4auo - Revision history

OCA at 11:36, 20 December 2023

OCA — Wed, 20 Dec 2023 11:36:01 GMT

←Older revision		Revision as of 11:36, 20 December 2023
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	<StructureSection load='4auo' size='340' side='right'caption='[[4auo]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4auo' size='340' side='right'caption='[[4auo]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4auo]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AUO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4auo]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AUO FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~HYP~~:~~4-HYDROXYPROLINE~~'>~~HYP~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;~~'>~~[[1ayk\|1ayk]], [[1cge\|1cge]], [[1cgf\|1cgf]], [[1cgl\|1cgl]], [[1hfc\|1hfc]], [[1su3\|1su3]], [[2ayk\|2ayk]], [[2clt\|2clt]], [[2j0t\|2j0t]], [[2tcl\|2tcl]], [[3ayk\|3ayk]], [[4ayk\|4ayk]], [[966c\|966c]]~~</~~div~~><~~/td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Interstitial_collagenase Interstitial collagenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.7 3.4.24.7]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4auo OCA], [https://pdbe.org/4auo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4auo RCSB], [https://www.ebi.ac.uk/pdbsum/4auo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4auo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4auo OCA], [https://pdbe.org/4auo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4auo RCSB], [https://www.ebi.ac.uk/pdbsum/4auo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4auo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MMP1_HUMAN MMP1_HUMAN]] Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.<ref>PMID:1645757</ref>	+	[https://www.uniprot.org/uniprot/MMP1_HUMAN MMP1_HUMAN] Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.<ref>PMID:1645757</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Interstitial collagenase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bihan, D]]	+	[[Category: Synthetic construct]]
-	[[Category: Carafoli, F]]	+	[[Category: Bihan D]]
-	[[Category: Enghild~~, J J~~]]	+	[[Category: Carafoli F]]
-	[[Category: Farndale~~, R W~~]]	+	[[Category: Enghild JJ]]
-	[[Category: Hohenester, E]]	+	[[Category: Farndale RW]]
-	[[Category: Manka~~, S W~~]]	+	[[Category: Hohenester E]]
-	[[Category: Murphy, G]]	+	[[Category: Manka SW]]
-	[[Category: Nagase, H]]	+	[[Category: Murphy G]]
-	[[Category: Raynal, N]]	+	[[Category: Nagase H]]
-	[[Category: Visse, R]]	+	[[Category: Raynal N]]
-	~~[[Category: Hydrolase-peptide complex~~]]	+	[[Category: Visse R]]

OCA at 05:46, 25 August 2022

OCA — Thu, 25 Aug 2022 05:46:52 GMT

←Older revision		Revision as of 05:46, 25 August 2022
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	<StructureSection load='4auo' size='340' side='right'caption='[[4auo]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4auo' size='340' side='right'caption='[[4auo]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4auo]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AUO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4auo]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AUO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ayk\|1ayk]], [[1cge\|1cge]], [[1cgf\|1cgf]], [[1cgl\|1cgl]], [[1hfc\|1hfc]], [[1su3\|1su3]], [[2ayk\|2ayk]], [[2clt\|2clt]], [[2j0t\|2j0t]], [[2tcl\|2tcl]], [[3ayk\|3ayk]], [[4ayk\|4ayk]], [[966c\|966c]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ayk\|1ayk]], [[1cge\|1cge]], [[1cgf\|1cgf]], [[1cgl\|1cgl]], [[1hfc\|1hfc]], [[1su3\|1su3]], [[2ayk\|2ayk]], [[2clt\|2clt]], [[2j0t\|2j0t]], [[2tcl\|2tcl]], [[3ayk\|3ayk]], [[4ayk\|4ayk]], [[966c\|966c]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Interstitial_collagenase Interstitial collagenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.7 3.4.24.7] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Interstitial_collagenase Interstitial collagenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.7 3.4.24.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4auo OCA], [~~http~~://pdbe.org/4auo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4auo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4auo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4auo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4auo OCA], [https://pdbe.org/4auo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4auo RCSB], [https://www.ebi.ac.uk/pdbsum/4auo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4auo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MMP1_HUMAN MMP1_HUMAN]] Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.<ref>PMID:1645757</ref>	+	[[https://www.uniprot.org/uniprot/MMP1_HUMAN MMP1_HUMAN]] Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.<ref>PMID:1645757</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Matrix metalloproteinase\|Matrix metalloproteinase]]	+	*[[Matrix metalloproteinase 3D structures\|Matrix metalloproteinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 30:
	[[Category: Human]]		[[Category: Human]]
	[[Category: Interstitial collagenase]]		[[Category: Interstitial collagenase]]
		+	[[Category: Large Structures]]
	[[Category: Bihan, D]]		[[Category: Bihan, D]]
	[[Category: Carafoli, F]]		[[Category: Carafoli, F]]

OCA at 08:49, 6 March 2019

OCA — Wed, 06 Mar 2019 08:49:03 GMT

←Older revision		Revision as of 08:49, 6 March 2019
Line 1:		Line 1:

	==Crystal structure of MMP-1(E200A) in complex with a triple-helical collagen peptide==		==Crystal structure of MMP-1(E200A) in complex with a triple-helical collagen peptide==
-	<StructureSection load='4auo' size='340' side='right' caption='[[4auo]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='4auo' size='340' side='right'caption='[[4auo]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4auo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AUO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4auo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AUO FirstGlance]. <br>
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4auo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4auo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Matrix metalloproteinase\|Matrix metalloproteinase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:54, 5 August 2016

OCA — Fri, 05 Aug 2016 11:54:41 GMT

←Older revision		Revision as of 11:54, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of MMP-1(E200A) in complex with a triple-helical collagen peptide==		==Crystal structure of MMP-1(E200A) in complex with a triple-helical collagen peptide==
	<StructureSection load='4auo' size='340' side='right' caption='[[4auo]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4auo' size='340' side='right' caption='[[4auo]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4auo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AUO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4auo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AUO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ayk\|1ayk]], [[1cge\|1cge]], [[1cgf\|1cgf]], [[1cgl\|1cgl]], [[1hfc\|1hfc]], [[1su3\|1su3]], [[2ayk\|2ayk]], [[2clt\|2clt]], [[2j0t\|2j0t]], [[2tcl\|2tcl]], [[3ayk\|3ayk]], [[4ayk\|4ayk]], [[966c\|966c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ayk\|1ayk]], [[1cge\|1cge]], [[1cgf\|1cgf]], [[1cgl\|1cgl]], [[1hfc\|1hfc]], [[1su3\|1su3]], [[2ayk\|2ayk]], [[2clt\|2clt]], [[2j0t\|2j0t]], [[2tcl\|2tcl]], [[3ayk\|3ayk]], [[4ayk\|4ayk]], [[966c\|966c]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Interstitial_collagenase Interstitial collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.7 3.4.24.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Interstitial_collagenase Interstitial collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.7 3.4.24.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4auo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4auo RCSB], [http://www.ebi.ac.uk/pdbsum/4auo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4auo OCA], [http://pdbe.org/4auo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4auo RCSB], [http://www.ebi.ac.uk/pdbsum/4auo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4auo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4auo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Interstitial collagenase]]		[[Category: Interstitial collagenase]]
	[[Category: Bihan, D]]		[[Category: Bihan, D]]

OCA at 18:36, 25 December 2014

OCA — Thu, 25 Dec 2014 18:36:13 GMT

←Older revision		Revision as of 18:36, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4auo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AUO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4auo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AUO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ayk\|1ayk]], [[1cge\|1cge]], [[1cgf\|1cgf]], [[1cgl\|1cgl]], [[1hfc\|1hfc]], [[1su3\|1su3]], [[2ayk\|2ayk]], [[2clt\|2clt]], [[2j0t\|2j0t]], [[2tcl\|2tcl]], [[3ayk\|3ayk]], [[4ayk\|4ayk]], [[966c\|966c]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ayk\|1ayk]], [[1cge\|1cge]], [[1cgf\|1cgf]], [[1cgl\|1cgl]], [[1hfc\|1hfc]], [[1su3\|1su3]], [[2ayk\|2ayk]], [[2clt\|2clt]], [[2j0t\|2j0t]], [[2tcl\|2tcl]], [[3ayk\|3ayk]], [[4ayk\|4ayk]], [[966c\|966c]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Interstitial_collagenase Interstitial collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.7 3.4.24.7] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Interstitial_collagenase Interstitial collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.7 3.4.24.7] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4auo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4auo RCSB], [http://www.ebi.ac.uk/pdbsum/4auo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4auo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4auo RCSB], [http://www.ebi.ac.uk/pdbsum/4auo PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MMP1_HUMAN MMP1_HUMAN]] Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.<ref>PMID:1645757</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 25:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Interstitial collagenase]]		[[Category: Interstitial collagenase]]
-	[[Category: Bihan, D.]]	+	[[Category: Bihan, D]]
-	[[Category: Carafoli, F.]]	+	[[Category: Carafoli, F]]
-	[[Category: Enghild, J J.]]	+	[[Category: Enghild, J J]]
-	[[Category: Farndale, R W.]]	+	[[Category: Farndale, R W]]
-	[[Category: Hohenester, E.]]	+	[[Category: Hohenester, E]]
-	[[Category: Manka, S W.]]	+	[[Category: Manka, S W]]
-	[[Category: Murphy, G.]]	+	[[Category: Murphy, G]]
-	[[Category: Nagase, H.]]	+	[[Category: Nagase, H]]
-	[[Category: Raynal, N.]]	+	[[Category: Raynal, N]]
-	[[Category: Visse, R.]]	+	[[Category: Visse, R]]
	[[Category: Hydrolase-peptide complex]]		[[Category: Hydrolase-peptide complex]]

OCA at 09:13, 11 June 2014

OCA — Wed, 11 Jun 2014 09:13:08 GMT

←Older revision		Revision as of 09:13, 11 June 2014
Line 1:		Line 1:
-	[[~~Image:~~4auo.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of MMP-1(E200A) in complex with a triple-helical collagen peptide==
		+	<StructureSection load='4auo' size='340' side='right' caption='[[4auo]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4auo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AUO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ayk\|1ayk]], [[1cge\|1cge]], [[1cgf\|1cgf]], [[1cgl\|1cgl]], [[1hfc\|1hfc]], [[1su3\|1su3]], [[2ayk\|2ayk]], [[2clt\|2clt]], [[2j0t\|2j0t]], [[2tcl\|2tcl]], [[3ayk\|3ayk]], [[4ayk\|4ayk]], [[966c\|966c]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Interstitial_collagenase Interstitial collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.7 3.4.24.7] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4auo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4auo RCSB], [http://www.ebi.ac.uk/pdbsum/4auo PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Collagenases of the matrix metalloproteinase (MMP) family play major roles in morphogenesis, tissue repair, and human diseases, but how they recognize and cleave the collagen triple helix is not fully understood. Here, we report temperature-dependent binding of a catalytically inactive MMP-1 mutant (E200A) to collagen through the cooperative action of its catalytic and hemopexin domains. Contact between the two molecules was mapped by screening the Collagen Toolkit peptide library and by hydrogen/deuterium exchange. The crystal structure of MMP-1(E200A) bound to a triple-helical collagen peptide revealed extensive interactions of the 115-A-long triple helix with both MMP-1 domains. An exosite in the hemopexin domain, which binds the leucine 10 residues C-terminal to the scissile bond, is critical for collagenolysis and represents a unique target for inhibitor development. The scissile bond is not correctly positioned for hydrolysis in the crystallized complex. A productive binding mode is readily modeled, without altering the MMP-1 structure or the exosite interactions, by axial rotation of the collagen homotrimer. Interdomain flexing of the enzyme and a localized excursion of the collagen chain closest to the active site, facilitated by thermal loosening of the substrate, may lead to the first transition state of collagenolysis.

-	~~{{STRUCTURE_4auo\| PDB=4auo \| SCENE= }}~~	+	Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1.,Manka SW, Carafoli F, Visse R, Bihan D, Raynal N, Farndale RW, Murphy G, Enghild JJ, Hohenester E, Nagase H Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12461-6. Epub 2012 Jul 3. PMID:22761315<ref>PMID:22761315</ref>

-	~~===Crystal structure~~ of ~~MMP-1(E200A) in complex with a triple-helical collagen peptide===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22761315}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[4auo]] is a 8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4AUO OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022761315<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Interstitial collagenase]]		[[Category: Interstitial collagenase]]

OCA at 04:52, 15 August 2012

OCA — Wed, 15 Aug 2012 04:52:03 GMT

←Older revision		Revision as of 04:52, 15 August 2012
Line 1:		Line 1:
-	[[Image:4auo.~~jpg~~\|left\|200px]]	+	[[Image:4auo.png\|left\|200px]]

	{{STRUCTURE_4auo\| PDB=4auo \| SCENE= }}		{{STRUCTURE_4auo\| PDB=4auo \| SCENE= }}
Line 5:		Line 5:
	===Crystal structure of MMP-1(E200A) in complex with a triple-helical collagen peptide===		===Crystal structure of MMP-1(E200A) in complex with a triple-helical collagen peptide===

		+	{{ABSTRACT_PUBMED_22761315}}

	==About this Structure==		==About this Structure==
	[[4auo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUO OCA].		[[4auo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUO OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022761315</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Interstitial collagenase]]		[[Category: Interstitial collagenase]]

OCA at 08:22, 11 July 2012

OCA — Wed, 11 Jul 2012 08:22:14 GMT

←Older revision		Revision as of 08:22, 11 July 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4auo.jpg\|left\|200px]]

-	~~The entry~~ 4auo ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4auo\| PDB=4auo \| SCENE= }}

-	~~Authors: Manka, S.W., Carafoli, F., Visse, R., Bihan, D., Raynal, N., Farndale, R.W., Murphy, G., Enghild, J.J., Hohenester, E., Nagase, H.~~	+	===Crystal structure of MMP-1(E200A) in complex with a triple-helical collagen peptide===

-	~~Description: Crystal~~ structure ~~of MMP-1(E200A) in complex~~ with ~~a triple~~-~~helical collagen~~ peptide	+
		+	==About this Structure==
		+	[[4auo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUO OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Interstitial collagenase]]
		+	[[Category: Bihan, D.]]
		+	[[Category: Carafoli, F.]]
		+	[[Category: Enghild, J J.]]
		+	[[Category: Farndale, R W.]]
		+	[[Category: Hohenester, E.]]
		+	[[Category: Manka, S W.]]
		+	[[Category: Murphy, G.]]
		+	[[Category: Nagase, H.]]
		+	[[Category: Raynal, N.]]
		+	[[Category: Visse, R.]]
		+	[[Category: Hydrolase-peptide complex]]

OCA: Protected "4auo" [edit=sysop:move=sysop]

OCA — Wed, 30 May 2012 05:21:30 GMT

Protected "4auo" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:21, 30 May 2012

OCA: New page: '''Unreleased structure''' The entry 4auo is ON HOLD until Paper Publication Authors: Manka, S.W., Carafoli, F., Visse, R., Bihan, D., Raynal, N., Farndale, R.W., Murphy, G., Enghild, J...

OCA — Wed, 30 May 2012 05:21:29 GMT

New page: '''Unreleased structure''' The entry 4auo is ON HOLD until Paper Publication Authors: Manka, S.W., Carafoli, F., Visse, R., Bihan, D., Raynal, N., Farndale, R.W., Murphy, G., Enghild, J...

New page

'''Unreleased structure'''

The entry 4auo is ON HOLD until Paper Publication

Authors: Manka, S.W., Carafoli, F., Visse, R., Bihan, D., Raynal, N., Farndale, R.W., Murphy, G., Enghild, J.J., Hohenester, E., Nagase, H.

Description: Crystal structure of MMP-1(E200A) in complex with a triple-helical collagen peptide