4asw - Revision history

OCA at 07:20, 29 March 2023

OCA — Wed, 29 Mar 2023 07:20:21 GMT

←Older revision		Revision as of 07:20, 29 March 2023
Line 1:		Line 1:

	==Structure of the complex between the N-terminal dimerisation domain of Sgt2 and the UBL domain of Get5==		==Structure of the complex between the N-terminal dimerisation domain of Sgt2 and the UBL domain of Get5==
-	<StructureSection load='4asw' size='340' side='right'caption='[[4asw~~]], [[NMR_Ensembles_of_Models \| 9 NMR models~~]]' scene=''>	+	<StructureSection load='4asw' size='340' side='right'caption='[[4asw]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4asw]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ASW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4asw]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ASW FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4a20\|4a20]], [[4asv\|4asv]]</div></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4asw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asw OCA], [https://pdbe.org/4asw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4asw RCSB], [https://www.ebi.ac.uk/pdbsum/4asw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4asw ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4asw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asw OCA], [https://pdbe.org/4asw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4asw RCSB], [https://www.ebi.ac.uk/pdbsum/4asw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4asw ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SGT2_YEAST SGT2_YEAST]] Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity (By similarity). Required for recovery from heat shock.<ref>PMID:12482202</ref> [[https://www.uniprot.org/uniprot/MDY2_YEAST MDY2_YEAST]] Required for efficient mating. Involved in the production of alpha-factor, the KAR9 and TUB1 location to the shmoo tip and nuclear migration into pheromone-induced shmoos.<ref>PMID:10514570</ref> <ref>PMID:16390866</ref>	+	[https://www.uniprot.org/uniprot/SGT2_YEAST SGT2_YEAST] Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity (By similarity). Required for recovery from heat shock.<ref>PMID:12482202</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Goldstone~~, R M~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: High, S]]	+	[[Category: Goldstone RM]]
-	[[Category: Isaacson~~, R L~~]]	+	[[Category: High S]]
-	[[Category: Krysztofinska~~, E M~~]]	+	[[Category: Isaacson RL]]
-	[[Category: Murray~~, J W~~]]	+	[[Category: Krysztofinska EM]]
-	[[Category: Simon~~, A C~~]]	+	[[Category: Murray JW]]
-	[[Category: Simpson~~, P J]]~~	+	[[Category: Simon AC]]
-	~~[[Category: Chaperone]]~~	+	[[Category: Simpson PJ]]
-	~~[[Category: Post-translational targeting]]~~	+
-	~~[[Category: Tail-anchored~~]]	+

OCA at 07:35, 25 June 2021

OCA — Fri, 25 Jun 2021 07:35:17 GMT

←Older revision		Revision as of 07:35, 25 June 2021
Line 3:		Line 3:
	<StructureSection load='4asw' size='340' side='right'caption='[[4asw]], [[NMR_Ensembles_of_Models \| 9 NMR models]]' scene=''>		<StructureSection load='4asw' size='340' side='right'caption='[[4asw]], [[NMR_Ensembles_of_Models \| 9 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4asw]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ASW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4asw]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ASW FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a20\|4a20]], [[4asv\|4asv]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4a20\|4a20]], [[4asv\|4asv]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4asw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asw OCA], [~~http~~://pdbe.org/4asw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4asw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4asw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4asw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4asw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asw OCA], [https://pdbe.org/4asw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4asw RCSB], [https://www.ebi.ac.uk/pdbsum/4asw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4asw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SGT2_YEAST SGT2_YEAST]] Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity (By similarity). Required for recovery from heat shock.<ref>PMID:12482202</ref> [[~~http~~://www.uniprot.org/uniprot/MDY2_YEAST MDY2_YEAST]] Required for efficient mating. Involved in the production of alpha-factor, the KAR9 and TUB1 location to the shmoo tip and nuclear migration into pheromone-induced shmoos.<ref>PMID:10514570</ref> <ref>PMID:16390866</ref>	+	[[https://www.uniprot.org/uniprot/SGT2_YEAST SGT2_YEAST]] Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity (By similarity). Required for recovery from heat shock.<ref>PMID:12482202</ref> [[https://www.uniprot.org/uniprot/MDY2_YEAST MDY2_YEAST]] Required for efficient mating. Involved in the production of alpha-factor, the KAR9 and TUB1 location to the shmoo tip and nuclear migration into pheromone-induced shmoos.<ref>PMID:10514570</ref> <ref>PMID:16390866</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4asw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4asw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Small glutamine-rich tetratricopeptide repeat containing protein alpha\|Small glutamine-rich tetratricopeptide repeat containing protein alpha]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Goldstone, R M]]		[[Category: Goldstone, R M]]
	[[Category: High, S]]		[[Category: High, S]]

OCA at 09:20, 6 March 2019

OCA — Wed, 06 Mar 2019 09:20:29 GMT

←Older revision		Revision as of 09:20, 6 March 2019
Line 1:		Line 1:

	==Structure of the complex between the N-terminal dimerisation domain of Sgt2 and the UBL domain of Get5==		==Structure of the complex between the N-terminal dimerisation domain of Sgt2 and the UBL domain of Get5==
-	<StructureSection load='4asw' size='340' side='right' caption='[[4asw]], [[NMR_Ensembles_of_Models \| 9 NMR models]]' scene=''>	+	<StructureSection load='4asw' size='340' side='right'caption='[[4asw]], [[NMR_Ensembles_of_Models \| 9 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4asw]] is a 3 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4asw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASW FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a20\|4a20]], [[4asv\|4asv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a20\|4a20]], [[4asv\|4asv]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4asw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asw OCA], [http://pdbe.org/4asw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4asw RCSB], [http://www.ebi.ac.uk/pdbsum/4asw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4asw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4asw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asw OCA], [http://pdbe.org/4asw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4asw RCSB], [http://www.ebi.ac.uk/pdbsum/4asw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4asw ProSAT]</span></td></tr>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 18824]]
	[[Category: Goldstone, R M]]		[[Category: Goldstone, R M]]
	[[Category: High, S]]		[[Category: High, S]]

OCA at 18:41, 10 December 2016

OCA — Sat, 10 Dec 2016 18:41:49 GMT

←Older revision		Revision as of 18:41, 10 December 2016
Line 3:		Line 3:
	<StructureSection load='4asw' size='340' side='right' caption='[[4asw]], [[NMR_Ensembles_of_Models \| 9 NMR models]]' scene=''>		<StructureSection load='4asw' size='340' side='right' caption='[[4asw]], [[NMR_Ensembles_of_Models \| 9 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4asw]] is a 3 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]~~. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4asw]] is a 3 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASW FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a20\|4a20]], [[4asv\|4asv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a20\|4a20]], [[4asv\|4asv]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4asw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asw OCA], [http://pdbe.org/4asw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4asw RCSB], [http://www.ebi.ac.uk/pdbsum/4asw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4asw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4asw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asw OCA], [http://pdbe.org/4asw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4asw RCSB], [http://www.ebi.ac.uk/pdbsum/4asw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4asw ProSAT]</span></td></tr>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Goldstone, R M]]		[[Category: Goldstone, R M]]
	[[Category: High, S]]		[[Category: High, S]]

OCA at 20:25, 5 August 2016

OCA — Fri, 05 Aug 2016 20:25:30 GMT

←Older revision		Revision as of 20:25, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of the complex between the N-terminal dimerisation domain of Sgt2 and the UBL domain of Get5==		==Structure of the complex between the N-terminal dimerisation domain of Sgt2 and the UBL domain of Get5==
	<StructureSection load='4asw' size='340' side='right' caption='[[4asw]], [[NMR_Ensembles_of_Models \| 9 NMR models]]' scene=''>		<StructureSection load='4asw' size='340' side='right' caption='[[4asw]], [[NMR_Ensembles_of_Models \| 9 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4asw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4asw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASW FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a20\|4a20]], [[4asv\|4asv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a20\|4a20]], [[4asv\|4asv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4asw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4asw RCSB], [http://www.ebi.ac.uk/pdbsum/4asw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4asw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asw OCA], [http://pdbe.org/4asw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4asw RCSB], [http://www.ebi.ac.uk/pdbsum/4asw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4asw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/MDY2_YEAST MDY2_YEAST]] Required for efficient mating. Involved in the production of alpha-factor, the KAR9 and TUB1 location to the shmoo tip and nuclear migration into pheromone-induced shmoos.<ref>PMID:10514570</ref> <ref>PMID:16390866</ref>	+	[[http://www.uniprot.org/uniprot/SGT2_YEAST SGT2_YEAST]] Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity (By similarity). Required for recovery from heat shock.<ref>PMID:12482202</ref> [[http://www.uniprot.org/uniprot/MDY2_YEAST MDY2_YEAST]] Required for efficient mating. Involved in the production of alpha-factor, the KAR9 and TUB1 location to the shmoo tip and nuclear migration into pheromone-induced shmoos.<ref>PMID:10514570</ref> <ref>PMID:16390866</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4asw" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Goldstone, R M]]		[[Category: Goldstone, R M]]
	[[Category: High, S]]		[[Category: High, S]]

OCA at 21:37, 25 December 2014

OCA — Thu, 25 Dec 2014 21:37:45 GMT

←Older revision		Revision as of 21:37, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4asw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4asw RCSB], [http://www.ebi.ac.uk/pdbsum/4asw PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4asw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4asw RCSB], [http://www.ebi.ac.uk/pdbsum/4asw PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MDY2_YEAST MDY2_YEAST]] Required for efficient mating. Involved in the production of alpha-factor, the KAR9 and TUB1 location to the shmoo tip and nuclear migration into pheromone-induced shmoos.<ref>PMID:10514570</ref> <ref>PMID:16390866</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:17, 9 December 2014

OCA — Tue, 09 Dec 2014 17:17:46 GMT

←Older revision		Revision as of 17:17, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4asw.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of the complex between the N-terminal dimerisation domain of Sgt2 and the UBL domain of Get5==
		+	<StructureSection load='4asw' size='340' side='right' caption='[[4asw]], [[NMR_Ensembles_of_Models \| 9 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4asw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASW FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4a20\|4a20]], [[4asv\|4asv]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4asw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4asw RCSB], [http://www.ebi.ac.uk/pdbsum/4asw PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Small, glutamine-rich, tetratricopeptide repeat protein 2 (Sgt2) is the first known port of call for many newly synthesized tail-anchored (TA) proteins released from the ribosome and destined for the GET (Guided Entry of TA proteins) pathway. This leads them to the residential membrane of the endoplasmic reticulum via an alternative to the cotranslational, signal recognition particle-dependent mechanism that their topology denies them. In yeast, the first stage of the GET pathway involves Sgt2 passing TA proteins on to the Get4/Get5 complex through a direct interaction between the N-terminal (NT) domain of Sgt2 and the ubiquitin-like (UBL) domain of Get5. Here we characterize this interaction at a molecular level by solving both a solution structure of Sgt2_NT, which adopts a unique helical fold, and a crystal structure of the Get5_UBL. Furthermore, using reciprocal chemical shift perturbation data and experimental restraints, we solve a structure of the Sgt2_NT/Get5_UBL complex, validate it via site-directed mutagenesis, and empirically determine its stoichiometry using relaxation experiments and isothermal titration calorimetry. Taken together, these data provide detailed structural information about the interaction between two key players in the coordinated delivery of TA protein substrates into the GET pathway.

-	~~{{STRUCTURE_4asw\| PDB=4asw \| SCENE= }}~~	+	Structure of the Sgt2/Get5 complex provides insights into GET-mediated targeting of tail-anchored membrane proteins.,Simon AC, Simpson PJ, Goldstone RM, Krysztofinska EM, Murray JW, High S, Isaacson RL Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1327-32. doi:, 10.1073/pnas.1207518110. Epub 2013 Jan 7. PMID:23297211<ref>PMID:23297211</ref>

-	~~===Structure~~ of the ~~complex between the N-terminal dimerisation domain~~ of ~~Sgt2 and the UBL domain of Get5===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23297211}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[4asw]] is a 3 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASW OCA].~~	+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Goldstone, R M.]]	+	[[Category: Goldstone, R M]]
-	[[Category: High, S.]]	+	[[Category: High, S]]
-	[[Category: Isaacson, R L.]]	+	[[Category: Isaacson, R L]]
-	[[Category: Krysztofinska, E M.]]	+	[[Category: Krysztofinska, E M]]
-	[[Category: Murray, J W.]]	+	[[Category: Murray, J W]]
-	[[Category: Simon, A C.]]	+	[[Category: Simon, A C]]
-	[[Category: Simpson, P J.]]	+	[[Category: Simpson, P J]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Post-translational targeting]]		[[Category: Post-translational targeting]]
	[[Category: Tail-anchored]]		[[Category: Tail-anchored]]

OCA at 12:27, 30 January 2013

OCA — Wed, 30 Jan 2013 12:27:06 GMT

←Older revision		Revision as of 12:27, 30 January 2013
Line 1:		Line 1:
-	[[Image:4asw.~~jpg~~\|left\|200px]]	+	[[Image:4asw.png\|left\|200px]]

	{{STRUCTURE_4asw\| PDB=4asw \| SCENE= }}		{{STRUCTURE_4asw\| PDB=4asw \| SCENE= }}
Line 5:		Line 5:
	===Structure of the complex between the N-terminal dimerisation domain of Sgt2 and the UBL domain of Get5===		===Structure of the complex between the N-terminal dimerisation domain of Sgt2 and the UBL domain of Get5===

		+	{{ABSTRACT_PUBMED_23297211}}

	==About this Structure==		==About this Structure==

OCA at 09:07, 16 January 2013

OCA — Wed, 16 Jan 2013 09:07:24 GMT

←Older revision		Revision as of 09:07, 16 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4asw.jpg\|left\|200px]]

-	~~The entry~~ 4asw ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4asw\| PDB=4asw \| SCENE= }}

-	~~Authors: Simon, A.C., Simpson, P.J., Goldstone, R.M., Krysztofinska, E.M., Murray, J.W., High, S., Isaacson, R.L.~~	+	===Structure of the complex between the N-terminal dimerisation domain of Sgt2 and the UBL domain of Get5===

-	~~Description:~~ Structure ~~of the complex between the N~~-~~terminal dimerisation domain of Sgt2 and the UBL domain of Get5~~	+
		+	==About this Structure==
		+	[[4asw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASW OCA].
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Goldstone, R M.]]
		+	[[Category: High, S.]]
		+	[[Category: Isaacson, R L.]]
		+	[[Category: Krysztofinska, E M.]]
		+	[[Category: Murray, J W.]]
		+	[[Category: Simon, A C.]]
		+	[[Category: Simpson, P J.]]
		+	[[Category: Chaperone]]
		+	[[Category: Post-translational targeting]]
		+	[[Category: Tail-anchored]]

OCA at 10:50, 19 December 2012

OCA — Wed, 19 Dec 2012 10:50:48 GMT

←Older revision		Revision as of 10:50, 19 December 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4asw is ON HOLD	+	The entry 4asw is ON HOLD until Paper Publication

	Authors: Simon, A.C., Simpson, P.J., Goldstone, R.M., Krysztofinska, E.M., Murray, J.W., High, S., Isaacson, R.L.		Authors: Simon, A.C., Simpson, P.J., Goldstone, R.M., Krysztofinska, E.M., Murray, J.W., High, S., Isaacson, R.L.

	Description: Structure of the complex between the N-terminal dimerisation domain of Sgt2 and the UBL domain of Get5		Description: Structure of the complex between the N-terminal dimerisation domain of Sgt2 and the UBL domain of Get5