] Defects in MASP1 are the cause of 3MC syndrome type~~ 1 (~~3MC1~~) ~~[MIM:[http://omim~~.~~org/entry/257920 257920]]. 3MC1 is a disorder characterized by facial dysmorphism that includes hypertelorism~~, ~~blepharophimosis~~, ~~blepharoptosis and highly arched eyebrows~~, ~~cleft lip and/or palate~~, ~~craniosynostosis~~, ~~learning disability and genital~~, ~~limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale~~, ~~Mingarelli~~, ~~Malpuech, and Michels syndromes~~.<ref>PMID:~~21258343~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/MASP1_HUMAN MASP1_HUMAN]] Functions in the lectin pathway of complement~~, ~~which performs~~ a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the ~~associated proteases MASP1 and MASP2~~. ~~Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction~~. ~~Isoform 2 may have an inhibitory effect on the activation of the lectin pathway~~ of ~~complement or may cleave IGFBP5~~.<~~ref~~>~~PMID:11485744~~</~~ref~~>~~<ref>PMID:17182967</ref>~~	+	</div>
-		+	== References ==
-	==~~About this Structure==~~	+	<references/>
-	[[4aqb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQB OCA].	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Garred, P.]]	+	[[Category: Garred, P]]
-	[[Category: Hummelshoj, T.]]	+	[[Category: Hummelshoj, T]]
-	[[Category: Johnson, S.]]	+	[[Category: Johnson, S]]
-	[[Category: Lea, S M.]]	+	[[Category: Lea, S M]]
-	[[Category: Palarasah, Y.]]	+	[[Category: Palarasah, Y]]
-	[[Category: Roversi, P.]]	+	[[Category: Roversi, P]]
-	[[Category: Skjoedt, M O.]]	+	[[Category: Skjoedt, M O]]
	[[Category: Blood clotting]]		[[Category: Blood clotting]]
	[[Category: Complement]]		[[Category: Complement]]

OCA at 03:31, 25 March 2013

OCA — Mon, 25 Mar 2013 03:31:05 GMT

←Older revision		Revision as of 03:31, 25 March 2013
Line 1:		Line 1:
-	[[Image:4aqb.png\|left\|200px]]
-
	{{STRUCTURE_4aqb\| PDB=4aqb \| SCENE= }}		{{STRUCTURE_4aqb\| PDB=4aqb \| SCENE= }}
-
	===MBL-Ficolin Associated Protein-1, MAP-1 aka MAP44===		===MBL-Ficolin Associated Protein-1, MAP-1 aka MAP44===
-
	{{ABSTRACT_PUBMED_22854970}}		{{ABSTRACT_PUBMED_22854970}}
		+
		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/MASP1_HUMAN MASP1_HUMAN]] Defects in MASP1 are the cause of 3MC syndrome type 1 (3MC1) [MIM:[http://omim.org/entry/257920 257920]]. 3MC1 is a disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly arched eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes.<ref>PMID:21258343</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/MASP1_HUMAN MASP1_HUMAN]] Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.<ref>PMID:11485744</ref><ref>PMID:17182967</ref>

	==About this Structure==		==About this Structure==
	[[4aqb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQB OCA].		[[4aqb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQB OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Garred, P.]]		[[Category: Garred, P.]]

OCA at 06:11, 3 October 2012

OCA — Wed, 03 Oct 2012 06:11:18 GMT

←Older revision		Revision as of 06:11, 3 October 2012
Line 1:		Line 1:
-	[[Image:4aqb.~~jpg~~\|left\|200px]]	+	[[Image:4aqb.png\|left\|200px]]

	{{STRUCTURE_4aqb\| PDB=4aqb \| SCENE= }}		{{STRUCTURE_4aqb\| PDB=4aqb \| SCENE= }}
Line 5:		Line 5:
	===MBL-Ficolin Associated Protein-1, MAP-1 aka MAP44===		===MBL-Ficolin Associated Protein-1, MAP-1 aka MAP44===

		+	{{ABSTRACT_PUBMED_22854970}}

	==About this Structure==		==About this Structure==

OCA at 05:32, 8 August 2012

OCA — Wed, 08 Aug 2012 05:32:11 GMT

←Older revision		Revision as of 05:32, 8 August 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4aqb.jpg\|left\|200px]]

-	~~The entry~~ 4aqb ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4aqb\| PDB=4aqb \| SCENE= }}

-	~~Authors: Skjoedt~~, ~~M.O., Roversi, P., Hummelshoj, T., Palarasah, Y., Johnson, S., Lea, S.M., Garred, P.~~	+	===MBL-Ficolin Associated Protein-1, MAP-1 aka MAP44===

-	~~Description~~: ~~MBL~~-Ficolin ~~Associated Protein~~-~~1, MAP~~-1 ~~aka MAP44~~	+
		+	==About this Structure==
		+	[[4aqb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQB OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Garred, P.]]
		+	[[Category: Hummelshoj, T.]]
		+	[[Category: Johnson, S.]]
		+	[[Category: Lea, S M.]]
		+	[[Category: Palarasah, Y.]]
		+	[[Category: Roversi, P.]]
		+	[[Category: Skjoedt, M O.]]
		+	[[Category: Blood clotting]]
		+	[[Category: Complement]]
		+	[[Category: Ficolin]]
		+	[[Category: Lectin complement pathway]]
		+	[[Category: Mannan-binding protein]]
		+	[[Category: Mannose- binding lectin]]
		+	[[Category: Map1]]
		+	[[Category: Map44]]
		+	[[Category: Mbl/ficolin associated protein-1]]
		+	[[Category: Mbl/ficolin associated serine protease]]

OCA at 05:17, 1 August 2012

OCA — Wed, 01 Aug 2012 05:17:03 GMT

←Older revision		Revision as of 05:17, 1 August 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4aqb is ON HOLD	+	The entry 4aqb is ON HOLD until Paper Publication

	Authors: Skjoedt, M.O., Roversi, P., Hummelshoj, T., Palarasah, Y., Johnson, S., Lea, S.M., Garred, P.		Authors: Skjoedt, M.O., Roversi, P., Hummelshoj, T., Palarasah, Y., Johnson, S., Lea, S.M., Garred, P.

	Description: MBL-Ficolin Associated Protein-1, MAP-1 aka MAP44		Description: MBL-Ficolin Associated Protein-1, MAP-1 aka MAP44

OCA: Protected "4aqb" [edit=sysop:move=sysop]

OCA — Wed, 25 Apr 2012 08:47:22 GMT

Protected "4aqb" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:47, 25 April 2012