4b2y - Revision history

OCA at 10:56, 9 May 2024

OCA — Thu, 09 May 2024 10:56:29 GMT

←Older revision		Revision as of 10:56, 9 May 2024
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	<StructureSection load='4b2y' size='340' side='right'caption='[[4b2y]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4b2y' size='340' side='right'caption='[[4b2y]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b2y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_16463 Atcc 16463~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B2Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b2y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycothermus_thermophilus Mycothermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B2Y FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~, ~~<scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[4aue\|4aue]], [[4aul\|4aul]], [[4aum\|4aum]], [[4aun\|4aun]], [[4b31\|4b31]], [[4b40\|4b40]], [[4b5k\|4b5k]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Catalase Catalase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2y OCA], [https://pdbe.org/4b2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b2y RCSB], [https://www.ebi.ac.uk/pdbsum/4b2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b2y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2y OCA], [https://pdbe.org/4b2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b2y RCSB], [https://www.ebi.ac.uk/pdbsum/4b2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b2y ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/R4GRT6_9PEZI R4GRT6_9PEZI] Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.[RuleBase:RU004142] Serves to protect cells from the toxic effects of hydrogen peroxide.[PIRNR:PIRNR038927]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 16463]]
-	[[Category: Catalase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~McPherson, M J~~]]	+	[[Category: Mycothermus thermophilus]]
-	[[Category: ~~Ogel, Z B~~]]	+	[[Category: McPherson MJ]]
-	[[Category: ~~Pearson, A R~~]]	+	[[Category: Ogel ZB]]
-	[[Category: ~~Trinh, C H~~]]	+	[[Category: Pearson AR]]
-	[[Category: ~~Yuzugullu, Y~~]]	+	[[Category: Trinh CH]]
-	[[Category: ~~Molecular channel]]~~	+	[[Category: Yuzugullu Y]]
-	~~[[Category: Oxidative activity]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 06:57, 31 August 2022

OCA — Wed, 31 Aug 2022 06:57:59 GMT

←Older revision		Revision as of 06:57, 31 August 2022
Line 3:		Line 3:
	<StructureSection load='4b2y' size='340' side='right'caption='[[4b2y]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4b2y' size='340' side='right'caption='[[4b2y]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b2y]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_16463 Atcc 16463]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4B2Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b2y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_16463 Atcc 16463]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B2Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4aue\|4aue]], [[4aul\|4aul]], [[4aum\|4aum]], [[4aun\|4aun]], [[4b31\|4b31]], [[4b40\|4b40]], [[4b5k\|4b5k]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4aue\|4aue]], [[4aul\|4aul]], [[4aum\|4aum]], [[4aun\|4aun]], [[4b31\|4b31]], [[4b40\|4b40]], [[4b5k\|4b5k]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Catalase Catalase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Catalase Catalase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4b2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2y OCA], [~~http~~://pdbe.org/4b2y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4b2y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4b2y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4b2y ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2y OCA], [https://pdbe.org/4b2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b2y RCSB], [https://www.ebi.ac.uk/pdbsum/4b2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b2y ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:17, 30 October 2019

OCA — Wed, 30 Oct 2019 09:17:45 GMT

←Older revision		Revision as of 09:17, 30 October 2019
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Catalase\|Catalase]]	+	*[[Catalase 3D structures\|Catalase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:38, 13 March 2019

OCA — Wed, 13 Mar 2019 13:38:16 GMT

←Older revision		Revision as of 13:38, 13 March 2019
Line 1:		Line 1:

	==Probing the active center of catalase-phenol oxidase from Scytalidium thermophilum==		==Probing the active center of catalase-phenol oxidase from Scytalidium thermophilum==
-	<StructureSection load='4b2y' size='340' side='right' caption='[[4b2y]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4b2y' size='340' side='right'caption='[[4b2y]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b2y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycothermus_thermophilus Mycothermus thermophilus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B2Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b2y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_16463 Atcc 16463]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B2Y FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4aue\|4aue]], [[4aul\|4aul]], [[4aum\|4aum]], [[4aun\|4aun]], [[4b31\|4b31]], [[4b40\|4b40]], [[4b5k\|4b5k]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4aue\|4aue]], [[4aul\|4aul]], [[4aum\|4aum]], [[4aun\|4aun]], [[4b31\|4b31]], [[4b40\|4b40]], [[4b5k\|4b5k]]</td></tr>
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 16463]]
	[[Category: Catalase]]		[[Category: Catalase]]
-	[[Category: ~~Mycothermus thermophilus~~]]	+	[[Category: Large Structures]]
	[[Category: McPherson, M J]]		[[Category: McPherson, M J]]
	[[Category: Ogel, Z B]]		[[Category: Ogel, Z B]]

OCA at 19:41, 4 August 2016

OCA — Thu, 04 Aug 2016 19:41:57 GMT

←Older revision		Revision as of 19:41, 4 August 2016
Line 1:		Line 1:
		+
	==Probing the active center of catalase-phenol oxidase from Scytalidium thermophilum==		==Probing the active center of catalase-phenol oxidase from Scytalidium thermophilum==
	<StructureSection load='4b2y' size='340' side='right' caption='[[4b2y]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4b2y' size='340' side='right' caption='[[4b2y]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b2y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Scytalidium_thermophilum Scytalidium thermophilum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B2Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b2y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycothermus_thermophilus Mycothermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B2Y FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4aue\|4aue]], [[4aul\|4aul]], [[4aum\|4aum]], [[4aun\|4aun]], [[4b31\|4b31]], [[4b40\|4b40]], [[4b5k\|4b5k]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4aue\|4aue]], [[4aul\|4aul]], [[4aum\|4aum]], [[4aun\|4aun]], [[4b31\|4b31]], [[4b40\|4b40]], [[4b5k\|4b5k]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catalase Catalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catalase Catalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b2y RCSB], [http://www.ebi.ac.uk/pdbsum/4b2y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2y OCA], [http://pdbe.org/4b2y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b2y RCSB], [http://www.ebi.ac.uk/pdbsum/4b2y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b2y ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4b2y" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Catalase]]		[[Category: Catalase]]
-	[[Category: ~~Scytalidium thermophilum~~]]	+	[[Category: Mycothermus thermophilus]]
	[[Category: McPherson, M J]]		[[Category: McPherson, M J]]
	[[Category: Ogel, Z B]]		[[Category: Ogel, Z B]]

OCA at 09:47, 21 December 2014

OCA — Sun, 21 Dec 2014 09:47:07 GMT

←Older revision		Revision as of 09:47, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4b2y\| PDB=4b2y \| SCENE= }}~~	+	==Probing the active center of catalase-phenol oxidase from Scytalidium thermophilum==
-	===Probing the active center of catalase-phenol oxidase from Scytalidium thermophilum===	+	<StructureSection load='4b2y' size='340' side='right' caption='[[4b2y]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23545640}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4b2y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Scytalidium_thermophilum Scytalidium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B2Y FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4aue\|4aue]], [[4aul\|4aul]], [[4aum\|4aum]], [[4aun\|4aun]], [[4b31\|4b31]], [[4b40\|4b40]], [[4b5k\|4b5k]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catalase Catalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b2y RCSB], [http://www.ebi.ac.uk/pdbsum/4b2y PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Almost all monofunctional haem catalases contain a highly conserved core containing the active site, which is connected to the exterior of the enzyme by three channels. These channels have been identified as potential routes for substrate flow and product release. To further investigate the role of these molecular channels, a series of mutants of Scytalidium thermophilum catalase were generated. The three-dimensional structures of four catalase variants, N155A, V123A, V123C and V123T, have been determined at resolutions of 2.25, 1.93, 1.9 and 1.7 A, respectively. The V123C variant contains a new covalent bond between the S atom of Cys123 and the imidazole ring of the essential His82. This variant enzyme has only residual catalase activity and contains haem b instead of the normal haem d. The H82A variant demonstrates low catalase and phenol oxidase activities (0.2 and 20% of those of recombinant wild-type catalase-phenol oxidase, respectively). The N155A and N155H variants exhibit 4.5 and 3% of the wild-type catalase activity and contain haem d, showing that Asn155 is essential for catalysis but is not required for the conversion of haem b to haem d. Structural analysis suggests that the cause of the effect of these mutations on catalysis is the disruption of the ability of dioxygen substrates to efficiently access the active site. Additional mutants have been characterized biochemically to further probe the roles of the different channels. Introducing smaller or polar side chains in place of Val123 reduces the catalase activity. The F160V, F161V and F168V mutants show a marked decrease in catalase activity but have a much lower effect on the phenol oxidase activity, despite containing substoichiometric amounts of haem.

-	~~==About this Structure==~~	+	Investigating the active centre of the Scytalidium thermophilum catalase.,Yuzugullu Y, Trinh CH, Fairhurst L, Ogel ZB, McPherson MJ, Pearson AR Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Apr 1;69(Pt 4):369-75., doi: 10.1107/S1744309113004211. Epub 2013 Mar 28. PMID:23545640<ref>PMID:23545640</ref>
-	~~[[4b2y]] is a~~ 4 ~~chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Scytalidium_thermophilum Scytalidium thermophilum]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id~~=~~4B2Y OCA~~].	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+
		+	==See Also==
		+	*[[Catalase\|Catalase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Catalase]]		[[Category: Catalase]]
	[[Category: Scytalidium thermophilum]]		[[Category: Scytalidium thermophilum]]
-	[[Category: McPherson, M J.]]	+	[[Category: McPherson, M J]]
-	[[Category: Ogel, Z B.]]	+	[[Category: Ogel, Z B]]
-	[[Category: Pearson, A R.]]	+	[[Category: Pearson, A R]]
-	[[Category: Trinh, C H.]]	+	[[Category: Trinh, C H]]
-	[[Category: Yuzugullu, Y.]]	+	[[Category: Yuzugullu, Y]]
	[[Category: Molecular channel]]		[[Category: Molecular channel]]
	[[Category: Oxidative activity]]		[[Category: Oxidative activity]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 19:26, 17 April 2013

OCA — Wed, 17 Apr 2013 19:26:35 GMT

←Older revision		Revision as of 19:26, 17 April 2013
Line 1:		Line 1:
	{{STRUCTURE_4b2y\| PDB=4b2y \| SCENE= }}		{{STRUCTURE_4b2y\| PDB=4b2y \| SCENE= }}
	===Probing the active center of catalase-phenol oxidase from Scytalidium thermophilum===		===Probing the active center of catalase-phenol oxidase from Scytalidium thermophilum===
		+	{{ABSTRACT_PUBMED_23545640}}

	==About this Structure==		==About this Structure==

OCA at 22:39, 10 April 2013

OCA — Wed, 10 Apr 2013 22:39:13 GMT

←Older revision		Revision as of 22:39, 10 April 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4b2y\| PDB=4b2y \| SCENE= }}
		+	===Probing the active center of catalase-phenol oxidase from Scytalidium thermophilum===

-	~~The entry~~ 4b2y is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4b2y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Scytalidium_thermophilum Scytalidium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2Y OCA].
-	~~Authors~~: ~~Yuzugullu~~, Y., ~~Trinh, C~~.~~H.,~~ Pearson, A.R., ~~Ogel, Z~~.~~B., McPherson~~, ~~M.J~~.	+	[[Category: Catalase]]
-		+	[[Category: Scytalidium thermophilum]]
-	~~Description~~: ~~Probing the active center of catalase-phenol oxidase from Scytalidium thermophilum~~	+	[[Category: McPherson, M J.]]
		+	[[Category: Ogel, Z B.]]
		+	[[Category: Pearson, A R.]]
		+	[[Category: Trinh, C H.]]
		+	[[Category: Yuzugullu, Y.]]
		+	[[Category: Molecular channel]]
		+	[[Category: Oxidative activity]]
		+	[[Category: Oxidoreductase]]

OCA at 05:11, 15 August 2012

OCA — Wed, 15 Aug 2012 05:11:35 GMT

←Older revision		Revision as of 05:11, 15 August 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4b2y is ON HOLD	+	The entry 4b2y is ON HOLD until Paper Publication

	Authors: Yuzugullu, Y., Trinh, C.H., Pearson, A.R., Ogel, Z.B., McPherson, M.J.		Authors: Yuzugullu, Y., Trinh, C.H., Pearson, A.R., Ogel, Z.B., McPherson, M.J.

	Description: Probing the active center of catalase-phenol oxidase from Scytalidium thermophilum		Description: Probing the active center of catalase-phenol oxidase from Scytalidium thermophilum

OCA: Protected "4b2y" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 06:39:36 GMT

Protected "4b2y" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:39, 25 July 2012