4b7q - Revision history

OCA at 07:02, 31 August 2022

OCA — Wed, 31 Aug 2022 07:02:47 GMT

←Older revision		Revision as of 07:02, 31 August 2022
Line 3:		Line 3:
	<StructureSection load='4b7q' size='340' side='right'caption='[[4b7q]], [[Resolution\|resolution]] 2.73Å' scene=''>		<StructureSection load='4b7q' size='340' side='right'caption='[[4b7q]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b7q]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Influenza_a_virus_(a/california/07/2009(h1n1)) Influenza a virus (a/california/07/2009(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4B7Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b7q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_a_virus_(a/california/07/2009(h1n1)) Influenza a virus (a/california/07/2009(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B7Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4b7j\|4b7j]], [[4b7m\|4b7m]], [[4b7n\|4b7n]], [[4b7r\|4b7r]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4b7j\|4b7j]], [[4b7m\|4b7m]], [[4b7n\|4b7n]], [[4b7r\|4b7r]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4b7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b7q OCA], [~~http~~://pdbe.org/4b7q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4b7q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4b7q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4b7q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b7q OCA], [https://pdbe.org/4b7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b7q RCSB], [https://www.ebi.ac.uk/pdbsum/4b7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b7q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/C7FH46_9INFA C7FH46_9INFA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]	+	[[https://www.uniprot.org/uniprot/C7FH46_9INFA C7FH46_9INFA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Neuraminidase\|Neuraminidase]]	+	*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:57, 13 March 2019

OCA — Wed, 13 Mar 2019 12:57:43 GMT

←Older revision		Revision as of 12:57, 13 March 2019
Line 1:		Line 1:

	==H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis==		==H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis==
-	<StructureSection load='4b7q' size='340' side='right' caption='[[4b7q]], [[Resolution\|resolution]] 2.73Å' scene=''>	+	<StructureSection load='4b7q' size='340' side='right'caption='[[4b7q]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4b7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/california/07/2009(h1n1)) Influenza a virus (a/california/07/2009(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B7Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[4b7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/california/07/2009(h1n1)) Influenza a virus (a/california/07/2009(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B7Q FirstGlance]. <br>
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Boucher, C A.B]]		[[Category: Boucher, C A.B]]
	[[Category: Collins, P J]]		[[Category: Collins, P J]]
Line 37:		Line 38:
	[[Category: Skehel, J J]]		[[Category: Skehel, J J]]
	[[Category: Vachieri, S G]]		[[Category: Vachieri, S G]]
-	[[Category: Vries, E ~~Van Der~~]]	+	[[Category: Vries, E van der]]
	[[Category: Walker, P A]]		[[Category: Walker, P A]]
	[[Category: Xiong, X]]		[[Category: Xiong, X]]

OCA at 02:37, 11 December 2016

OCA — Sun, 11 Dec 2016 02:37:50 GMT

←Older revision		Revision as of 02:37, 11 December 2016
Line 1:		Line 1:
		+
	==H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis==		==H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis==
	<StructureSection load='4b7q' size='340' side='right' caption='[[4b7q]], [[Resolution\|resolution]] 2.73Å' scene=''>		<StructureSection load='4b7q' size='340' side='right' caption='[[4b7q]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4b7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Viruses Viruses~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B7Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4b7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/california/07/2009(h1n1)) Influenza a virus (a/california/07/2009(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B7Q FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4b7j\|4b7j]], [[4b7m\|4b7m]], [[4b7n\|4b7n]], [[4b7r\|4b7r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4b7j\|4b7j]], [[4b7m\|4b7m]], [[4b7n\|4b7n]], [[4b7r\|4b7r]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b7q RCSB], [http://www.ebi.ac.uk/pdbsum/4b7q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b7q OCA], [http://pdbe.org/4b7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b7q RCSB], [http://www.ebi.ac.uk/pdbsum/4b7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b7q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4b7q" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Viruses]]
	[[Category: Boucher, C A.B]]		[[Category: Boucher, C A.B]]
	[[Category: Collins, P J]]		[[Category: Collins, P J]]

OCA at 08:59, 15 February 2015

OCA — Sun, 15 Feb 2015 08:59:00 GMT

←Older revision		Revision as of 08:59, 15 February 2015
Line 1:		Line 1:
-	[[~~Image:~~4b7q.~~png~~\|~~left~~\|~~200px~~]]	+	==H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis==
		+	<StructureSection load='4b7q' size='340' side='right' caption='[[4b7q]], [[Resolution\|resolution]] 2.73Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4b7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B7Q FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4b7j\|4b7j]], [[4b7m\|4b7m]], [[4b7n\|4b7n]], [[4b7r\|4b7r]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b7q RCSB], [http://www.ebi.ac.uk/pdbsum/4b7q PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/C7FH46_9INFA C7FH46_9INFA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Two classes of antiviral drugs, neuraminidase inhibitors and adamantanes, are approved for prophylaxis and therapy against influenza virus infections. A major concern is that antiviral resistant viruses emerge and spread in the human population. The 2009 pandemic H1N1 virus is already resistant to adamantanes. Recently, a novel neuraminidase inhibitor resistance mutation I223R was identified in the neuraminidase of this subtype. To understand the resistance mechanism of this mutation, the enzymatic properties of the I223R mutant, together with the most frequently observed resistance mutation, H275Y, and the double mutant I223R/H275Y were compared. Relative to wild type, K(M) values for MUNANA increased only 2-fold for the single I223R mutant and up to 8-fold for the double mutant. Oseltamivir inhibition constants (K(I)) increased 48-fold in the single I223R mutant and 7500-fold in the double mutant. In both cases the change was largely accounted for by an increased dissociation rate constant for oseltamivir, but the inhibition constants for zanamivir were less increased. We have used X-ray crystallography to better understand the effect of mutation I223R on drug binding. We find that there is shrinkage of a hydrophobic pocket in the active site as a result of the I223R change. Furthermore, R223 interacts with S247 which changes the rotamer it adopts and, consequently, binding of the pentoxyl substituent of oseltamivir is not as favorable as in the wild type. However, the polar glycerol substituent present in zanamivir, which mimics the natural substrate, is accommodated in the I223R mutant structure in a similar way to wild type, thus explaining the kinetic data. Our structural data also show that, in contrast to a recently reported structure, the active site of 2009 pandemic neuraminidase can adopt an open conformation.

-	~~{{STRUCTURE_4b7q\| PDB=4b7q \| SCENE= }}~~	+	H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis.,van der Vries E, Collins PJ, Vachieri SG, Xiong X, Liu J, Walker PA, Haire LF, Hay AJ, Schutten M, Osterhaus AD, Martin SR, Boucher CA, Skehel JJ, Gamblin SJ PLoS Pathog. 2012 Sep;8(9):e1002914. doi: 10.1371/journal.ppat.1002914. Epub 2012, Sep 20. PMID:23028314<ref>PMID:23028314</ref>

-	~~===H1N1 2009 Pandemic Influenza Virus: Resistance~~ of the ~~I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_23028314}}~~	+	==See Also==
-		+	*[[Neuraminidase\|Neuraminidase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4b7q~~]] ~~is a 4 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7Q OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Viruses]]		[[Category: Viruses]]
-	[[Category: Boucher, C A.B.]]	+	[[Category: Boucher, C A.B]]
-	[[Category: Collins, P J.]]	+	[[Category: Collins, P J]]
-	[[Category: Gamblin, S J.]]	+	[[Category: Gamblin, S J]]
-	[[Category: Haire, L F.]]	+	[[Category: Haire, L F]]
-	[[Category: Hay, A J.]]	+	[[Category: Hay, A J]]
-	[[Category: Liu, J.]]	+	[[Category: Liu, J]]
-	[[Category: Martin, S R.]]	+	[[Category: Martin, S R]]
-	[[Category: Osterhaus, A D.M E.]]	+	[[Category: Osterhaus, A D.M E]]
-	[[Category: Schutten, M.]]	+	[[Category: Schutten, M]]
-	[[Category: Skehel, J J.]]	+	[[Category: Skehel, J J]]
-	[[Category: Vachieri, S G.]]	+	[[Category: Vachieri, S G]]
-	[[Category: Vries, E Van Der.]]	+	[[Category: Vries, E Van Der]]
-	[[Category: Walker, P A.]]	+	[[Category: Walker, P A]]
-	[[Category: Xiong, X.]]	+	[[Category: Xiong, X]]
	[[Category: Antiviral resistance]]		[[Category: Antiviral resistance]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-	[[Category: Nai]]
	[[Category: Nai]]		[[Category: Nai]]
	[[Category: Neuraminidase inhibitor]]		[[Category: Neuraminidase inhibitor]]
	[[Category: Oseltamivir]]		[[Category: Oseltamivir]]

OCA at 06:18, 10 October 2012

OCA — Wed, 10 Oct 2012 06:18:07 GMT

←Older revision		Revision as of 06:18, 10 October 2012
Line 1:		Line 1:
-	[[Image:4b7q.~~jpg~~\|left\|200px]]	+	[[Image:4b7q.png\|left\|200px]]

	{{STRUCTURE_4b7q\| PDB=4b7q \| SCENE= }}		{{STRUCTURE_4b7q\| PDB=4b7q \| SCENE= }}
Line 5:		Line 5:
	===H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis===		===H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis===

		+	{{ABSTRACT_PUBMED_23028314}}

	==About this Structure==		==About this Structure==

OCA at 06:24, 3 October 2012

OCA — Wed, 03 Oct 2012 06:24:24 GMT

←Older revision		Revision as of 06:24, 3 October 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4b7q.jpg\|left\|200px]]

-	~~The entry~~ 4b7q ~~is ON HOLD~~	+	{{STRUCTURE_4b7q\| PDB=4b7q \| SCENE= }}

-	~~Authors~~: ~~Liu, J., van der Vries, E., Vachieri, S.G., Xiong, X., Collins, P.J., Walker, P.A., Haire, L.F., Hay, A.J., Schutten, M., Osterhaus, A.D.M.E., Martin, S.R., Boucher, C.B., Skehel, J.J., Gamblin, S.J.~~	+	===H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis===

-	~~Description~~: ~~H1N1 2009 Pandemic Influenza Virus~~: ~~Resistance of the I223R~~ Neuraminidase ~~Mutant Explained by Kinetic and Structural Analysis~~	+
		+	==About this Structure==
		+	[[4b7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7Q OCA].
		+	[[Category: Viruses]]
		+	[[Category: Boucher, C A.B.]]
		+	[[Category: Collins, P J.]]
		+	[[Category: Gamblin, S J.]]
		+	[[Category: Haire, L F.]]
		+	[[Category: Hay, A J.]]
		+	[[Category: Liu, J.]]
		+	[[Category: Martin, S R.]]
		+	[[Category: Osterhaus, A D.M E.]]
		+	[[Category: Schutten, M.]]
		+	[[Category: Skehel, J J.]]
		+	[[Category: Vachieri, S G.]]
		+	[[Category: Vries, E Van Der.]]
		+	[[Category: Walker, P A.]]
		+	[[Category: Xiong, X.]]
		+	[[Category: Antiviral resistance]]
		+	[[Category: Hydrolase]]
		+	[[Category: Nai]]
		+	[[Category: Nai]]
		+	[[Category: Neuraminidase inhibitor]]
		+	[[Category: Oseltamivir]]

OCA: Protected "4b7q" [edit=sysop:move=sysop]

OCA — Wed, 29 Aug 2012 04:36:26 GMT

Protected "4b7q" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:36, 29 August 2012

OCA: New page: '''Unreleased structure''' The entry 4b7q is ON HOLD Authors: Liu, J., van der Vries, E., Vachieri, S.G., Xiong, X., Collins, P.J., Walker, P.A., Haire, L.F., Hay, A.J., Schutten, M., O...

OCA — Wed, 29 Aug 2012 04:36:25 GMT

New page: '''Unreleased structure''' The entry 4b7q is ON HOLD Authors: Liu, J., van der Vries, E., Vachieri, S.G., Xiong, X., Collins, P.J., Walker, P.A., Haire, L.F., Hay, A.J., Schutten, M., O...

New page

'''Unreleased structure'''

The entry 4b7q is ON HOLD

Authors: Liu, J., van der Vries, E., Vachieri, S.G., Xiong, X., Collins, P.J., Walker, P.A., Haire, L.F., Hay, A.J., Schutten, M., Osterhaus, A.D.M.E., Martin, S.R., Boucher, C.B., Skehel, J.J., Gamblin, S.J.

Description: H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis