4aqt - Revision history

OCA at 11:33, 20 December 2023

OCA — Wed, 20 Dec 2023 11:33:19 GMT

←Older revision		Revision as of 11:33, 20 December 2023
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	<StructureSection load='4aqt' size='340' side='right'caption='[[4aqt]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='4aqt' size='340' side='right'caption='[[4aqt]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4aqt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AQT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4aqt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AQT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1klo\|1klo]], [[1npe\|1npe]], [[1tle\|1tle]], [[4aqs\|4aqs]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqt OCA], [https://pdbe.org/4aqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aqt RCSB], [https://www.ebi.ac.uk/pdbsum/4aqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqt OCA], [https://pdbe.org/4aqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aqt RCSB], [https://www.ebi.ac.uk/pdbsum/4aqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LAMC1_MOUSE LAMC1_MOUSE]] Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.	+	[https://www.uniprot.org/uniprot/LAMC1_MOUSE LAMC1_MOUSE] Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Carafoli, F~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Hohenester, E~~]]	+	[[Category: Carafoli F]]
-	[[Category: ~~Hussain, S~~]]	+	[[Category: Hohenester E]]
-	[[Category: ~~Cell adhesion~~]]	+	[[Category: Hussain S]]

OCA at 05:43, 25 August 2022

OCA — Thu, 25 Aug 2022 05:43:11 GMT

←Older revision		Revision as of 05:43, 25 August 2022
Line 3:		Line 3:
	<StructureSection load='4aqt' size='340' side='right'caption='[[4aqt]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='4aqt' size='340' side='right'caption='[[4aqt]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4aqt]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AQT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4aqt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AQT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1klo\|1klo]], [[1npe\|1npe]], [[1tle\|1tle]], [[4aqs\|4aqs]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1klo\|1klo]], [[1npe\|1npe]], [[1tle\|1tle]], [[4aqs\|4aqs]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4aqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqt OCA], [~~http~~://pdbe.org/4aqt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4aqt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4aqt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqt OCA], [https://pdbe.org/4aqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aqt RCSB], [https://www.ebi.ac.uk/pdbsum/4aqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LAMC1_MOUSE LAMC1_MOUSE]] Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.	+	[[https://www.uniprot.org/uniprot/LAMC1_MOUSE LAMC1_MOUSE]] Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4aqt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4aqt" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Laminin\|Laminin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Large Structures]]
	[[Category: Carafoli, F]]		[[Category: Carafoli, F]]
	[[Category: Hohenester, E]]		[[Category: Hohenester, E]]
	[[Category: Hussain, S]]		[[Category: Hussain, S]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]

OCA at 08:46, 6 March 2019

OCA — Wed, 06 Mar 2019 08:46:08 GMT

←Older revision		Revision as of 08:46, 6 March 2019
Line 1:		Line 1:

	==Laminin gamma1 LN-LE1-2 structure==		==Laminin gamma1 LN-LE1-2 structure==
-	<StructureSection load='4aqt' size='340' side='right' caption='[[4aqt]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='4aqt' size='340' side='right'caption='[[4aqt]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4aqt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4aqt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQT FirstGlance]. <br>

OCA at 08:34, 4 August 2016

OCA — Thu, 04 Aug 2016 08:34:02 GMT

←Older revision		Revision as of 08:34, 4 August 2016
Line 1:		Line 1:
		+
	==Laminin gamma1 LN-LE1-2 structure==		==Laminin gamma1 LN-LE1-2 structure==
	<StructureSection load='4aqt' size='340' side='right' caption='[[4aqt]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='4aqt' size='340' side='right' caption='[[4aqt]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4aqt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4aqt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1klo\|1klo]], [[1npe\|1npe]], [[1tle\|1tle]], [[4aqs\|4aqs]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1klo\|1klo]], [[1npe\|1npe]], [[1tle\|1tle]], [[4aqs\|4aqs]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aqt RCSB], [http://www.ebi.ac.uk/pdbsum/4aqt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqt OCA], [http://pdbe.org/4aqt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4aqt RCSB], [http://www.ebi.ac.uk/pdbsum/4aqt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4aqt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Carafoli, F]]		[[Category: Carafoli, F]]
	[[Category: Hohenester, E]]		[[Category: Hohenester, E]]
	[[Category: Hussain, S]]		[[Category: Hussain, S]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]

OCA at 07:22, 25 December 2014

OCA — Thu, 25 Dec 2014 07:22:33 GMT

←Older revision		Revision as of 07:22, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4aqt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4aqt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1klo\|1klo]], [[1npe\|1npe]], [[1tle\|1tle]], [[4aqs\|4aqs]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1klo\|1klo]], [[1npe\|1npe]], [[1tle\|1tle]], [[4aqs\|4aqs]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aqt RCSB], [http://www.ebi.ac.uk/pdbsum/4aqt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aqt RCSB], [http://www.ebi.ac.uk/pdbsum/4aqt PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LAMC1_MOUSE LAMC1_MOUSE]] Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Carafoli, F.]]	+	[[Category: Carafoli, F]]
-	[[Category: Hohenester, E.]]	+	[[Category: Hohenester, E]]
-	[[Category: Hussain, S.]]	+	[[Category: Hussain, S]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]

OCA at 09:11, 11 June 2014

OCA — Wed, 11 Jun 2014 09:11:36 GMT

←Older revision		Revision as of 09:11, 11 June 2014
Line 1:		Line 1:
-	[[~~Image:~~4aqt.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Laminin gamma1 LN-LE1-2 structure==
		+	<StructureSection load='4aqt' size='340' side='right' caption='[[4aqt]], [[Resolution\|resolution]] 3.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4aqt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1klo\|1klo]], [[1npe\|1npe]], [[1tle\|1tle]], [[4aqs\|4aqs]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aqt RCSB], [http://www.ebi.ac.uk/pdbsum/4aqt PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The heterotrimeric laminins are a defining component of basement membranes and essential for tissue formation and function in all animals. The three short arms of the cross-shaped laminin molecule are composed of one chain each and their tips mediate the formation of a polymeric network. The structural basis for laminin polymerisation is unknown. We have determined crystal structures of the short-arm tips of the mouse laminin beta1 and gamma1 chains, which are grossly similar to the previously determined structure of the corresponding alpha5 chain region. The short-arm tips consist of a laminin N-terminal (LN) domain that is attached like the head of a flower to a rod-like stem formed by tandem laminin-type epidermal growth factor-like (LE) domains. The LN domain is a beta-sandwich with elaborate loop regions that differ between chains. The gamma1 LN domain uniquely contains a calcium binding site. The LE domains have little regular structure and are stabilised by cysteines that are disulphide-linked 1-3, 2-4, 5-6 and 7-8 in all chains. The LN surface is not conserved across the alpha, beta and gamma chains, but within each chain subfamily there is a striking concentration of conserved residues on one face of the beta-sandwich, while the opposite face invariably is shielded by glycans. We propose that the extensive conserved patches on the beta and gamma LN domains mediate the binding of these two chains to each other, and that the alpha chain LN domain subsequently binds to the composite beta-gamma surface. Mutations in the laminin beta2 LN domain causing Pierson syndrome are likely to impair the folding of the beta2 chain or its ability to form network interactions.

-	~~{{STRUCTURE_4aqt\| PDB=4aqt \| SCENE= }}~~	+	Crystal Structures of the Network-Forming Short-Arm Tips of the Laminin beta1 and gamma1 Chains.,Carafoli F, Hussain SA, Hohenester E PLoS One. 2012;7(7):e42473. Epub 2012 Jul 31. PMID:22860131<ref>PMID:22860131</ref>

-	~~===Laminin gamma1 LN-LE1-2 structure===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22860131}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[4aqt]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4AQT OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022860131<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Carafoli, F.]]		[[Category: Carafoli, F.]]

OCA at 05:43, 15 August 2012

OCA — Wed, 15 Aug 2012 05:43:26 GMT

←Older revision		Revision as of 05:43, 15 August 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4aqt.jpg\|left\|200px]]

-	~~The entry~~ 4aqt ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4aqt\| PDB=4aqt \| SCENE= }}

-	~~Authors: Carafoli, F., Hussain, S., Hohenester, E.~~	+	===Laminin gamma1 LN-LE1-2 structure===

-	~~Description~~: ~~Laminin gamma1 LN~~-~~LE1-2 structure~~	+	{{ABSTRACT_PUBMED_22860131}}
		+
		+	==About this Structure==
		+	[[4aqt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQT OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022860131</ref><references group="xtra"/>
		+	[[Category: Mus musculus]]
		+	[[Category: Carafoli, F.]]
		+	[[Category: Hohenester, E.]]
		+	[[Category: Hussain, S.]]
		+	[[Category: Cell adhesion]]

OCA at 18:49, 2 May 2012

OCA — Wed, 02 May 2012 18:49:46 GMT

←Older revision		Revision as of 18:49, 2 May 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4aqt is ON HOLD until ~~sometime in the future~~	+	The entry 4aqt is ON HOLD until Paper Publication

	Authors: Carafoli, F., Hussain, S., Hohenester, E.		Authors: Carafoli, F., Hussain, S., Hohenester, E.

	Description: Laminin gamma1 LN-LE1-2 structure		Description: Laminin gamma1 LN-LE1-2 structure

OCA: Protected "4aqt" [edit=sysop:move=sysop]

OCA — Wed, 25 Apr 2012 08:48:03 GMT

Protected "4aqt" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:48, 25 April 2012

OCA: New page: '''Unreleased structure''' The entry 4aqt is ON HOLD until sometime in the future Authors: Carafoli, F., Hussain, S., Hohenester, E. Description: Laminin gamma1 LN-LE1-2 structure

OCA — Wed, 25 Apr 2012 08:48:02 GMT

New page: '''Unreleased structure''' The entry 4aqt is ON HOLD until sometime in the future Authors: Carafoli, F., Hussain, S., Hohenester, E. Description: Laminin gamma1 LN-LE1-2 structure

New page

'''Unreleased structure'''

The entry 4aqt is ON HOLD until sometime in the future

Authors: Carafoli, F., Hussain, S., Hohenester, E.

Description: Laminin gamma1 LN-LE1-2 structure