4ayt - Revision history

OCA at 11:38, 20 December 2023

OCA — Wed, 20 Dec 2023 11:38:56 GMT

←Older revision		Revision as of 11:38, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='4ayt' size='340' side='right'caption='[[4ayt]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='4ayt' size='340' side='right'caption='[[4ayt]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ayt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2yl4 2yl4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AYT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ayt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2yl4 2yl4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AYT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.85Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4ayw\|4ayw]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ayt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayt OCA], [https://pdbe.org/4ayt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ayt RCSB], [https://www.ebi.ac.uk/pdbsum/4ayt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ayt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ayt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayt OCA], [https://pdbe.org/4ayt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ayt RCSB], [https://www.ebi.ac.uk/pdbsum/4ayt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ayt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ABCBA_HUMAN ABCBA_HUMAN]] May mediate critical mitochondrial transport functions related to heme biosynthesis (By similarity).	+	[https://www.uniprot.org/uniprot/ABCBA_HUMAN ABCBA_HUMAN] May mediate critical mitochondrial transport functions related to heme biosynthesis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Barr~~, A J~~]]	+	[[Category: Barr AJ]]
-	[[Category: Berridge, G]]	+	[[Category: Berridge G]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Bray~~, J E~~]]	+	[[Category: Bray JE]]
-	[[Category: Bullock~~, A N~~]]	+	[[Category: Bullock AN]]
-	[[Category: Burgess-Brown, N]]	+	[[Category: Burgess-Brown N]]
-	[[Category: Carpenter~~, E P~~]]	+	[[Category: Carpenter EP]]
-	[[Category: Chaikuad, A]]	+	[[Category: Chaikuad A]]
-	[[Category: Chalk, R]]	+	[[Category: Chalk R]]
-	[[Category: Das, S]]	+	[[Category: Das S]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Dong L]]
-	[[Category: Dong, L]]	+	[[Category: Dong Y]]
-	[[Category: Dong, Y]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Gileadi O]]
-	[[Category: Gileadi, O]]	+	[[Category: Goubin S]]
-	[[Category: Goubin, S]]	+	[[Category: Kim J]]
-	[[Category: Kim, J]]	+	[[Category: Krojer T]]
-	[[Category: Krojer, T]]	+	[[Category: Li Q]]
-	[[Category: Li, Q]]	+	[[Category: Mahajan P]]
-	[[Category: Mahajan, P]]	+	[[Category: Mukhopadhyay S]]
-	[[Category: Mukhopadhyay, S]]	+	[[Category: Muniz JRC]]
-	[[Category: Muniz~~, J R.C~~]]	+	[[Category: Pike ACW]]
-	[[Category: Pike~~, A C.W~~]]	+	[[Category: Quigley A]]
-	[[Category: Quigley, A]]	+	[[Category: Shintre CA]]
-	[[Category: Shintre~~, C A~~]]	+	[[Category: Shrestha L]]
-	[[Category: Shrestha, L]]	+	[[Category: Vollmar M]]
-	[[Category: Vollmar, M]]	+	[[Category: Weigelt J]]
-	[[Category: Weigelt, J]]	+	[[Category: Xia X]]
-	[[Category: Xia, X]]	+	[[Category: Yang J]]
-	[[Category: Yang, J]]	+	[[Category: Von Delft F]]
-	[[Category: ~~Membrane protein]]~~	+
-	~~[[Category: Mitochondrial transport~~]]	+

OCA at 05:51, 25 August 2022

OCA — Thu, 25 Aug 2022 05:51:13 GMT

←Older revision		Revision as of 05:51, 25 August 2022
Line 3:		Line 3:
	<StructureSection load='4ayt' size='340' side='right'caption='[[4ayt]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='4ayt' size='340' side='right'caption='[[4ayt]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ayt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2yl4 2yl4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4AYT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ayt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2yl4 2yl4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AYT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ayw\|4ayw]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4ayw\|4ayw]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ayt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayt OCA], [~~http~~://pdbe.org/4ayt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ayt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ayt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ayt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ayt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayt OCA], [https://pdbe.org/4ayt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ayt RCSB], [https://www.ebi.ac.uk/pdbsum/4ayt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ayt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ABCBA_HUMAN ABCBA_HUMAN]] May mediate critical mitochondrial transport functions related to heme biosynthesis (By similarity).	+	[[https://www.uniprot.org/uniprot/ABCBA_HUMAN ABCBA_HUMAN]] May mediate critical mitochondrial transport functions related to heme biosynthesis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:16, 29 January 2020

OCA — Wed, 29 Jan 2020 17:16:18 GMT

←Older revision		Revision as of 17:16, 29 January 2020
Line 1:		Line 1:

	==STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10==		==STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10==
-	<StructureSection load='4ayt' size='340' side='right' caption='[[4ayt]], [[Resolution\|resolution]] 2.85Å' scene=''>	+	<StructureSection load='4ayt' size='340' side='right'caption='[[4ayt]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ayt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2yl4 2yl4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AYT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ayt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2yl4 2yl4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AYT FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4ayt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ayt" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[ABC transporter 3D structures\|ABC transporter 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Barr, A J]]		[[Category: Barr, A J]]

OCA at 19:46, 24 January 2018

OCA — Wed, 24 Jan 2018 19:46:04 GMT

←Older revision		Revision as of 19:46, 24 January 2018
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4ayt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ayt" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[ABC transporter\|ABC transporter]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 35:
	[[Category: Chalk, R]]		[[Category: Chalk, R]]
	[[Category: Das, S]]		[[Category: Das, S]]
-	[[Category: Delft, F ~~Von~~]]	+	[[Category: Delft, F von]]
	[[Category: Dong, L]]		[[Category: Dong, L]]
	[[Category: Dong, Y]]		[[Category: Dong, Y]]

OCA at 17:00, 2 January 2017

OCA — Mon, 02 Jan 2017 17:00:43 GMT

←Older revision		Revision as of 17:00, 2 January 2017
Line 1:		Line 1:
		+
	==STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10==		==STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10==
	<StructureSection load='4ayt' size='340' side='right' caption='[[4ayt]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='4ayt' size='340' side='right' caption='[[4ayt]], [[Resolution\|resolution]] 2.85Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ayw\|4ayw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ayw\|4ayw]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ayt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ayt RCSB], [http://www.ebi.ac.uk/pdbsum/4ayt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ayt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayt OCA], [http://pdbe.org/4ayt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ayt RCSB], [http://www.ebi.ac.uk/pdbsum/4ayt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ayt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ayt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 07:48, 26 March 2015

OCA — Thu, 26 Mar 2015 07:48:45 GMT

←Older revision		Revision as of 07:48, 26 March 2015
Line 2:		Line 2:
	<StructureSection load='4ayt' size='340' side='right' caption='[[4ayt]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='4ayt' size='340' side='right' caption='[[4ayt]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ayt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2yl4 2yl4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AYT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ayt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2yl4 2yl4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AYT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ayw\|4ayw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ayw\|4ayw]]</td></tr>
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[ABC transporter\|ABC transporter]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Barr, A J]]		[[Category: Barr, A J]]

OCA at 02:01, 25 December 2014

OCA — Thu, 25 Dec 2014 02:01:19 GMT

←Older revision		Revision as of 02:01, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ayt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ayt RCSB], [http://www.ebi.ac.uk/pdbsum/4ayt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ayt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ayt RCSB], [http://www.ebi.ac.uk/pdbsum/4ayt PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ABCBA_HUMAN ABCBA_HUMAN]] May mediate critical mitochondrial transport functions related to heme biosynthesis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:54, 21 December 2014

OCA — Sun, 21 Dec 2014 09:54:56 GMT

←Older revision		Revision as of 09:54, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4ayt\| PDB=4ayt \| SCENE= }}~~	+	==STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10==
-	===STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10===	+	<StructureSection load='4ayt' size='340' side='right' caption='[[4ayt]], [[Resolution\|resolution]] 2.85Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23716676}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ayt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2yl4 2yl4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AYT FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ayw\|4ayw]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ayt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ayt RCSB], [http://www.ebi.ac.uk/pdbsum/4ayt PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ABCB10 is one of the three ATP-binding cassette (ABC) transporters found in the inner membrane of mitochondria. In mammals ABCB10 is essential for erythropoiesis, and for protection of mitochondria against oxidative stress. ABCB10 is therefore a potential therapeutic target for diseases in which increased mitochondrial reactive oxygen species production and oxidative stress play a major role. The crystal structure of apo-ABCB10 shows a classic exporter fold ABC transporter structure, in an open-inwards conformation, ready to bind the substrate or nucleotide from the inner mitochondrial matrix or membrane. Unexpectedly, however, ABCB10 adopts an open-inwards conformation when complexed with nonhydrolysable ATP analogs, in contrast to other transporter structures which adopt an open-outwards conformation in complex with ATP. The three complexes of ABCB10/ATP analogs reported here showed varying degrees of opening of the transport substrate binding site, indicating that in this conformation there is some flexibility between the two halves of the protein. These structures suggest that the observed plasticity, together with a portal between two helices in the transmembrane region of ABCB10, assist transport substrate entry into the substrate binding cavity. These structures indicate that ABC transporters may exist in an open-inwards conformation when nucleotide is bound. We discuss ways in which this observation can be aligned with the current views on mechanisms of ABC transporters.

-	~~==Function==~~	+	Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.,Shintre CA, Pike AC, Li Q, Kim JI, Barr AJ, Goubin S, Shrestha L, Yang J, Berridge G, Ross J, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, Marsden BD, von Delft F, Bullock AN, Gileadi O, Burgess-Brown NA, Carpenter EP Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9710-5. doi:, 10.1073/pnas.1217042110. Epub 2013 May 28. PMID:23716676<ref>PMID:23716676</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/~~uniprot/ABCBA_HUMAN ABCBA_HUMAN]]~~ May ~~mediate critical mitochondrial transport functions related to heme biosynthesis (By similarity)~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4ayt]] is~~ a ~~1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes~~ the ~~now removed PDB entry [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/send-pdb?obs=1&id=2yl4 2yl4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYT OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023716676</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Barr, A J.]]	+	[[Category: Barr, A J]]
-	[[Category: Berridge, G.]]	+	[[Category: Berridge, G]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Bray, J E.]]	+	[[Category: Bray, J E]]
-	[[Category: Bullock, A N.]]	+	[[Category: Bullock, A N]]
-	[[Category: Burgess-Brown, N.]]	+	[[Category: Burgess-Brown, N]]
-	[[Category: Carpenter, E P.]]	+	[[Category: Carpenter, E P]]
-	[[Category: Chaikuad, A.]]	+	[[Category: Chaikuad, A]]
-	[[Category: Chalk, R.]]	+	[[Category: Chalk, R]]
-	[[Category: Das, S.]]	+	[[Category: Das, S]]
-	[[Category: Delft, F Von.]]	+	[[Category: Delft, F Von]]
-	[[Category: Dong, L.]]	+	[[Category: Dong, L]]
-	[[Category: Dong, Y.]]	+	[[Category: Dong, Y]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Gileadi, O.]]	+	[[Category: Gileadi, O]]
-	[[Category: Goubin, S.]]	+	[[Category: Goubin, S]]
-	[[Category: Kim, J.]]	+	[[Category: Kim, J]]
-	[[Category: Krojer, T.]]	+	[[Category: Krojer, T]]
-	[[Category: Li, Q.]]	+	[[Category: Li, Q]]
-	[[Category: Mahajan, P.]]	+	[[Category: Mahajan, P]]
-	[[Category: Mukhopadhyay, S.]]	+	[[Category: Mukhopadhyay, S]]
-	[[Category: Muniz, J R.C.]]	+	[[Category: Muniz, J R.C]]
-	[[Category: Pike, A C.W.]]	+	[[Category: Pike, A C.W]]
-	[[Category: Quigley, A.]]	+	[[Category: Quigley, A]]
-	[[Category: Shintre, C A.]]	+	[[Category: Shintre, C A]]
-	[[Category: Shrestha, L.]]	+	[[Category: Shrestha, L]]
-	[[Category: Vollmar, M.]]	+	[[Category: Vollmar, M]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
-	[[Category: Xia, X.]]	+	[[Category: Xia, X]]
-	[[Category: Yang, J.]]	+	[[Category: Yang, J]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Mitochondrial transport]]		[[Category: Mitochondrial transport]]

OCA at 17:56, 19 June 2013

OCA — Wed, 19 Jun 2013 17:56:58 GMT

←Older revision		Revision as of 17:56, 19 June 2013
Line 1:		Line 1:
-	[[Image:4ayt.jpg\|left\|200px]]
-
	{{STRUCTURE_4ayt\| PDB=4ayt \| SCENE= }}		{{STRUCTURE_4ayt\| PDB=4ayt \| SCENE= }}
-
	===STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10===		===STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10===
		+	{{ABSTRACT_PUBMED_23716676}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/ABCBA_HUMAN ABCBA_HUMAN]] May mediate critical mitochondrial transport functions related to heme biosynthesis (By similarity).

	==About this Structure==		==About this Structure==
	[[4ayt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2yl4 2yl4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYT OCA].		[[4ayt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2yl4 2yl4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYT OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023716676</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
-	[[Category: Barr, A.]]	+	[[Category: Barr, A J.]]
	[[Category: Berridge, G.]]		[[Category: Berridge, G.]]
	[[Category: Bountra, C.]]		[[Category: Bountra, C.]]
	[[Category: Bray, J E.]]		[[Category: Bray, J E.]]
-	[[Category: Bullock, A.]]	+	[[Category: Bullock, A N.]]
	[[Category: Burgess-Brown, N.]]		[[Category: Burgess-Brown, N.]]
	[[Category: Carpenter, E P.]]		[[Category: Carpenter, E P.]]

OCA at 08:06, 11 July 2012

OCA — Wed, 11 Jul 2012 08:06:53 GMT

←Older revision		Revision as of 08:06, 11 July 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4ayt.jpg\|left\|200px]]

-	~~The entry~~ 4ayt ~~is ON HOLD~~	+	{{STRUCTURE_4ayt\| PDB=4ayt \| SCENE= }}

-	~~Authors: PIKE~~, A.C.W., SHINTRE, C.A., LI, Q., KIM, J., VON DELFT, F., BARR, A., DAS, S., CHAIKUAD, A., XIA, X., QUIGLEY, A., DONG, Y., DONG, L., KROJER, T., VOLLMAR, M., MUNIZ, J.R.C., BRAY, J.E., BERRIDGE, G., CHALK, R., GILEADI, O., BURGESS-BROWN, N., SHRESTHA, L., GOUBIN, S., YANG, J., MAHAJAN, P., MUKHOPADHYAY, S., BULLOCK, A., ARROWSMITH, C.H., WEIGELT, J., BOUNTRA, C., EDWARDS, A.M., CARPENTER, E.P.	+	===STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10===

-	~~Description~~: ~~STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER~~, ~~ABCB10~~	+
		+	==About this Structure==
		+	[[4ayt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2yl4 2yl4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYT OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Barr, A.]]
		+	[[Category: Berridge, G.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Bray, J E.]]
		+	[[Category: Bullock, A.]]
		+	[[Category: Burgess-Brown, N.]]
		+	[[Category: Carpenter, E P.]]
		+	[[Category: Chaikuad, A.]]
		+	[[Category: Chalk, R.]]
		+	[[Category: Das, S.]]
		+	[[Category: Delft, F Von.]]
		+	[[Category: Dong, L.]]
		+	[[Category: Dong, Y.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: Gileadi, O.]]
		+	[[Category: Goubin, S.]]
		+	[[Category: Kim, J.]]
		+	[[Category: Krojer, T.]]
		+	[[Category: Li, Q.]]
		+	[[Category: Mahajan, P.]]
		+	[[Category: Mukhopadhyay, S.]]
		+	[[Category: Muniz, J R.C.]]
		+	[[Category: Pike, A C.W.]]
		+	[[Category: Quigley, A.]]
		+	[[Category: Shintre, C A.]]
		+	[[Category: Shrestha, L.]]
		+	[[Category: Vollmar, M.]]
		+	[[Category: Weigelt, J.]]
		+	[[Category: Xia, X.]]
		+	[[Category: Yang, J.]]
		+	[[Category: Membrane protein]]
		+	[[Category: Mitochondrial transport]]