4asj - Revision history

OCA at 11:34, 20 December 2023

OCA — Wed, 20 Dec 2023 11:34:44 GMT

←Older revision		Revision as of 11:34, 20 December 2023
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	<StructureSection load='4asj' size='340' side='right'caption='[[4asj]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='4asj' size='340' side='right'caption='[[4asj]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4asj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ASJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4asj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ASJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=N6A:N-(6-AMINO-1-BENZYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL)-N-METHYLBENZENESULFONAMIDE'>N6A</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.25Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4arw\|4arw]], [[4as6\|4as6]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=N6A:N-(6-AMINO-1-BENZYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL)-N-METHYLBENZENESULFONAMIDE'>N6A</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/1L-myo-inositol_1-phosphate_cytidylyltransferase 1L-myo-inositol 1-phosphate cytidylyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.74 2.7.7.74] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4asj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asj OCA], [https://pdbe.org/4asj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4asj RCSB], [https://www.ebi.ac.uk/pdbsum/4asj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4asj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4asj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asj OCA], [https://pdbe.org/4asj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4asj RCSB], [https://www.ebi.ac.uk/pdbsum/4asj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4asj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~G3XCK4_PSEAI G3XCK4_PSEAI]~~] Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity).[RuleBase:RU003706]	+	[https://www.uniprot.org/uniprot/Q9HU22_PSEAE Q9HU22_PSEAE] Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity).[RuleBase:RU003706]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 1L-myo-inositol 1-phosphate cytidylyltransferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pseae~~]]	+	[[Category: Pseudomonas aeruginosa PAO1]]
-	[[Category: Alphey~~, M S~~]]	+	[[Category: Alphey MS]]
-	[[Category: Gardiner, M]]	+	[[Category: Gardiner M]]
-	[[Category: Gray, D]]	+	[[Category: Gray D]]
-	[[Category: Naismith~~, J H~~]]	+	[[Category: Naismith JH]]
-	[[Category: Pirrie, L]]	+	[[Category: Pirrie L]]
-	[[Category: Torrie~~, L S~~]]	+	[[Category: Torrie LS]]
-	[[Category: Westwood~~, N J]]~~	+	[[Category: Westwood NJ]]
-	~~[[Category: Transferase~~]]	+

OCA at 05:44, 25 August 2022

OCA — Thu, 25 Aug 2022 05:44:52 GMT

←Older revision		Revision as of 05:44, 25 August 2022
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	<StructureSection load='4asj' size='340' side='right'caption='[[4asj]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='4asj' size='340' side='right'caption='[[4asj]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4asj]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ASJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4asj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ASJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=N6A:N-(6-AMINO-1-BENZYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL)-N-METHYLBENZENESULFONAMIDE'>N6A</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=N6A:N-(6-AMINO-1-BENZYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL)-N-METHYLBENZENESULFONAMIDE'>N6A</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4arw\|4arw]], [[4as6\|4as6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4arw\|4arw]], [[4as6\|4as6]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/1L-myo-inositol_1-phosphate_cytidylyltransferase 1L-myo-inositol 1-phosphate cytidylyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.74 2.7.7.74] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/1L-myo-inositol_1-phosphate_cytidylyltransferase 1L-myo-inositol 1-phosphate cytidylyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.74 2.7.7.74] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4asj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asj OCA], [~~http~~://pdbe.org/4asj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4asj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4asj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4asj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4asj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asj OCA], [https://pdbe.org/4asj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4asj RCSB], [https://www.ebi.ac.uk/pdbsum/4asj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4asj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/G3XCK4_PSEAI G3XCK4_PSEAI]] Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity).[RuleBase:RU003706]	+	[[https://www.uniprot.org/uniprot/G3XCK4_PSEAI G3XCK4_PSEAI]] Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity).[RuleBase:RU003706]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 16:52, 29 January 2020

OCA — Wed, 29 Jan 2020 16:52:15 GMT

←Older revision		Revision as of 16:52, 29 January 2020
Line 1:		Line 1:

	==Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor==		==Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor==
-	<StructureSection load='4asj' size='340' side='right' caption='[[4asj]], [[Resolution\|resolution]] 2.25Å' scene=''>	+	<StructureSection load='4asj' size='340' side='right'caption='[[4asj]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4asj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4asj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASJ FirstGlance]. <br>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4asj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4asj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glucose-1-phosphate thymidylyltransferase 3D structures\|Glucose-1-phosphate thymidylyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: 1L-myo-inositol 1-phosphate cytidylyltransferase]]		[[Category: 1L-myo-inositol 1-phosphate cytidylyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Pseae]]		[[Category: Pseae]]
	[[Category: Alphey, M S]]		[[Category: Alphey, M S]]

OCA at 07:42, 16 November 2017

OCA — Thu, 16 Nov 2017 07:42:31 GMT

←Older revision		Revision as of 07:42, 16 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4asj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4asj" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Glucose-1-phosphate thymidylyltransferase\|Glucose-1-phosphate thymidylyltransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:40, 4 August 2016

OCA — Thu, 04 Aug 2016 07:40:34 GMT

←Older revision		Revision as of 07:40, 4 August 2016
Line 1:		Line 1:
		+
	==Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor==		==Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor==
	<StructureSection load='4asj' size='340' side='right' caption='[[4asj]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='4asj' size='340' side='right' caption='[[4asj]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4asj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4asj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=N6A:N-(6-AMINO-1-BENZYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL)-N-METHYLBENZENESULFONAMIDE'>N6A</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=N6A:N-(6-AMINO-1-BENZYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL)-N-METHYLBENZENESULFONAMIDE'>N6A</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4arw\|4arw]], [[4as6\|4as6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4arw\|4arw]], [[4as6\|4as6]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1L-myo-inositol_1-phosphate_cytidylyltransferase 1L-myo-inositol 1-phosphate cytidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.74 2.7.7.74] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1L-myo-inositol_1-phosphate_cytidylyltransferase 1L-myo-inositol 1-phosphate cytidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.74 2.7.7.74] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4asj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4asj RCSB], [http://www.ebi.ac.uk/pdbsum/4asj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4asj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asj OCA], [http://pdbe.org/4asj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4asj RCSB], [http://www.ebi.ac.uk/pdbsum/4asj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4asj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4asj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: 1L-myo-inositol 1-phosphate cytidylyltransferase]]		[[Category: 1L-myo-inositol 1-phosphate cytidylyltransferase]]
-	[[Category: ~~Pseudomonas aeruginosa pao1~~]]	+	[[Category: Pseae]]
	[[Category: Alphey, M S]]		[[Category: Alphey, M S]]
	[[Category: Gardiner, M]]		[[Category: Gardiner, M]]

OCA at 07:05, 24 December 2014

OCA — Wed, 24 Dec 2014 07:05:50 GMT

←Older revision		Revision as of 07:05, 24 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4asj.~~png~~\|~~left~~\|~~200px~~]]	+	==Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor==
		+	<StructureSection load='4asj' size='340' side='right' caption='[[4asj]], [[Resolution\|resolution]] 2.25Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4asj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=N6A:N-(6-AMINO-1-BENZYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL)-N-METHYLBENZENESULFONAMIDE'>N6A</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4arw\|4arw]], [[4as6\|4as6]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1L-myo-inositol_1-phosphate_cytidylyltransferase 1L-myo-inositol 1-phosphate cytidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.74 2.7.7.74] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4asj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4asj RCSB], [http://www.ebi.ac.uk/pdbsum/4asj PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/G3XCK4_PSEAI G3XCK4_PSEAI]] Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity).[RuleBase:RU003706]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glucose-1-phosphate thymidylyltransferase (RmlA) catalyzes the condensation of glucose-1-phosphate (G1P) with deoxy-thymidine tri-phosphate (dTTP) to yield dTDP-L-rhamnose and pyrophosphate. This is the first step in the L-rhamnose biosynthetic pathway. L-rhamnose is an important component of the cell wall of many microorganisms, including Mycobacterium tuberculosis and Pseudomonas aeruginosa. Here we describe the first nanomolar inhibitors of P. aeruginosa RmlA. These thymine analogs were identified by high-throughput screening and subsequently optimized by a combination of protein crystallography, in silico screening and synthetic chemistry. Some of the inhibitors show inhibitory activity against M. tuberculosis. The inhibitors do not bind at the active site of RmlA but bind at a second site remote from the active site. Despite this, the compounds act as competitive inhibitors of G1P but with high cooperativity. This novel behavior was probed by structural analysis which suggests that the inhibitors work by preventing RmlA from undergoing the conformational change key to its ordered bi-bi mechanism.

-	~~{{STRUCTURE_4asj\| PDB=4asj \| SCENE= }}~~	+	Allosteric Competitive Inhibitors of the Glucose-1-Phosphate Thymidylyltransferase (RmlA) from Pseudomonas aeruginosa.,Alphey MS, Pirrie L, Torrie LS, Boulkeroura WA, Gardiner M, Sarkar A, Maringer M, Oehlmann W, Brenk R, Scherman MS, McNeil M, Rejzek M, Field RA, Singh M, Gray D, Westwood NJ, Naismith JH ACS Chem Biol. 2012 Nov 8. PMID:23138692<ref>PMID:23138692</ref>

-	~~===Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_23138692}}~~	+	==See Also==
-		+	*[[Glucose-1-phosphate thymidylyltransferase\|Glucose-1-phosphate thymidylyltransferase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4asj~~]] ~~is a 4 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASJ OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: 1L-myo-inositol 1-phosphate cytidylyltransferase]]		[[Category: 1L-myo-inositol 1-phosphate cytidylyltransferase]]
	[[Category: Pseudomonas aeruginosa pao1]]		[[Category: Pseudomonas aeruginosa pao1]]
-	[[Category: Alphey, M S.]]	+	[[Category: Alphey, M S]]
-	[[Category: Gardiner, M.]]	+	[[Category: Gardiner, M]]
-	[[Category: Gray, D.]]	+	[[Category: Gray, D]]
-	[[Category: Naismith, J H.]]	+	[[Category: Naismith, J H]]
-	[[Category: Pirrie, L.]]	+	[[Category: Pirrie, L]]
-	[[Category: Torrie, L S.]]	+	[[Category: Torrie, L S]]
-	[[Category: Westwood, N J.]]	+	[[Category: Westwood, N J]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 09:31, 21 November 2012

OCA — Wed, 21 Nov 2012 09:31:53 GMT

←Older revision		Revision as of 09:31, 21 November 2012
Line 1:		Line 1:
-	[[Image:4asj.~~jpg~~\|left\|200px]]	+	[[Image:4asj.png\|left\|200px]]

	{{STRUCTURE_4asj\| PDB=4asj \| SCENE= }}		{{STRUCTURE_4asj\| PDB=4asj \| SCENE= }}
Line 5:		Line 5:
	===Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor===		===Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor===

		+	{{ABSTRACT_PUBMED_23138692}}

	==About this Structure==		==About this Structure==
Line 15:		Line 16:
	[[Category: Naismith, J H.]]		[[Category: Naismith, J H.]]
	[[Category: Pirrie, L.]]		[[Category: Pirrie, L.]]
-	[[Category: Torrie, L.]]	+	[[Category: Torrie, L S.]]
	[[Category: Westwood, N J.]]		[[Category: Westwood, N J.]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 09:19, 31 October 2012

OCA — Wed, 31 Oct 2012 09:19:32 GMT

←Older revision		Revision as of 09:19, 31 October 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4asj.jpg\|left\|200px]]

-	~~The entry~~ 4asj ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4asj\| PDB=4asj \| SCENE= }}

-	~~Authors: Alphey, M.S., Pirrie, L., Torrie, L., Gardiner, M., Westwood, N.J., Gray, D., Naismith, J.H.~~	+	===Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor===

-	~~Description~~: Pseudomonas aeruginosa ~~RmlA in complex with allosteric inhibitor~~	+
		+	==About this Structure==
		+	[[4asj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASJ OCA].
		+	[[Category: 1L-myo-inositol 1-phosphate cytidylyltransferase]]
		+	[[Category: Pseudomonas aeruginosa pao1]]
		+	[[Category: Alphey, M S.]]
		+	[[Category: Gardiner, M.]]
		+	[[Category: Gray, D.]]
		+	[[Category: Naismith, J H.]]
		+	[[Category: Pirrie, L.]]
		+	[[Category: Torrie, L.]]
		+	[[Category: Westwood, N J.]]
		+	[[Category: Transferase]]

OCA at 05:20, 30 May 2012

OCA — Wed, 30 May 2012 05:20:48 GMT

←Older revision		Revision as of 05:20, 30 May 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4asj is ON HOLD	+	The entry 4asj is ON HOLD until Paper Publication

	Authors: Alphey, M.S., Pirrie, L., Torrie, L., Gardiner, M., Westwood, N.J., Gray, D., Naismith, J.H.		Authors: Alphey, M.S., Pirrie, L., Torrie, L., Gardiner, M., Westwood, N.J., Gray, D., Naismith, J.H.

	Description: Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor		Description: Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor

OCA: Protected "4asj" [edit=sysop:move=sysop]

OCA — Wed, 09 May 2012 08:42:05 GMT

Protected "4asj" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:42, 9 May 2012