4ari - Revision history

OCA at 11:33, 20 December 2023

OCA — Wed, 20 Dec 2023 11:33:52 GMT

←Older revision		Revision as of 11:33, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4ari' size='340' side='right'caption='[[4ari]], [[Resolution\|resolution]] 2.08Å' scene=''>		<StructureSection load='4ari' size='340' side='right'caption='[[4ari]], [[Resolution\|resolution]] 2.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ari]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ARI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ARI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ari]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ARI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ARI FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.08Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=N79:[(1S,5R,6R,8R)-6-(6-AMINOPURIN-9-YL)SPIRO[2,4,7-TRIOXA-3-BORANUIDABICYCLO[3.3.0]OCTANE-3,9-8-OXA-9-BORANUIDABICYCLO[4.3.0]NONA-1(6),2,4-TRIENE]-8-YL]METHYL+DIHYDROGEN+PHOSPHATE'>N79</scene~~></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=N79:[(1S,5R,6R,8R)-6-(6-AMINOPURIN-9-YL)SPIRO[2,4,7-TRIOXA-3-BORANUIDABICYCLO[3.3.0]OCTANE-3,9-8-OXA-9-BORANUIDABICYCLO[4.3.0]NONA-1(6),2,4-TRIENE]-8-YL]METHYL+DIHYDROGEN+PHOSPHATE'>N79</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ajg\|2ajg]], [[2ajh\|2ajh]], [[2aji\|2aji]], [[4aq7\|4aq7]], [[4arc\|4arc]], [[4as1\|4as1]]</div></td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Leucine--tRNA_ligase Leucine--tRNA ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.4 6.1.1.4] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ari FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ari OCA], [https://pdbe.org/4ari PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ari RCSB], [https://www.ebi.ac.uk/pdbsum/4ari PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ari ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ari FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ari OCA], [https://pdbe.org/4ari PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ari RCSB], [https://www.ebi.ac.uk/pdbsum/4ari PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ari ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SYL_ECOLI SYL_ECOLI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Leucine--tRNA ligase]]~~	+	[[Category: Crepin T]]
-	[[Category: Crepin, T]]	+	[[Category: Cusack S]]
-	[[Category: Cusack, S]]	+	[[Category: Lincecum Jr TL]]
-	[[Category: Jr~~, T L.Lincecum~~]]	+	[[Category: Martinis SA]]
-	[[Category: Martinis~~, S A~~]]	+	[[Category: Palencia A]]
-	[[Category: Palencia, A]]	+	[[Category: Vu MT]]
-	[[Category: Vu~~, M T]]~~	+
-	~~[[Category: Class i aminoacyl-trna synthetase]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Ligase-rna complex]]~~	+
-	~~[[Category: Protein biosynthesis~~]]	+

OCA at 05:43, 25 August 2022

OCA — Thu, 25 Aug 2022 05:43:52 GMT

←Older revision		Revision as of 05:43, 25 August 2022
Line 3:		Line 3:
	<StructureSection load='4ari' size='340' side='right'caption='[[4ari]], [[Resolution\|resolution]] 2.08Å' scene=''>		<StructureSection load='4ari' size='340' side='right'caption='[[4ari]], [[Resolution\|resolution]] 2.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ari]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ARI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ARI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ari]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ARI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ARI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=N79:[(1S,5R,6R,8R)-6-(6-AMINOPURIN-9-YL)SPIRO[2,4,7-TRIOXA-3-BORANUIDABICYCLO[3.3.0]OCTANE-3,9-8-OXA-9-BORANUIDABICYCLO[4.3.0]NONA-1(6),2,4-TRIENE]-8-YL]METHYL+DIHYDROGEN+PHOSPHATE'>N79</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=N79:[(1S,5R,6R,8R)-6-(6-AMINOPURIN-9-YL)SPIRO[2,4,7-TRIOXA-3-BORANUIDABICYCLO[3.3.0]OCTANE-3,9-8-OXA-9-BORANUIDABICYCLO[4.3.0]NONA-1(6),2,4-TRIENE]-8-YL]METHYL+DIHYDROGEN+PHOSPHATE'>N79</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ajg\|2ajg]], [[2ajh\|2ajh]], [[2aji\|2aji]], [[4aq7\|4aq7]], [[4arc\|4arc]], [[4as1\|4as1]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ajg\|2ajg]], [[2ajh\|2ajh]], [[2aji\|2aji]], [[4aq7\|4aq7]], [[4arc\|4arc]], [[4as1\|4as1]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Leucine--tRNA_ligase Leucine--tRNA ligase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.4 6.1.1.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Leucine--tRNA_ligase Leucine--tRNA ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.4 6.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ari FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ari OCA], [~~http~~://pdbe.org/4ari PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ari RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ari PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ari ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ari FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ari OCA], [https://pdbe.org/4ari PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ari RCSB], [https://www.ebi.ac.uk/pdbsum/4ari PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ari ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:56, 21 May 2019

OCA — Tue, 21 May 2019 07:56:00 GMT

←Older revision		Revision as of 07:56, 21 May 2019
Line 21:		Line 21:

	==See Also==		==See Also==
		+	*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]
	*[[Transfer RNA (tRNA)\|Transfer RNA (tRNA)]]		*[[Transfer RNA (tRNA)\|Transfer RNA (tRNA)]]
	== References ==		== References ==
Line 27:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Ecoli]]		[[Category: Ecoli]]
		+	[[Category: Large Structures]]
	[[Category: Leucine--tRNA ligase]]		[[Category: Leucine--tRNA ligase]]
	[[Category: Crepin, T]]		[[Category: Crepin, T]]

OCA at 09:19, 6 March 2019

OCA — Wed, 06 Mar 2019 09:19:08 GMT

←Older revision		Revision as of 09:19, 6 March 2019
Line 1:		Line 1:

	==Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and the benzoxaborole AN2679 in the editing conformation==		==Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and the benzoxaborole AN2679 in the editing conformation==
-	<StructureSection load='4ari' size='340' side='right' caption='[[4ari]], [[Resolution\|resolution]] 2.08Å' scene=''>	+	<StructureSection load='4ari' size='340' side='right'caption='[[4ari]], [[Resolution\|resolution]] 2.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ari]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ARI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ARI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ari]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ARI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ARI FirstGlance]. <br>
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[~~TRNA~~\|~~TRNA~~]]	+	*[[Transfer RNA (tRNA)\|Transfer RNA (tRNA)]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:21, 11 August 2016

OCA — Thu, 11 Aug 2016 10:21:07 GMT

←Older revision		Revision as of 10:21, 11 August 2016
Line 1:		Line 1:
		+
	==Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and the benzoxaborole AN2679 in the editing conformation==		==Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and the benzoxaborole AN2679 in the editing conformation==
	<StructureSection load='4ari' size='340' side='right' caption='[[4ari]], [[Resolution\|resolution]] 2.08Å' scene=''>		<StructureSection load='4ari' size='340' side='right' caption='[[4ari]], [[Resolution\|resolution]] 2.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ari]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia coli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ARI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ARI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ari]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ARI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ARI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=N79:[(1S,5R,6R,8R)-6-(6-AMINOPURIN-9-YL)SPIRO[2,4,7-TRIOXA-3-BORANUIDABICYCLO[3.3.0]OCTANE-3,9-8-OXA-9-BORANUIDABICYCLO[4.3.0]NONA-1(6),2,4-TRIENE]-8-YL]METHYL+DIHYDROGEN+PHOSPHATE'>N79</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=N79:[(1S,5R,6R,8R)-6-(6-AMINOPURIN-9-YL)SPIRO[2,4,7-TRIOXA-3-BORANUIDABICYCLO[3.3.0]OCTANE-3,9-8-OXA-9-BORANUIDABICYCLO[4.3.0]NONA-1(6),2,4-TRIENE]-8-YL]METHYL+DIHYDROGEN+PHOSPHATE'>N79</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ajg\|2ajg]], [[2ajh\|2ajh]], [[2aji\|2aji]], [[4aq7\|4aq7]], [[4arc\|4arc]], [[4as1\|4as1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ajg\|2ajg]], [[2ajh\|2ajh]], [[2aji\|2aji]], [[4aq7\|4aq7]], [[4arc\|4arc]], [[4as1\|4as1]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leucine--tRNA_ligase Leucine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.4 6.1.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leucine--tRNA_ligase Leucine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.4 6.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ari FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ari OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ari RCSB], [http://www.ebi.ac.uk/pdbsum/4ari PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ari FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ari OCA], [http://pdbe.org/4ari PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ari RCSB], [http://www.ebi.ac.uk/pdbsum/4ari PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ari ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ari" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[TRNA\|TRNA]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia coli~~]]	+	[[Category: Ecoli]]
	[[Category: Leucine--tRNA ligase]]		[[Category: Leucine--tRNA ligase]]
	[[Category: Crepin, T]]		[[Category: Crepin, T]]

OCA at 14:08, 4 January 2015

OCA — Sun, 04 Jan 2015 14:08:22 GMT

←Older revision		Revision as of 14:08, 4 January 2015
Line 1:		Line 1:
-	[[~~Image:~~4ari.~~png~~\|~~left~~\|~~200px~~]]	+	==Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and the benzoxaborole AN2679 in the editing conformation==
		+	<StructureSection load='4ari' size='340' side='right' caption='[[4ari]], [[Resolution\|resolution]] 2.08Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ari]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ARI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ARI FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=N79:[(1S,5R,6R,8R)-6-(6-AMINOPURIN-9-YL)SPIRO[2,4,7-TRIOXA-3-BORANUIDABICYCLO[3.3.0]OCTANE-3,9-8-OXA-9-BORANUIDABICYCLO[4.3.0]NONA-1(6),2,4-TRIENE]-8-YL]METHYL+DIHYDROGEN+PHOSPHATE'>N79</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ajg\|2ajg]], [[2ajh\|2ajh]], [[2aji\|2aji]], [[4aq7\|4aq7]], [[4arc\|4arc]], [[4as1\|4as1]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leucine--tRNA_ligase Leucine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.4 6.1.1.4] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ari FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ari OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ari RCSB], [http://www.ebi.ac.uk/pdbsum/4ari PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Leucyl-tRNA synthetase (LeuRS) produces error-free leucyl-tRNA(Leu) by coordinating translocation of the 3' end of (mis-)charged tRNAs from its synthetic site to a separate proofreading site for editing. Here we report cocrystal structures of the Escherichia coli LeuRS-tRNA(Leu) complex in the aminoacylation or editing conformations, showing that translocation involves correlated rotations of four flexibly linked LeuRS domains. This pivots the tRNA to guide its charged 3' end from the closed aminoacylation state to the editing site. The editing domain unexpectedly stabilizes the tRNA during aminoacylation, and a large rotation of the leucine-specific domain positions the conserved KMSKS loop to bind the 3' end of the tRNA, promoting catalysis. Our results give new insight into the structural dynamics of a molecular machine that is essential for accurate protein synthesis.

-	~~{{STRUCTURE_4ari\| PDB=4ari \| SCENE= }}~~	+	Structural dynamics of the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase.,Palencia A, Crepin T, Vu MT, Lincecum TL Jr, Martinis SA, Cusack S Nat Struct Mol Biol. 2012 Jun 10. doi: 10.1038/nsmb.2317. PMID:22683997<ref>PMID:22683997</ref>

-	~~===Ternary complex~~ of ~~E. coli leucyl-tRNA synthetase, tRNA(leu) and~~ the ~~benzoxaborole AN2679 in the editing conformation===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22683997}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[4ari]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4ARI OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022683997<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Leucine--tRNA ligase]]		[[Category: Leucine--tRNA ligase]]
-	[[Category: Crepin, T.]]	+	[[Category: Crepin, T]]
-	[[Category: Cusack, S.]]	+	[[Category: Cusack, S]]
-	[[Category: Jr, T L.Lincecum.]]	+	[[Category: Jr, T L.Lincecum]]
-	[[Category: Martinis, S A.]]	+	[[Category: Martinis, S A]]
-	[[Category: Palencia, A.]]	+	[[Category: Palencia, A]]
-	[[Category: Vu, M T.]]	+	[[Category: Vu, M T]]
	[[Category: Class i aminoacyl-trna synthetase]]		[[Category: Class i aminoacyl-trna synthetase]]
	[[Category: Ligase]]		[[Category: Ligase]]
	[[Category: Ligase-rna complex]]		[[Category: Ligase-rna complex]]
	[[Category: Protein biosynthesis]]		[[Category: Protein biosynthesis]]

OCA at 07:45, 20 June 2012

OCA — Wed, 20 Jun 2012 07:45:10 GMT

←Older revision		Revision as of 07:45, 20 June 2012
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	[[Image:4ari.png\|left\|200px]]		[[Image:4ari.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_4ari", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_4ari\| PDB=4ari \| SCENE= }}		{{STRUCTURE_4ari\| PDB=4ari \| SCENE= }}

	===Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and the benzoxaborole AN2679 in the editing conformation===		===Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and the benzoxaborole AN2679 in the editing conformation===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22683997}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22683997 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22683997}}		{{ABSTRACT_PUBMED_22683997}}

OCA at 06:49, 20 June 2012

OCA — Wed, 20 Jun 2012 06:49:39 GMT

←Older revision		Revision as of 06:49, 20 June 2012
Line 1:		Line 1:
-	[[Image:4ari.~~jpg~~\|left\|200px]]	+	[[Image:4ari.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and the benzoxaborole AN2679 in the editing conformation===		===Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and the benzoxaborole AN2679 in the editing conformation===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22683997}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22683997 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22683997}}

	==About this Structure==		==About this Structure==
	[[4ari]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ARI OCA].		[[4ari]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ARI OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022683997</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Leucine--tRNA ligase]]		[[Category: Leucine--tRNA ligase]]

OCA at 06:21, 13 June 2012

OCA — Wed, 13 Jun 2012 06:21:20 GMT

←Older revision		Revision as of 06:21, 13 June 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4ari.jpg\|left\|200px]]

-	The ~~entry 4ari~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4ari", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4ari\| PDB=4ari \| SCENE= }}

-	~~Authors: Palencia, A~~., ~~Crepin, T., Vu, M.T., Lincecum Jr, T.L., Martinis, S.A., Cusack, S.~~	+	===Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and the benzoxaborole AN2679 in the editing conformation===

-	~~Description~~: ~~Ternary complex of E~~. coli ~~leucyl~~-tRNA ~~synthetase~~, ~~tRNA(leu) and the benzoxaborole AN2679 in the editing conformation~~	+
		+	==About this Structure==
		+	[[4ari]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ARI OCA].
		+	[[Category: Escherichia coli]]
		+	[[Category: Leucine--tRNA ligase]]
		+	[[Category: Crepin, T.]]
		+	[[Category: Cusack, S.]]
		+	[[Category: Jr, T L.Lincecum.]]
		+	[[Category: Martinis, S A.]]
		+	[[Category: Palencia, A.]]
		+	[[Category: Vu, M T.]]
		+	[[Category: Class i aminoacyl-trna synthetase]]
		+	[[Category: Ligase]]
		+	[[Category: Ligase-rna complex]]
		+	[[Category: Protein biosynthesis]]

OCA at 08:41, 9 May 2012

OCA — Wed, 09 May 2012 08:41:24 GMT

←Older revision		Revision as of 08:41, 9 May 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ari is ON HOLD	+	The entry 4ari is ON HOLD until Paper Publication

	Authors: Palencia, A., Crepin, T., Vu, M.T., Lincecum Jr, T.L., Martinis, S.A., Cusack, S.		Authors: Palencia, A., Crepin, T., Vu, M.T., Lincecum Jr, T.L., Martinis, S.A., Cusack, S.

	Description: Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and the benzoxaborole AN2679 in the editing conformation		Description: Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and the benzoxaborole AN2679 in the editing conformation