4aqk - Revision history

OCA at 11:33, 20 December 2023

OCA — Wed, 20 Dec 2023 11:33:05 GMT

←Older revision		Revision as of 11:33, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4aqk' size='340' side='right'caption='[[4aqk]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4aqk' size='340' side='right'caption='[[4aqk]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4aqk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AQK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4aqk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AQK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xal\|2xal]], [[2xam\|2xam]], [[2xan\|2xan]], [[2xao\|2xao]], [[2xar\|2xar]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Inositol-pentakisphosphate_2-kinase Inositol-pentakisphosphate 2-kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.158 2.7.1.158] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqk OCA], [https://pdbe.org/4aqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aqk RCSB], [https://www.ebi.ac.uk/pdbsum/4aqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqk OCA], [https://pdbe.org/4aqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aqk RCSB], [https://www.ebi.ac.uk/pdbsum/4aqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/IPPK_ARATH IPPK_ARATH]] Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5.<ref>PMID:16107538</ref> <ref>PMID:16223361</ref>	+	[https://www.uniprot.org/uniprot/IPPK_ARATH IPPK_ARATH] Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5.<ref>PMID:16107538</ref> <ref>PMID:16223361</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath]]~~	+	[[Category: Arabidopsis thaliana]]
-	~~[[Category: Inositol-pentakisphosphate 2-kinase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Banos-Sanz, J I]]~~	+	[[Category: Gonzalez B]]
-	[[Category: Gonzalez, B]]	+	[[Category: I Banos-Sanz J]]
-	[[Category: Sanz~~-Aparicio,~~ J]]	+	[[Category: Sanz-Aparicio J]]
-	[[Category: ~~Inositide kinase]]~~	+
-	~~[[Category: Inositide signalling]]~~	+
-	~~[[Category: Insp5 2~~-~~k]]~~	+
-	~~[[Category: Phytic acid]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 05:42, 25 August 2022

OCA — Thu, 25 Aug 2022 05:42:57 GMT

←Older revision		Revision as of 05:42, 25 August 2022
Line 3:		Line 3:
	<StructureSection load='4aqk' size='340' side='right'caption='[[4aqk]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4aqk' size='340' side='right'caption='[[4aqk]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4aqk]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=4AQK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4aqk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AQK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xal\|2xal]], [[2xam\|2xam]], [[2xan\|2xan]], [[2xao\|2xao]], [[2xar\|2xar]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xal\|2xal]], [[2xam\|2xam]], [[2xan\|2xan]], [[2xao\|2xao]], [[2xar\|2xar]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Inositol-pentakisphosphate_2-kinase Inositol-pentakisphosphate 2-kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.158 2.7.1.158] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Inositol-pentakisphosphate_2-kinase Inositol-pentakisphosphate 2-kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.158 2.7.1.158] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=4aqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqk OCA], [~~http~~://pdbe.org/4aqk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4aqk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4aqk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqk OCA], [https://pdbe.org/4aqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aqk RCSB], [https://www.ebi.ac.uk/pdbsum/4aqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/IPPK_ARATH IPPK_ARATH]] Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5.<ref>PMID:16107538</ref> <ref>PMID:16223361</ref>	+	[[https://www.uniprot.org/uniprot/IPPK_ARATH IPPK_ARATH]] Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5.<ref>PMID:16107538</ref> <ref>PMID:16223361</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:24, 7 October 2020

OCA — Wed, 07 Oct 2020 06:24:28 GMT

←Older revision		Revision as of 06:24, 7 October 2020
Line 3:		Line 3:
	<StructureSection load='4aqk' size='340' side='right'caption='[[4aqk]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4aqk' size='340' side='right'caption='[[4aqk]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4aqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQK OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AQK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4aqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4AQK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=~~I6P~~:INOSITOL+~~1,2,3,4,5,6-~~HEXAKISPHOSPHATE'>~~I6P~~</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xal\|2xal]], [[2xam\|2xam]], [[2xan\|2xan]], [[2xao\|2xao]], [[2xar\|2xar]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xal\|2xal]], [[2xam\|2xam]], [[2xan\|2xan]], [[2xao\|2xao]], [[2xar\|2xar]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-pentakisphosphate_2-kinase Inositol-pentakisphosphate 2-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.158 2.7.1.158] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-pentakisphosphate_2-kinase Inositol-pentakisphosphate 2-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.158 2.7.1.158] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4aqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqk OCA], [http://pdbe.org/4aqk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4aqk RCSB], [http://www.ebi.ac.uk/pdbsum/4aqk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4aqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqk OCA], [http://pdbe.org/4aqk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4aqk RCSB], [http://www.ebi.ac.uk/pdbsum/4aqk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	[[Category: Arath]]		[[Category: Arath]]
	[[Category: Inositol-pentakisphosphate 2-kinase]]		[[Category: Inositol-pentakisphosphate 2-kinase]]
		+	[[Category: Large Structures]]
	[[Category: Banos-Sanz, J I]]		[[Category: Banos-Sanz, J I]]
	[[Category: Gonzalez, B]]		[[Category: Gonzalez, B]]

OCA at 09:02, 6 March 2019

OCA — Wed, 06 Mar 2019 09:02:41 GMT

←Older revision		Revision as of 09:02, 6 March 2019
Line 1:		Line 1:

	==Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP and IP6==		==Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP and IP6==
-	<StructureSection load='4aqk' size='340' side='right' caption='[[4aqk]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='4aqk' size='340' side='right'caption='[[4aqk]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4aqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4aqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQK FirstGlance]. <br>

OCA at 09:37, 5 August 2016

OCA — Fri, 05 Aug 2016 09:37:58 GMT

←Older revision		Revision as of 09:37, 5 August 2016
Line 1:		Line 1:
		+
	==Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP and IP6==		==Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP and IP6==
	<StructureSection load='4aqk' size='340' side='right' caption='[[4aqk]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4aqk' size='340' side='right' caption='[[4aqk]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xal\|2xal]], [[2xam\|2xam]], [[2xan\|2xan]], [[2xao\|2xao]], [[2xar\|2xar]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xal\|2xal]], [[2xam\|2xam]], [[2xan\|2xan]], [[2xao\|2xao]], [[2xar\|2xar]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-pentakisphosphate_2-kinase Inositol-pentakisphosphate 2-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.158 2.7.1.158] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-pentakisphosphate_2-kinase Inositol-pentakisphosphate 2-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.158 2.7.1.158] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aqk RCSB], [http://www.ebi.ac.uk/pdbsum/4aqk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqk OCA], [http://pdbe.org/4aqk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4aqk RCSB], [http://www.ebi.ac.uk/pdbsum/4aqk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4aqk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:43, 25 December 2014

OCA — Thu, 25 Dec 2014 17:43:44 GMT

←Older revision		Revision as of 17:43, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4aqk\| PDB=4aqk \| SCENE= }}~~	+	==Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP and IP6==
-	===Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP and IP6===	+	<StructureSection load='4aqk' size='340' side='right' caption='[[4aqk]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22684075}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4aqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQK FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=I6P:INOSITOL+1,2,3,4,5,6-HEXAKISPHOSPHATE'>I6P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xal\|2xal]], [[2xam\|2xam]], [[2xan\|2xan]], [[2xao\|2xao]], [[2xar\|2xar]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-pentakisphosphate_2-kinase Inositol-pentakisphosphate 2-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.158 2.7.1.158] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aqk RCSB], [http://www.ebi.ac.uk/pdbsum/4aqk PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/IPPK_ARATH IPPK_ARATH]] Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5.<ref>PMID:16107538</ref> <ref>PMID:16223361</ref>		[[http://www.uniprot.org/uniprot/IPPK_ARATH IPPK_ARATH]] Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5.<ref>PMID:16107538</ref> <ref>PMID:16223361</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IP(5) 2-K) is a key enzyme that catalyzes the synthesis of phytic acid (IP(6)) from inositol 1,3,4,5,6-pentakisphosphate (IP(5)) and ATP. The first structure of IP(5) 2-K, that from Arabidopsis thaliana, has been solved previously; it only crystallized in the presence of inositol, either the substrate IP(5) or the product IP(6), and failed to crystallize in its free state (without inositol). Based on structural analysis, a point mutation of IP(5) 2-K (W129A) has been produced in order to overcome this limitation and obtain information about protein conformational changes upon substrate binding. Here, the production and crystallization of W129A IP(5) 2-K in its free state and with bound nucleotide is described. These crystals differed from the native crystals and belonged to the orthorhombic space group P2(1)2(1)2, with unit-cell parameters a = 66.00, b = 68.23, c = 105.80 A and a = 63.06, b = 71.80, c = 100.23 A, respectively. The crystals diffracted to resolutions of 2.22 A (apo) and 2.05 A (nucleotide bound) using synchrotron radiation and contained one molecule per asymmetric unit. The structures have been determined using the molecular-replacement method and refinement is being undertaken.

-	~~==About this Structure==~~	+	Expression, purification, crystallization and preliminary X-ray diffraction analysis of the apo form of InsP5 2-K from Arabidopsis thaliana.,Banos-Sanz JI, Sanz-Aparicio J, Brearley CA, Gonzalez B Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jun 1;68(Pt 6):701-4. doi:, 10.1107/S1744309112017307. Epub 2012 May 23. PMID:22684075<ref>PMID:22684075</ref>
-	~~[[4aqk]] is a 1 chain structure with sequence~~ from ~~[http://en~~.~~wikipedia~~.~~org/wiki/Arath Arath]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4AQK OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:022684075</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Arath]]		[[Category: Arath]]
	[[Category: Inositol-pentakisphosphate 2-kinase]]		[[Category: Inositol-pentakisphosphate 2-kinase]]
-	[[Category: Banos-Sanz, J I.]]	+	[[Category: Banos-Sanz, J I]]
-	[[Category: Gonzalez, B.]]	+	[[Category: Gonzalez, B]]
-	[[Category: Sanz-Aparicio, J.]]	+	[[Category: Sanz-Aparicio, J]]
	[[Category: Inositide kinase]]		[[Category: Inositide kinase]]
	[[Category: Inositide signalling]]		[[Category: Inositide signalling]]

OCA at 09:02, 5 February 2014

OCA — Wed, 05 Feb 2014 09:02:03 GMT

←Older revision		Revision as of 09:02, 5 February 2014
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-	[[Image:4aqk.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_4aqk", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_4aqk\| PDB=4aqk \| SCENE= }}		{{STRUCTURE_4aqk\| PDB=4aqk \| SCENE= }}
-
	===Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP and IP6===		===Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP and IP6===
		+	{{ABSTRACT_PUBMED_22684075}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/IPPK_ARATH IPPK_ARATH]] Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5.<ref>PMID:16107538</ref> <ref>PMID:16223361</ref>

	==About this Structure==		==About this Structure==
-	[[4aqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Arabidopsis_thaliana Arabidopsis thaliana~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQK OCA].	+	[[4aqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQK OCA].
-	[[Category: ~~Arabidopsis thaliana~~]]	+
		+	==Reference==
		+	<ref group="xtra">PMID:022684075</ref><references group="xtra"/><references/>
		+	[[Category: Arath]]
	[[Category: Inositol-pentakisphosphate 2-kinase]]		[[Category: Inositol-pentakisphosphate 2-kinase]]
	[[Category: Banos-Sanz, J I.]]		[[Category: Banos-Sanz, J I.]]

OCA at 19:28, 2 May 2012

OCA — Wed, 02 May 2012 19:28:27 GMT

←Older revision		Revision as of 19:28, 2 May 2012
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-	~~'''Unreleased structure'''~~	+	[[Image:4aqk.jpg\|left\|200px]]

-	The ~~entry 4aqk~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4aqk", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4aqk\| PDB=4aqk \| SCENE= }}

-	~~Authors: I Banos-Sanz~~, J., ~~Sanz-Aparicio~~, J., ~~Gonzalez, B.~~	+	===Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP and IP6===

-	~~Description~~: Inositol ~~1,3,4,5,6~~-pentakisphosphate 2-kinase ~~in complex with ADP and IP6~~	+
		+	==About this Structure==
		+	[[4aqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQK OCA].
		+	[[Category: Arabidopsis thaliana]]
		+	[[Category: Inositol-pentakisphosphate 2-kinase]]
		+	[[Category: Banos-Sanz, J I.]]
		+	[[Category: Gonzalez, B.]]
		+	[[Category: Sanz-Aparicio, J.]]
		+	[[Category: Inositide kinase]]
		+	[[Category: Inositide signalling]]
		+	[[Category: Insp5 2-k]]
		+	[[Category: Phytic acid]]
		+	[[Category: Transferase]]

OCA: Protected "4aqk" [edit=sysop:move=sysop]

OCA — Wed, 25 Apr 2012 08:47:43 GMT

Protected "4aqk" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:47, 25 April 2012

OCA: New page: '''Unreleased structure''' The entry 4aqk is ON HOLD Authors: I Banos-Sanz, J., Sanz-Aparicio, J., Gonzalez, B. Description: Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex wi...

OCA — Wed, 25 Apr 2012 08:47:42 GMT

New page: '''Unreleased structure''' The entry 4aqk is ON HOLD Authors: I Banos-Sanz, J., Sanz-Aparicio, J., Gonzalez, B. Description: Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex wi...

New page

'''Unreleased structure'''

The entry 4aqk is ON HOLD

Authors: I Banos-Sanz, J., Sanz-Aparicio, J., Gonzalez, B.

Description: Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP and IP6