4aup - Revision history

OCA at 05:46, 25 August 2022

OCA — Thu, 25 Aug 2022 05:46:55 GMT

←Older revision		Revision as of 05:46, 25 August 2022
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	<StructureSection load='4aup' size='340' side='right'caption='[[4aup]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4aup' size='340' side='right'caption='[[4aup]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4aup]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Tubbo Tubbo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AUP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4aup]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Tubbo Tubbo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AUP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4aup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aup OCA], [~~http~~://pdbe.org/4aup PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4aup RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4aup PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4aup ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aup OCA], [https://pdbe.org/4aup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aup RCSB], [https://www.ebi.ac.uk/pdbsum/4aup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aup ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 18:

	==See Also==		==See Also==
-	*[[Phospholipase A2\|Phospholipase A2]]	+	*[[Phospholipase A2 3D structures\|Phospholipase A2 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:47, 17 July 2019

OCA — Wed, 17 Jul 2019 11:47:59 GMT

←Older revision		Revision as of 11:47, 17 July 2019
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Tubbo]]		[[Category: Tubbo]]
	[[Category: Bolchi, A]]		[[Category: Bolchi, A]]

OCA at 08:46, 6 March 2019

OCA — Wed, 06 Mar 2019 08:46:26 GMT

←Older revision		Revision as of 08:46, 6 March 2019
Line 1:		Line 1:

	==Tuber borchii Phospholipase A2==		==Tuber borchii Phospholipase A2==
-	<StructureSection load='4aup' size='340' side='right' caption='[[4aup]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4aup' size='340' side='right'caption='[[4aup]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4aup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Tubbo Tubbo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AUP FirstGlance]. <br>		<table><tr><td colspan='2'>[[4aup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Tubbo Tubbo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AUP FirstGlance]. <br>

OCA at 02:40, 11 December 2016

OCA — Sun, 11 Dec 2016 02:40:19 GMT

←Older revision		Revision as of 02:40, 11 December 2016
Line 1:		Line 1:
		+
	==Tuber borchii Phospholipase A2==		==Tuber borchii Phospholipase A2==
	<StructureSection load='4aup' size='340' side='right' caption='[[4aup]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4aup' size='340' side='right' caption='[[4aup]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4aup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Tuber_borchii Tuber borchii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AUP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4aup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Tubbo Tubbo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AUP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aup OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aup RCSB], [http://www.ebi.ac.uk/pdbsum/4aup PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aup OCA], [http://pdbe.org/4aup PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4aup RCSB], [http://www.ebi.ac.uk/pdbsum/4aup PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4aup ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4aup" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Tuber borchii~~]]	+	[[Category: Tubbo]]
	[[Category: Bolchi, A]]		[[Category: Bolchi, A]]
	[[Category: Cavazzini, D]]		[[Category: Cavazzini, D]]

OCA at 14:27, 9 December 2014

OCA — Tue, 09 Dec 2014 14:27:15 GMT

←Older revision		Revision as of 14:27, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4aup.~~png~~\|~~left\|200px~~]]	+	==Tuber borchii Phospholipase A2==
		+	<StructureSection load='4aup' size='340' side='right' caption='[[4aup]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4aup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Tuber_borchii Tuber borchii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AUP FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aup OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aup RCSB], [http://www.ebi.ac.uk/pdbsum/4aup PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Fungal phospholipases are members of the fungal/bacterial group XIV secreted phospholipases A2 (sPLA2). TbSP1, the sPLA2 primarily addressed in this study, is upregulated by nutrient deprivation and is preferentially expressed in the symbiotic stage of the ectomycorrhizal fungus Tuber borchii. A peculiar feature of this phospholipase and of its ortholog from the black truffle T. melanosporum is the presence of a 54 amino acid sequence of unknown functional significance, interposed between the signal peptide and the start of the conserved catalytic core of the enzyme. X-ray diffraction analysis of a recombinant TbSP1 form corresponding to the secreted protein previously identified in T. borchii mycelia, revealed a structure comprising the five alpha-helices that form the phospholipase catalytic module, but lacking the N-terminal 54 amino acids. This finding led to a series of functional studies that showed that TbSP1, as well as its T. melanosporum ortholog, is a self-processing pro-phospholipase A2, whose phospholipase activity increases up to 80-fold following autoproteolytic removal of the N-terminal peptide. Proteolytic cleavage occurs within a serine-rich, intrinsically flexible region of TbSP1, does not involve the phospholipase active site, and proceeds via an intermolecular mechanism. Autoproteolytic activation, which also takes place at the surface of nutrient-starved, sPLA2 overexpressing hyphae, may strengthen and further control the effects of phospholipase upregulation in response to nutrient deprivation, also in the context of symbiosis establishment and mycorrhiza formation.

-	~~{{STRUCTURE_4aup\| PDB=4aup \| SCENE= }}~~	+	Autoproteolytic activation of a symbiosis-regulated truffle phospholipase A2.,Cavazzini D, Meschi F, Corsini R, Bolchi A, Rossi GL, Einsle O, Ottonello S J Biol Chem. 2012 Nov 28. PMID:23192346<ref>PMID:23192346</ref>

-	~~===Tuber borchii Phospholipase A2===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_23192346}}~~	+	==See Also==
-		+	*[[Phospholipase A2\|Phospholipase A2]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4aup~~]] ~~is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Tuber_borchii Tuber borchii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUP OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Tuber borchii]]		[[Category: Tuber borchii]]
-	[[Category: Bolchi, A.]]	+	[[Category: Bolchi, A]]
-	[[Category: Cavazzini, D.]]	+	[[Category: Cavazzini, D]]
-	[[Category: Corsini, R.]]	+	[[Category: Corsini, R]]
-	[[Category: Einsle, O.]]	+	[[Category: Einsle, O]]
-	[[Category: Meschi, F.]]	+	[[Category: Meschi, F]]
-	[[Category: Ottonello, S.]]	+	[[Category: Ottonello, S]]
-	[[Category: Rossi, G L.]]	+	[[Category: Rossi, G L]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 12:48, 30 January 2013

OCA — Wed, 30 Jan 2013 12:48:53 GMT

←Older revision		Revision as of 12:48, 30 January 2013
Line 1:		Line 1:
-	[[Image:4aup.~~jpg~~\|left\|200px]]	+	[[Image:4aup.png\|left\|200px]]

	{{STRUCTURE_4aup\| PDB=4aup \| SCENE= }}		{{STRUCTURE_4aup\| PDB=4aup \| SCENE= }}

OCA at 21:11, 12 December 2012

OCA — Wed, 12 Dec 2012 21:11:51 GMT

←Older revision		Revision as of 21:11, 12 December 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4aup.jpg\|left\|200px]]

-	~~The entry~~ 4aup ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4aup\| PDB=4aup \| SCENE= }}

-	~~Authors: Cavazzini, D., Meschi, F., Corsini, R., Bolchi, A., Rossi, G.-L., Einsle, O., Ottonello, S.~~	+	===Tuber borchii Phospholipase A2===

-	~~Description~~: Tuber borchii ~~Phospholipase A2~~	+	{{ABSTRACT_PUBMED_23192346}}
		+
		+	==About this Structure==
		+	[[4aup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Tuber_borchii Tuber borchii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUP OCA].
		+	[[Category: Tuber borchii]]
		+	[[Category: Bolchi, A.]]
		+	[[Category: Cavazzini, D.]]
		+	[[Category: Corsini, R.]]
		+	[[Category: Einsle, O.]]
		+	[[Category: Meschi, F.]]
		+	[[Category: Ottonello, S.]]
		+	[[Category: Rossi, G L.]]
		+	[[Category: Hydrolase]]

OCA at 07:11, 6 June 2012

OCA — Wed, 06 Jun 2012 07:11:36 GMT

←Older revision		Revision as of 07:11, 6 June 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4aup is ON HOLD	+	The entry 4aup is ON HOLD until Paper Publication

	Authors: Cavazzini, D., Meschi, F., Corsini, R., Bolchi, A., Rossi, G.-L., Einsle, O., Ottonello, S.		Authors: Cavazzini, D., Meschi, F., Corsini, R., Bolchi, A., Rossi, G.-L., Einsle, O., Ottonello, S.

	Description: Tuber borchii Phospholipase A2		Description: Tuber borchii Phospholipase A2

OCA: Protected "4aup" [edit=sysop:move=sysop]

OCA — Wed, 30 May 2012 05:21:31 GMT

Protected "4aup" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:21, 30 May 2012

OCA: New page: '''Unreleased structure''' The entry 4aup is ON HOLD Authors: Cavazzini, D., Meschi, F., Corsini, R., Bolchi, A., Rossi, G.-L., Einsle, O., Ottonello, S. Description: Tuber borchii Pho...

OCA — Wed, 30 May 2012 05:21:30 GMT

New page: '''Unreleased structure''' The entry 4aup is ON HOLD Authors: Cavazzini, D., Meschi, F., Corsini, R., Bolchi, A., Rossi, G.-L., Einsle, O., Ottonello, S. Description: Tuber borchii Pho...

New page

'''Unreleased structure'''

The entry 4aup is ON HOLD

Authors: Cavazzini, D., Meschi, F., Corsini, R., Bolchi, A., Rossi, G.-L., Einsle, O., Ottonello, S.

Description: Tuber borchii Phospholipase A2